Browsing Artículos (Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER)) by Title
Now showing items 41-60 of 146
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Gene gating at nuclear pores prevents the formation of R loops
(Taylor and Francis Ltd., 2018)Transcription is an important source of genetic variability. A large amount of transcription-associated genome variation ...
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Gene-Diet Interactions in Type 2 Diabetes: The Chicken and Egg Debate
(MDPI, 2017)Consistent evidence from both experimental and human studies indicates that Type 2 diabetes mellitus (T2DM) is a complex ...
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Generation of a human iPS cell line from a patient with retinitis pigmentosa due to EYS mutation
(Elsevier, 2018-11-16)Retinitis pigmentosa (RP) is an inherited retinal degenerative disease. Mutations in EYS have been associated with autosomal ...
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Generation of a Vero-Based Packaging Cell Line to Produce SV40 Gene Delivery Vectors for Use in Clinical Gene Therapy Studies
(Elsevier, 2017)Replication-defective (RD) recombinant simian virus 40 (SV40)-based gene delivery vectors hold a great potential for ...
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Golgi localisation of GMAP210 requires two distinct cis-membrane binding mechanisms
(BMC, 2009)Background The Golgi apparatus in mammals appears as a ribbon made up of interconnected stacks of flattened cisternae ...
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Guidelines for DNA recombination and repair studies: Cellular assays of DNA repair pathways
(Shared Science Publishers OG, 2019)Understanding the plasticity of genomes has been greatly aided by assays for recombination, repair and mutagenesis. These ...
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Harmful DNA:RNA hybrids are formed in cis and in a Rad51-independent manner
(eLife Sciences Publications, 2020)DNA:RNA hybrids constitute a well-known source of recombinogenic DNA damage. The current literature is in agreement with ...
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Harmful R-loops are prevented via different cell cycle-specific mechanisms
(Springer Nature, 2021)Identifying how R-loops are generated is crucial to know how transcription compromises genome integrity. We show by ...
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Highly efficient neural conversion of human pluripotent stem cells in adherent and animal-free conditions
(Wiley, 2017)Neural differentiation of human embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs) can produce a ...
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Histone deacetylases facilitate the accurate repair of broken forks
(Taylor & Francis, 2020)We have recently uncovered that loss of the yeast histone deacetylases Rpd3 (Reduced Potassium Dependency 3) and Hda1 ...
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Histone depletion prevents telomere fusions in pre-senescent cells
(Public Library of Science, 2018-06-07)Upon telomerase inactivation, telomeres gradually shorten with each cell division until cells enter replicative senescence. ...
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Histone H3E73Q and H4E53A mutations cause recombinogenic DNA damage
(Shared Science Publishers OG, 2020)The stability and function of eukaryotic genomes is closely linked to histones and to chromatin structure. The state of ...
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Histone H3K56 Acetylation, Rad52, and Non-DNA Repair Factors Control Double-Strand Break Repair Choice with the Sister Chromatid
(Public Library of Science, 2013)DNA double-strand breaks (DSBs) are harmful lesions that arise mainly during replication. The choice of the sister chromatid ...
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Histone Mutants Separate R Loop Formation from Genome Instability Induction
(Elsevier, 2017)R loops have positive physiological roles, but they can also be deleterious by causing genome instability, and the mechanisms ...
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Homologous recombination and Mus81 promote replication completion in response to replication fork blockage
(Wiley-Blackwell, 2020)Impediments to DNA replication threaten genome stability. The homologous recombination (HR) pathway has been involved in ...
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Homologous Recombination: To Fork and Beyond
(MDPI, 2018)Accurate completion of genome duplication is threatened by multiple factors that hamper the advance and stability of the ...
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Human Mesenchymal Stem Cells Prevent Neurological Complications of Radiotherapy
(Frontiers Media S.A., 2019-05-16)Radiotherapy is a highly effective tool for the treatment of brain cancer. However, radiation also causes detrimental ...
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Human mitochondrial degradosome prevents harmful mitochondrial R loops and mitochondrial genome instability
(2018)R loops are nucleic acid structures comprising an DNA-RNA hybrid and a displaced single-stranded DNA. These structures may ...
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Human THO–Sin3A interaction reveals new mechanisms to prevent R-loops that cause genome instability
(Wiley-Blackwell, 2017)R-loops, formed by co-transcriptional DNA–RNA hybrids and a displaced DNA single strand (ssDNA), fulfill certain positive ...
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Immune signaling kinases in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD)
(Multidisciplinary Digital Publishing Institute (MDPI), 2021)Amyotrophic lateral sclerosis (ALS) is the most common neurodegenerative disorder of motor neurons in adults, with a median ...