Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER)
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Recent Submissions
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Molecular modelling of islet β-cell adaptation to inflammation in pregnancy and gestational diabetes mellitus [Article]
(Multidisciplinary Digital Publishing Institute (MDPI), 2019)Gestational diabetes mellitus (GDM), a metabolic disease that develops with the increase in insulin resistance during late ...
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TDP2 suppresses genomic instability induced by androgens in the epithelial cells of prostate glands [Article]
(Wiley-Blackwell, 2020)Androgens stimulate the proliferation of epithelial cells in the prostate by activating topoisomerase 2 (TOP2) and regulating ...
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The antitumor drugs trabectedin and lurbinectedin induce transcription-dependent replication stress and genome instability [Article]
(American Association for Cancer Research, 2019)R-loops are a major source of replication stress, DNA damage, and genome instability, which are major hallmarks of cancer ...
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The need to regulate replication fork speed [Article]
(American Association for the Advancement of Science, 2017) -
DNA-RNA hybrids: The risks of DNA breakage during transcription [Article]
(Springer Nature, 2017)Although R loops can occur at different genomic locations, the factors that determine their formation and frequency remain ...
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Transcription-replication conflicts: How they occur and how they are resolved [Article]
(Springer Nature, 2016)The frequent occurrence of transcription and DNA replication in cells results in many encounters, and thus conflicts, ...
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Histone H3E73Q and H4E53A mutations cause recombinogenic DNA damage [Article]
(Shared Science Publishers OG, 2020)The stability and function of eukaryotic genomes is closely linked to histones and to chromatin structure. The state of ...
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Harmful DNA:RNA hybrids are formed in cis and in a Rad51-independent manner [Article]
(eLife Sciences Publications, 2020)DNA:RNA hybrids constitute a well-known source of recombinogenic DNA damage. The current literature is in agreement with ...
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Histone deacetylases facilitate the accurate repair of broken forks [Article]
(Taylor & Francis, 2020)We have recently uncovered that loss of the yeast histone deacetylases Rpd3 (Reduced Potassium Dependency 3) and Hda1 ...
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UAP56/DDX39B is a major cotranscriptional RNA–DNA helicase that unwinds harmful R loops genome-wide [Article]
(Cold Spring Harbor Laboratory Press, 2020)Nonscheduled R loops represent a major source of DNA damage and replication stress. Cells have different ways to prevent ...
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The THO Complex as a Paradigm for the Prevention of Cotranscriptional R-Loops [Article]
(Cold Spring Harbor Laboratory Press, 2019)Different proteins associate with the nascent RNA and the RNA polymerase (RNAP) to catalyze the transcription cycle and ...
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Spontaneous DNA-RNA hybrids: differential impacts throughout the cell cycle [Article]
(Taylor & Francis, 2020)A large body of research supports that transcription plays a major role among the many sources of replicative stress ...
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Retinal pigment epithelium degeneration caused by aggregation of PRPF31 and the role of HSP70 family of proteins [Article]
(BMC (part of Springer Nature), 2020)Mutations in pre-mRNA splicing factor PRPF31 can lead to retinitis pigmentosa (RP). Although the exact disease mechanism ...
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Therapeutic Potential of Mesenchymal Stem Cells for Cancer Therapy [Article]
(Frontiers Media S.A., 2020)Mesenchymal stem cells (MSCs) are among the most frequently used cell type for regenerative medicine. A large number of ...
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Endogenous topoisomerase II-mediated DNA breaks drive thymic cancer predisposition linked to ATM deficiency [Article]
(Springer Nature, 2020)The ATM kinase is a master regulator of the DNA damage response to double-strand breaks (DSBs) and a well-established ...
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PHF2 regulates homology-directed DNA repair by controlling the resection of DNA double strand breaks [Article]
(Oxford University Press, 2020)Post-translational histone modifications and chromatin remodelling play a critical role controlling the integrity of the ...
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Programming Skeletal Muscle Metabolic Flexibility in Offspring of Male Rats in Response to Maternal Consumption of Slow Digesting Carbohydrates during Pregnancy [Article]
(MDPI, 2020)Skeletal muscle plays a relevant role in metabolic flexibility and fuel usage and the associated muscle metabolic inflexibility ...
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Crosstalk between chromatin structure, cohesin activity and transcription [Article]
(BMC (part of Springer Nature), 2019)Background: A complex interplay between chromatin and topological machineries is critical for genome architec‑ ture and ...
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Sumoylation of Smc5 Promotes Error-free Bypass at Damaged Replication Forks [Article]
(Elsevier (Cell Press): OAJ, 2019)Replication of a damaged DNA template can threaten the integrity of the genome, requiring the use of various mechanisms ...
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What causes an RNA-DNA hybrid to compromise genome integrity? [Article]
(Elsevier, 2019)Transcription is a source of genome instability that stimulates mutation and recombination. Part of the damage produced ...