Browsing Artículos (Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER)) by Issue Date
Now showing items 1-20 of 163
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CDK targets Sae2 to control DNA-end resection and homologous recombination
(Nature Publishing Group, 2008)DNA double-strand breaks (DSBs) are repaired by two principal mechanisms: non-homologous end-joining (NHEJ) and homologous ...
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Transcription at the proximity of the nuclear pore: A role for the THP1-SAC3-SUS1-CDC31 (THSC) complex
(Landes Bioscience, 2009)A key aspect of eukaryotic gene expression is the coupling of transcription with RNA processing, polyadenylation and export. ...
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Dysfunction of the unfolded protein response increases neurodegeneration in aged rat hippocampus following proteasome inhibition
(Wiley-Blackwell, 2009)Dysfunctions of the ubiquitin proteasome system (UPS) have been proposed to be involved in the aetiology and/or progression ...
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Golgi localisation of GMAP210 requires two distinct cis-membrane binding mechanisms
(BMC, 2009)Background The Golgi apparatus in mammals appears as a ribbon made up of interconnected stacks of flattened cisternae ...
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TDP2/TTRAP Is the Major 5′-Tyrosyl DNA Phosphodiesterase Activity in Vertebrate Cells and Is Critical for Cellular Resistance to Topoisomerase II-induced DNA Damage
(American Society for Biochemistry and Molecular Biology, 2011)Topoisomerase II (Top2) activity involves an intermediate in which the topoisomerase is covalently bound to a DNA double-strand ...
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The Rad50 coiled-coil domain is indispensable for Mre11 complex functions
(Nature Publishing Group, 2011)The Mre11 complex (Mre11, Rad50 and Xrs2 in Saccharomyces cerevisiae) influences diverse functions in the DNA damage ...
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PS Integrins and Laminins: Key Regulators of Cell Migration during Drosophila Embryogenesis
(Public Library of Science, 2011)During embryonic development, there are numerous cases where organ or tissue formation depends upon the migration of ...
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Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers
(2011)One key step in gene expression is the biogenesis of mRNA ribonucleoparticle complexes (mRNPs). Formation of the mRNP ...
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Immunohistochemical assessment of Pax8 expression during pancreatic islet development and in human neuroendocrine tumors
(Springer Verlag, 2011)The paired box transcription factor Pax8 is critical for development of the eye, thyroid gland as well as the urinary and ...
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Application of flow focusing to the break-up of a magnetite suspension jet for the production of paramagnetic microparticles
(2011)Paramagnetic particles offer an extensive improvement in the magnetic separation or purification of a wide variety of ...
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Zim17/Tim15 links mitochondrial iron–sulfur cluster biosynthesis to nuclear genome stability
(Oxford University Press, 2011)Genomic instability is related to a wide-range of human diseases. Here, we show that mitochondrial iron–sulfur cluster ...
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The replication checkpoint protects fork stability by releasing transcribed genes from nuclear pores
(Elsevier, 2011)Transcription hinders replication fork progression and stability, and the Mec1/ATR checkpoint protects fork integrity. ...
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Inhibition of RhoA GTPase and the subsequent activation of PTP1B protects cultured hippocampal neurons against amyloid b toxicity
(BioMed Central, 2011)Background: Amyloid beta (Ab) is the main agent responsible for the advent and progression of Alzheimer’s disease. This ...