Browsing Artículos (Química orgánica) by Title
Now showing items 1-20 of 68
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A broadened scope for the use of hydrazones as neutral nucleophiles in the presence of H-bonding organocatalysts [Article]
(2006)Using thioureas as H-bonding organocatalysts, nitroalkenes can be activated for the conjugate addition of hydrazones as neutral nucleophiles. Formaldehyde derivatives react at the azomethine carbon as expected, whereas ...
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A Dynamic Kinetic Asymmetric Heck Reaction for the Simultaneous Generation of Central and Axial Chirality [Article]
(American Chemical Society, 2018)A highly diastereo- and enantioselective, scalable Pd-catalyzed dynamic kinetic asymmetric Heck reaction of heterobiaryl sulfonates with electron-rich olefins is described. The coupling of 2,3-dihydrofuran or N-boc protected ...
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A novel approach to the synthesis of N-substituted 1-C-aminomethyl glycofuranosides [Article]
(2006)Reductive amination of formyl C-glycofuranosides, easily available from hexose-derived equatorial-2-OH-glycopyranosides by DAST-promoted ring contraction, afforded N-substituted 1-C-aminomethyl glycofuranosides in most ...
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A Practical Synthesis of Enantiopure 4,5-Dihydroisoxazole-5-carboxylic Acids [Article]
(2005)The 1,3-dipolar cycloaddition of a variety of aromatic and aliphatic nitrile oxides to 2,5-trans-2,5-diphenylpyrrolidine derived acrylamide and cinnamamide efficiently affords the corresponding 4,5-dihydroisoxazole-5- ...
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Analysis of the lipid moiety of lipopolysaccharide from Rhizobium tropici CIAT899: identification of 29-hydroxytriacontanoic acid [Article]
(American Society for Microbiology, 1994)The lipid moieties of two lipid A's isolated from the phenolic and aqueous fractions of lipopolysaccharide from Rhizobium tropici CIAT899 have been studied. Several 3-hydroxy fatty acids and two long-chain hydroxy fatty ...
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Arylisoquinoline-derived organoboron dyes with a triaryl skeleton show dual fluorescence [Article]
(Beilstein-Institut, 2019)Se prepararon cuatro nuevos colorantes que derivan de arilisoquinolinas boryiladas, que contienen un tercer residuo de arilo (naftilo, 4-metoxinaftilo, pirenilo o antrilo) que se une a través de un eje estereogénico ...
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Azabicyclic vinyl sulfones for residue-specific dual protein labelling [Article]
(Royal Society of Chemistry, 2019)We have developed [2.2.1]azabicyclic vinyl sulfone reagents that simultaneously enable cysteine-selective protein modification and introduce a handle for further bioorthogonal ligation. The reaction is fast and selective ...
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Bicyclic (galacto)nojirimycin analogues as glycosidase inhibitors: Effect of structural modifications in their pharmacological chaperone potential towards β-glucocerebrosidase [Article]
(Royal Society of Chemistry (Great Britain), 2011)A molecular-diversity-oriented approach for the preparation of bicyclic sp2-iminosugar glycomimetics related to nojirimycin and galactonojirimycin is reported. The synthetic strategy takes advantage of the ability of ...
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Biocatalysis as Useful Tool in Asymmetric Synthesis: An Assessment of Recently Granted Patents (2014–2019) [Article]
(MDPI, 2019-09-25)The broad interdisciplinary nature of biocatalysis fosters innovation, as different technical fields are interconnected and synergized. A way to depict that innovation is by conducting a survey on patent activities. This ...
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Carbon disulfide (CS2) [Article]
(Georg Thieme Verlag, 2009) -
Chemical and Enzymatic Approaches to Carbohydrate-Derived Spiroketals: Di-D-Fructose Dianhydrides (DFAs) [Article]
(MDPI AG, 2008)Di-D-fructose dianhydrides (DFAs) comprise a unique family of stereoisomeric spiro-tricyclic disaccharides formed upon thermal and/or acidic activation of sucrose- and/or D-fructose-rich materials. The recent discovery of ...
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Ciclos de mejora docente en la asignatura de Química General basados en el trabajo guiado [Article]
(Universidad de Sevilla, 2018)En esta comunicación se presentan una estrategia de mejora docente progresiva basada en los denominados Ciclos de Mejora Docente, los cuales se han realizado en una parte del temario de la asignatura “Química General” ...
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Cyclodextrin- and calixarene-based polycationic amphiphiles as gene delivery systems: A structure-activity relationship study [Article]
(Royal Society of Chemistry, 2015)Multi-head/multi-tail facial amphiphiles built on cyclodextrin (CD) and calixarene (CA) scaffolds are paradigmatic examples of monodisperse gene delivery systems. The possibility to precisely control the architectural ...
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Cyclodextrin-scaffolded amphiphilic aminoglucoside clusters: self-assembling and gene delivery capabilities [Article]
(Royal Society of Chemistry, 2014)Precise control over the architecture of gene carriers is instrumental to manipulate gene delivery efficiency. Combining cationic centers and carbohydrate motifs into monodisperse architectures has been proposed as a ...
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Debates: An Useful Tool to Promote Students Deeper Thinking in Stem Disciplines [Article]
(MDPI AG, 2018)The utility of debates for the evaluation of a series of transversal competences related to critical thinking is highlighted. Our main target has been to depict a novel evaluation methodology via discussion through a ...
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Design and Synthesis of CNS-targeted Flavones and Analogues with Neuroprotective Potential Against H2O2- and Aβ1-42-Induced Toxicity in SH-SY5Y Human Neuroblastoma Cells [Article]
(MDPI, 2019)With the lack of available drugs able to prevent the progression of Alzheimer’s disease (AD), the discovery of new neuroprotective treatments able to rescue neurons from cell injury is presently a matter of extreme importance ...
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