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Synthesis and Antiproliferative Activity of Sulfa-Michael Adducts and Thiochromenes Derived from Carbohydrates

dc.creatorLuque Agudo, V.es
dc.creatorAlbarran Velo, J.es
dc.creatorFernández-Bolaños Guzmán, José Maríaes
dc.creatorLópez López, Óscares
dc.creatorLight, M.E.es
dc.creatorPadrón, J.M.es
dc.creatorLagunes, I.es
dc.creatorRomán, E.es
dc.creatorSerrano, J.A.es
dc.creatorGil, M.V. es
dc.date.accessioned2022-12-20T19:16:00Z
dc.date.available2022-12-20T19:16:00Z
dc.date.issued2017
dc.identifier.citationLuque Agudo, V., Albarran Velo, J., Fernández-Bolaños Guzmán, J.M., López López, Ó., Light, M.E., Padrón, J.M.,...,Gil, M.V. . (2017). Synthesis and Antiproliferative Activity of Sulfa-Michael Adducts and Thiochromenes Derived from Carbohydrates. New Journal of Chemistry, 41 (8), 3154-3162. https://doi.org/10.1039/C6NJ03940E.
dc.identifier.issn1144-0546es
dc.identifier.issn1369-9261es
dc.identifier.urihttps://hdl.handle.net/11441/140700
dc.description.abstractThe Michael addition reactions of carbohydrate-derived nitroalkenes with ethyl thioglycolate and 2-mercaptobenzyl alcohol were studied. Reactions were conducted under mild, solvent-free conditions with DABCO as a catalyst, affording the corresponding adducts in good yields. Furthermore, compounds resulting from the addition with 2-mercaptobenzyl alcohol were used as starting materials for the synthesis of chiral 3-nitro-2H-thiochromenes. For some of the compounds synthesized herein, the antioxidant and antiproliferative activities against a panel of human solid tumor cell lines were assayed and compared with those of carbohydrate-nitroalkene substrates.es
dc.description.sponsorshipJunta de Extremadura GR15022es
dc.description.sponsorshipUnión Europea FP7-REGPOT-2012-CT2012-31637-IMBRAINes
dc.formatapplication/pdfes
dc.format.extent9 p.es
dc.language.isoenges
dc.publisherRoyal Society of Chemistryes
dc.relation.ispartofNew Journal of Chemistry, 41 (8), 3154-3162.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleSynthesis and Antiproliferative Activity of Sulfa-Michael Adducts and Thiochromenes Derived from Carbohydrateses
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/acceptedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Química orgánicaes
dc.relation.projectIDGR15022es
dc.relation.projectIDFP7-REGPOT-2012-CT2012-31637-IMBRAINes
dc.relation.publisherversionhttps://dx.doi.org/10.1039/C6NJ03940Ees
dc.identifier.doi10.1039/C6NJ03940Ees
dc.journaltitleNew Journal of Chemistryes
dc.publication.volumen41es
dc.publication.issue8es
dc.publication.initialPage3154es
dc.publication.endPage3162es
dc.contributor.funderJunta de Extremaduraes
dc.contributor.funderUnión Europeaes

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