Artículo
Synthesis of axially chiral heterobiaryl alkynes via dynamic kinetic asymmetric alkynylation
Autor/es | Hornillos, Valentín
Ros, Abel |
Director | |
Departamento | Universidad de Sevilla. Departamento de Química orgánica |
Fecha de publicación | 2016 |
Fecha de depósito | 2022-05-27 |
Publicado en |
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Resumen | The dynamic kinetic Pd0
-catalyzed alkynylation of racemic heterobiaryl sulfonates was used for the asymmetric synthesis of axially
chiral heterobiaryl alkynes with a broad scope. The use of Pd(OAc)2/
(S)-QUINAP as the ... The dynamic kinetic Pd0 -catalyzed alkynylation of racemic heterobiaryl sulfonates was used for the asymmetric synthesis of axially chiral heterobiaryl alkynes with a broad scope. The use of Pd(OAc)2/ (S)-QUINAP as the precatalyst provides products in excellent yields and enantioselectivities under mild conditions (DMSO, 40 8C). Semireduction, 1,3-dipolar cycladdition or N-oxidation served to illustrate the synthetic potential of the methodology. |
Cita | Hornillos, V. y Ros, A. (2016). Synthesis of axially chiral heterobiaryl alkynes via dynamic kinetic asymmetric alkynylation. Chemical Communications, 52, 14121-14124. |
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