Artículos (Química Orgánica)
Recent Submissions
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Article
New tacrine dimers with antioxidant linkers as dual drugs: Anti-Alzheimer's and antiproliferative agents
(Elsevier, 2017)We have designed a series of tacrine-based homo- and heterodimers that incorporate an antioxidant tether (selenoureido, ...
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Synthesis and Structure-activity Relationship of New Nicotinamide Phosphoribosyltransferase Inhibitors with Antitumor Activity on Solid and Haematological Cancer
(Elsevier, 2023)Cancer cells are highly dependent on Nicotinamide phosphoribosyltransferase (NAMPT) activity for proliferation, therefore ...
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Iminosugar-Phosphines as Organocatalysts in the [3 + 2] Cycloaddition of Allenoates and N-Tosylimines
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)Iminosugar derivatives containing a pyrrolidine-phosphine moiety were prepared from carbohydrates and used as catalysts ...
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Serine-/Cysteine-based sp2-Iminoglycolipids as novel TLR4 agonists: evaluation of their adjuvancy and immunotherapeutic properties in a murine model of asthma
(American Chemical Society, 2023)Glycolipids with TLR4 agonistic properties can serve either as therapeutic agents or as vaccine adjuvants by stimulating ...
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Fluoro-labelled sp2-iminoglycolipids with immunomodulatory properties
(Elsevier, 2023)The unique electronic properties of the fluorine atom make its strategic incorporation into a bioactive compound a very ...
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Structure-Based Identification and Biological Characterization of New NAPRT Inhibitors
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)NAPRT, the rate-limiting enzyme of the Preiss–Handler NAD biosynthetic pathway, has emerged as a key biomarker for the ...
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Tackling Antibiotic Resistance: Influence of Aliphatic Branches on Broad-Spectrum Antibacterial Polytriazoles against ESKAPE Group Pathogens
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)One of the most important threats to public health is the appearance of multidrug-resistant pathogenic bacteria, since ...
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A β-Cyclodextrin-Based Nanoparticle with Very High Transfection Efficiency Unveils siRNA-Activated TLR3 Responses in Human Prostate Cancer Cells
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)Synthetic double-stranded small interfering RNAs (siRNAs) mimic interference RNAs (RNAi) and can bind target mRNAs with a ...
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Scope and Limitations of Current Antibiotic Therapies against Helicobacter pylori: Reviewing Amoxicillin Gastroretentive Formulations
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)Even though general improvement of quality of life has happened around the globe, statistics show that gastric cancer is ...
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Article
Synthesis of β-galactosylamides as ligands of the peanut lectin. Insights into the recognition process
(Elsevier, 2017)The synthesis of mono and divalent β-galactosylamides linked to a hydroxylated chain having a C2 symmetry axis derived ...
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Article
Selenium and sulphur derivatives of hydroxytyrosol: inhibition of lipid peroxidation in liver microsomes of vitamin E-deficient rats
(Springer Nature, 2019)Purpose: The objective of this study was to evaluate the capacity of modified phenols synthesized from hydroxytyrosol, a ...
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Article
Carbon Dioxide as a Traceless Caramelization Promotor: Preparation of Prebiotic Difructose Dianhydrides (DFAs)-Enriched Caramels from D-Fructose
(American Chemical Society, 2017)Activation of a concentrated solution of D-fructose with carbonic acid, generated from carbon dioxide, induces the formation ...
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Article
Non-Ionic Osmotic Stress Induces the Biosynthesis of Nodulation Factors and Affects Other Symbiotic Traits in Sinorhizobium fredii HH103
(MDPI, 2023)Simple Summary: Rhizobia are soil proteobacteria able to establish nitrogen-fixing symbiosis with host legumes. This ...
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Article
A versatile stereocontrolled synthesis of 2-deoxyiminosugarC-glycosides and their evaluation as glycosidase inhibitors
(Royal Society of Chemistry, 2021)A highly enantioselective synthesis of (R,S) or (S,S)-2,6-disubstituted dehydropiperidines has been previously achieved ...
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Article
Toward a Suitable Structural Analysis of Gene Delivery Carrier Based on Polycationic Carbohydrates by Electron Transfer Dissociation Tandem Mass Spectrometry
(Elsevier, 2016)Polycationic carbohydrates represent an attractive class of biomolecules for several applications and particularly as non ...
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Article
Synthesis of β-galactosylamides as Ligands of the Peanut Lectin. Insights into the Recognition Process
(Elsevier, 2017)The synthesis of mono and divalent β-galactosylamides linked to a hydroxylated chain having a C2 symmetry axis derived ...
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Article
Synthesis and Antiproliferative Activity of Sulfa-Michael Adducts and Thiochromenes Derived from Carbohydrates
(Royal Society of Chemistry, 2017)The Michael addition reactions of carbohydrate-derived nitroalkenes with ethyl thioglycolate and 2-mercaptobenzyl alcohol ...
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Article
Molecular Determinants for Cyclo-oligosaccharide-based Nanoparticle-mediated Effective siRNA Transfection
(Future Medicine Ltd., 2017)Aim: To study the structural requirements that a cyclooligosaccharide-based nanoparticle must fulfill to be an efficient ...
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Article
Mechanistic Insight into the Binding of Multivalent Pyrrolidines to α-Mannosidases
(Wiley-Blackwell, 2017)Novel pyrrolidine-based multivalent iminosugars, synthesized by a CuAAC approach, have shown remarkable multivalent effects ...
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Article
N-Heterotricyclic Cationic Carbene Ligands. Synthesis, Reactivity and Coordination Chemistry
(Royal Society of Chemistry, 2018)The direct dialkylation of triazolo[4,3-b]isoquinolin-3-ylidene structures readily affords dicationic N-heterotricyclic ...