Artículo
Synthesis and Biological Evaluation of Modified 2-Deoxystreptamine Dimers
Autor/es | Coste, G.
Horlacher, T. Molina Sanz, Lidia Moreno Vargas, Antonio José Carmona Asenjo, Ana Teresa Robina Ramírez, Inmaculada Seeberger, P.H. Gerber-Lemaire, S. |
Departamento | Universidad de Sevilla. Departamento de Química orgánica |
Fecha de publicación | 2011 |
Fecha de depósito | 2020-06-03 |
Publicado en |
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Resumen | Aminoglycosides are powerful antibiotics, but the emergence of resistant bacterial strains has prompted the search for analogues with better pharmacological profiles. The synthesis of 2-deoxystreptamine (2-DOS) dimers ... Aminoglycosides are powerful antibiotics, but the emergence of resistant bacterial strains has prompted the search for analogues with better pharmacological profiles. The synthesis of 2-deoxystreptamine (2-DOS) dimers linked by polyamines and analogues based on furylcarbopeptoid skeletons is described. Potent and selective ligands for bacterial 16S rRNA were identified using microarray techniques by determining the affinity of these derivatives toward bacterial and human ribosomal RNAs |
Cita | Coste, G., Horlacher, T., Molina Sanz, L., Moreno Vargas, A.J., Carmona Asenjo, A.T., Robina Ramírez, I.,...,Gerber-Lemaire, S. (2011). Synthesis and Biological Evaluation of Modified 2-Deoxystreptamine Dimers. Synthesis, 11, 1759-1770. |
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