Browsing Artículos (Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER)) by Title
Now showing items 1-20 of 144
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267 Spanish Exomes Reveal Population-Specific Differences in Disease-Related Genetic Variation
(Oxford University Press, 2016)Recent results from large-scale genomic projects suggest that allele frequencies, which are highly relevant for medical ...
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A CDK-regulated chromatin segregase promoting chromosome replication
(Springer Nature, 2021)The replication of chromosomes during S phase is critical for cellular and organismal function. Replicative stress can ...
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A Meiotic Checkpoint Alters Repair Partner Bias to Permit Inter-sister Repair of Persistent DSBs
(Elsevier B.V., 2019)Accurate meiotic chromosome segregation critically depends on the formation of inter-homolog crossovers initiated by ...
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A population of hematopoietic stem cells derives from GATA4-expressing progenitors located in the placenta and lateral mesoderm of mice
(Ferrata Storti Foundation, 2017)GATA transcription factors are expressed in the mesoderm and endoderm during development. GATA1-3, but not GATA4, ...
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A positioned +1 nucleosome enhances promoter-proximal pausing
(Oxford University Press, 2015)Chromatin distribution is not uniform along the human genome. In most genes there is a promoter-associated nucleosome free ...
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A transcription-based mechanism for oncogenic β-catenin-induced lethality in BRCA1/2-deficient cells
(Springer Nature, 2021)BRCA1 or BRCA2 germline mutations predispose to breast, ovarian and other cancers. High-throughput sequencing of tumour ...
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Adipose-derived mesenchymal stem cells (AdMSC) for the treatment of secondary-progressive multiple sclerosis: A triple blinded, placebo controlled, randomized phase I/II safety and feasibility study
(Public Library of Science, 2018)Background Currently available treatments for secondary progressive multiple sclerosis(SPMS) have limited efficacy ...
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Analysis of the relationship between coexpression domains and chromatin 3D organization
(Public Library of Science, 2017)Gene order is not random in eukaryotic chromosomes, and co-regulated genes tend to be clustered. The mechanisms that ...
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Application of flow focusing to the break-up of a magnetite suspension jet for the production of paramagnetic microparticles
(2011)Paramagnetic particles offer an extensive improvement in the magnetic separation or purification of a wide variety of ...
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Architecture and nucleic acids recognition mechanism of the THO complex, an mRNP assembly factor
(Wiley-Blackwell, 2012)The THO complex is a key factor in co-transcriptional formation of export-competent messenger ribonucleoprotein particles, ...
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ATRX-Deficient High-Grade Glioma Cells Exhibit Increased Sensitivity to RTK and PDGFR Inhibitors
(MDPI, 2022)High-grade glioma, including anaplastic astrocytoma and glioblastoma (GBM) patients, have a poor prognosis due to the lack ...
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BRCA1 Accelerates CtIP-Mediated DNA-End Resection
(Elsevier, 2014)DNA-end resection is a highly regulated and critical step in the response and repair of DNA double-strand breaks. In ...
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CDK targets Sae2 to control DNA-end resection and homologous recombination
(Nature Publishing Group, 2008)DNA double-strand breaks (DSBs) are repaired by two principal mechanisms: non-homologous end-joining (NHEJ) and homologous ...
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Cells Deficient in the Fanconi Anemia Protein FANCD2 are Hypersensitive to the Cytotoxicity and DNA Damage Induced by Coffee and Caffeic Acid
(MDPI AG, 2016)Epidemiological studies have found a positive association between coffee consumption and a lower risk of cardiovascular ...
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Chaperoned amyloid proteins for immune manipulation: a-Synuclein/Hsp70 shifts immunity toward a modulatory phenotype
(Wiley Open Access, 2014)α-Synuclein (αSyn) is a 140-residue amyloid-forming protein whose aggregation is linked to Parkinson's disease (PD). It ...
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Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programme
(Nature Publishing Group, 2017)Mutations in chromatin modifier genes are frequently associated with neurodevelopmental diseases. We herein demonstrate ...
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Commentary: Immunochemical Markers of the Amyloid Cascade in the Hippocampus in Motor Neuron Diseases
(Frontiers Media, 2017)In case we needed reminding, age-related neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease ...
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Competing roles of DNA end resection and non-homologous end joining functions in the repair of replication-born double-strand breaks by sister-chromatid recombination
(Oxford University Press, 2013)While regulating the choice between homologous recombination and non-homologous end joining (NHEJ) as mechanisms of ...