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Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programme
(Nature Publishing Group, 2017)
Mutations in chromatin modifier genes are frequently associated with neurodevelopmental diseases. We herein demonstrate that the chromodomain helicase DNA-binding protein 7 (Chd7), frequently associated with CHARGE syndrome, ...
Non-redundant Functions of ATM and DNA-PKcs in Response to DNA Double-Strand Breaks
DNA double-strand breaks (DSBs) elicit the so-called DNA damage response (DDR), largely relying on ataxia telangiectasia mutated (ATM) and DNA-dependent protein kinase (DNA-PKcs), two members of the PI3K-like kinase family, ...