• Article
  

  Atroposelective transformation of axially chiral (hetero)biaryls. From desymmetrization to modern resolution strategies 

  Carmona, José A.; Rodríguez Franco, Carlos; Fernández Fernández, Rosario Fátima; Hornillos Gómez-Recuero, Valentín; Lassaletta, José M. (Royal Society of Chemistry, 2021)

  This tutorial review provides a systematic overview of the available methodologies for the atroposelective transformation ...

• Article
  

  Ros3 (Lem3p/CDC50) Gene Dosage Is Implicated in Miltefosine Susceptibility in Leishmania (Viannia) braziliensis Clinical Isolates and in Leishmania (Leishmania) major 

  Espada, Caroline R.; Albuquerque Wendt, Andreia; Hornillos Gómez-Recuero, Valentín; Gluenz, Eva; Coelho, Adriano C.; Uliana, Silvia R. B. (American Chemical Society, 2021)

  The Ros3 protein is a component of the MT-Ros3 transporter complex, considered as the main route of miltefosine entry in ...

• Article
  

  Trifaceted Mickey Mouse Amphiphiles for Programmable Self-Assembly, DNA Complexation and Organ-Selective Gene Delivery 

  Carbajo-Gordillo, Ana I.; González Cuesta, Manuel; Jiménez Blanco, José Luis; Benito, Juan M.; Santana, María L.; Carmona, Thais; Ortiz Mellet, Carmen; García Fernández, José M. (Wiley, 2021)

  Instilling segregated cationic and lipophilic domains with an angular disposition in a trehalose-based trifaceted macrocyclic ...

• Article
  

  Recent trends in synthetic enzymatic cascades promoted by alcohol dehydrogenases 

  Gonzalo Calvo, Gonzalo de; Paul, Caroline E. (Elsevier, 2021)

  Alcohol dehydrogenases have fascinated chemists over the span of a few decades to catalyze oxidation and reduction reactions ...

• Article
  

  Tuning the activity of iminosugars: novel N-alkylated deoxynojirimycin derivatives as strong BuChE inhibitors 

  Ahuja Casarín, Ana I.; Merino Montiel, Penélope; Vega Báez, José Luis; Montiel Smith, Sara; Fernandes, Miguel X,; Lagunes, Irene; Maya Castilla, Inés; López López, Óscar; Fernández-Bolaños Guzmán, José María (Taylor & Francis Open Access, 2021)

  We have designed unprecedented cholinesterase inhibitors based on 1-deoxynojirimycin as potential anti-Alzheimer’s agents. ...

• Article
  

  Development of tacrine clusters as positively cooperative systems for the inhibition of acetylcholinesterase 

  Evangelista, Tereza Cristina Santos; López López, Óscar; Ferreira, Sabrina Baptista; Fernández-Bolaños Guzmán, José María; Sydnes, Magne O.; Lindbäck, Emil (Taylor & Francis Open Access, 2021)

  The synthesis of four tetra-tacrine clusters where the tacrine binding units are attached to a central scaffold via linkers ...

• Article
  

  Discovery of human hexosaminidase inhibitors by in situ screening of a library of mono- and divalent pyrrolidine iminosugars 

  Pingitore, Valeria; Martínez Bailén, Macarena; Carmona Asenjo, Ana Teresa; Mészáros, Zuzana; Kulik, Natalia; Slámová, Kristýna; Křen, Vladimír; Bojarová, Pavla; Robina Ramírez, Inmaculada; Moreno Vargas, Antonio José (Elsevier, 2022)

  Two libraries of mono- and dimeric pyrrolidine iminosugars were synthesized by CuAAC and (thio)urea-bond-forming reactions ...

• Article
  

  Oleuropein and its peracetylated derivative negatively regulate osteoclastogenesis by controlling the expression of genes involved in osteoclast differentiation and function 

  Rosillo Ramírez, María de los Ángeles; Montserrat de la Paz, Sergio; Abia, Rocío; Castejón Martínez, María Luisa; Millán Linares, María Carmen; Alarcón de la Lastra Romero, Catalina; Fernández-Bolaños Guzmán, José María; Muriana, Francisco J. G. (Royal Society of Chemistry, 2020)

  During chronic inflammation, macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor-κB ...

• Article
  

  Asymmetric synthesis of dibenzo[b,d]azepines by Cu-catalyzed reductive or borylative cyclization 

  Rodríguez Salamanca, Patricia; Martín de la Calle, Rocío; Rodríguez Bravo, Verónica; Merino, Pedro; Fernández Fernández, Rosario Fátima; Lassaletta, José M.; Hornillos, Valentín (Royal Society of Chemistry, 2021)

  A copper-catalyzed asymmetric intramolecular reductive cyclization for the synthesis of dibenzo[b,d]azepines is described. ...

• Article
  

  Iridium-and Palladium-Based Catalysts in the Pharmaceutical Industry 

  López López, Óscar; Padrón, José M. (Multidisciplinary Digital Publishing Institute (MDPI), 2022)

  Transition metal catalysts play a vital role in a wide range of industrial organic processes. The large-scale production ...

• Article
  

  Latest Trends in Surface Modification for Dental Implantology: Innovative Developments and Analytical Applications 

  Accioni, Francesca; Vázquez Cabello, Juan; Merinero de los Santos, Manuel; Begines Ruiz, Belén; Alcudia Cruz, Ana (Multidisciplinary Digital Publishing Institute (MDPI), 2022)

  An increase in the world population and its life expectancy, as well as the ongoing concern about our physical appearance, ...

• Article
  

  2-Aminobenzoxazole-appended coumarins as potent and selective inhibitors of tumour-associated carbonic anhydrases 

  Fuentes Aguilar, Alma; Merino Montiel, Penélope; Montiel Smith, Sara; Meza Reyes, Socorro; Vega Báez, José Luis; Fernández-Bolaños Guzmán, José María; López López, Óscar (Taylor & Francis, 2022)

  We have carried out the design, synthesis, and evaluation of a small library of 2-aminobenzoxazole-appended coumarins as ...

• Article
  

  Synthesis, conformational analysis and: In vivo assays of an anti-cancer vaccine that features an unnatural antigen based on an sp2-iminosugar fragment 

  Bermejo, Iris A; Navo, Claudio D.; Castro López, Jorge; Guerreiro, Ana; Jiménez Moreno, Ester; Sánchez Fernández, Elena Matilde; Ortiz Mellet, Carmen; Corzana, Francisco (Royal Society of Chemistry, 2020)

  The Tn antigen (GalNAc-α-1-O-Thr/Ser) is a well-known tumor-associated carbohydrate determinant. The use of glycopeptides ...

• Article
  

  NleB/SseK-catalyzed arginine-glycosylation and enteropathogen virulence are finely tuned by a single variable position contiguous to the catalytic machinery 

  García García, Ana; Hicks, Thomas; El Qaidi, Samir; Zhu, Congrui; Hardwidge, Philip R.; Angulo Álvarez, Jesús; Hurtado Guerrero, Ramón (Royal Society of Chemistry, 2021)

  NleB/SseK effectors are arginine-GlcNAc-transferases expressed by enteric bacterial pathogens that modify host cell proteins ...

• Article
  

  Ambiphilic boryl groups in a neutral Ni(ii) complex: a new activation mode of H2 

  Ríos Moreno, Pablo; Borge, Javier; Fernández de Córdova Martín, Francisco José; Sciortino, Giuseppe; Lledós, Agustí; Rodríguez, Amor (Royal Society of Chemistry, 2021)

  The concept of metal–ligand cooperation opens new avenues for the design of catalytic systems that may offer alternative ...

• Article
  

  Thio- and selenosemicarbazones as antiprotozoal agents against Trypanosoma cruzi and Trichomonas vaginalis 

  Ibáñez Escribano, Alexandra; Fonseca Berzal, Cristina; Martínez Montiel, Mónica; Álvarez Márquez, Manuel; Gómez Núñez, María; Lacueva Arnedo, Manuel; Espinosa Buitrago, Teresa; Martín Pérez, Tania; Escario, José Antonio; Merino Montiel, Penélope; Montiel Smith, Sara; Gómez Barrio, Alicia; López López, Óscar; Fernández-Bolaños Guzmán, José María (Taylor & Francis, 2022)

  Herein, we report the preparation of a panel of Schiff bases analogues as antiprotozoal agents by modification of the ...

• Article
  

  Chemoselective Preparation of New Families of Phenolic-Organoselenium Hybrids—A Biological Assessment 

  Begines Aguilar, Paloma; Martos Delgado, Sergio; Lagunes, Irene; Maya Castilla, Inés; Padrón, José M.; López López, Óscar; Fernández-Bolaños Guzmán, José María (Multidisciplinary Digital Publishing Institute (MDPI), 2022)

  Being aware of the enormous biological potential of organoselenium and polyphenolic compounds, we have accomplished the ...

• Article
  

  Synthesis of tri- and tetramines containing two 2,3-dihydroxypyrrolidine moieties and their inhibitory activity toward α-mannosidases 

  Gerber-Lemaire, S.; Popowycz, Florence; Rodriguez García, Eliazar; Schütz, Catherine; Carmona Asenjo, Ana Teresa; Robina Ramírez, Inmaculada; Vogel, Pierre (ARKAT USA INC, 2002)

  Through the reductive amination of N-[(tert-butoxy)carbonyl]-2,5-dideoxy-2,5-imino-3,4-Oisopropylidene-L-ribose with ...

• Article
  

  Influence of the surfactant degree of oligomerization on the formation of cyclodextrin: surfactant inclusion complexes 

  Martín, Victoria I.; López-Cornejo, María del Pilar; López López, Manuel; Blanco Arévalo, Daniel; Moreno Vargas, Antonio José; Angulo, Manuel; Laschewsky, André; Moyá Morán, María Luisa (Elsevier, 2020)

  Supramolecular complexation is an attractive strategy to modulate the performance of surfactants, e.g., by host-guest ...

• Article
  

  Tensioactivos. XX. ω-Monoésteres grasos de ditioacetales de azúcares 

  Fernández Bolaños Vázquez, José Manuel; Fernández Mesa, M.J.; Fernández-Bolaños Guzmán, José María (CSIC, 1995)

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