• Article
  

  Anti-Inflammatory (M2) Response Is Induced by a sp2-Iminosugar Glycolipid Sulfoxide in Diabetic Retinopathy 

  Cano Cano, Fátima; Alcalde Estévez, Elena; Gómez Jaramillo, Laura; Iturregui, Marta; Sánchez Fernández, Elena Matilde; García Fernández, José Manuel; Ortiz Mellet, Carmen; Campos Caro, Antonio; López Tinoco, Cristina (Frontiers, 2021)

  Diabetic retinopathy (DR) is one of the most common complications of Diabetes Mellitus (DM) and is directly associated ...

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  Self-acetylation at the active site of phosphoenolpyruvate carboxykinase (PCK1) controls enzyme activity 

  Latorre Muro, Pedro; Baeza, Josue; Hurtado Guerrero, Ramón; Hicks, Thomas; Delso, Ignacio; Hernández Ruiz, Cristina; Velázquez Campoy, Adrián; Lawton, Alexis J.; Angulo Álvarez, Jesús; Denu, John M.; Carrodeguas, José Alberto (American Society for Biochemistry and Molecular Biology Inc., 2021)

  Acetylation is known to regulate the activity of cytosolic phosphoenolpyruvate carboxykinase (PCK1), a key enzyme in ...

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  Structural basis of trehalose recognition by the mycobacterial LpqY-SugABC transporter 

  Furze, Christopher M.; Delso, Ignacio; Casal, Enriqueta; Seddon, Chloe; Brown, Chelsea M.; Parker, Hadyn L.; Radhakrishnan, Anjana; Pacheco Gómez, Raul; Stansfeld, Phillip J.; Angulo Álvarez, Jesús; Cameron, Alexander D.; Fullam, Elizabeth (American Society for Biochemistry and Molecular Biology Inc., 2021)

  The Mycobacterium tuberculosis (Mtb) LpqY-SugABC ATPbinding cassette transporter is a recycling system that imports trehalose ...

• Article
  

  Encased Gold Nanoparticle Synthesis as a Probe for Oleuropein Self-Assembled Structure Formation 

  Jiménez Ruiz, Aila; Prado Gotor, Rafael; Fernández Bolaños, José G.; González Benjumea, Alejandro; Carnerero Panduro, José María (MDPI, 2020-12)

  Stable oleuropein-coated gold nanoparticles in aqueous media were synthesized for the first time. Oleuropein (OLE) ...

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  Cyclodextrin-Based Functional Glyconanomaterials 

  Rivero Barbarroja, Gonzalo; Benito Hernández, Juan Manuel; Ortiz Mellet, Carmen; García Fernández, José Manuel (MDPI, 2020-12)

  Cyclodextrins (CDs) have long occupied a prominent position in most pharmaceutical laboratories as “off-the-shelve” tools ...

• Article
  

  Fucosidases from the human gut symbiont Ruminococcus gnavus 

  Wu, Haiyang; Rebello, Osmond; Owen, C. David; Walpole, Samuel; Bennati Granier, Chloe; Ndeh, Didier; Monaco, Serena; Angulo Álvarez, Jesús (Springer, 2021)

  The availability and repartition of fucosylated glycans within the gastrointestinal tract contributes to the adaptation ...

• Article
  

  Room Temperature Ionic Liquids in Asymmetric Hetero-Ene Type Reactions: Improving Organocatalyst Performance at Lower Temperatures 

  Bisogno, Fabricio R.; Fernández Fernández, Rosario Fátima; Lassaletta Simón, José María; Gonzalo Calvo, Gonzalo de (MDPI, 2021-01)

  Abstract: Room temperature ionic liquids (RTILs) have been widely used as (co)solvents in several catalytic processes ...

• Article
  

  1,4-Dideoxy-1,4-imino-d-arabinitol (DAB) Analogues Possessing a Hydrazide Imide Moiety as Potent and Selective α-Mannosidase Inhibitors 

  Haarr, Marianne B.; López López, Oscar; Pejov, Ljupcho; Fernández Bolaños, José G.; Lindbäck, Emil; Sydnes, Magne O. (American Chemical Society, 2020)

  The synthesis of two polyhydroxylated pyrrolidines as 1,4-dideoxy-1,4-imino-d-arabinitol (DAB) analogues bearing a hydrazide ...

• Article
  

  Uncovering a novel molecular mechanism for scavenging sialic acids in bacteria 

  Bell, Andrew; Severi, Emmanuele; Lee, Micah; Monaco, Serena; Latousakis, Dimitrios; Angulo, Jesús; Thomas, Gavin H.; Naismith, James H.; Juge, Nathalie (American Society for Biochemistry and Molecular Biology, 2020)

  The human gut symbiont Ruminococcus gnavus scavenges host-derived N-acetylneuraminic acid (Neu5Ac) from mucins by converting ...

• Article
  

  Cyclodextrin-Based Nanostructure Efficiently Delivers siRNA to Glioblastoma Cells Preferentially via Macropinocytosis 

  Manzanares, Darío; Pérez Carrión, Mª Dolores; Jiménez Blanco, José Luis; Ortiz Mellet, Carmen; García Fernández, José Manuel; Ceña, Valentín (MDPI, 2020)

  Small interfering ribonucleic acid (siRNA) has the potential to revolutionize therapeutics since it can knockdown very ...

• Article
  

  Masked Phenolic-Selenium Conjugates: Potent and Selective Antiproliferative Agents Overcoming P-gp Resistance 

  Begines Aguilar, Paloma; Sevilla Horrillo, Lucía; Puerta, Adrián; Puckett, Rebeca; Bayort, Samuel; Lagunes, Irene; Maya, Inés; Padrón, José M.; López López, Óscar; Fernández-Bolaños Guzmán, José María (MDPI, 2020)

  Cancer accounts for one of the most complex diseases nowadays due to its multifactorial nature. Despite the vast number ...

• Article
  

  Bacterial enzymes involved in lignin degradation 

  Gonzalo Calvo, Gonzalo de; Colpa, Dana I.; Habib, Mohamed H.; Fraaije, Marco Wilhelmus (Elsevier, 2016)

  Lignin forms a large part of plant biomass. It is a highly heterogeneous polymer of 4-hydroxyphenylpropanoid units and is ...

• Article
  

  Synthesis of “All-Cis” Trihydroxypiperidines from a Carbohydrate-Derived Ketone: Hints for the Design of New β-Gal and GCase Inhibitors 

  Davighi, Maria Giulia; Clemente, Francesca; Matassini, Camilla; Martínez Bailén, Macarena; Cardona, Francesca; Goti, Andrea (MDPI, 2020)

  Pharmacological chaperones (PCs) are small compounds able to rescue the activity of mutated lysosomal enzymes when used ...

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  Biocatalytic Properties and Structural Analysis of Eugenol Oxidase from Rhodococcus jostii RHA1: A Versatile Oxidative Biocatalyst 

  Nguyen, Quoc‐Thai; Gonzalo Calvo, Gonzalo de; Binda, Claudia; Rioz Martínez, Ana; Mattevi, Andrea; Fraaije, Marco W. (wiley, 2016)

  Eugenol oxidase (EUGO) from Rhodococcus jostii RHA1 had previously been shown to convert only a limited set of phenolic ...

• Article
  

  Biocatalyzed redox processes employing green reaction media 

  Aranda, Carmen; Gonzalo Calvo, Gonzalo de (Multidisciplinary Digital Publishing Institute (MDPI), 2020)

  The application of biocatalysts to perform reductive/oxidative chemical processes has attracted great interest in recent ...

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  Positive impact of natural deep eutectic solvents on the biocatalytic performance of 5-hydroxymethyl-furfural oxidase 

  Gonzalo Calvo, Gonzalo de; Martin, Caterina; Fraaije, Marco Wilhelmus (Multidisciplinary Digital Publishing Institute (MDPI), 2020)

  Deep eutectic solvents (DESs) have been applied as cosolvents in various biocatalytic processes during recent years. ...

• Article
  

  Fragment-based screening of the donor substrate specificity of human blood group B galactosyltransferase using saturation transfer difference NMR 

  Blume, Astrid; Angulo Álvarez, Jesús; Biet, Thorsten; Peters, Hannelore; Benie, Andrew J.; Palcic, Monica; Peters, Thomas (American Society for Biochemistry and Molecular Biology, 2006)

  Saturation transfer difference NMR experiments on human blood group B α-(1,3)-galactosyltransferase (GTB) for the first ...

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  Spin Saturation Transfer Difference NMR (SSTD NMR): A New Tool to Obtain Kinetic Parameters of Chemical Exchange Processes 

  Quirós, María Teresa; Macdonald, Colin; Angulo Álvarez, Jesús; Muñoz, María Paz (Journal of Visualized Experiments (JoVE), 2016)

  This detailed protocol describes the new Spin Saturation Transfer Difference Nuclear Magnetic Resonance protocol (SSTD ...

• Article
  

  Chirality and catalysis with aromatic N-fused heterobicyclic carbenes 

  Iglesias Sigüenza, Francisco Javier; Izquierdo Cancho, Cristina; Díez Martín, Elena; Fernández Fernández, Rosario Fátima; Lassaletta Simón, José María (Royal Society of Chemistry, 2016)

  The benzoannulation of the most common families of aromatic NHCs, imidazol-2-ylidenes and 1,2,4-triazol-3-ylidenes, results ...

• Article
  

  Mantonico and Pecorello Grape Seed Extracts: Chemical Characterization and Evaluation of In Vitro Wound-Healing and Anti-Inflammatory Activities 

  Carullo, Gabriele; Sciubba, Fabio; Governa, Paolo; Mazzotta, Sarah; Frattaruolo, Luca; Grillo, Giorgio; Cappello, Anna Rita; Cravotto, Giancarlo; Cocco, Maria Enrica Di; Aiello, Francesca (MDPI, 2020)

  The winemaking process produces a huge number of pomaces that generally are used for energy purposes. Further valuable ...

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