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  Histone variant H2A.Z is needed for efficient transcription-coupled NER and genome integrity in UV challenged yeast cells 

  Gaillard, Hélène; Ciudad, Toni; Aguilera López, Andrés; Wellinger, Ralf Erik (Public Library of Science, 2024-09-10)

  The genome of living cells is constantly challenged by DNA lesions that interfere with cellular processes such as transcription ...

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  Spontaneous deamination of cytosine to uracil is biased to the non-transcribed DNA strand in yeast 

  Williams, Jonathan D.; Zhu, Demi; García Rubio, María Luisa; Shaltz, Samantha; Aguilera López, Andrés; Jinks-Robertson, Sue (Elsevier, 2023-06)

  Transcription in Saccharomyces cerevisiae is associated with elevated mutation and this partially reflects enhanced damage ...

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  PLK1 Regulates CtIP and DNA2 Interplay in Long-range DNA end Resection. 

  Ceppi, Ilaria; Cannavo, Elda; Bret, Helene; Camarillo Daza, María Rosa; Vivalda, Francesca; Thakur, Roshan Singh; Romero Franco, Amador; Sartori, Alessandro A.; Huertas Sánchez, Pablo; Guerois, Raphael; Cejka, Petr (Cold Spring Harbor Laboratory Press, 2023)

  DNA double-strand break (DSB) repair is initiated by DNA end resection. CtIP acts in short-range resection to stimulate ...

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  EXO1 and DNA2-mediated ssDNA gap expansion is essential for ATR activation and to maintain viability in BRCA1-deficient cells 

  García Rodríguez, Néstor; Domínguez García, Iria; Domínguez Pérez, María del Carmen; Huertas Sánchez, Pablo (Oxford University Press, 2024-06-24)

  DNA replication faces challenges from DNA lesions originated from endogenous or exogenous sources of stress, leading to ...

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  Prevalence of dens invaginatus assessed by cbct: systematic review and meta-analysis 

  González-Mancilla, Sara; Montero Miralles, Paloma; Sauco Márquez, Juan José; Areal Quecuty, Victoria; Cabanillas Balsera, Daniel; Segura Egea, Juan José (Medicina Oral S.L, 2022)

  Background: Dens invaginatus is a developmental dental anomaly resulting from an invagination of dental tissues folding ...

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  Prevalence of root canal treatments among diabetic patients: systematic review and meta-analysis 

  León-López, María; Cabanillas Balsera, Daniel; Martín González, Jenifer; Díaz Flores, Víctor; Areal Quecuty, Victoria; Crespo Gallardo, Isabel; Montero Miralles, Paloma; Segura Egea, Juan José (Mdpi, 2023)

  (1) Apical periodontitis (AP) is the inflammatory response of the periapical tissue to bacterial antigens and toxins ...

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  UBE2D3 Facilitates NHEJ by Orchestrating ATM Signalling through Multi-level Control of RNF168 

  Yalçin, Zeliha; Lam, Shiu Yeung; Peuscher, Marieke H.; van der Torre, Jaco; Zhu, Sha; Iyengar, Prasanna V.; Salas Lloret, Daniel; de Krijger, Inge; Moatti, Nathalie; van der Lugt, Ruben; González Prieto, Román; Jacobs, Jacqueline J.L. (Springer Nature, 2024)

  Maintenance of genome integrity requires tight control of DNA damage response (DDR) signalling and repair, with phosphorylation ...

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  Physical interactions between specifically regulated subpopulations of the MCM and RNR complexes prevent genetic instability 

  Yáñez Vilches, Aurora; Romero, Antonia M.; Barrientos Moreno, Marta; Cruz, Esther; González Prieto, Román; Sharma, Sushma; Vertegaal, Alfred C.O.; Prado, Félix (Public Library of Science, 2024-05-22)

  The helicase MCM and the ribonucleotide reductase RNR are the complexes that provide the substrates (ssDNA templates and ...

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  Roles of Extracellular Vesicles Associated Non-coding RNAs in Diabetes Mellitus 

  Gauthier, B.R.; Cobo Vuilleumier, Nadia; López Noriega, Livia (Frontiers Media SA, 2022)

  Extracellular vesicles (EVs), especially exosomes (50 to 150 nm), have been shown to play important roles in a wide range ...

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  Physical Forces and Transient Nuclear Envelope Rupture During Metastasis: The Key for Success? 

  Gauthier, B.R.; Lorenzo, P.I.; Comaills, Valentine (Multidisciplinary Digital Publishing Institute (MDPI), 2022)

  During metastasis, invading tumor cells and circulating tumor cells (CTC) face multiple mechanical challenges during ...

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  NR5A2/LRH-1 Regulates the PTGS2-PGE2-PTGER1 Pathway Contributing to Pancreatic Islet Survival and Function 

  Martin Vázquez, Eugenia; Cobo Vuilleumier, Nadia; Araujo Legido, Raquel; Marín Cañas, Sandra; Nola, Emanuele; Dorronsoro, Akaitz; López Bermudo, Lucía; Crespo, Alejandra; Romero Zerbo, Silvana Y.; Comaills, Valentine; Gauthier, Benoit R. (Elsevier, 2022)

  LRH-1/NR5A2 is implicated in islet morphogenesis postnatally, and its activation using the agonist BL001 protects islets ...

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  The PTGS2/COX2-PGE2 Signaling Cascade in Inflammation: Pro or Anti? A Case Study with Type 1 Diabetes Mellitus 

  Martín Vázquez, Eugenia; Cobo Vuilleumier, Nadia; López Noriega, Livia; Lorenzo, Petra I.; Gauthier, Benoit R. (Ivyspring International Publisher, 2023)

  Prostaglandins are lipid mediators involved in physiological processes, such as constriction or dilation of blood vessels, ...

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  Metabolic Reprogramming by Acly Inhibition Using SB-204990 Alters Glucoregulation and Modulates Molecular Mechanisms Associated with Aging 

  Sola García, Alejandro; Cáliz Molina, María Ángeles; Espadas, Isabel; Petr, Michael; Panadero Morón, Concepción; González Morán, Daniel; Martín Vázquez, María Eugenia; Narbona Pérez, Álvaro Jesús; López Noriega, Livia; Martínez Corrales, Guillermo; Martín Montalvo, Alejandro (Springer Nature, 2023)

  ATP-citrate lyase is a central integrator of cellular metabolism in the interface of protein, carbohydrate, and lipid ...

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  Enzyme-Responsive Zr-Based Metal-Organic Frameworks for Controlled Drug Delivery: Taking Advantage of Clickable PEG-Phosphate Ligands 

  Carrillo Carrión, Carolina; Comaills, Valentine; Visiga, Ana M.; Gauthier, Benoit R.; Khiar, Noureddine (American Chemical Society, 2023)

  We report for the first time the controlled drug release from a nanoscale Zr-based metal-organic framework (MOF), UiO-66, ...

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  Expression of human RECQL5 in Saccharomyces cerevisiae causes transcription defects and transcription-associated genome instability 

  Lafuente Barquero, Juan Francisco; Svejstrup, Jesper Q.; Luna Varo, Rosa María; Aguilera López, Andrés (Springer Nature, 2024-05-26)

  RECQL5 is a member of the conserved RecQ family of DNA helicases involved in the maintenance of genome stability that is ...

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  BRCA1/BARD1 ubiquitinates PCNA in unperturbed conditions to promote continuous DNA synthesis 

  Salas Lloret, Daniel; García Rodríguez, Néstor; Soto Hidalgo, Emily; González Vinceiro, Lourdes; Espejo Serrano, Carmen; Giebel, Lisanne; Huertas Sánchez, Pablo; González Prieto, Román (Nature Research, 2024-05-20)

  Deficiencies in the BRCA1 tumor suppressor gene are the main cause of hereditary breast and ovarian cancer. BRCA1 is ...

• Article
  

  Sperm-contributed centrioles segregate stochastically into blastomeres of 4-cell stage Caenorhabditis elegans embryos 

  Gönczy, Pierre; Romero Balestra, Fernando (Oxford University Press, 2023-03-29)

  Whereas both sperm and egg contribute nuclear genetic material to the zygote in metazoan organisms, the inheritance of ...

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  Structural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy 

  Nguyen, Binh An; Singh, Virender; Afrin, Shumaila; Yakubovska, Anna; Wang, Lanie; Ahmed, Yasmin; González Prieto, Román; Saelices, Lorena (Nature Research, 2024-01-17)

  ATTR amyloidosis is caused by the deposition of transthyretin in the form of amyloid fibrils in virtually every organ of ...

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  Nucleus-translocated mitochondrial cytochrome c liberates nucleophosmin-sequestered ARF tumor suppressor by changing nucleolar liquid-liquid phase separation. 

  González Arzola, Katiuska; Díaz Quintana, Antonio Jesús; Bernardo García, Noelia; Martínez Fábregas, Jonathan; Rivero Rodríguez, Francisco; Casado Combreras, Miguel Ángel; Elena-Real, Carlos A.; Velázquez Cruz, Alejandro; Gil Caballero, Sergio; Velázquez Campoy, Adrián; Szulc, Elzbieta; Gavilán Dorronzoro, María de la Paz; Ayala, Isabel; Arranz, Rocío; Ríos, Rosa M.; Salvatella, Xavier; Valpuesta, José María; Hermoso, Juan A.; Rosa Acosta, Miguel Ángel de la; Díaz Moreno, Irene (Nature Research, 2022-10-11)

  The regular functioning of the nucleolus and nucleus-mitochondria crosstalk are considered unrelated processes, yet ...

• Article
  

  The chromatin network helps prevent cancer-associated mutagenesis at transcription-replication conflicts 

  Bayona Feliu, Aleix; Herrera Moyano, Emilia; Badra Fajardo, Nibal; Galván Femenía, Iván; Soler Oliva, María Eugenia; Aguilera López, Andrés (Nature Research, 2023)

  Genome instability is a feature of cancer cells, transcription being an important source of DNA damage. This is in large ...

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