• Article
  

  Thyroid hormones in diabetes, cancer, and aging 

  Gauthier, Benoit R.; Sola García, Alejandro; Cáliz Molina, María Ángeles; Lorenzo, Petra Isabel; Cobo Vuilleumier, Nadia (Wiley, 2020)

  Thyroid function is central in the control of physiological and pathophysiological processes. Studies in animal models and ...

• Article
  

  Molecular modelling of islet β-cell adaptation to inflammation in pregnancy and gestational diabetes mellitus 

  Lorenzo, Petra I.; Martín Montalvo, Alejandro; Cobo Vuilleumier, Nadia; Gauthier, Benoit R. (Multidisciplinary Digital Publishing Institute (MDPI), 2019)

  Gestational diabetes mellitus (GDM), a metabolic disease that develops with the increase in insulin resistance during late ...

• Article
  

  TDP2 suppresses genomic instability induced by androgens in the epithelial cells of prostate glands 

  Al Mahmud, Md Rasel; Ishii, Kenichiro; Bernal Lozano, Cristina; Delgado Sainz, Irene; Toi, Masakazu; Akamatsu, Shusuke; Fukumoto, Manabu; Watanabe, Masatoshi; Takeda, Shunichi; Cortés Ledesma, Felipe; Sasanuma, Hiroyuki (Wiley-Blackwell, 2020)

  Androgens stimulate the proliferation of epithelial cells in the prostate by activating topoisomerase 2 (TOP2) and regulating ...

• Article
  

  The antitumor drugs trabectedin and lurbinectedin induce transcription-dependent replication stress and genome instability 

  Tumini, Emanuela; Herrera Moyano, Emilia; San Martín Alonso, Marta; Barroso Ceballos, Sonia Inés; Galmarini, Carlos María; Aguilera López, Andrés (American Association for Cancer Research, 2019)

  R-loops are a major source of replication stress, DNA damage, and genome instability, which are major hallmarks of cancer ...

• Article
  

  The need to regulate replication fork speed 

  Gómez González, Belén María; Aguilera López, Andrés (American Association for the Advancement of Science, 2017)
• Article
  

  DNA-RNA hybrids: The risks of DNA breakage during transcription 

  Aguilera López, Andrés; Gómez González, Belén María (Springer Nature, 2017)

  Although R loops can occur at different genomic locations, the factors that determine their formation and frequency remain ...

• Article
  

  Transcription-replication conflicts: How they occur and how they are resolved 

  García Muse, Tatiana; Aguilera López, Andrés (Springer Nature, 2016)

  The frequent occurrence of transcription and DNA replication in cells results in many encounters, and thus conflicts, ...

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  Histone H3E73Q and H4E53A mutations cause recombinogenic DNA damage 

  Ortega Moreno, Pedro; García Pichardo, Desiré; San Martín Alonso, Marta; García Rondón, Ana; Gómez González, Belén María; Aguilera López, Andrés (Shared Science Publishers OG, 2020)

  The stability and function of eukaryotic genomes is closely linked to histones and to chromatin structure. The state of ...

• Article
  

  Harmful DNA:RNA hybrids are formed in cis and in a Rad51-independent manner 

  Lafuente Barquero, Juan; García Rubio, María Luisa; San Martín Alonso, Marta; Gómez González, Belén; Aguilera López, Andrés (eLife Sciences Publications, 2020)

  DNA:RNA hybrids constitute a well-known source of recombinogenic DNA damage. The current literature is in agreement with ...

• Article
  

  Histone deacetylases facilitate the accurate repair of broken forks 

  Gómez González, Belén; Ortega Moreno, Pedro; Aguilera López, Andrés (Taylor & Francis, 2020)

  We have recently uncovered that loss of the yeast histone deacetylases Rpd3 (Reduced Potassium Dependency 3) and Hda1 ...

• Article
  

  UAP56/DDX39B is a major cotranscriptional RNA–DNA helicase that unwinds harmful R loops genome-wide 

  Pérez Calero, Carmen; Bayona Feliu, Aleix; Xue, Xiaoyu; Barroso Ceballos, Sonia Inés; Muñoz Sánchez, Sergio; González Basallote, Víctor M.; Sung, Patrick; Aguilera López, Andrés (Cold Spring Harbor Laboratory Press, 2020)

  Nonscheduled R loops represent a major source of DNA damage and replication stress. Cells have different ways to prevent ...

• Article
  

  The THO Complex as a Paradigm for the Prevention of Cotranscriptional R-Loops 

  Luna Varo, Rosa María; García Rondón, Ana; Pérez Calero, Carmen; Salas Armenteros, Irene; Aguilera López, Andrés (Cold Spring Harbor Laboratory Press, 2019)

  Different proteins associate with the nascent RNA and the RNA polymerase (RNAP) to catalyze the transcription cycle and ...

• Article
  

  Spontaneous DNA-RNA hybrids: differential impacts throughout the cell cycle 

  Gómez González, Belén; Barroso Ceballos, Sonia Inés; Herrera Moyano, Emilia; Aguilera López, Andrés (Taylor & Francis, 2020)

  A large body of research supports that transcription plays a major role among the many sources of replicative stress ...

• Article
  

  Retinal pigment epithelium degeneration caused by aggregation of PRPF31 and the role of HSP70 family of proteins 

  Valdés Sánchez, Lourdes; Calado, Sofía M.; Cerda, Berta De la; Aramburu, Ana; García Delgado, Ana Belén; Massalini, Simone; Montero Sánchez, Adoración; Bhatia, Vaibhav; Rodríguez Bocanegra, Eduardo; Diez Lloret, Andrea; Rodríguez Martínez, Daniel; Chakarova, Christina; Bhattacharya, Shomi S.; Díaz Corrales, Francisco Javier (BMC (part of Springer Nature), 2020)

  Mutations in pre-mRNA splicing factor PRPF31 can lead to retinitis pigmentosa (RP). Although the exact disease mechanism ...

• Article
  

  Therapeutic Potential of Mesenchymal Stem Cells for Cancer Therapy 

  Hmadcha, Abdelkrim; Martín Montalvo, Alejandro; Gauthier, Benoit R.; Soria Escoms, Bernat; Capilla González, Vivian (Frontiers Media S.A., 2020)

  Mesenchymal stem cells (MSCs) are among the most frequently used cell type for regenerative medicine. A large number of ...

• Article
  

  Endogenous topoisomerase II-mediated DNA breaks drive thymic cancer predisposition linked to ATM deficiency 

  Álvarez Quilón, Alejandro; Terrón Bautista, José; Delgado Sainz, Irene; Serrano Benítez, Almudena; Romero Granados, Rocío; Martínez García, Pedro Manuel; Jimeno González, Silvia; Bernal Lozano, Cristina; Quintero, Cristina; García Quintanilla, Lourdes; Cortés Ledesma, Felipe (Springer Nature, 2020)

  The ATM kinase is a master regulator of the DNA damage response to double-strand breaks (DSBs) and a well-established ...

• Article
  

  PHF2 regulates homology-directed DNA repair by controlling the resection of DNA double strand breaks 

  Alonso de la Vega, Ignacio; Paz Cabrera, María Cristina; Rother, Magdalena B; Wiegant, Wouter W; Checa Rodríguez, Cintia; Hernández Fernaud, Juan Ramón; Huertas, Pablo; Freire, Raimundo; Attikum, Haico van; Smits, Veronique A J (Oxford University Press, 2020)

  Post-translational histone modifications and chromatin remodelling play a critical role controlling the integrity of the ...

• Article
  

  Programming Skeletal Muscle Metabolic Flexibility in Offspring of Male Rats in Response to Maternal Consumption of Slow Digesting Carbohydrates during Pregnancy 

  Pérez Alegre, Mónica; Salto, Rafael; Girón, María D.; Manzano, Manuel; Martín, María J.; Vílchez, Jose D.; Bueno Vargas, Pilar; Andújar, Eloísa (MDPI, 2020)

  Skeletal muscle plays a relevant role in metabolic flexibility and fuel usage and the associated muscle metabolic inflexibility ...

• Article
  

  Crosstalk between chromatin structure, cohesin activity and transcription 

  Maya Miles, Douglas; Andújar, Eloísa; Pérez Alegre, Mónica; Murillo Pineda, Marina; Barrientos Moreno, Marta; Cabello Lobato, María José; Gómez Marín, Elena; Morillo Huesca, Macarena; Prado, Félix (BMC (part of Springer Nature), 2019)

  Background: A complex interplay between chromatin and topological machineries is critical for genome architec‑ ture and ...

• Article
  

  Sumoylation of Smc5 Promotes Error-free Bypass at Damaged Replication Forks 

  Zapatka, Mariel; Pociño Merino, Irene; Heluani Gahete, Hayat; Bermúdez López, Marcelino; Tarrés, Marc; Ibars, Eva; Solé Soler, Roger; Gutiérrez Escribano, Pilar; Apostolova, Sonia; Casas, Celia; Aragon, Luis; Wellinger, Ralf Erik; Colomina, Neus; Torres Rosell, Jordi (Elsevier (Cell Press): OAJ, 2019)

  Replication of a damaged DNA template can threaten the integrity of the genome, requiring the use of various mechanisms ...

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