• Article
  

  Stereoselective Synthesis of Iminosugar 2-Deoxy(thio)glycosides from Bicyclic Iminoglycal Carbamates Promoted by Cerium(IV) Ammonium Nitrate and Cooperative Brønsted Acid-Type Organocatalysis 

  Herrera González, Irene; Sánchez Fernández, Elena Matilde; Sau, Abhijit; Nativi, Cristina; Garciá Fernández, José M.; Galán, M. Carmen; Ortiz Mellet, Carmen (American Chemical Society, 2020)

  The first examples of iminosugar-type 2-deoxy(thio)glycoside mimetics are reported. The key step is the activation of a ...

• Article
  

  Stable Pyrrole-Linked Bioconjugates through Tetrazine-Triggered Azanorbornadiene Fragmentation 

  Gil de Montes, Enrique; Istrate, Alena; Navo, Claudio D.; Jiménez Moreno, Ester; Hoyt, Emily A.; Corzana, Francisco; Robina Ramírez, Inmaculada; Jiménez Osés, Gonzalo; Moreno Vargas, Antonio José; Bernardes, Gonçalo J.L. (Wiley-Blackwell, 2020)

  An azanorbornadiene bromovinyl sulfone reagent for cysteine-selective bioconjugation has been developed. Subsequent reaction ...

• Article
  

  Catalytic Enantioselective Synthesis of a-aryl a-hydrazino Esters and Amides 

  Velázquez Muñoz, Marta; Alberca Manzano, Saúl; Iglesias Sigüenza, Francisco Javier; Fernández Fernández, Rosario Fátima; Lassaletta, José M; Monge Fernández, David (Royal Society of Chemistry, 2020)

  Catalysts generated by combinations of Pd(TFA)2and pyridine-hydrazone ligands have allowed the asymmetric 1,2-addition of ...

• Article
  

  AuI-Catalyzed Hydroalkynylation of Haloalkynes 

  García Fernández, Pedro David; Iglesias Sigüenza, Francisco Javier; Rivero Jerez, Paula S.; Díez Martín, Elena; Gómez Bengoa, Enrique; Fernández Fernández, Rosario Fátima; Lassaletta, José M. (American Chemical Society, 2020)

  The AuI-catalyzed reaction between terminal alkynes and aromatic haloalkynes proceeds through divergent pathways depending ...

• Article
  

  Phosphorylation: Synthesis, Membrane Permeability, and Exploratory Target Assessment within the Scope of Type 2 Diabetes and Alzheimer's Disease 

  De Matos, Ana M.; Blázquez Sánchez, M. Teresa; Bento Oliveira, Andreia; de Almeida, Rodrigo F.M.; Nunes, Rafael; Lopes, Pedro E.M.; Machuqueiro, Miguel; Cristóvão, Joana S.; López López, Óscar; Fernández-Bolaños Guzmán, José María; Amélia P. (American Chemical Society, 2020)

  Despite the rapidly increasing number of patients suffering from type 2 diabetes, Alzheimer's disease, and diabetes-induced ...

• Article
  

  Enantio- and Diastereoselective Nucleophilic Addition of N-tert-Butylhydrazones to Isoquinolinium Ions through Anion-Binding Catalysis 

  Matador Martínez, Esteban; Iglesias Sigüenza, Francisco Javier; Monge Fernández, David; Merino, Pedro; Fernández Fernández, Rosario Fátima; Lassaletta, J. M. (Wiley-Blackwell, 2021)

  A highly enantio- and diastereoselective thiourea-catalyzed dearomatization of isoquinolines employing N-tert-butylhydrazones ...

• Article
  

  Application of Biobased Solvents in Asymmetric Catalysis 

  Miele, Margherita; Pillari, Veronica; Pace, Vittorio; Alcántara, Andrés R.; Gonzalo Calvo, Gonzalo de (Multidisciplinary Digital Publishing Institute (MDPI), 2022)

  The necessity of more sustainable conditions that follow the twelve principles of Green Chemistry have pushed researchers ...

• Article
  

  Insights in Cellular Uptake Mechanisms of pDNA-polycationic Amphiphilic Cyclodextrin Nanoparticles (CDplexes) 

  Díaz Moscoso, Alejandro; Vercauteren, Dries; Rejman, Joanna; Benito, Juan M.; Ortiz Mellet, Carmen; De Smedt, Stefaan C.; Fernández, José M. García (Elsevier, 2010)

  It is generally recognized that the major obstacle to efficient gene delivery is cellular internalization and endosomal ...

• Article
  

  Alkoxyamine-cyanoborane adducts: Efficient cyanoborane transfer agents 

  Márquez, José M.; Martínez Castro, Elisa; Gabrielli, Serena; López López, Óscar; Maya Castilla, Inés; Angulo, Manuel; Álvarez, Eleuterio; Fernández-Bolaños Guzmán, José María (Royal Society of Chemistry, 2011)

  We report the synthesis of the hitherto unknown zwitterionic alkoxyamino cyanoboranes by reduction of O-alkyloximes with ...

• Article
  

  Pharmacological chaperone therapy for Gaucher disease: A patent review 

  Benito, Juan M.; García Fernández, José M.; Ortiz Mellet, Carmen (Taylor & Francis, 2011)

  Introduction: Mutations in the gene encoding for acid β-glucosidase (β-glucocerebrosidase, GlcCerase) are seen in Gaucher ...

• Article
  

  Enhanced Gene Delivery Triggered by Dual pH/Redox Responsive Host-Guest Dimerization of Cyclooligosaccharide Star Polycations 

  Carbajo Gordillo, Ana Isabel; López Fernández, José; Benito, Juan M.; Jiménez Blanco, José Luis; Santana Armas, María L.; Marcelo, Gema; Ortiz Mellet, Carmen; García Fernández, José M. (Wiley, 2022)

  A robust strategy is reported to build perfectly monodisperse star polycationscombining a trehalose-based cyclooligosaccharide ...

• Article
  

  Cyclodextrin-mediated Crystallization of Acid β-glucosidase in Complex with Amphiphilic Bicyclic Nojirimycin Analogues 

  Brumshtein, Boris; Aguilar Moncayo, Matilde; Benito, Juan M.; García Fernández, José M.; Silman, Israel; Shaaltiel, Yoseph; Aviezer, David; Sussman, Joel L.; Futerman, Anthony H.; Ortiz Mellet, Carmen (Royal Society of Chemistry, 2011)

  Cyclodextrin-based host-guest chemistry has been exploited to facilitate co-crystallization of recombinant human acid ...

• Article
  

  Axially Chiral Triazoloisoquinolin-3-ylidene Ligands in Gold(I)-catalyzed Asymmetric Intermolecular (4 + 2) Cycloadditions of Allenamides and Dienes 

  Francos, Javier; Grande Carmona, Francisca; Faustino, Hélio; Iglesias Sigüenza, Francisco Javier; Díez Martín, Elena; Alonso, Isaac; Fernández Fernández, Rosario Fátima; Lassaletta, José M.; López, Fernando; Mascareñas, José L. (American Chemical Society, 2012)

  The first highly enantioselective intermolecular (4 + 2) cycloaddition between allenes and dienes is reported. The reaction ...

• Article
  

  Inhibition of Type 1 Fimbriae-mediated Escherichia Coli Adhesion and Biofilm Formation by Trimeric Cluster Thiomannosides Conjugated to Diamond Nanoparticles 

  Khanal, Manakamana; Larsonneur, Fanny; Raks, Victoriia; Barras, Alexandre; Baumann, Jean-Sébastien; Martin, Fernando Ariel; Martin, Fernando Ariel; Boukherroub, Rabah; Ghigo, Jean Marc; Ortiz Mellet, Carmen; Zaitsev, Vladimir; Garcia Fernandez, Jose M.; Beloin, Christophe; Siriwardena, Aloysius; Szunerits, Sabine (Royal Society of Chemistry, 2015)

  Recent advances in nanotechnology have seen the development of a number of microbiocidal and/or anti-adhesive nanoparticles ...

• Article
  

  Strongly Emissive and Photostable Four-Coordinate Organoboron N,C Chelates and Their Use in Fluorescence Microscopy 

  Pais, Vânia F.; Alcaide, María M.; López Rodríguez, Rocío; Collado, Daniel; Nájera, Francisco; Pérez Inestrosa, Ezequiel; Álvarez, Eleuterio; Lassaletta, José M.; Fernández Fernández, Rosario Fátima; Ros Lao, Abel; Pischel, Uwe (Wiley-Blackwell, 2015)

  Six strongly fluorescent four-coordinate organoboron N,C chelates containing an aryl isoquinoline skeleton were prepared. ...

• Article
  

  Pyridine–hydrazone ligands in enantioselective palladium-catalyzed Suzuki–Miyaura cross-couplings 

  Álvarez Casao, Yolanda; Estepa, Beatriz; Monge Fernández, David; Ros, Abel; Iglesias Sigüenza, Francisco Javier; Álvarez, Eleuterio; Fernández Fernández, Rosario Fátima; Lassaletta, José M. (Elsevier, 2016)

  The geometries and coordination properties of modular pyridineehydrazone N,N-ligands containing C2- symmetric ...

• Article
  

  A gliclazide complex based on palladium towards Alzheimer's disease: promising protective activity against Aβ-induced toxicity in C. elegans 

  García García, Amalia; Rojas, Sara; Rivas García, Lorenzo; Navarro Hortal, María D.; Romero Márquez, José M.; Fernández-Bolaños Guzmán, José María; López López, Óscar; Rodríguez-Diéguez, Antonio (Royal Society of Chemistry, 2022)

  A new palladium coordination compound based on gliclazide with the chemical formula [Pd(glz)2] (where glz = gliclazide) ...

• Patent
  

  Derivados sp2, imnoazúcar como inhibidores de las alfa-glicosidasas. 

  Garcia Fernandez, Jose M.; Risquez-Cuadro, Rocio; Sánchez Fernández, Elena Matilde; Ortiz Mellet, Carmen (Oficina Española de Patentes y Marcas , 2011-12-23)

  Derivados sp2 imnoazúcar como inhibidores de las ?-glicosidasas.Derivados glicosilados de fórmula I, donde los significados ...

• Patent
  

  Nuevos derivados de ciclodextrinas selectivamente fucionalizados en su cara secundaria, procedimiento de preparacion y utilizacion de los mismos. 

  Balbuena Oliva, Patricia; Garcia Fernandez, Jose Manuel; Duval, Raphael; Ortiz Mellet, Carmen (Oficina Española de Patentes y Marcas , 2008-04-01)

  Nuevos derivados de coclodextrinas selectivamnet funcionalizados en su cara secundaria, procedimiento de preparación y ...

• Patent
  

  Composición para el tratamiento de enfermedades asociadas a trastornos lisosomales 

  García Fernández, José Manuel; Sánchez Alcázar, José Antonio; De La Mata Fernández, Mario; Ortiz Mellet, Carmen (Oficina Española de Patentes y Marcas , 2017-01-20)

  Composición para el tratamiento de enfermedades asociadas a trastornos lisosomales.Composición farmacéutica que comprende ...

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