Artículos (Química orgánica)
Recent Submissions
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Atroposelective transformation of axially chiral (hetero)biaryls. From desymmetrization to modern resolution strategies
(Royal Society of Chemistry, 2021)This tutorial review provides a systematic overview of the available methodologies for the atroposelective transformation ...
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Ros3 (Lem3p/CDC50) Gene Dosage Is Implicated in Miltefosine Susceptibility in Leishmania (Viannia) braziliensis Clinical Isolates and in Leishmania (Leishmania) major
(American Chemical Society, 2021)The Ros3 protein is a component of the MT-Ros3 transporter complex, considered as the main route of miltefosine entry in ...
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Trifaceted Mickey Mouse Amphiphiles for Programmable Self-Assembly, DNA Complexation and Organ-Selective Gene Delivery
(Wiley, 2021)Instilling segregated cationic and lipophilic domains with an angular disposition in a trehalose-based trifaceted macrocyclic ...
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Recent trends in synthetic enzymatic cascades promoted by alcohol dehydrogenases
(Elsevier, 2021)Alcohol dehydrogenases have fascinated chemists over the span of a few decades to catalyze oxidation and reduction reactions ...
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Tuning the activity of iminosugars: novel N-alkylated deoxynojirimycin derivatives as strong BuChE inhibitors
(Taylor & Francis Open Access, 2021)We have designed unprecedented cholinesterase inhibitors based on 1-deoxynojirimycin as potential anti-Alzheimer’s agents. ...
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Development of tacrine clusters as positively cooperative systems for the inhibition of acetylcholinesterase
(Taylor & Francis Open Access, 2021)The synthesis of four tetra-tacrine clusters where the tacrine binding units are attached to a central scaffold via linkers ...
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Discovery of human hexosaminidase inhibitors by in situ screening of a library of mono- and divalent pyrrolidine iminosugars
(Elsevier, 2022)Two libraries of mono- and dimeric pyrrolidine iminosugars were synthesized by CuAAC and (thio)urea-bond-forming reactions ...
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Oleuropein and its peracetylated derivative negatively regulate osteoclastogenesis by controlling the expression of genes involved in osteoclast differentiation and function
(Royal Society of Chemistry, 2020)During chronic inflammation, macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor-κB ...
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Asymmetric synthesis of dibenzo[b,d]azepines by Cu-catalyzed reductive or borylative cyclization
(Royal Society of Chemistry, 2021)A copper-catalyzed asymmetric intramolecular reductive cyclization for the synthesis of dibenzo[b,d]azepines is described. ...
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Iridium-and Palladium-Based Catalysts in the Pharmaceutical Industry
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)Transition metal catalysts play a vital role in a wide range of industrial organic processes. The large-scale production ...
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Latest Trends in Surface Modification for Dental Implantology: Innovative Developments and Analytical Applications
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)An increase in the world population and its life expectancy, as well as the ongoing concern about our physical appearance, ...
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2-Aminobenzoxazole-appended coumarins as potent and selective inhibitors of tumour-associated carbonic anhydrases
(Taylor & Francis, 2022)We have carried out the design, synthesis, and evaluation of a small library of 2-aminobenzoxazole-appended coumarins as ...
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Synthesis, conformational analysis and: In vivo assays of an anti-cancer vaccine that features an unnatural antigen based on an sp2-iminosugar fragment
(Royal Society of Chemistry, 2020)The Tn antigen (GalNAc-α-1-O-Thr/Ser) is a well-known tumor-associated carbohydrate determinant. The use of glycopeptides ...
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NleB/SseK-catalyzed arginine-glycosylation and enteropathogen virulence are finely tuned by a single variable position contiguous to the catalytic machinery
(Royal Society of Chemistry, 2021)NleB/SseK effectors are arginine-GlcNAc-transferases expressed by enteric bacterial pathogens that modify host cell proteins ...
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Ambiphilic boryl groups in a neutral Ni(ii) complex: a new activation mode of H2
(Royal Society of Chemistry, 2021)The concept of metal–ligand cooperation opens new avenues for the design of catalytic systems that may offer alternative ...
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Thio- and selenosemicarbazones as antiprotozoal agents against Trypanosoma cruzi and Trichomonas vaginalis
(Taylor & Francis, 2022)Herein, we report the preparation of a panel of Schiff bases analogues as antiprotozoal agents by modification of the ...
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Article
Chemoselective Preparation of New Families of Phenolic-Organoselenium Hybrids—A Biological Assessment
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)Being aware of the enormous biological potential of organoselenium and polyphenolic compounds, we have accomplished the ...
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Synthesis of tri- and tetramines containing two 2,3-dihydroxypyrrolidine moieties and their inhibitory activity toward α-mannosidases
(ARKAT USA INC, 2002)Through the reductive amination of N-[(tert-butoxy)carbonyl]-2,5-dideoxy-2,5-imino-3,4-Oisopropylidene-L-ribose with ...
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Influence of the surfactant degree of oligomerization on the formation of cyclodextrin: surfactant inclusion complexes
(Elsevier, 2020)Supramolecular complexation is an attractive strategy to modulate the performance of surfactants, e.g., by host-guest ...
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