Data

NameFernández-Bolaños Guzmán, José María
DepartmentQuímica Orgánica
Knowledge areaQuímica Orgánica
Professional categoryCatedrático de Universidad
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  Publications

 

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2-Aminobenzoxazole-appended coumarins as potent and selective inhibitors of tumour-associated carbonic anhydrases

Fuentes Aguilar, Alma; Merino Montiel, Penélope; Montiel Smith, Sara; Meza Reyes, Socorro; Vega Báez, José Luis; Fernández-Bolaños Guzmán, José María; López López, Óscar (Taylor & Francis, 2022-01-01)
We have carried out the design, synthesis, and evaluation of a small library of 2-aminobenzoxazole-appended coumarins as ...
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Chemoselective Preparation of New Families of Phenolic-Organoselenium Hybrids—A Biological Assessment

Begines Aguilar, Paloma; Martos Delgado, Sergio; Lagunes, Irene; Maya Castilla, Inés; Padrón, José M.; López López, Óscar; Fernández-Bolaños Guzmán, José María (Multidisciplinary Digital Publishing Institute (MDPI), 2022-01-01)
Being aware of the enormous biological potential of organoselenium and polyphenolic compounds, we have accomplished the ...
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Thio- and selenosemicarbazones as antiprotozoal agents against Trypanosoma cruzi and Trichomonas vaginalis

Ibáñez Escribano, Alexandra; Fonseca Berzal, Cristina; Martínez Montiel, Mónica; Álvarez Márquez, Manuel; Gómez Núñez, María; Lacueva Arnedo, Manuel; Espinosa Buitrago, Teresa; Martín Pérez, Tania; Escario, José Antonio; Merino Montiel, Penélope; Montiel Smith, Sara; Gómez Barrio, Alicia; López López, Óscar; Fernández-Bolaños Guzmán, José María (Taylor & Francis, 2022-01-01)
Herein, we report the preparation of a panel of Schiff bases analogues as antiprotozoal agents by modification of the ...
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Identification of an acetyl esterase in the supernatant of the environmental strain Bacillus sp. HR21-6

Sánchez Barrionuevo, Leyre; Mateos, Jesús; Fernández Puente, Patricia; Begines Aguilar, Paloma; Fernández-Bolaños Guzmán, José María; Gutiérrez Pozo, Gabriel; Cánovas López, David; Mellado Durán, María Encarnación (Elsevier, 2022-01-01)
Bacillus sp. HR21-6 is capable of the chemo- and regioselective synthesis of lipophilic partially acetylated phenolic ...
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Squaramide-Tethered Sulfonamides and Coumarins: Synthesis, Inhibition of Tumor-Associated CAs IX and XII and Docking Simulations

Arrighi, Giulia; Puerta, Adrián; Petrini, Andrea; Hicke, Francisco J.; Nocentini, Alessio; Fernandes, Miguel X.; Padrón, José M.; Supuran, Claudiu T.; Fernández-Bolaños Guzmán, José María; López López, Óscar (Multidisciplinary Digital Publishing Institute (MDPI), 2022-01-01)
(1) Background: carbonic anhydrases (CAs) are attractive targets for the development of new anticancer therapies; in ...
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A New Peracetylated Oleuropein Derivative Ameliorates Joint Inflammation and Destruction in a Murine Collagen-Induced Arthritis Model via Activation of the Nrf-2/Ho-1 Antioxidant Pathway and Suppression of MAPKs and NF-κB Activation

López-Castejón, María Luisa; Alarcón de la Lastra Romero, Catalina; Rosillo Ramírez, María de los Ángeles; Montoya García, Tatiana; Fernández-Bolaños Guzmán, José María; González Benjumea, Alejandro; Sánchez Hidalgo, Marina (MDPI, 2021-01-01)
Oleuropein (OL), an olive tree secoiridoid and its peracetylated derivate (Per-OL) haveexhibited several beneficial effects ...
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Inhibitory effect of olive phenolic compounds isolated from olive oil by-product on melanosis of shrimps

Lama Muñoz, Antonio; Gómez Carretero, Antonio; Rubio-Senent, Fátima; Bermúdez Oria, Alejandra; Maya Castilla, Inés; Fernández-Bolaños Guzmán, José María; Vioque Cubero, Blanca; Fernández-Bolaños Guzmán, Juan (Multidisciplinary Digital Publishing Institute (MDPI), 2021-01-01)
Melanosis is an unsolved problem of the crustacean industry and the cause of great loss of value. This study investigates ...
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Development of tacrine clusters as positively cooperative systems for the inhibition of acetylcholinesterase

Evangelista, Tereza Cristina Santos; López López, Óscar; Ferreira, Sabrina Baptista; Fernández-Bolaños Guzmán, José María; Sydnes, Magne O.; Lindbäck, Emil (Taylor & Francis Open Access, 2021-01-01)
The synthesis of four tetra-tacrine clusters where the tacrine binding units are attached to a central scaffold via linkers ...
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Tuning the activity of iminosugars: novel N-alkylated deoxynojirimycin derivatives as strong BuChE inhibitors

Ahuja Casarín, Ana I.; Merino Montiel, Penélope; Vega Báez, José Luis; Montiel Smith, Sara; Fernandes, Miguel X,; Lagunes, Irene; Maya Castilla, Inés; López López, Óscar; Fernández-Bolaños Guzmán, José María (Taylor & Francis Open Access, 2021-01-01)
We have designed unprecedented cholinesterase inhibitors based on 1-deoxynojirimycin as potential anti-Alzheimer’s agents. ...
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Encased Gold Nanoparticle Synthesis as a Probe for Oleuropein Self-Assembled Structure Formation

Jiménez Ruiz, Aila; Prado Gotor, Rafael; Fernández-Bolaños Guzmán, José María; González Benjumea, Alejandro; Carnerero Panduro, José María (MDPI, 2020-12-01)
Stable oleuropein-coated gold nanoparticles in aqueous media were synthesized for the first time. Oleuropein (OLE) ...
PhD Thesis
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Síntesis y evaluación de nuevas moléculas multidiana en la prevención de enfermedades degenerativas

Fernández-Bolaños Guzmán, José María; Maya Castilla, Inés; López López, Óscar; Roldán Peña, Jesús Miguel (2020-03-13)
En la presente Tesis Doctoral se ha llevado a cabo la síntesis y evaluación de nuevos compuestos orgánicos como fármacos ...
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Osteoarthritis treatment with a novel nutraceutical acetylated ligstroside aglycone, a chemically modified extra-virgin olive oil polyphenol

Andrés, María C de; Meiss, Mia S; Sánchez Hidalgo, Marina; González Benjumea, Alejandro; Fernández-Bolaños Guzmán, José María; Alarcón de la Lastra Romero, Catalina; Oreffo, Richard OC (Sage, 2020-01-01)
Recent studies have shown that dietary patterns confer protection from certain chronic diseases related to oxidative stress, ...
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Masked Phenolic-Selenium Conjugates: Potent and Selective Antiproliferative Agents Overcoming P-gp Resistance

Begines Aguilar, Paloma; Sevilla Horrillo, Lucía; Puerta, Adrián; Puckett, Rebeca; Bayort, Samuel; Lagunes, Irene; Maya Castilla, Inés; Padrón, José M.; López López, Óscar; Fernández-Bolaños Guzmán, José María (MDPI, 2020-01-01)
Cancer accounts for one of the most complex diseases nowadays due to its multifactorial nature. Despite the vast number ...
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1,4-Dideoxy-1,4-imino-d-arabinitol (DAB) Analogues Possessing a Hydrazide Imide Moiety as Potent and Selective α-Mannosidase Inhibitors

Haarr, Marianne B.; López López, Óscar; Pejov, Ljupcho; Fernández-Bolaños Guzmán, José María; Lindbäck, Emil; Sydnes, Magne O. (American Chemical Society, 2020-01-01)
The synthesis of two polyhydroxylated pyrrolidines as 1,4-dideoxy-1,4-imino-d-arabinitol (DAB) analogues bearing a hydrazide ...
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Oleuropein and its peracetylated derivative negatively regulate osteoclastogenesis by controlling the expression of genes involved in osteoclast differentiation and function

Rosillo Ramírez, María de los Ángeles; Montserrat de la Paz, Sergio; Abia, Rocío; Castejón Martínez, María Luisa; Millán Linares, María Carmen; Alarcón de la Lastra Romero, Catalina; Fernández-Bolaños Guzmán, José María; Muriana, Francisco J. G. (Royal Society of Chemistry, 2020-01-01)
During chronic inflammation, macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor-κB ...
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Design and Synthesis of CNS-targeted Flavones and Analogues with Neuroprotective Potential Against H2O2- and Aβ1-42-Induced Toxicity in SH-SY5Y Human Neuroblastoma Cells

Matos, Ana M. de; Martins, Alice; Man,Teresa; Evans, David; Walter, Magnus; Oliveira, Maria Conceição; López López, Óscar; Fernández-Bolaños Guzmán, José María; Rauter, Amélia P. (MDPI, 2019-01-01)
With the lack of available drugs able to prevent the progression of Alzheimer’s disease (AD), the discovery of new ...
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Olive-Oil-Derived Polyphenols Effectively Attenuate Inflammatory Responses of Human Keratinocytes by Interfering with the NF-κB Pathway

Aparicio Soto, Marina; Redhu, Davender; Sánchez Hidalgo, Marina; Fernández-Bolaños Guzmán, José María; Alarcón de la Lastra Romero, Catalina; Worm, Margitta; Babina, Magda (Wiley, 2019-01-01)
Primary human keratinocytes are pretreated with HTy-Ac or HTy for 30 min and stimulated with IL-1β or Toll-like receptor ...
PhD Thesis
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Síntesis química y enzimática de biofenoles lipofilos del olivo con actividad antiinflamatoria. Optimización de la reacción de Krapcho

Maya Castilla, Inés; Fernández-Bolaños Guzmán, José María; González Benjumea, Alejandro (2017-09-15)
En la presente Tesis Doctoral se ha realizado la síntesis de una serie de compuestos lipófilos, a partir de biofenoles ...
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A Straightforward Access to New Families of Lipophilic Polyphenols by Using Lipolytic Bacteria

Sánchez Barrionuevo, Leyre; González Benjumea, Alejandro; Escobar Niño, Almudena; García Gutiérrez, María Teresa; López López, Óscar; Maya Castilla, Inés; Fernández-Bolaños Guzmán, José María; Cánovas López, David; Mellado Durán, María Encarnación (Public Library of Science, 2016-01-01)
The chemical synthesis of new lipophilic polyphenols with improved properties presents technical difficulties. Here we ...
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Isolation and identification of minor secoiridoids and phenolic components from thermally treated olive oil by-products

Rubio-Senent, Fátima; Martos, Sergio; Lama Muñoz, Antonio; Fernández-Bolaños Guzmán, José María; Rodríguez-Gutiérrez, Guillermo; Fernández Bolaños, Juan (Elsevier, 2015-11-15)
The application of an industrial process based on the hydrothermal treatment of 160 °C/60 min of alperujo, a by-product ...
PhD Thesis
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Síntesis de nuevos antioxidantes derivados del hidroxitirosol. Interacción con ciclodextrinas

Maya Castilla, Inés; Fernández-Bolaños Guzmán, José María; López López, Óscar; Marset Castro, Azucena (2014-02-26)
En la presente Tesis Doctoral se ha llevado a cabo la preparación de derivados funcionales del hidroxitirosol (HT), con ...
PhD Thesis
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Síntesis de compuestos organoselénicos derivados del hidroxitirosol. Determinación de su actividad como antioxidantes

Fernández-Bolaños Guzmán, José María; Fernandez-Bolaños Guzman, Juan; Maya Castilla, Inés; Gómez Carretero, Antonio (2012-01-13)
1. Introducción Los polifenoles son una amplia familia de compuestos que se encuentran, entre otros alimentos, en la fruta, ...
PhD Thesis
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Compuestos organoselénicos derivados de carbohidratos. Isoselenocianatos, selenoureas y selenoheterociclos

Fernández-Bolaños Guzmán, José María; Maya Castilla, Inés; López López, Óscar; Maza Pérez, Susana (2007-12-20)
En esta Tesis Doctoral se ha puesto a punto un procedimiento eficaz de conversión de tioureas derivadas de azúcar en las ...
PhD Thesis
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Sulfoazúcares, sulfoglicolípidos y taurinas N-sustituidas

Fuentes Mota, José; Fernández-Bolaños Guzmán, José María; Robina Ramírez, Inmaculada; Ulgar Ruiz, Víctor Manuel (2001-04-01)
En esta Tesis Doctoral se han preparado C-sulfoazúcares y C-sulfopolioles que contienen un grupo sulfonato (SO3M) en ...
PhD Thesis
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Tioaminoazúcares y derivados. El grupo tiocarbamato como isotiocianato latente

Fuentes Mota, José; Fernández-Bolaños Guzmán, José María; Zafra Rodríguez, Encarnación (2000-01-01)
Dentro de un contexto general sobre síntesis de derivados de carbohidratos, mono-, di y oligosacáridos funcionalizados con ...
PhD Thesis
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Feniltio y fenilsulfinil glicósidos: síntesis de análogos de factoes Nod y de y de C-sulfocelobiosas

Robina Ramírez, Inmaculada; Fernández-Bolaños Guzmán, José María; Fuentes Mota, José; Gómez Bujedo, Silvia (1999-01-01)
La presente Tesis Doctoral se encuadra dentro de los proyectos de investigación sobre Isotiocianato, tioamnio- y ...
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Tensioactivos. XX. ω-Monoésteres grasos de ditioacetales de azúcares

Fernández Bolaños Vázquez, José Manuel; Fernández Mesa, M.J.; Fernández-Bolaños Guzmán, José María (CSIC, 1995-01-01)
PhD Thesis
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Síntesis de tioaminoazúcares y sulfoaminoazúcares

Fernández-Bolaños Guzmán, José María; Fernández-Bolaños, J.; García Rodríguez, María Salud (1994-01-30)
En esta tesis se describe la preparación de una serie de nuevos tioaminoazúcares por reacción de desplazamiento nucleófilo ...
PhD Thesis
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Síntesis de pentahidroxipentil-furanos

García Fonzález, F.; Fernández-Bolaños Guzmán, José María; Alfonso Rodríguez, Rafael (1977-02-26)
PhD Thesis
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Polihidroxialquil nitroimidazoles

Fernández-Bolaños Guzmán, José María; Cert Ventulá, Arturo; Delgado Cobos, Pedro (1976-03-11)
PhD Thesis
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Anticancerosos potenciales esteres sulfónicos y graso D-nanitol

Viguera Lobo, José María; Fernández-Bolaños Guzmán, José María; Collantes de Terán Palacios, Fernando (1975-06-28)