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Artículo
Histone H3E73Q and H4E53A mutations cause recombinogenic DNA damage
(Shared Science Publishers OG, 2020)
The stability and function of eukaryotic genomes is closely linked to histones and to chromatin structure. The state of the chromatin not only affects the probability of DNA to undergo damage but also DNA repair. DNA damage ...
Artículo
The DNA damage response acts as a safeguardagainst harmful DNA–RNA hybrids ofdifferent origins
(EMBO Press, 2019-07-24)
Despite playing physiological roles in specific situations, DNA–RNA hybrids threat genome integrity. To investigate how cells do counteract spontaneous DNA–RNA hybrids, here we screen an siRNA library covering 240 human ...
Artículo
What causes an RNA-DNA hybrid to compromise genome integrity?
(Elsevier, 2019)
Transcription is a source of genome instability that stimulates mutation and recombination. Part of the damage produced by transcription is mediated by R-loops, non-B DNA structures that normally form by the re-annealing ...
Artículo
MutSβ regulates G4-associated telomeric R-loops to maintain telomere integrity in ALT cancer cells
(Elsevier, 2022)
Up to 15% of human cancers maintain their telomeres through a telomerase-independent mechanism, termed “alternative lengthening of telomeres” (ALT) that relies on homologous recombination between telomeric sequences. ...
Artículo
Elongation Factor TFIIS Prevents Transcription Stress and R-Loop Accumulation to Maintain Genome Stability
(Elsevier, 2019)
Although correlations between RNA polymerase II (RNAPII) transcription stress, R-loops, and genome instability have been established, the mechanisms underlying these connections remain poorly understood. Here, we used a ...
Artículo
Break-induced RNA–DNA hybrids (BIRDHs) in homologous recombination: friend or foe?
(Wiley-Blackwell, 2023)
Double-strand breaks (DSBs) are the most harmful DNA lesions, with a strong impact on cell proliferation and genome integrity. Depending on cell cycle stage, DSBs are preferentially repaired by non-homologous end joining ...
Artículo
Transcription as a Threat to Genome Integrity
(Annual Reviews Inc., 2016)
Genomes undergo different types of sporadic alterations, including DNA damage, point mutations, and genome rearrangements, that constitute the basis for evolution. However, these changes may occur at high levels as a result ...
Artículo
The chromatin network helps prevent cancer-associated mutagenesis at transcription-replication conflicts
(Nature Research, 2023)
Genome instability is a feature of cancer cells, transcription being an important source of DNA damage. This is in large part associated with R-loops, which hamper replication, especially at head-on transcription-replication ...
Artículo
Depletion of the MFAP1/SPP381 Splicing Factor Causes R-Loop-Independent Genome Instability
(Elsevier, 2019)
THO/TREX is a conserved complex with a role in messenger ribonucleoprotein biogenesis that links gene expression and genome instability. Here, we show that human THO interacts with MFAP1 (microfibrillar-associated protein ...
Artículo
The need to regulate replication fork speed
(American Association for the Advancement of Science, 2017)