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DYKAT and desymmetrization strategies for the synthesis of axially chiral heterobiaryls [PhD Thesis]
(2020-01-31)The main objective of this PhD thesis is the development of new methodologies for the synthesis of axially chiral heterobiaryls through asymmetric functionalization of this type of systems. In this regard, the approaches ...
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Arylisoquinoline-derived organoboron dyes with a triaryl skeleton show dual fluorescence [Article]
(Beilstein-Institut, 2019)Se prepararon cuatro nuevos colorantes que derivan de arilisoquinolinas boryiladas, que contienen un tercer residuo de arilo (naftilo, 4-metoxinaftilo, pirenilo o antrilo) que se une a través de un eje estereogénico ...
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Biocatalysis as Useful Tool in Asymmetric Synthesis: An Assessment of Recently Granted Patents (2014–2019) [Article]
(MDPI, 2019-09-25)The broad interdisciplinary nature of biocatalysis fosters innovation, as different technical fields are interconnected and synergized. A way to depict that innovation is by conducting a survey on patent activities. This ...
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Biotransformations of industrial interest catalyzed by fungal peroxygenases [PhD Thesis]
(2019-10-11)In this Thesis, the selective synthesis of different products of industrial interest such as antioxidants derived from trans-stilbene and other stilbenoids, flavour-and-fragrance additives derived from α-isophorone, and ...
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Thiol-ene "Click" Synthesis and Pharmacological Evaluation of C-Glycoside sp2-Iminosugar Glycolipids [Article]
(MDPI, 2019)The unique stereoelectronic properties of sp2-iminosugars enable their participation in glycosylation reactions, thereby behaving as true carbohydrate chemical mimics. Among sp2-iminosugar conjugates, the sp2-iminosugar ...
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Trehalose-based Siamese twin amphiphiles with tunable self-assembling, DNA nanocomplexing and gene delivery properties [Article]
(The Society, 2019-06-19)An original family of multivalent vectors encompassing gemini and facial amphiphilicity, namely cationic Siamese twin surfactants, has been prepared from the disaccharide trehalose; molecular engineering lets us modulate ...
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Dynamization strategies for the atroposelective synthesis of (hetero)biaryls [PhD Thesis]
(2019-07-22)The central objective in this PhD thesis has been the development of asymmetric catalysis methodologies for the atroposelective synthesis of (hetero)biaryls through dynamization strategies. These methodologies comprise ...
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Debates: An Useful Tool to Promote Students Deeper Thinking in Stem Disciplines [Article]
(MDPI AG, 2018)The utility of debates for the evaluation of a series of transversal competences related to critical thinking is highlighted. Our main target has been to depict a novel evaluation methodology via discussion through a ...
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P450BM3-Catalyzed Oxidations Employing Dual Functional Small Molecules [Article]
(MDPI, 2019)A set of dual functional small molecules (DFSMs) containing different amino acids has been synthesized and employed together with three different variants of the cytochrome P450 monooxygenase P450BM3 from Bacillus ...
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Design and Synthesis of CNS-targeted Flavones and Analogues with Neuroprotective Potential Against H2O2- and Aβ1-42-Induced Toxicity in SH-SY5Y Human Neuroblastoma Cells [Article]
(MDPI, 2019)With the lack of available drugs able to prevent the progression of Alzheimer’s disease (AD), the discovery of new neuroprotective treatments able to rescue neurons from cell injury is presently a matter of extreme importance ...
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Control de las propiedades supramoleculares de ciclodextrinas mediante la incorporación de “clips” aromáticos. Aplicación al transporte de material génico. [PhD Thesis]
(2019-06-28)Las ciclodextrinas son ciclooligosacáridos naturales formados por unidades de D-glucopiranosa unidas mediante enlaces α-(14). Sus propiedades supramoleculares, dictadas por su peculiar arquitectura molecular (un troncocono ...
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Azabicyclic vinyl sulfones for residue-specific dual protein labelling [Article]
(Royal Society of Chemistry, 2019)We have developed [2.2.1]azabicyclic vinyl sulfone reagents that simultaneously enable cysteine-selective protein modification and introduce a handle for further bioorthogonal ligation. The reaction is fast and selective ...
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Componentes bioactivos del alperujo: propiedades y aplicación en fibra alimentaria [PhD Thesis]
(2019-05-28)La industria del aceite de oliva, consciente de la necesidad de eliminar los residuos medioambientalmente nocivos, está evolucionando para lograr el aprovechamiento integral de cada uno de los residuos que se generan de ...
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Probing the inhibitor versus chaperone properties of sp2-iminosugars towards human β-glucocerebrosidase: A picomolar chaperone for gaucher disease [Article]
(Multidisciplinary Digital Publishing Institute (MDPI), 2018)A series of sp2-iminosugar glycomimetics differing in the reducing or nonreducing character, the configurational pattern (D-gluco or L-ido), the architecture of the glycone skeleton, and the nature of the nonglycone ...
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Nuevas estrategias en el proceso de enseñanza-aprendizaje de la asignatura Experimentación Química II del Grado en Ingeniería Química Industrial [Article]
(Universidad de Sevilla, 2018)El trabajo realizado durante el desarrollo del ciclo de mejora experimentado en la asignatura Experimentación en Química II se ha centrado en dos pilares fundamentales: 1) Interconexión de los contenidos teórico-prácticos ...
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Sistemas dendríticos para la presentación multivalente de glicosaminoglicanos [PhD Thesis]
(2019-04-26)Los glicosaminoglicanos (GAGs) son polisacáridos altamente sulfatados y heterogéneos que participan en un gran número de procesos biológicos por interacción con determinadas proteínas. Con el fin de conocer el ...
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Ciclos de mejora docente en la asignatura de Química General basados en el trabajo guiado [Article]
(Universidad de Sevilla, 2018)En esta comunicación se presentan una estrategia de mejora docente progresiva basada en los denominados Ciclos de Mejora Docente, los cuales se han realizado en una parte del temario de la asignatura “Química General” ...
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Carbohydrate multivalent systems to functionalize proteins and surfaces for lectin interaction studies [PhD Thesis]
(2019-04-11)Las interacciones entre proteínas y carbohidratos están involucradas en muchos eventos biológicos fundamentales. En estos procesos, una clase de proteínas que reconocen azúcares denominadas lectinas juegan un papel ...
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