Listar Artículos (Química Orgánica) por título
Mostrando ítems 199-218 de 243
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Structure-Based Identification and Biological Characterization of New NAPRT Inhibitors
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)NAPRT, the rate-limiting enzyme of the Preiss–Handler NAD biosynthetic pathway, has emerged as a key biomarker for the ...
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Studies on the Synthesis of 2-Alkyl-5-aryl-1,3,4-oxadiazolines from N-Acylhydrazones
(2012)Reaction of N-acylhydrazones with benzyloxyacetyl chloride in the presence of i-Pr 2EtN affords new 1,3,4-oxadiazolines ...
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Syntheses and biological activities of 1,4-iminoalditol derivatives as α-L-fucosidase inhibitors
(Schweizerische Chemische Gesellschaft (Swiss Chemistry Society), 2011)A review dealing with 1,4-iminoalditol (hydroxylated pyrrolidine) derivatives as inhibitors of α-l-fucosidases including the different synthetic approaches for their preparation as well as their inhibitory properties is presented.
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Synthesis and Antiproliferative Activity of Sulfa-Michael Adducts and Thiochromenes Derived from Carbohydrates
(Royal Society of Chemistry, 2017)The Michael addition reactions of carbohydrate-derived nitroalkenes with ethyl thioglycolate and 2-mercaptobenzyl alcohol ...
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Synthesis and Biological Evaluation of Modified 2-Deoxystreptamine Dimers
(Thieme Publishing; Georg Thieme Verlag, 2011)Aminoglycosides are powerful antibiotics, but the emergence of resistant bacterial strains has prompted the search for ...
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Synthesis and cancer growth inhibitory activities of 2-fatty-alkylated pyrrolidine-3,4-diol derivatives
(Arkat USA, 2014)A series of new amphiphilic pyrrolidines containing dodecyl and oleyl apolar side chains were prepared and evaluated for ...
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Synthesis and Structure-activity Relationship of New Nicotinamide Phosphoribosyltransferase Inhibitors with Antitumor Activity on Solid and Haematological Cancer
(Elsevier, 2023)Cancer cells are highly dependent on Nicotinamide phosphoribosyltransferase (NAMPT) activity for proliferation, therefore ...
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Synthesis of axially chiral heterobiaryl alkynes via dynamic kinetic asymmetric alkynylation
(Wiley, 2016)The dynamic kinetic Pd0 -catalyzed alkynylation of racemic heterobiaryl sulfonates was used for the asymmetric synthesis ...
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Synthesis of hyperpolarizable biomaterials at molecular level based on pyridinium-chitosan complexes
(Universidade Federal do Espírito Santo, 2015)Potential NLO-phore materials based on chitosan are described for the first time in this study. A series of fluorescent ...
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Synthesis of Novel 3-Amino(Hydroxy)methyl-l-fuco-Azafagomines as Leads for Selective Inhibitors of α-l-Fucosidases
(2010)The synthesis of 3-substituted l-fuco-azafagomines from d-lyxose is reported. They represent the first example of ...
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Synthesis of sp2-Iminosugar Selenoglycolipids as Multitarget Drug Candidates with Antiproliferative, Leishmanicidal and Anti-Inflammatory Properties
(Multidisciplinary Digital Publishing Institute (MDPI), 2021)sp2-Iminosugar glycolipids (sp2-IGLs) represent a consolidated family of glycoconjugate mimetics encompassing a ...
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Synthesis of sugar oxazolines by intramolecular Ritter-like reaction of D-fructose precursors
(2004)Treatment of D-fructopyranose and D-fructofuranosc 1,2-O-acetonide derivatives with triflic acid in the presence of a ...
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Synthesis of tri- and tetramines containing two 2,3-dihydroxypyrrolidine moieties and their inhibitory activity toward α-mannosidases
(Arkat USA, 2002)Through the reductive amination of N-[(tert-butoxy)carbonyl]-2,5-dideoxy-2, 5-imino-3,4-O-isopropylidene-L-ribose with ...
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Synthesis of tri- and tetramines containing two 2,3-dihydroxypyrrolidine moieties and their inhibitory activity toward α-mannosidases
(ARKAT USA INC, 2002)Through the reductive amination of N-[(tert-butoxy)carbonyl]-2,5-dideoxy-2,5-imino-3,4-Oisopropylidene-L-ribose with ...
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Synthesis of unprecedented steroidal spiro heterocycles as potential antiproliferative drugs
(Elsevier, 2018-01-01)Herein we report the straightforward preparation of novel conformationally-restricted steroids from trans-androsterone and ...
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Synthesis of β-galactosylamides as Ligands of the Peanut Lectin. Insights into the Recognition Process
(Elsevier, 2017)The synthesis of mono and divalent β-galactosylamides linked to a hydroxylated chain having a C2 symmetry axis derived ...
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Synthesis of β-galactosylamides as ligands of the peanut lectin. Insights into the recognition process
(Elsevier, 2017)The synthesis of mono and divalent β-galactosylamides linked to a hydroxylated chain having a C2 symmetry axis derived ...
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Synthesis of “All-Cis” Trihydroxypiperidines from a Carbohydrate-Derived Ketone: Hints for the Design of New β-Gal and GCase Inhibitors
(MDPI, 2020)Pharmacological chaperones (PCs) are small compounds able to rescue the activity of mutated lysosomal enzymes when used ...
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Synthesis, characterisation and crystal structure of a three-dimensional network of an h-bonded Ni (II) Hexametylenetetramine complex
(Royal Society of Chemistry, 2010)A three-dimensional network of H-bonding nickel (II) hexamethylenetetramine complex has been synthesized and characterised ...
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Synthesis, conformational analysis and: In vivo assays of an anti-cancer vaccine that features an unnatural antigen based on an sp2-iminosugar fragment
(Royal Society of Chemistry, 2020)The Tn antigen (GalNAc-α-1-O-Thr/Ser) is a well-known tumor-associated carbohydrate determinant. The use of glycopeptides ...