Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER)
Collections in this community
Recent Submissions
-
Article
The chromatin network helps prevent cancer-associated mutagenesis at transcription-replication conflicts
(Nature Research, 2023)Genome instability is a feature of cancer cells, transcription being an important source of DNA damage. This is in large ...
-
Article
Break-induced RNA–DNA hybrids (BIRDHs) in homologous recombination: friend or foe?
(Wiley-Blackwell, 2023)Double-strand breaks (DSBs) are the most harmful DNA lesions, with a strong impact on cell proliferation and genome ...
-
Article
Mitochondrial Factors in the Cell Nucleus
(Multidisciplinary Digital Publishing Institute (MDPI), 2023)The origin of eukaryotic organisms involved the integration of mitochondria into the ancestor cell, with a massive gene ...
-
Article
Actin nucleators safeguard replication forks by limiting nascent strand degradation
(Oxford University Press, 2023)Accurate genome replication is essential for all life and a key mechanism of disease prevention, underpinned by the ability ...
-
Article
Cell consequences of loss of function of the epigenetic factor EHMT1
(Elsevier, 2023)EHMT1 is an epigenetic factor with histone methyltransferase activity that appears mutated in Kleefstra syndrome, a ...
-
Article
WASp modulates RPA function on single-stranded DNA in response to replication stress and DNA damage.
(Nature Research, 2022)Perturbation in the replication-stress response (RSR) and DNA-damage response (DDR) causes genomic instability. Genomic ...
-
Article
DDX47, MeCP2, and other functionally heterogeneous factors protect cells from harmful R loops
(Elsevier, 2023)Unscheduled R loops can be a source of genome instability, a hallmark of cancer cells. Although targeted proteomic ...
-
Article
CtIP-mediated Alternative mRNA Splicing Fine-tunes the DNA Damage Response
(Cold Spring Harbor Laboratory Press, 2021)In order to survive to the exposure of DNA damaging agents, cells activate a complex response that coordinates the cellular ...
-
Article
Limiting glutamine utilization activates a GCN2/TRAIL-R2/Caspase-8 apoptotic pathway in glutamine-addicted tumor cells
(Springer Nature, 2022)Oncogenic transformation leads to changes in glutamine metabolism that make transformed cells highly dependent on glutamine ...
-
Article
FANCD2 maintains replication fork stability during misincorporation of the DNA demethylation products 5-hydroxymethyl-2’-deoxycytidine and 5-hydroxymethyl-2’-deoxyuridine
(Springer Nature, 2022)Fanconi anemia (FA) is a rare hereditary disorder caused by mutations in any one of the FANC genes. FA cells are mainly ...
-
Article
Adaptive response of saccharomyces hosts to totiviridae L-A dsRNA viruses Is achieved through intrinsically balanced action of targeted transcription factors
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)Totiviridae L-A virus is a widespread yeast dsRNA virus. The persistence of the L-A virus alone appears to be symptomless, ...
-
Article
Glutamine, MTOR and autophagy: a multiconnection relationship
(Taylor & Francis, 2022)Cancer cells metabolize glutamine mostly through glutaminolysis, a metabolic pathway that activates MTORC1. The AMPK-MTORC1 ...
-
Article
CENP-V is required for proper chromosome segregation through interaction with spindle microtubules in mouse oocytes
(Springer Nature, 2021)Proper chromosome segregation is essential to avoid aneuploidy, yet this process fails with increasing age in mammalian ...
-
Article
Topoisomerase 1-dependent R-loop deficiency drives accelerated replication and genomic instability
(Elsevier, 2022)DNA replication is a complex process tightly regulated to ensure faithful genome duplication, and its perturbation leads ...
-
Article
Titanium Surface Characteristics Induce the Specific Reprogramming of Toll-like Receptor Signaling in Macrophages
(MDPI, 2022)Most of the research on titanium-based dental implants (Ti-discs) is focused on how they are able to stimulate the formation ...
-
Article
Manganese is a physiologically relevant TORC1 activator in yeast and mammals
(eLife Sciences Publications, 2022)The essential biometal manganese (Mn) serves as a cofactor for several enzymes that are crucial for the prevention of human ...
-
Article
Guidelines and recommendations on yeast cell death nomenclature
(Shared Science Publishers, 2018)Elucidating the biology of yeast in its full complexity has major implications for science, medicine and industry. One of ...
-
Article
Golgi localisation of GMAP210 requires two distinct cis-membrane binding mechanisms
(BMC, 2009)Background The Golgi apparatus in mammals appears as a ribbon made up of interconnected stacks of flattened cisternae ...
-
Article
Looping the (R) Loop in DSB Repair via RNA Methylation
(Elsevier, 2020)In this issue of Molecular Cell, Zhang et al. (2020) reveal that ATM triggers RNA methylation of DNA-RNA hybrids formed ...
-
Article
ATRX-Deficient High-Grade Glioma Cells Exhibit Increased Sensitivity to RTK and PDGFR Inhibitors
(MDPI, 2022)High-grade glioma, including anaplastic astrocytoma and glioblastoma (GBM) patients, have a poor prognosis due to the lack ...