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  Limiting glutamine utilization activates a GCN2/TRAIL-R2/Caspase-8 apoptotic pathway in glutamine-addicted tumor cells 

  Yerbes, Rosario; Mora Molina, Rocío; Fernández Farrán, F. Javier; Hiraldo, Laura; López Rivas, Abelardo; Palacios, Carmen (Springer Nature, 2022)

  Oncogenic transformation leads to changes in glutamine metabolism that make transformed cells highly dependent on glutamine ...

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  FANCD2 maintains replication fork stability during misincorporation of the DNA demethylation products 5-hydroxymethyl-2’-deoxycytidine and 5-hydroxymethyl-2’-deoxyuridine 

  Peña Gómez, Mª José; Moreno Gordillo, Paula; Narmonté, Milda; García Calderón, Clara Beatriz; Ruksenaité, Audronė; Klimašauskas, Saulius; Valle Rosado, Iván (Springer Nature, 2022)

  Fanconi anemia (FA) is a rare hereditary disorder caused by mutations in any one of the FANC genes. FA cells are mainly ...

• Article
  

  Adaptive response of saccharomyces hosts to totiviridae L-A dsRNA viruses Is achieved through intrinsically balanced action of targeted transcription factors 

  Ravoitytė, Bazilė; Lukša, Juliana; Wellinger, Ralf Erik; Serva, Saulius; Servienė, Elena (Multidisciplinary Digital Publishing Institute (MDPI), 2022)

  Totiviridae L-A virus is a widespread yeast dsRNA virus. The persistence of the L-A virus alone appears to be symptomless, ...

• Article
  

  Glutamine, MTOR and autophagy: a multiconnection relationship 

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  Cancer cells metabolize glutamine mostly through glutaminolysis, a metabolic pathway that activates MTORC1. The AMPK-MTORC1 ...

• Article
  

  CENP-V is required for proper chromosome segregation through interaction with spindle microtubules in mouse oocytes 

  Nabi, Dalileh; Drechsler, Hauke; Pschirer, Johannes; Korn, Franz; Schuler, Nadine; Diez, Stefan; Jessberger, Rolf; Chacón Rodríguez, Mariola (Springer Nature, 2021)

  Proper chromosome segregation is essential to avoid aneuploidy, yet this process fails with increasing age in mammalian ...

• Article
  

  Topoisomerase 1-dependent R-loop deficiency drives accelerated replication and genomic instability 

  Sarni, Dan; Barroso Ceballos, Sonia Inés; Shtrikman, Alon; Irony-Tur Sinai, Michal; Oren, Yifat S.; Aguilera López, Andrés; Kerem, Batsheva (Elsevier, 2022)

  DNA replication is a complex process tightly regulated to ensure faithful genome duplication, and its perturbation leads ...

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  Titanium Surface Characteristics Induce the Specific Reprogramming of Toll-like Receptor Signaling in Macrophages 

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  Most of the research on titanium-based dental implants (Ti-discs) is focused on how they are able to stimulate the formation ...

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  Manganese is a physiologically relevant TORC1 activator in yeast and mammals 

  Nicastro, Raffaele; Gaillard, Hélène; Zarzuela, Laura; Peli-Gulli, Marie-Pierre; Fernández García, Elisabet; Tomé, Mercedes; García Rodríguez, Néstor; Durán, Raúl V.; De Virgilio, Claudio; Wellinger, Ralf Erik (eLife Sciences Publications, 2022)

  The essential biometal manganese (Mn) serves as a cofactor for several enzymes that are crucial for the prevention of human ...

• Article
  

  Guidelines and recommendations on yeast cell death nomenclature 

  Carmona Gutiérrez, D.; Bauer, M. A.; Zimmermann, A.; Aguilera López, Andrés; Austriaco, N.; Ayscough, K.; Balzan, R.; Bar-Nun, S.; Madeo, F. (Shared Science Publishers, 2018)

  Elucidating the biology of yeast in its full complexity has major implications for science, medicine and industry. One of ...

• Article
  

  Golgi localisation of GMAP210 requires two distinct cis-membrane binding mechanisms 

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  Background The Golgi apparatus in mammals appears as a ribbon made up of interconnected stacks of flattened cisternae ...

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  Looping the (R) Loop in DSB Repair via RNA Methylation 

  Gómez González, Belén; Aguilera López, Andrés (Elsevier, 2020)

  In this issue of Molecular Cell, Zhang et al. (2020) reveal that ATM triggers RNA methylation of DNA-RNA hybrids formed ...

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  ATRX-Deficient High-Grade Glioma Cells Exhibit Increased Sensitivity to RTK and PDGFR Inhibitors 

  Pladevall Morera, David; Castejón Griñán, María; Aguilera, Paula; Gaardahl, Karina; Ingham, Andreas; Brosnan Cashman, Jacqueline A.; Meeker, Alan K.; López Contreras, Andrés J. (MDPI, 2022)

  High-grade glioma, including anaplastic astrocytoma and glioblastoma (GBM) patients, have a poor prognosis due to the lack ...

• Article
  

  MutSβ regulates G4-associated telomeric R-loops to maintain telomere integrity in ALT cancer cells 

  Sakellariou, Despoina; Bak, Sara Thornby; Isik, Esin; Barroso Ceballos, Sonia Inés; Porro, Antonio; Aguilera López, Andrés; Bartek, Jiri; Janscak, Pavel; Peña Díaz, Javier (Elsevier, 2022)

  Up to 15% of human cancers maintain their telomeres through a telomerase-independent mechanism, termed “alternative ...

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  Homologous recombination and Mus81 promote replication completion in response to replication fork blockage 

  Pardo, Benjamín; Moriel Carretero, María; Vicat, Thibaud; Aguilera López, Andrés; Pasero, Philippe (Wiley-Blackwell, 2020)

  Impediments to DNA replication threaten genome stability. The homologous recombination (HR) pathway has been involved in ...

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  Peña, Álvaro; Gewartowski, Kamil; Mroczek, Seweryn; Cuéllar, Jorge; Szykowska, Aleksandra; Prokop, Andrzej; Czarnocki-Cieciura, Mariusz; Piwowarski, Jan; Tous Rivera, Cristina; Aguilera López, Andrés; Carrascosa, José L.; Valpuesta, José María; Dziembowski, Andrzej (Wiley-Blackwell, 2012)

  The THO complex is a key factor in co-transcriptional formation of export-competent messenger ribonucleoprotein particles, ...

• Article
  

  XRCC1 Prevents Replication Fork Instability during Misincorporation of the DNA Demethylation Bases 5-Hydroxymethyl-2′-Deoxycytidine and 5-Hydroxymethyl-2′-Deoxyuridine 

  Peña Gómez, Mª José; Suárez Pizarro, Marina; Valle Rosado, Iván (MDPI, 2022)

  Whilst avoidance of chemical modifications of DNA bases is essential to maintain genome stability, during evolution ...

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  VID22 counteracts G-quadruplex-induced genome instability 

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  Genome instability is a condition characterized by the accumulation of genetic alterations and is a hallmark of cancer ...

• Article
  

  Immune signaling kinases in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) 

  García García, Raquel; Martín Herrero, Laura; Blanca Pariente, Laura; Pérez Cabello, Jesús; Roodveldt, Cintia (Multidisciplinary Digital Publishing Institute (MDPI), 2021)

  Amyotrophic lateral sclerosis (ALS) is the most common neurodegenerative disorder of motor neurons in adults, with a median ...

• Article
  

  Distinct responses of human peripheral blood cells to different misfolded protein oligomers 

  Leal Lasarte, Magdalena; Mannini, Benedetta; Chiti, Fabrizio; Vendruscolo, Michele; Dobson, Christopher M.; Roodveldt, Cintia; Pozo Pérez, David (Wiley-Blackwell, 2021)

  Increasing evidence indicates that peripheral immune cells play a prominent role in neurodegeneration connected to protein ...

• Chapter of Book
  

  Analysis of repair of replication-born double-strand breaks by sister chromatid recombination in yeast 

  Gómez González, Belén; Ortega Moreno, Pedro; Aguilera López, Andrés (Elsevier, 2021)

  The repair of DNA double-strand breaks is crucial for cell viability and the maintenance of genome integrity. When present, ...

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