Artículos (Química Orgánica)
Envíos recientes
-
Artículo
Evolution of the catalytic mechanism at the dawn of the Baeyer-Villiger monooxygenases
(Elsevier, 2024-05-28)Enzymes are crucial for the emergence and sustenance of life on earth. How they became catalytically active during their ...
-
Artículo
sp2-Iminosugar Azobenzene O-glycosides: Light-sensitive Glycosidase Inhibitors with Unprecedented Tunability and Switching Factors
(Elsevier, 2024)The conventional approach to developing light-sensitive glycosidase activity regulators, involving the combination of a ...
-
Artículo
Speeding-up the Determination of Protein-Ligand Affinities by STD NMR: The Reduced Data Set STD NMR Approach (rd-STD NMR)
(American Chemical Society, 2024-01-02)STD NMR spectroscopy is a powerful ligand-observed NMR tool for screening and characterizing the interactions of small ...
-
Artículo
Mechanically Planar-to-Point Chirality Transmission in [2]Rotaxanes
(American Chemical Society, 2024-01-24)Herein we describe an effective transmission of chirality, from mechanically planar chirality to point chirality, in ...
-
Artículo
High-Mannose Oligosaccharide Hemimimetics that Recapitulate the Conformation and Binding Mode to Concanavalin A, DC-SIGN and Langerin
(Wiley, 2023-10-12)The “carbohydrate chemical mimicry” exhibited by sp2-iminosugars has been utilized to develop practical syntheses for ...
-
Artículo
Coumarins-lipophilic cations conjugates: Efficient mitocans targeting carbonic anhydrases
(Elsevier, 2024-02-13)Being aware of the need to develop more efficient therapies against cancer, herein we disclose an innovative approach for ...
-
Artículo
Atroposelective Synthesis of 2-(Quinolin-8-yl)benzyl Alcohols by Biocatalytic Dynamic Kinetic Resolutions
(Wiley, 2023-12-22)A highly enantioselective biocatalytic dynamic kinetic resolution (DKR) of 2-(quinoline-8-yl) 3-methylbenzaldehydes and ...
-
Artículo
Divergent approach to nanoscale glycomicelles and photo-responsive supramolecular glycogels. Implications for drug delivery and photoswitching lectin affinity
(Royal Society of Chemistry, 2023-10-09)The field of stimuli-responsive supramolecular biomaterials has rapidly advanced in recent years, with potential applications ...
-
Artículo
Continuous flow synthesis of PCN-222 (MOF-545) with controlled size and morphology: a sustainable approach for efficient production
(Royal Society of Chemistry, 2023-11-21)Zirconium-based MOFs, such as PCN-222 (MOF-545), have gained attention due to their regular porosity, tuneable pore size, ...
-
Artículo
Silver-free gold-catalyzed heterocyclizations through intermolecular H-bonding activation.
(AMER Chemical Soc, 2023-01-27)Modulable monosulfonyl squaramides have been shown to exert activation of gold(I) chloride complexes through H-bonding in ...
-
Artículo
N-Substituted 3-Aminooxindoles and N-Propargyl Derivatives: Potential Biological Activities against Alzheimer's Disease
(Elsevier, 2023-07-08)The oxindole core is an important structural motif in many natural and synthetic substances with various biological ...
-
Artículo
Multivalent glycosystems for human lectins
(Royal Society of Chemistry, 2022-08-30)Human lectins are involved in a wide variety of biological processes, both physiological and pathological, which have ...
-
Artículo
Green Oxidative Catalytic Processes for the Preparation of APIs and Precursors
(MDPI, 2023-03-22)Asymmetric oxidation processes have constituted a valuable tool for the synthesis of active pharmaceutical ingredients ...
-
Artículo
Excited-state dynamics in borylated arylisoquinoline complexes in solution and in cellulo
(Wiley-V C H Verlag GMBH, 2022-12-07)Two four-coordinate organoboron N,C-chelate complexes with different functional terminals on the PEG chains are studied ...
-
Artículo
Dynamic Kinetic Resolution of Indole-Based Sulfenylated Heterobiaryls by Rhodium-Catalyzed Atroposelective Reductive Aldol Reaction
(Amer chemical SOC, 2023-08-30)A highly enantio- and diastereoselective dynamic kinetic resolution (DKR) of configurationally labile 3-aryl indole-2-carbaldehydes ...
-
Artículo
Dynamic kinetic resolution of 2-(Quinolin-8-yl)benzaldehydes: atroposelective iridium-catalyzed transfer hydrogenative allylation
(Wiley-V C H Verlag GMBH, 2023-06-30)An atroposelective Ir-catalyzed dynamic kinetic resolution (DKR) of 2-(quinolin-8- yl)benzaldehydes/1-naphthaldehydes ...
-
Artículo
Azaborahelicene fluorophores derived from four-coordinate N,C-boron chelates: synthesis, photophysical and chiroptical properties
(Royal Society of Chemistry, 2023-12-12)A series of six azaborahelicenes with varying electron-donor substitution at the 4-position of the aryl residue (i.e., ...
-
Artículo
Asymmetric Dearomatization of Phthalazines by Anion-BindingCatalysis
(American Chemical Society, 2023-12-01)A straightforward methodology for the enantioselective synthesis of 1,2-dihydrophthalazines via dearomatization of ...
-
Artículo
A selenoureido-iminoglycolipid transported by zeolitic-imidazolate framework nanoparticles: a novel antioxidant therapeutic approach
(Royal Society of Chemistry, 2023-10-05)A selenium-containing metal–organic framework with remarkable antioxidant capacity and ROS-scavenging activity was ...
-
Artículo
A Multitarget Approach against Neuroinflammation: Alkyl Substituted Coumarins as Inhibitors of Enzymes Involved in Neurodegeneration
(MDPI, 2023-11-25)Neurodegenerative disorders (NDs) include a large range of diseases characterized by neural dysfunction with a multifactorial ...