• Article
  

  Guidelines and recommendations on yeast cell death nomenclature 

  Carmona Gutiérrez, D.; Bauer, M. A.; Zimmermann, A.; Aguilera López, Andrés; Austriaco, N.; Ayscough, K.; Balzan, R.; Bar-Nun, S.; Madeo, F. (Shared Science Publishers, 2018)

  Elucidating the biology of yeast in its full complexity has major implications for science, medicine and industry. One of ...

• Article
  

  Golgi localisation of GMAP210 requires two distinct cis-membrane binding mechanisms 

  Cárdenas, Jesús; Rivero Canalejo, Sabrina; Goud, Bruno; Bornens, Michel; Ríos, Rosa M. (BMC, 2009)

  Background The Golgi apparatus in mammals appears as a ribbon made up of interconnected stacks of flattened cisternae ...

• Article
  

  Looping the (R) Loop in DSB Repair via RNA Methylation 

  Gómez González, Belén; Aguilera López, Andrés (Elsevier, 2020)

  In this issue of Molecular Cell, Zhang et al. (2020) reveal that ATM triggers RNA methylation of DNA-RNA hybrids formed ...

• Article
  

  ATRX-Deficient High-Grade Glioma Cells Exhibit Increased Sensitivity to RTK and PDGFR Inhibitors 

  Pladevall Morera, David; Castejón Griñán, María; Aguilera, Paula; Gaardahl, Karina; Ingham, Andreas; Brosnan Cashman, Jacqueline A.; Meeker, Alan K.; López Contreras, Andrés J. (MDPI, 2022)

  High-grade glioma, including anaplastic astrocytoma and glioblastoma (GBM) patients, have a poor prognosis due to the lack ...

• Article
  

  MutSβ regulates G4-associated telomeric R-loops to maintain telomere integrity in ALT cancer cells 

  Sakellariou, Despoina; Bak, Sara Thornby; Isik, Esin; Barroso Ceballos, Sonia Inés; Porro, Antonio; Aguilera López, Andrés; Bartek, Jiri; Janscak, Pavel; Peña Díaz, Javier (Elsevier, 2022)

  Up to 15% of human cancers maintain their telomeres through a telomerase-independent mechanism, termed “alternative ...

• Article
  

  Homologous recombination and Mus81 promote replication completion in response to replication fork blockage 

  Pardo, Benjamín; Moriel Carretero, María; Vicat, Thibaud; Aguilera López, Andrés; Pasero, Philippe (Wiley-Blackwell, 2020)

  Impediments to DNA replication threaten genome stability. The homologous recombination (HR) pathway has been involved in ...

• Article
  

  Architecture and nucleic acids recognition mechanism of the THO complex, an mRNP assembly factor 

  Peña, Álvaro; Gewartowski, Kamil; Mroczek, Seweryn; Cuéllar, Jorge; Szykowska, Aleksandra; Prokop, Andrzej; Czarnocki-Cieciura, Mariusz; Piwowarski, Jan; Tous Rivera, Cristina; Aguilera López, Andrés; Carrascosa, José L.; Valpuesta, José María; Dziembowski, Andrzej (Wiley-Blackwell, 2012)

  The THO complex is a key factor in co-transcriptional formation of export-competent messenger ribonucleoprotein particles, ...

• Article
  

  XRCC1 Prevents Replication Fork Instability during Misincorporation of the DNA Demethylation Bases 5-Hydroxymethyl-2′-Deoxycytidine and 5-Hydroxymethyl-2′-Deoxyuridine 

  Peña Gómez, Mª José; Suárez Pizarro, Marina; Valle Rosado, Iván (MDPI, 2022)

  Whilst avoidance of chemical modifications of DNA bases is essential to maintain genome stability, during evolution ...

• Article
  

  VID22 counteracts G-quadruplex-induced genome instability 

  Galati, Elena; Bosio, Maria C.; Novarina, Daniele; Chiara, Matteo; Bernini, Giulia M.; Mozzarelli, Alessandro M.; García Rubio, María Luisa; Gómez González, Belén; Aguilera López, Andrés; Carzaniga, Thomas; Todisco, Marco; Bellini, Tommaso; Nava, Giulia M.; Frige, Gianmaria; Lazzaro, Federico (Oxford University Press, 2021)

  Genome instability is a condition characterized by the accumulation of genetic alterations and is a hallmark of cancer ...

• Article
  

  Immune signaling kinases in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) 

  García García, Raquel; Martín Herrero, Laura; Blanca Pariente, Laura; Pérez Cabello, Jesús; Roodveldt, Cintia (Multidisciplinary Digital Publishing Institute (MDPI), 2021)

  Amyotrophic lateral sclerosis (ALS) is the most common neurodegenerative disorder of motor neurons in adults, with a median ...

• Article
  

  Distinct responses of human peripheral blood cells to different misfolded protein oligomers 

  Leal Lasarte, Magdalena; Mannini, Benedetta; Chiti, Fabrizio; Vendruscolo, Michele; Dobson, Christopher M.; Roodveldt, Cintia; Pozo Pérez, David (Wiley-Blackwell, 2021)

  Increasing evidence indicates that peripheral immune cells play a prominent role in neurodegeneration connected to protein ...

• Article
  

  Non-recombinogenic roles for Rad52 in translesion synthesis during DNA damage tolerance 

  Cano Linares, María Isabel; Yáñez Vilches, Aurora; García Rodríguez, Néstor; Barrientos Moreno, Marta; González Prieto, Román; San Segundo, Pedro; Ulrich, Helle D.; Prado, Félix (Wiley-Blackwell, 2021)

  DNA damage tolerance relies on homologous recombination (HR) and translesion synthesis (TLS) mechanisms to fill in the ...

• Article
  

  A CDK-regulated chromatin segregase promoting chromosome replication 

  Chacin, Erika; Bansal, Priyanka; Reusswig, Karl-Uwe; Díaz Santín, Luis M.; Ortega Moreno, Pedro; Vizjak, Petra; Gómez González, Belén; Müller-Planitz, Felix; Aguilera López, Andrés; Pfander, Boris; Cheung, Alan C. M.; Kurat, Christoph F. (Springer Nature, 2021)

  The replication of chromosomes during S phase is critical for cellular and organismal function. Replicative stress can ...

• Article
  

  A transcription-based mechanism for oncogenic β-catenin-induced lethality in BRCA1/2-deficient cells 

  Dagg, Rebecca A.; Zonderland, Gijs; Puig Lombardi, Emilia; Rossetti, Giacomo G.; Groelly, Florian J.; Barroso Ceballos, Sonia Inés; Tacconi, Eliana M. C.; Wright, Benjamin; Lockstone, Helen; Aguilera López, Andrés; Halazonetis, Thanos D.; Tarsounas, Madalena (Springer Nature, 2021)

  BRCA1 or BRCA2 germline mutations predispose to breast, ovarian and other cancers. High-throughput sequencing of tumour ...

• Article
  

  Harmful R-loops are prevented via different cell cycle-specific mechanisms 

  San Martín Alonso, Marta; Soler Oliva, María Eugenia; García Rubio, María Luisa; García Muse, Tatiana; Aguilera López, Andrés (Springer Nature, 2021)

  Identifying how R-loops are generated is crucial to know how transcription compromises genome integrity. We show by ...

• Article
  

  Dna-rna hybrids at dsbs interfere with repair by homologous recombination 

  Ortega Moreno, Pedro; Mérida Cerro, José Antonio; García Rondón, Ana; Gómez González, Belén; Aguilera López, Andrés (eLife Sciences Publications, 2021)

  DNA double-strand breaks (DSBs) are the most harmful DNA lesions and their repair is crucial for cell viability and genome ...

• Article
  

  White Button Mushroom Extracts Modulate Hepatic Fibrosis Progression, Inflammation, and Oxidative Stress In Vitro and in LDLR-/- Mice 

  Gallego Yerga, Paloma; Luque Sierra, Amparo; Falcón García, Gonzalo; Carbonero Aguilar, María del Pilar; Grande Santamaría, Lourdes; Bautista Palomas, Juan Dionisio; Martín, Franz (MDPI, 2021)

  Liver fibrosis can be caused by non-alcoholic steatohepatitis (NASH), among other conditions. We performed a study to ...

• Article
  

  Nuclear Envelope Integrity in Health and Disease: Consequences on Genome Instability and Inflammation 

  Gauthier, Benoit R.; Comaills, Valentine (Multidisciplinary Digital Publishing Institute (MDPI), 2021)

  The dynamic nature of the nuclear envelope (NE) is often underestimated. The NE protects, regulates, and organizes the ...

• Article
  

  Thyroid hormones in diabetes, cancer, and aging 

  Gauthier, Benoit R.; Sola García, Alejandro; Cáliz Molina, María Ángeles; Lorenzo, Petra Isabel; Cobo Vuilleumier, Nadia (Wiley, 2020)

  Thyroid function is central in the control of physiological and pathophysiological processes. Studies in animal models and ...

• Article
  

  Molecular modelling of islet β-cell adaptation to inflammation in pregnancy and gestational diabetes mellitus 

  Lorenzo, Petra I.; Martín Montalvo, Alejandro; Cobo Vuilleumier, Nadia; Gauthier, Benoit R. (Multidisciplinary Digital Publishing Institute (MDPI), 2019)

  Gestational diabetes mellitus (GDM), a metabolic disease that develops with the increase in insulin resistance during late ...

View more