Artículos (Química orgánica)
Recent Submissions
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Role of surface tryptophan for peroxidase oxidation of nonphenolic lignin [Article]
(BMC (part of Springer Nature), 2016)Background: Despite claims as key enzymes in enzymatic delignification, very scarce information on the reaction rates between the ligninolytic versatile peroxidase (VP) and lignin peroxidase (LiP) and the lignin polymer ...
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Arylisoquinoline-derived organoboron dyes with a triaryl skeleton show dual fluorescence [Article]
(Beilstein-Institut, 2019)Se prepararon cuatro nuevos colorantes que derivan de arilisoquinolinas boryiladas, que contienen un tercer residuo de arilo (naftilo, 4-metoxinaftilo, pirenilo o antrilo) que se une a través de un eje estereogénico ...
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Biocatalysis as Useful Tool in Asymmetric Synthesis: An Assessment of Recently Granted Patents (2014–2019) [Article]
(MDPI, 2019-09-25)The broad interdisciplinary nature of biocatalysis fosters innovation, as different technical fields are interconnected and synergized. A way to depict that innovation is by conducting a survey on patent activities. This ...
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Thiol-ene "Click" Synthesis and Pharmacological Evaluation of C-Glycoside sp2-Iminosugar Glycolipids [Article]
(MDPI, 2019)The unique stereoelectronic properties of sp2-iminosugars enable their participation in glycosylation reactions, thereby behaving as true carbohydrate chemical mimics. Among sp2-iminosugar conjugates, the sp2-iminosugar ...
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Trehalose-based Siamese twin amphiphiles with tunable self-assembling, DNA nanocomplexing and gene delivery properties [Article]
(The Society, 2019-06-19)An original family of multivalent vectors encompassing gemini and facial amphiphilicity, namely cationic Siamese twin surfactants, has been prepared from the disaccharide trehalose; molecular engineering lets us modulate ...
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Debates: An Useful Tool to Promote Students Deeper Thinking in Stem Disciplines [Article]
(MDPI AG, 2018)The utility of debates for the evaluation of a series of transversal competences related to critical thinking is highlighted. Our main target has been to depict a novel evaluation methodology via discussion through a ...
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P450BM3-Catalyzed Oxidations Employing Dual Functional Small Molecules [Article]
(MDPI, 2019)A set of dual functional small molecules (DFSMs) containing different amino acids has been synthesized and employed together with three different variants of the cytochrome P450 monooxygenase P450BM3 from Bacillus ...
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Design and Synthesis of CNS-targeted Flavones and Analogues with Neuroprotective Potential Against H2O2- and Aβ1-42-Induced Toxicity in SH-SY5Y Human Neuroblastoma Cells [Article]
(MDPI, 2019)With the lack of available drugs able to prevent the progression of Alzheimer’s disease (AD), the discovery of new neuroprotective treatments able to rescue neurons from cell injury is presently a matter of extreme importance ...
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Azabicyclic vinyl sulfones for residue-specific dual protein labelling [Article]
(Royal Society of Chemistry, 2019)We have developed [2.2.1]azabicyclic vinyl sulfone reagents that simultaneously enable cysteine-selective protein modification and introduce a handle for further bioorthogonal ligation. The reaction is fast and selective ...
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Nuevas estrategias en el proceso de enseñanza-aprendizaje de la asignatura Experimentación Química II del Grado en Ingeniería Química Industrial [Article]
(Universidad de Sevilla, 2018)El trabajo realizado durante el desarrollo del ciclo de mejora experimentado en la asignatura Experimentación en Química II se ha centrado en dos pilares fundamentales: 1) Interconexión de los contenidos teórico-prácticos ...
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Ciclos de mejora docente en la asignatura de Química General basados en el trabajo guiado [Article]
(Universidad de Sevilla, 2018)En esta comunicación se presentan una estrategia de mejora docente progresiva basada en los denominados Ciclos de Mejora Docente, los cuales se han realizado en una parte del temario de la asignatura “Química General” ...
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Investigation of the pathways related to intrinsic miltefosine tolerance in Leishmania (Viannia) braziliensis clinical isolates reveals differences in drug uptake [Article]
(Elsevier, 2019)In Brazil, cutaneous leishmaniasis is caused predominantly by L. (V.) braziliensis. The few therapeutic drugs available exhibit several limitations, mainly related to drug toxicity and reduced efficacy in some regions. ...
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Osmotic stress activates nif and fix genes and induces the Rhizobium tropici CIAT 899 Nod factor production via NodD2 by up-regulation of the nodA2 operon and the nodA3 gene [Article]
(Public Library of Science, 2019)The symbiosis between rhizobia and legumes is characterized by a complex molecular dialogue in which the bacterial NodD protein plays a major role due to its capacity to activate the expression of the nodulation genes in ...
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Dynamic Control of the Self-Assembling Properties of Cyclodextrins by the Interplay of Aromatic and Host-Guest Interactions [Article]
(Frontiers Media, 2019)The presence of a doubly-linked naphthylene clip at the O-2I and O-3II positions in the secondary ring of β-cyclodextrin (βCD) derivatives promoted their self-assembly into head-to-head supramolecular dimers in which the ...
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A Dynamic Kinetic Asymmetric Heck Reaction for the Simultaneous Generation of Central and Axial Chirality [Article]
(American Chemical Society, 2018)A highly diastereo- and enantioselective, scalable Pd-catalyzed dynamic kinetic asymmetric Heck reaction of heterobiaryl sulfonates with electron-rich olefins is described. The coupling of 2,3-dihydrofuran or N-boc protected ...
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Dynamic Kinetic Resolution of Hetero biaryl Ketones by Zinc- Catalyzed Asymmetr ic Hydrosil ylation [Article]
(Wiley, 2018)Adiastereo- and highly enantioselective dynamic kinetic resolution (DKR) of configurationally labile hetero- biaryl ketones is described. The DKR proceeds by zinc- catalyze dhydrosilylation of the ...
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Discovery of a Potent α ‑ Galactosidase Inhibitor by in Situ Analysis of a Library of Pyrrolizidine − (Thio)urea Hybrid Molecules Generated via Click Chemistry [Article]
(American Chemical Society, 2018)The parallel synthesis of a 26-membered-library of aromatic/aliphatic-(thio)urea-linked pyrrolizidines followed by in situ biological evaluation toward α -galactosidases has been carried out. The combination of the ...
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Germination and Early Seedling Development in Quercus ilex Recalcitrant and Non-dormant Seeds: Targeted Transcriptional, Hormonal, and Sugar Analysis [Article]
(Frontiers Media, 2018)Seed germination and early seedling development have been studied in the recalcitrant species Quercus ilex using targeted transcriptional, hormonal, and sugar analysis. Embryos and seedlings were collected at eight ...
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Analysis of the lipid moiety of lipopolysaccharide from Rhizobium tropici CIAT899: identification of 29-hydroxytriacontanoic acid [Article]
(American Society for Microbiology, 1994)The lipid moieties of two lipid A's isolated from the phenolic and aqueous fractions of lipopolysaccharide from Rhizobium tropici CIAT899 have been studied. Several 3-hydroxy fatty acids and two long-chain hydroxy fatty ...