Browsing Artículos (Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER)) by Title
Now showing items 34-53 of 146
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Editorial: Molecular chaperones and neurodegeneration
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EGF-induced adipose tissue mesothelial cells undergo functional vascular smooth muscle differentiation
(Nature Publishing Group, 2014)Recent studies suggested that the post-natal mesothelium retain differentiative potential of the embryonic mesothelium, ...
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Elongation Factor TFIIS Prevents Transcription Stress and R-Loop Accumulation to Maintain Genome Stability
(Elsevier, 2019)Although correlations between RNA polymerase II (RNAPII) transcription stress, R-loops, and genome instability have been ...
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Endogenous topoisomerase II-mediated DNA breaks drive thymic cancer predisposition linked to ATM deficiency
(Springer Nature, 2020)The ATM kinase is a master regulator of the DNA damage response to double-strand breaks (DSBs) and a well-established ...
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Epigenetic features of human telomeres
(Oxford University Press, 2018)Although subtelomeric regions in humans are heterochromatic, the epigenetic nature of human telomeres remains controversial. ...
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Expression of TDRD9 in a subset of lung carcinomas by CpG island hypomethylation protects from DNA damage
(Impact Journals, 2018)Tudor domain containing protein 9 (TDRD9) is a RNA helicase normally expressed in the germline, where it is involved in ...
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FANCD2 facilitates replication through common fragile sites
(Elsevier, 2016)Common fragile sites (CFSs) are genomic regions that are unstable under conditions of replicative stress. Although the ...
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Gene gating at nuclear pores prevents the formation of R loops
(Taylor and Francis Ltd., 2018)Transcription is an important source of genetic variability. A large amount of transcription-associated genome variation ...
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Gene-Diet Interactions in Type 2 Diabetes: The Chicken and Egg Debate
(MDPI, 2017)Consistent evidence from both experimental and human studies indicates that Type 2 diabetes mellitus (T2DM) is a complex ...
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Generation of a human iPS cell line from a patient with retinitis pigmentosa due to EYS mutation
(Elsevier, 2018-11-16)Retinitis pigmentosa (RP) is an inherited retinal degenerative disease. Mutations in EYS have been associated with autosomal ...
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Generation of a Vero-Based Packaging Cell Line to Produce SV40 Gene Delivery Vectors for Use in Clinical Gene Therapy Studies
(Elsevier, 2017)Replication-defective (RD) recombinant simian virus 40 (SV40)-based gene delivery vectors hold a great potential for ...
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Golgi localisation of GMAP210 requires two distinct cis-membrane binding mechanisms
(BMC, 2009)Background The Golgi apparatus in mammals appears as a ribbon made up of interconnected stacks of flattened cisternae ...
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Guidelines for DNA recombination and repair studies: Cellular assays of DNA repair pathways
(Shared Science Publishers OG, 2019)Understanding the plasticity of genomes has been greatly aided by assays for recombination, repair and mutagenesis. These ...
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Harmful DNA:RNA hybrids are formed in cis and in a Rad51-independent manner
(eLife Sciences Publications, 2020)DNA:RNA hybrids constitute a well-known source of recombinogenic DNA damage. The current literature is in agreement with ...
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Harmful R-loops are prevented via different cell cycle-specific mechanisms
(Springer Nature, 2021)Identifying how R-loops are generated is crucial to know how transcription compromises genome integrity. We show by ...
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Highly efficient neural conversion of human pluripotent stem cells in adherent and animal-free conditions
(Wiley, 2017)Neural differentiation of human embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs) can produce a ...
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Histone deacetylases facilitate the accurate repair of broken forks
(Taylor & Francis, 2020)We have recently uncovered that loss of the yeast histone deacetylases Rpd3 (Reduced Potassium Dependency 3) and Hda1 ...
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Histone depletion prevents telomere fusions in pre-senescent cells
(Public Library of Science, 2018-06-07)Upon telomerase inactivation, telomeres gradually shorten with each cell division until cells enter replicative senescence. ...
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Histone H3E73Q and H4E53A mutations cause recombinogenic DNA damage
(Shared Science Publishers OG, 2020)The stability and function of eukaryotic genomes is closely linked to histones and to chromatin structure. The state of ...
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Histone H3K56 Acetylation, Rad52, and Non-DNA Repair Factors Control Double-Strand Break Repair Choice with the Sister Chromatid
(Public Library of Science, 2013)DNA double-strand breaks (DSBs) are harmful lesions that arise mainly during replication. The choice of the sister chromatid ...