Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER)
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Article
Histone variant H2A.Z is needed for efficient transcription-coupled NER and genome integrity in UV challenged yeast cells
(Public Library of Science, 2024-09-10)The genome of living cells is constantly challenged by DNA lesions that interfere with cellular processes such as transcription ...
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Article
Spontaneous deamination of cytosine to uracil is biased to the non-transcribed DNA strand in yeast
(Elsevier, 2023-06)Transcription in Saccharomyces cerevisiae is associated with elevated mutation and this partially reflects enhanced damage ...
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Article
PLK1 Regulates CtIP and DNA2 Interplay in Long-range DNA end Resection.
(Cold Spring Harbor Laboratory Press, 2023)DNA double-strand break (DSB) repair is initiated by DNA end resection. CtIP acts in short-range resection to stimulate ...
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EXO1 and DNA2-mediated ssDNA gap expansion is essential for ATR activation and to maintain viability in BRCA1-deficient cells
(Oxford University Press, 2024-06-24)DNA replication faces challenges from DNA lesions originated from endogenous or exogenous sources of stress, leading to ...
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Article
Prevalence of dens invaginatus assessed by cbct: systematic review and meta-analysis
(Medicina Oral S.L, 2022)Background: Dens invaginatus is a developmental dental anomaly resulting from an invagination of dental tissues folding ...
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Prevalence of root canal treatments among diabetic patients: systematic review and meta-analysis
(Mdpi, 2023)(1) Apical periodontitis (AP) is the inflammatory response of the periapical tissue to bacterial antigens and toxins ...
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UBE2D3 Facilitates NHEJ by Orchestrating ATM Signalling through Multi-level Control of RNF168
(Springer Nature, 2024)Maintenance of genome integrity requires tight control of DNA damage response (DDR) signalling and repair, with phosphorylation ...
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Article
Physical interactions between specifically regulated subpopulations of the MCM and RNR complexes prevent genetic instability
(Public Library of Science, 2024-05-22)The helicase MCM and the ribonucleotide reductase RNR are the complexes that provide the substrates (ssDNA templates and ...
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Article
Roles of Extracellular Vesicles Associated Non-coding RNAs in Diabetes Mellitus
(Frontiers Media SA, 2022)Extracellular vesicles (EVs), especially exosomes (50 to 150 nm), have been shown to play important roles in a wide range ...
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Article
Physical Forces and Transient Nuclear Envelope Rupture During Metastasis: The Key for Success?
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)During metastasis, invading tumor cells and circulating tumor cells (CTC) face multiple mechanical challenges during ...
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Article
NR5A2/LRH-1 Regulates the PTGS2-PGE2-PTGER1 Pathway Contributing to Pancreatic Islet Survival and Function
(Elsevier, 2022)LRH-1/NR5A2 is implicated in islet morphogenesis postnatally, and its activation using the agonist BL001 protects islets ...
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The PTGS2/COX2-PGE2 Signaling Cascade in Inflammation: Pro or Anti? A Case Study with Type 1 Diabetes Mellitus
(Ivyspring International Publisher, 2023)Prostaglandins are lipid mediators involved in physiological processes, such as constriction or dilation of blood vessels, ...
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Article
Metabolic Reprogramming by Acly Inhibition Using SB-204990 Alters Glucoregulation and Modulates Molecular Mechanisms Associated with Aging
(Springer Nature, 2023)ATP-citrate lyase is a central integrator of cellular metabolism in the interface of protein, carbohydrate, and lipid ...
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Article
Enzyme-Responsive Zr-Based Metal-Organic Frameworks for Controlled Drug Delivery: Taking Advantage of Clickable PEG-Phosphate Ligands
(American Chemical Society, 2023)We report for the first time the controlled drug release from a nanoscale Zr-based metal-organic framework (MOF), UiO-66, ...
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Article
Expression of human RECQL5 in Saccharomyces cerevisiae causes transcription defects and transcription-associated genome instability
(Springer Nature, 2024-05-26)RECQL5 is a member of the conserved RecQ family of DNA helicases involved in the maintenance of genome stability that is ...
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Article
BRCA1/BARD1 ubiquitinates PCNA in unperturbed conditions to promote continuous DNA synthesis
(Nature Research, 2024-05-20)Deficiencies in the BRCA1 tumor suppressor gene are the main cause of hereditary breast and ovarian cancer. BRCA1 is ...
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Article
Sperm-contributed centrioles segregate stochastically into blastomeres of 4-cell stage Caenorhabditis elegans embryos
(Oxford University Press, 2023-03-29)Whereas both sperm and egg contribute nuclear genetic material to the zygote in metazoan organisms, the inheritance of ...
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Article
Structural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy
(Nature Research, 2024-01-17)ATTR amyloidosis is caused by the deposition of transthyretin in the form of amyloid fibrils in virtually every organ of ...
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Article
Nucleus-translocated mitochondrial cytochrome c liberates nucleophosmin-sequestered ARF tumor suppressor by changing nucleolar liquid-liquid phase separation.
(Nature Research, 2022-10-11)The regular functioning of the nucleolus and nucleus-mitochondria crosstalk are considered unrelated processes, yet ...
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Article
The chromatin network helps prevent cancer-associated mutagenesis at transcription-replication conflicts
(Nature Research, 2023)Genome instability is a feature of cancer cells, transcription being an important source of DNA damage. This is in large ...