• Chapter of Book
  

  Analysis of repair of replication-born double-strand breaks by sister chromatid recombination in yeast 

  Gómez González, Belén María; Ortega Moreno, Pedro; Aguilera López, Andrés (Elsevier, 2021)

  The repair of DNA double-strand breaks is crucial for cell viability and the maintenance of genome integrity. When present, ...

• Article
  

  Non-recombinogenic roles for Rad52 in translesion synthesis during DNA damage tolerance 

  Cano Linares, María Isabel; Yáñez Vilches, Aurora; García Rodríguez, Néstor; Barrientos Moreno, Marta; González Prieto, Román; San Segundo, Pedro; Ulrich, Helle D.; Prado, Félix (Wiley-Blackwell, 2021)

  DNA damage tolerance relies on homologous recombination (HR) and translesion synthesis (TLS) mechanisms to fill in the ...

• Article
  

  A CDK-regulated chromatin segregase promoting chromosome replication 

  Chacin, Erika; Bansal, Priyanka; Reusswig, Karl-Uwe; Díaz Santín, Luis M.; Ortega Moreno, Pedro; Vizjak, Petra; Gómez González, Belén María; Müller-Planitz, Felix; Aguilera López, Andrés; Pfander, Boris; Cheung, Alan C. M.; Kurat, Christoph F. (Springer Nature, 2021)

  The replication of chromosomes during S phase is critical for cellular and organismal function. Replicative stress can ...

• Article
  

  A transcription-based mechanism for oncogenic β-catenin-induced lethality in BRCA1/2-deficient cells 

  Dagg, Rebecca A.; Zonderland, Gijs; Puig Lombardi, Emilia; Rossetti, Giacomo G.; Groelly, Florian J.; Barroso Ceballos, Sonia Inés; Tacconi, Eliana M. C.; Wright, Benjamin; Lockstone, Helen; Aguilera López, Andrés; Halazonetis, Thanos D.; Tarsounas, Madalena (Springer Nature, 2021)

  BRCA1 or BRCA2 germline mutations predispose to breast, ovarian and other cancers. High-throughput sequencing of tumour ...

• Article
  

  Harmful R-loops are prevented via different cell cycle-specific mechanisms 

  San Martín Alonso, Marta; Soler Oliva, María Eugenia; García Rubio, María Luisa; García Muse, Tatiana; Aguilera López, Andrés (Springer Nature, 2021)

  Identifying how R-loops are generated is crucial to know how transcription compromises genome integrity. We show by ...

• Article
  

  Dna-rna hybrids at dsbs interfere with repair by homologous recombination 

  Ortega Moreno, Pedro; Mérida Cerro, José Antonio; García Rondón, Ana; Gómez González, Belén; Aguilera López, Andrés (eLife Sciences Publications, 2021)

  DNA double-strand breaks (DSBs) are the most harmful DNA lesions and their repair is crucial for cell viability and genome ...

• Article
  

  White Button Mushroom Extracts Modulate Hepatic Fibrosis Progression, Inflammation, and Oxidative Stress In Vitro and in LDLR-/- Mice 

  Gallego Yerga, Paloma; Luque Sierra, Amparo; Falcón García, Gonzalo; Carbonero Aguilar, María del Pilar; Grande Santamaría, Lourdes; Bautista Palomas, Juan Dionisio; Martín, Franz (MDPI, 2021)

  Liver fibrosis can be caused by non-alcoholic steatohepatitis (NASH), among other conditions. We performed a study to ...

• Article
  

  Nuclear Envelope Integrity in Health and Disease: Consequences on Genome Instability and Inflammation 

  Gauthier, Benoit R.; Comaills, Valentine (Multidisciplinary Digital Publishing Institute (MDPI), 2021)

  The dynamic nature of the nuclear envelope (NE) is often underestimated. The NE protects, regulates, and organizes the ...

• Article
  

  Thyroid hormones in diabetes, cancer, and aging 

  Gauthier, Benoit R.; Sola García, Alejandro; Cáliz Molina, María Ángeles; Lorenzo, Petra Isabel; Cobo Vuilleumier, Nadia (Wiley, 2020)

  Thyroid function is central in the control of physiological and pathophysiological processes. Studies in animal models and ...

• Article
  

  Molecular modelling of islet β-cell adaptation to inflammation in pregnancy and gestational diabetes mellitus 

  Lorenzo, Petra I.; Martín Montalvo, Alejandro; Cobo Vuilleumier, Nadia; Gauthier, Benoit R. (Multidisciplinary Digital Publishing Institute (MDPI), 2019)

  Gestational diabetes mellitus (GDM), a metabolic disease that develops with the increase in insulin resistance during late ...

• Article
  

  TDP2 suppresses genomic instability induced by androgens in the epithelial cells of prostate glands 

  Al Mahmud, Md Rasel; Ishii, Kenichiro; Bernal Lozano, Cristina; Delgado Sainz, Irene; Toi, Masakazu; Akamatsu, Shusuke; Fukumoto, Manabu; Watanabe, Masatoshi; Takeda, Shunichi; Cortés Ledesma, Felipe; Sasanuma, Hiroyuki (Wiley-Blackwell, 2020)

  Androgens stimulate the proliferation of epithelial cells in the prostate by activating topoisomerase 2 (TOP2) and regulating ...

• Article
  

  The antitumor drugs trabectedin and lurbinectedin induce transcription-dependent replication stress and genome instability 

  Tumini, Emanuela; Herrera Moyano, Emilia; San Martín Alonso, Marta; Barroso Ceballos, Sonia Inés; Galmarini, Carlos María; Aguilera López, Andrés (American Association for Cancer Research, 2019)

  R-loops are a major source of replication stress, DNA damage, and genome instability, which are major hallmarks of cancer ...

• Article
  

  The need to regulate replication fork speed 

  Gómez González, Belén María; Aguilera López, Andrés (American Association for the Advancement of Science, 2017)
• Article
  

  DNA-RNA hybrids: The risks of DNA breakage during transcription 

  Aguilera López, Andrés; Gómez González, Belén María (Springer Nature, 2017)

  Although R loops can occur at different genomic locations, the factors that determine their formation and frequency remain ...

• Article
  

  Transcription-replication conflicts: How they occur and how they are resolved 

  García Muse, Tatiana; Aguilera López, Andrés (Springer Nature, 2016)

  The frequent occurrence of transcription and DNA replication in cells results in many encounters, and thus conflicts, ...

• Article
  

  Histone H3E73Q and H4E53A mutations cause recombinogenic DNA damage 

  Ortega Moreno, Pedro; García Pichardo, Desiré; San Martín Alonso, Marta; García Rondón, Ana; Gómez González, Belén María; Aguilera López, Andrés (Shared Science Publishers OG, 2020)

  The stability and function of eukaryotic genomes is closely linked to histones and to chromatin structure. The state of ...

• Article
  

  Harmful DNA:RNA hybrids are formed in cis and in a Rad51-independent manner 

  Lafuente Barquero, Juan; García Rubio, María Luisa; San Martín Alonso, Marta; Gómez González, Belén; Aguilera López, Andrés (eLife Sciences Publications, 2020)

  DNA:RNA hybrids constitute a well-known source of recombinogenic DNA damage. The current literature is in agreement with ...

• Article
  

  Histone deacetylases facilitate the accurate repair of broken forks 

  Gómez González, Belén; Ortega Moreno, Pedro; Aguilera López, Andrés (Taylor & Francis, 2020)

  We have recently uncovered that loss of the yeast histone deacetylases Rpd3 (Reduced Potassium Dependency 3) and Hda1 ...

• Article
  

  UAP56/DDX39B is a major cotranscriptional RNA–DNA helicase that unwinds harmful R loops genome-wide 

  Pérez Calero, Carmen; Bayona Feliu, Aleix; Xue, Xiaoyu; Barroso Ceballos, Sonia Inés; Muñoz Sánchez, Sergio; González Basallote, Víctor M.; Sung, Patrick; Aguilera López, Andrés (Cold Spring Harbor Laboratory Press, 2020)

  Nonscheduled R loops represent a major source of DNA damage and replication stress. Cells have different ways to prevent ...

• Article
  

  The THO Complex as a Paradigm for the Prevention of Cotranscriptional R-Loops 

  Luna Varo, Rosa María; García Rondón, Ana; Pérez Calero, Carmen; Salas Armenteros, Irene; Aguilera López, Andrés (Cold Spring Harbor Laboratory Press, 2019)

  Different proteins associate with the nascent RNA and the RNA polymerase (RNAP) to catalyze the transcription cycle and ...

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