Artículo
Synthesis and Antiproliferative Activity of Sulfa-Michael Adducts and Thiochromenes Derived from Carbohydrates
Autor/es | Luque Agudo, V.
Albarran Velo, J. Fernández-Bolaños Guzmán, José María López López, Óscar Light, M.E. Padrón, J.M. Lagunes, I. Román, E. Serrano, J.A. Gil, M.V. |
Departamento | Universidad de Sevilla. Departamento de Química orgánica |
Fecha de publicación | 2017 |
Fecha de depósito | 2022-12-20 |
Publicado en |
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Resumen | The Michael addition reactions of carbohydrate-derived nitroalkenes with ethyl thioglycolate and 2-mercaptobenzyl alcohol were studied. Reactions were conducted under mild, solvent-free conditions with DABCO as a catalyst, ... The Michael addition reactions of carbohydrate-derived nitroalkenes with ethyl thioglycolate and 2-mercaptobenzyl alcohol were studied. Reactions were conducted under mild, solvent-free conditions with DABCO as a catalyst, affording the corresponding adducts in good yields. Furthermore, compounds resulting from the addition with 2-mercaptobenzyl alcohol were used as starting materials for the synthesis of chiral 3-nitro-2H-thiochromenes. For some of the compounds synthesized herein, the antioxidant and antiproliferative activities against a panel of human solid tumor cell lines were assayed and compared with those of carbohydrate-nitroalkene substrates. |
Agencias financiadoras | Junta de Extremadura Unión Europea |
Identificador del proyecto | GR15022
FP7-REGPOT-2012-CT2012-31637-IMBRAIN |
Cita | Luque Agudo, V., Albarran Velo, J., Fernández-Bolaños Guzmán, J.M., López López, Ó., Light, M.E., Padrón, J.M.,...,Gil, M.V. . (2017). Synthesis and Antiproliferative Activity of Sulfa-Michael Adducts and Thiochromenes Derived from Carbohydrates. New Journal of Chemistry, 41 (8), 3154-3162. https://doi.org/10.1039/C6NJ03940E. |
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