Browsing Artículos (Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER)) by Title
Now showing items 91-110 of 147
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PAX4 preserves endoplasmic reticulum integrity preventing beta cell degeneration in a mouse model of type 1 diabetes mellitus
(Springer Nature, 2016)[Aims/hypothesis]: A strategy to enhance pancreatic islet functional beta cell mass (BCM) while restraining inflammation, ...
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PHF2 regulates homology-directed DNA repair by controlling the resection of DNA double strand breaks
(Oxford University Press, 2020)Post-translational histone modifications and chromatin remodelling play a critical role controlling the integrity of the ...
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Population Genetic Structure of the Grasshopper Eyprepocnemis plorans in the South and East of the Iberian Peninsula
(Public Library of Science, 2013)The grasshopper Eyprepocnemis plorans subsp. plorans harbors a very widespread polymorphism for supernumerary (B) chromosomes ...
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Potential use of adipose tissue stem cells in the control of aging
(Federation of Anti-Aging Medicine Societies, 2012)Cell therapy with adult stem cells is a new battle front for the control of aging. Before being used for this purpose, we ...
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Programming Skeletal Muscle Metabolic Flexibility in Offspring of Male Rats in Response to Maternal Consumption of Slow Digesting Carbohydrates during Pregnancy
(MDPI, 2020)Skeletal muscle plays a relevant role in metabolic flexibility and fuel usage and the associated muscle metabolic inflexibility ...
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PS Integrins and Laminins: Key Regulators of Cell Migration during Drosophila Embryogenesis
(Public Library of Science, 2011)During embryonic development, there are numerous cases where organ or tissue formation depends upon the migration of ...
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PTTG2 silencing results in induction of epithelial-to-mesenchymal transition and apoptosis
(Nature Publishing Group, 2013)Human securin, also known as human pituitary tumor-transforming gene 1 (pttg1), plays a key role in cell-cycle regulation. ...
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R Loops: From Physiologicalto Pathological Roles
(Elsevier, 2019-10-17)DNA-RNA hybrids play a physiological role in cellular processes, but often, they represent non-scheduled co-transcriptional ...
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Rat1p maintains RNA polymerase II CTD phosphorylation balance
(Cold Spring Harbor Laboratory Press, 2014)In S. cerevisiae, the 5′-3′ exonuclease Rat1p partakes in transcription termination. Although Rat1p-mediated RNA degradation ...
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Regulation of replication fork advance and stability by nucleosome assembly
(Multidisciplinary Digital Publishing Institute (MDPI), 2017)he advance of replication forks to duplicate chromosomes in dividing cells requires the disassembly of nucleosomes ahead ...
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Resveratrol Ameliorates the Maturation Process of β-Cell-Like Cells Obtained from an Optimized Differentiation Protocol of Human Embryonic Stem Cells
(Public Library of Science, 2015)Human embryonic stem cells (hESCs) retain the extraordinary capacity to differentiate into different cell types of an adult ...
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Retinal pigment epithelium degeneration caused by aggregation of PRPF31 and the role of HSP70 family of proteins
(BMC (part of Springer Nature), 2020)Mutations in pre-mRNA splicing factor PRPF31 can lead to retinitis pigmentosa (RP). Although the exact disease mechanism ...
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Rpd3L and Hda1 histone deacetylases facilitate repair of broken forks by promoting sister chromatid cohesion
(Nature Research, 2019)Genome stability involves accurate replication and DNA repair. Broken replication forks, such as those encountering a nick, ...
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Spontaneous DNA-RNA hybrids: differential impacts throughout the cell cycle
(Taylor & Francis, 2020)A large body of research supports that transcription plays a major role among the many sources of replicative stress ...
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SUMOylation of Rad52-Rad59 synergistically change the outcome of mitotic recombination
(Elsevier, 2016)Homologous recombination (HR) is essential for maintenance of genome stability through double-strand break (DSB) repair, ...
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Sumoylation of Smc5 Promotes Error-free Bypass at Damaged Replication Forks
(Elsevier (Cell Press): OAJ, 2019)Replication of a damaged DNA template can threaten the integrity of the genome, requiring the use of various mechanisms ...
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Targeting the centriolar replication factor STIL synergizes with DNA damaging agents for treatment of ovarian cancer
(Impact Journals, 2017)Advanced ovarian cancer is an incurable disease. Thus, novel therapies are required. We wished to identify new therapeutic ...
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TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcription
(Nature Publishing Group, 2017)DNA double-strand breaks (DSBs) induced by abortive topoisomerase II (TOP2) activity are a potential source of genome ...
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TDP2 suppresses genomic instability induced by androgens in the epithelial cells of prostate glands
(Wiley-Blackwell, 2020)Androgens stimulate the proliferation of epithelial cells in the prostate by activating topoisomerase 2 (TOP2) and regulating ...