dc.creator | Luque Agudo, V. | es |
dc.creator | Albarran Velo, J. | es |
dc.creator | Fernández-Bolaños Guzmán, José María | es |
dc.creator | López López, Óscar | es |
dc.creator | Light, M.E. | es |
dc.creator | Padrón, J.M. | es |
dc.creator | Lagunes, I. | es |
dc.creator | Román, E. | es |
dc.creator | Serrano, J.A. | es |
dc.creator | Gil, M.V. | es |
dc.date.accessioned | 2022-12-20T19:16:00Z | |
dc.date.available | 2022-12-20T19:16:00Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Luque Agudo, V., Albarran Velo, J., Fernández-Bolaños Guzmán, J.M., López López, Ó., Light, M.E., Padrón, J.M.,...,Gil, M.V. . (2017). Synthesis and Antiproliferative Activity of Sulfa-Michael Adducts and Thiochromenes Derived from Carbohydrates. New Journal of Chemistry, 41 (8), 3154-3162. https://doi.org/10.1039/C6NJ03940E. | |
dc.identifier.issn | 1144-0546 | es |
dc.identifier.issn | 1369-9261 | es |
dc.identifier.uri | https://hdl.handle.net/11441/140700 | |
dc.description.abstract | The Michael addition reactions of carbohydrate-derived nitroalkenes with ethyl thioglycolate and 2-mercaptobenzyl alcohol were studied. Reactions were conducted under mild, solvent-free conditions with DABCO as a catalyst, affording the corresponding adducts in good yields. Furthermore, compounds resulting from the addition with 2-mercaptobenzyl alcohol were used as starting materials for the synthesis of chiral 3-nitro-2H-thiochromenes. For some of the compounds synthesized herein, the antioxidant and antiproliferative activities against a panel of human solid tumor cell lines were assayed and compared with those of carbohydrate-nitroalkene substrates. | es |
dc.description.sponsorship | Junta de Extremadura GR15022 | es |
dc.description.sponsorship | Unión Europea FP7-REGPOT-2012-CT2012-31637-IMBRAIN | es |
dc.format | application/pdf | es |
dc.format.extent | 9 p. | es |
dc.language.iso | eng | es |
dc.publisher | Royal Society of Chemistry | es |
dc.relation.ispartof | New Journal of Chemistry, 41 (8), 3154-3162. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | Synthesis and Antiproliferative Activity of Sulfa-Michael Adducts and Thiochromenes Derived from Carbohydrates | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/acceptedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Química orgánica | es |
dc.relation.projectID | GR15022 | es |
dc.relation.projectID | FP7-REGPOT-2012-CT2012-31637-IMBRAIN | es |
dc.relation.publisherversion | https://dx.doi.org/10.1039/C6NJ03940E | es |
dc.identifier.doi | 10.1039/C6NJ03940E | es |
dc.journaltitle | New Journal of Chemistry | es |
dc.publication.volumen | 41 | es |
dc.publication.issue | 8 | es |
dc.publication.initialPage | 3154 | es |
dc.publication.endPage | 3162 | es |
dc.contributor.funder | Junta de Extremadura | es |
dc.contributor.funder | Unión Europea | es |