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  Actin nucleators safeguard replication forks by limiting nascent strand degradation 

  Nieminuszczy, J.; Martin, P. R.; Broderick, R.; Krwawicz, J.; Kanellou, A.; Mocanu, C.; Bousgouni, V.; Smith, C.; Aguilera López, Andrés; Niedzwiedz, Wojciech (Oxford University Press, 2023)

  Accurate genome replication is essential for all life and a key mechanism of disease prevention, underpinned by the ability ...

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  Cell consequences of loss of function of the epigenetic factor EHMT1 

  Iglesias Ortega, Lucía; Megías Fernández, Clara; Domínguez Giménez, Paloma; Jimeno González, Silvia; Rivero Canalejo, Sabrina (Elsevier, 2023)

  EHMT1 is an epigenetic factor with histone methyltransferase activity that appears mutated in Kleefstra syndrome, a ...

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  WASp modulates RPA function on single-stranded DNA in response to replication stress and DNA damage. 

  Han, Seong Su; Wen, Kuo Kuang; García Rubio, María Luisa; Wold, Marc S.; Aguilera López, Andrés; Niedzwiedz, Wojciech; Vyas, Yatin M. (Nature Research, 2022)

  Perturbation in the replication-stress response (RSR) and DNA-damage response (DDR) causes genomic instability. Genomic ...

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  DDX47, MeCP2, and other functionally heterogeneous factors protect cells from harmful R loops 

  Marchena Cruz, Esther; Camino, Lola P.; Bhandari, Jay; Pinela Da Silva, Sonia Cristina; Marqueta Gracia, José Javier; Amdeen, Shahad A.; Guillén Mendoza, Cristina; García Rubio, María Luisa; Calderón Montaño, José Manuel; Xue, Xiaoyu; Luna Varo, Rosa María; Aguilera López, Andrés (Elsevier, 2023)

  Unscheduled R loops can be a source of genome instability, a hallmark of cancer cells. Although targeted proteomic ...

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  CtIP-mediated Alternative mRNA Splicing Fine-tunes the DNA Damage Response 

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  In order to survive to the exposure of DNA damaging agents, cells activate a complex response that coordinates the cellular ...

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  Limiting glutamine utilization activates a GCN2/TRAIL-R2/Caspase-8 apoptotic pathway in glutamine-addicted tumor cells 

  Yerbes, Rosario; Mora Molina, Rocío; Fernández Farrán, F. Javier; Hiraldo, Laura; López Rivas, Abelardo; Palacios, Carmen (Springer Nature, 2022)

  Oncogenic transformation leads to changes in glutamine metabolism that make transformed cells highly dependent on glutamine ...

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  FANCD2 maintains replication fork stability during misincorporation of the DNA demethylation products 5-hydroxymethyl-2’-deoxycytidine and 5-hydroxymethyl-2’-deoxyuridine 

  Peña Gómez, Mª José; Moreno Gordillo, Paula; Narmonté, Milda; García Calderón, Clara Beatriz; Ruksenaité, Audronė; Klimašauskas, Saulius; Valle Rosado, Iván (Springer Nature, 2022)

  Fanconi anemia (FA) is a rare hereditary disorder caused by mutations in any one of the FANC genes. FA cells are mainly ...

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  Adaptive response of saccharomyces hosts to totiviridae L-A dsRNA viruses Is achieved through intrinsically balanced action of targeted transcription factors 

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  Totiviridae L-A virus is a widespread yeast dsRNA virus. The persistence of the L-A virus alone appears to be symptomless, ...

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  Glutamine, MTOR and autophagy: a multiconnection relationship 

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  Cancer cells metabolize glutamine mostly through glutaminolysis, a metabolic pathway that activates MTORC1. The AMPK-MTORC1 ...

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  CENP-V is required for proper chromosome segregation through interaction with spindle microtubules in mouse oocytes 

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  Proper chromosome segregation is essential to avoid aneuploidy, yet this process fails with increasing age in mammalian ...

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  Topoisomerase 1-dependent R-loop deficiency drives accelerated replication and genomic instability 

  Sarni, Dan; Barroso Ceballos, Sonia Inés; Shtrikman, Alon; Irony-Tur Sinai, Michal; Oren, Yifat S.; Aguilera López, Andrés; Kerem, Batsheva (Elsevier, 2022)

  DNA replication is a complex process tightly regulated to ensure faithful genome duplication, and its perturbation leads ...

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  Titanium Surface Characteristics Induce the Specific Reprogramming of Toll-like Receptor Signaling in Macrophages 

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  Most of the research on titanium-based dental implants (Ti-discs) is focused on how they are able to stimulate the formation ...

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  Manganese is a physiologically relevant TORC1 activator in yeast and mammals 

  Nicastro, Raffaele; Gaillard, Hélène; Zarzuela, Laura; Peli-Gulli, Marie-Pierre; Fernández García, Elisabet; Tomé, Mercedes; García Rodríguez, Néstor; Durán, Raúl V.; De Virgilio, Claudio; Wellinger, Ralf Erik (eLife Sciences Publications, 2022)

  The essential biometal manganese (Mn) serves as a cofactor for several enzymes that are crucial for the prevention of human ...

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  Guidelines and recommendations on yeast cell death nomenclature 

  Carmona Gutiérrez, D.; Bauer, M. A.; Zimmermann, A.; Aguilera López, Andrés; Austriaco, N.; Ayscough, K.; Balzan, R.; Bar-Nun, S.; Madeo, F. (Shared Science Publishers, 2018)

  Elucidating the biology of yeast in its full complexity has major implications for science, medicine and industry. One of ...

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  Golgi localisation of GMAP210 requires two distinct cis-membrane binding mechanisms 

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  Background The Golgi apparatus in mammals appears as a ribbon made up of interconnected stacks of flattened cisternae ...

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  Looping the (R) Loop in DSB Repair via RNA Methylation 

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  In this issue of Molecular Cell, Zhang et al. (2020) reveal that ATM triggers RNA methylation of DNA-RNA hybrids formed ...

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  ATRX-Deficient High-Grade Glioma Cells Exhibit Increased Sensitivity to RTK and PDGFR Inhibitors 

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  High-grade glioma, including anaplastic astrocytoma and glioblastoma (GBM) patients, have a poor prognosis due to the lack ...

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  MutSβ regulates G4-associated telomeric R-loops to maintain telomere integrity in ALT cancer cells 

  Sakellariou, Despoina; Bak, Sara Thornby; Isik, Esin; Barroso Ceballos, Sonia Inés; Porro, Antonio; Aguilera López, Andrés; Bartek, Jiri; Janscak, Pavel; Peña Díaz, Javier (Elsevier, 2022)

  Up to 15% of human cancers maintain their telomeres through a telomerase-independent mechanism, termed “alternative ...

• Article
  

  Homologous recombination and Mus81 promote replication completion in response to replication fork blockage 

  Pardo, Benjamín; Moriel Carretero, María; Vicat, Thibaud; Aguilera López, Andrés; Pasero, Philippe (Wiley-Blackwell, 2020)

  Impediments to DNA replication threaten genome stability. The homologous recombination (HR) pathway has been involved in ...

• Article
  

  Architecture and nucleic acids recognition mechanism of the THO complex, an mRNP assembly factor 

  Peña, Álvaro; Gewartowski, Kamil; Mroczek, Seweryn; Cuéllar, Jorge; Szykowska, Aleksandra; Prokop, Andrzej; Czarnocki-Cieciura, Mariusz; Piwowarski, Jan; Tous Rivera, Cristina; Aguilera López, Andrés; Carrascosa, José L.; Valpuesta, José María; Dziembowski, Andrzej (Wiley-Blackwell, 2012)

  The THO complex is a key factor in co-transcriptional formation of export-competent messenger ribonucleoprotein particles, ...

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