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  New tacrine dimers with antioxidant linkers as dual drugs: Anti-Alzheimer's and antiproliferative agents 

  Roldán Peña, Jesús Miguel; Alejandre Ramos, Daniel; López López, Óscar; Maya Castilla, Inés; Lagunes, Irene; Padrón, José M.; Peña Altamira, Luis Emiliano; Bartolini, Manuela; Monti, Barbara; Bolognesi, Maria L.; Fernández-Bolaños Guzmán, José María (Elsevier, 2017)

  We have designed a series of tacrine-based homo- and heterodimers that incorporate an antioxidant tether (selenoureido, ...

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  Synthesis and Structure-activity Relationship of New Nicotinamide Phosphoribosyltransferase Inhibitors with Antitumor Activity on Solid and Haematological Cancer 

  Fratta, Simone; Biniecka, Paulina; Moreno Vargas, Antonio José; Carmona Asenjo, Ana Teresa; Nahimana, Aimable; Duchosal, Michel A.; Piacente, Francesco; Bruzzone, Santina; Caffa, Irene; Nencioni, Alessio; Robina Ramírez, Inmaculada (Elsevier, 2023)

  Cancer cells are highly dependent on Nicotinamide phosphoribosyltransferase (NAMPT) activity for proliferation, therefore ...

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  Iminosugar-Phosphines as Organocatalysts in the [3 + 2] Cycloaddition of Allenoates and N-Tosylimines 

  Elías Rodríguez, María del Pilar; Carmona Asenjo, Ana Teresa; Moreno Vargas, Antonio José; Robina Ramírez, Inmaculada (Multidisciplinary Digital Publishing Institute (MDPI), 2022)

  Iminosugar derivatives containing a pyrrolidine-phosphine moiety were prepared from carbohydrates and used as catalysts ...

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  Serine-/Cysteine-based sp2-Iminoglycolipids as novel TLR4 agonists: evaluation of their adjuvancy and immunotherapeutic properties in a murine model of asthma 

  González Cuesta, Manuel; Lai, Alan Chuan Ying; Chi, Po Yu; Hsu, I. Ling; Liu, Nien Tzu; Wu, Ko Chien; García Fernández, José Manuel; Ortiz Mellet, Carmen (American Chemical Society, 2023)

  Glycolipids with TLR4 agonistic properties can serve either as therapeutic agents or as vaccine adjuvants by stimulating ...

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  Fluoro-labelled sp2-iminoglycolipids with immunomodulatory properties 

  Padilla Pérez, María del Carmen; Sánchez Fernández, Elena Matilde; González-Bakker, Aday; Puerta, Adrián; Padrón, José M.; Martín-Loro, Francisco; García Fernández, José Manuel; Ortiz Mellet, Carmen (Elsevier, 2023)

  The unique electronic properties of the fluorine atom make its strategic incorporation into a bioactive compound a very ...

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  Structure-Based Identification and Biological Characterization of New NAPRT Inhibitors 

  Franco, Jorge; Piacente, Francesco; Walter, Melanie; Fratta, Simone; Ghanem, Moustafa; Benzi, Andrea; Martínez Bailén, Macarena; Robina Ramírez, Inmaculada; Del Río, Alberto (Multidisciplinary Digital Publishing Institute (MDPI), 2022)

  NAPRT, the rate-limiting enzyme of the Preiss–Handler NAD biosynthetic pathway, has emerged as a key biomarker for the ...

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  Tackling Antibiotic Resistance: Influence of Aliphatic Branches on Broad-Spectrum Antibacterial Polytriazoles against ESKAPE Group Pathogens 

  Rangel Núñez, Cristian; Molina Pinilla, Inmaculada; Ramírez Trujillo, Cristina; Suárez Cruz, Adrián; Bernal Martínez, Samuel; Bueno Martínez, Manuel (Multidisciplinary Digital Publishing Institute (MDPI), 2022)

  One of the most important threats to public health is the appearance of multidrug-resistant pathogenic bacteria, since ...

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  A β-Cyclodextrin-Based Nanoparticle with Very High Transfection Efficiency Unveils siRNA-Activated TLR3 Responses in Human Prostate Cancer Cells 

  de la Torre, Cristina; Játiva, Pablo; Posadas, Inmaculada; Manzanares, Darío; Jiménez Blanco, José Luis; Ortiz Mellet, Carmen; García Fernández, José Manuel; Ceña, Valentín (Multidisciplinary Digital Publishing Institute (MDPI), 2022)

  Synthetic double-stranded small interfering RNAs (siRNAs) mimic interference RNAs (RNAi) and can bind target mRNAs with a ...

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  Scope and Limitations of Current Antibiotic Therapies against Helicobacter pylori: Reviewing Amoxicillin Gastroretentive Formulations 

  Grosso, Roberto; Paz Báñez, María Violante de (Multidisciplinary Digital Publishing Institute (MDPI), 2022)

  Even though general improvement of quality of life has happened around the globe, statistics show that gastric cancer is ...

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  Synthesis of β-galactosylamides as ligands of the peanut lectin. Insights into the recognition process 

  Cano, María Emilia; Varela, Oscar; García Moreno, M. Isabel; García Fernández, José Manuel; Kovensky, José; Uhrig, María Laura (Elsevier, 2017)

  The synthesis of mono and divalent β-galactosylamides linked to a hydroxylated chain having a C2 symmetry axis derived ...

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  Selenium and sulphur derivatives of hydroxytyrosol: inhibition of lipid peroxidation in liver microsomes of vitamin E-deficient rats 

  Rodríguez-Gutiérrez, Guillermo; Rubio-Senent, Fátima; Gómez Carretero, Antonio; Maya Castilla, Inés; Fernández Bolaños, Juan; Duthie, Garry G.; de Roos, Baukje (Springer Nature, 2019)

  Purpose: The objective of this study was to evaluate the capacity of modified phenols synthesized from hydroxytyrosol, a ...

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  Carbon Dioxide as a Traceless Caramelization Promotor: Preparation of Prebiotic Difructose Dianhydrides (DFAs)-Enriched Caramels from D-Fructose 

  Audemar, Maité; Atencio Genes, Loyda Esther; Ortiz Mellet, Carmen; Jérôme, F.; García Fernández, José Manuel; Oliveira Vigier, Karine De (American Chemical Society, 2017)

  Activation of a concentrated solution of D-fructose with carbonic acid, generated from carbon dioxide, induces the formation ...

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  Non-Ionic Osmotic Stress Induces the Biosynthesis of Nodulation Factors and Affects Other Symbiotic Traits in Sinorhizobium fredii HH103 

  Fuentes Romero, Francisco; Moyano Bravo, Isamar; Ayala García, Paula; Rodríguez Carvajal, Miguel Ángel; Pérez Montaño, Francisco de Asís; Acosta Jurado, Sebastián; Ollero Márquez, Francisco Javier; Vinardell González, José María (MDPI, 2023)

  Simple Summary: Rhizobia are soil proteobacteria able to establish nitrogen-fixing symbiosis with host legumes. This ...

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  A versatile stereocontrolled synthesis of 2-deoxyiminosugarC-glycosides and their evaluation as glycosidase inhibitors 

  Lumbroso, Alexandre; Berthonneau, Clément; Beaudet, Isabelle; Quintard, Jean Paul; Planchat, Aurélien; García Moreno, M. Isabel; Ortiz Mellet, Carmen; Le Grognec, Erwan (Royal Society of Chemistry, 2021)

  A highly enantioselective synthesis of (R,S) or (S,S)-2,6-disubstituted dehydropiperidines has been previously achieved ...

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  Toward a Suitable Structural Analysis of Gene Delivery Carrier Based on Polycationic Carbohydrates by Electron Transfer Dissociation Tandem Mass Spectrometry 

  Przybylski, Cédric; Benito, Juan Manuel; Bonnet, Véronique; Ortiz Mellet, Carmen; García Fernández, José Manuel (Elsevier, 2016)

  Polycationic carbohydrates represent an attractive class of biomolecules for several applications and particularly as non ...

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  Synthesis of β-galactosylamides as Ligands of the Peanut Lectin. Insights into the Recognition Process 

  Cano, María Emilia; Varela, Oscar; García Moreno, M. Isabel; García Fernández, José Manuel; Kovensky, José; Uhrig, María Laura (Elsevier, 2017)

  The synthesis of mono and divalent β-galactosylamides linked to a hydroxylated chain having a C2 symmetry axis derived ...

• Article
  

  Synthesis and Antiproliferative Activity of Sulfa-Michael Adducts and Thiochromenes Derived from Carbohydrates 

  Luque Agudo, V.; Albarran Velo, J.; Fernández-Bolaños Guzmán, José María; López López, Óscar; Light, M.E.; Padrón, J.M.; Lagunes, I.; Román, E.; Serrano, J.A.; Gil, M.V.  (Royal Society of Chemistry, 2017)

  The Michael addition reactions of carbohydrate-derived nitroalkenes with ethyl thioglycolate and 2-mercaptobenzyl alcohol ...

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  Molecular Determinants for Cyclo-oligosaccharide-based Nanoparticle-mediated Effective siRNA Transfection 

  Manzanares, Darío; Araya Durán, Ingrid; Gallego Yerga, Laura; Játiva, Pablo; Márquez Miranda, Valeria; Canan, Jonathan; Jiménez Blanco, José Luis; Ortiz Mellet, Carmen; González Nilo, Fernando Danilo; García Fernández, José Manuel; Ceña, Valentín (Future Medicine Ltd., 2017)

  Aim: To study the structural requirements that a cyclooligosaccharide-based nanoparticle must fulfill to be an efficient ...

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  Mechanistic Insight into the Binding of Multivalent Pyrrolidines to α-Mannosidases 

  Mirabella, Stefania; D'Adamio, Giampiero; Matassini, Camilla; Goti, Andrea; Delgado, Sandra; Gimeno, Ana; Robina Ramírez, Inmaculada; Moreno Vargas, Antonio José; Šesták, Sergej; Jiménez Barbero, Jesús; Cardona, Francesca (Wiley-Blackwell, 2017)

  Novel pyrrolidine-based multivalent iminosugars, synthesized by a CuAAC approach, have shown remarkable multivalent effects ...

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  N-Heterotricyclic Cationic Carbene Ligands. Synthesis, Reactivity and Coordination Chemistry 

  Iglesias Sigüenza, Francisco Javier; Izquierdo, Cristina; Díez Martín, Elena; Fernández Fernández, Rosario Fátima; Lassaletta, José M. (Royal Society of Chemistry, 2018)

  The direct dialkylation of triazolo[4,3-b]isoquinolin-3-ylidene structures readily affords dicationic N-heterotricyclic ...

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