Hepatobiliary tumors are a group of primary malignancies encompassing the liver, the intra- and extra-hepatic biliary ...

More than 50 years have passed since Nobel laureate Cristian de Duve described for the first time the presence of tiny ...

Stress granules are non-membrane bound RNA-protein granules essential for survival during acute cellular stress. TIA-1 is ...

Intrinsic protein flexibility is of overwhelming relevance for intermolecular recognition and adaptability of highly dynamic ...

Intrinsic protein flexibility is of overwhelming relevance for intermolecular recognition and adaptability of highly dynamic ...

t has been recently shown that electron transfer between mitochondrial cytochrome c and the cytochrome c1 subunit of the ...

Repair of injured DNA relies on nucleosome dismantling by histone chaperones and de-phosphorylation events carried out by ...

While most organelles are surrounded by membranes, cells also contain membraneless organelles, which remain separated in ...

Cell signaling mechanisms modulate gene expression in response to internal and external stimuli. Cellular adaptation ...

Despite mitochondria being key for the control of cell homeostasis and fate, their role in DNA damage response is usually ...

Post-translational modifications frequently modulate protein functions. Lysine acetylation in particular plays a key role ...

Cyclin M (CNNM1-4) proteins maintain cellular and body magnesium (Mg2+) homeostasis. Using various biochemical approaches, ...

The maintenance of genome integrity is a critical process for cell life. To face DNA lesions, living beings have developed ...

Cardiolipin oxidation and degradation by different factors under severe cell stress serve as a trigger for genetically ...

Post-translational modifications of proteins expand their functional diversity, regulating the response of cells to a ...

Mitochondria are the powerhouses of the cell, whilst their malfunction is related to several human pathologies, including ...

His/Cys coordination was recently found in several c-type cytochromes, which could act as sensors, in electron transport ...

HuR/ELAVL1 is an RNA-binding protein involved in differentiation and stress response that acts primarily by stabilizing ...

The four member family of “Cyclin and Cystathionine β-synthase (CBS) domain divalent metal cation transport mediators”, ...

The proper arrangement of protein components within the respiratory electron transport chain is nowadays a matter of intense ...

BACKGROUND: Even though liver kinase B1 (LKB1) is usually described as a tumor suppressor in a wide variety of tissues, ...

Malaria is caused by Apicomplexa protozoans from the Plasmodium genus entering the bloodstream of humans and animals through ...

Apoptosis is a highly regulated form of programmed cell death, essential to the development and homeostasis of multicellular ...

Respiratory cytochrome c has been found to be phosphorylated at tyrosine 97 in the postischemic brain upon neuroprotective ...

Despite the importance of electron transfer between redox proteins in photosynthesis and respiration, the inter-protein ...

Protein production using processed cell lysates is a core technology in synthetic biology and these systems are excellent ...

Understanding the molecular basis of the thermal stability and functionality of redox proteins has important practical ...

Over the past decade, evidence has emerged suggesting a broader role for cytochrome c (Cyt c) in programmed cell death. ...

The development, as well as the homeostatic control of multi-cellular organisms, requires programmed cell death processes. ...

Regulation of mitochondrial activity allows cells to adapt to changing conditions and to control oxidative stress, and its ...

Higher-order plants and mammals use similar mechanisms to repair and tolerate oxidative DNA damage. Most studies on the ...

TIA-1 (T-cell restricted intracellular antigen-1) is an RNA-binding protein involved in splicing and translational repression. ...

mRNA metabolism is tightly orchestrated by highly-regulated RNA Binding Proteins (RBPs) that determine mRNA fate, thereby ...

Generating the immune response requires the discrimination of peptides presented by the human leukocyte antigen complex ...

Protein complex formation is at least a two-step process in which the formation of a final, well-defined complex entails ...

Human antigen R (HuR) is a ubiquitous 32kDa protein comprising three RNA Recognition Motifs (RRMs), whose main function ...

The transient interactions of respiratory cytochrome c with complexes III and IV is herein investigated by using heterologous ...

Chromatin is pivotal for regulation of the DNA damage process insofar as it influences access to DNA and serves as a DNA ...

n plants, channeling of cytochrome c molecules between complexes III and IV has been purported to shuttle electrons within ...

The rapid transfer of electrons in the photosynthetic redox chain is achieved by the formation of short-lived complexes ...

Human antigen R (HuR) is a 32 kDa protein with 3 RNA Recognition Motifs (RRMs), which bind to Adenylate and uridylate Rich ...

T-cell intracellular antigen-1 (TIA-1) is a key DNA/RNA binding protein that regulates translation by sequestering target ...

Since the first description of apoptosis four decades ago, great efforts have been made to elucidate, both in vivo and in ...

En esta tesis se presenta un análisis estructural de la proteína de unión a ARN HuR y, en particular, se profundiza en el ...

l‐galactono‐1,4‐lactone dehydrogenase (GALDH) catalyzes the terminal step of vitamin C biosynthesis in plant mitochondria. ...

Background: The interaction of MSP119 with the cupredoxin azurin inhibits the growth of Plasmodium falciparum in red blood ...

Background: T-cell intracellular antigen- 1(TIA-1) is a key DNA/RNA binding protein in RNA metabolism. Results: The binding ...

Programmed cell death is an event displayed by many different organisms along the evolutionary scale. In plants, programmed ...

Human antigen R (HuR) is a multitasking RNA binding protein involved in posttranscriptional regulation by recognizing ...

Under nitroxidative stress, a minor fraction of cytochrome c can be modified by tyrosine nitration. Here we analyze the ...

Transient complexes, with a lifetime ranging between microseconds and seconds, are essential forbiochemical reactions ...

T-cell intracellular antigen-1 (TIA-1) plays a pleiotropic role in cell homeostasis through the regulation of alternative ...

Cytochrome c delicately tilts the balance between cell life (respiration) and cell death (apoptosis). Whereas cell life ...

Identifying the factors that govern the thermal resistance of cupredoxins is essential for understanding their folding and ...

KSRP is a multi-domain RNA-binding protein that recruits the exosome-containing mRNA degradation complex to mRNAs coding ...

The far upstream element (FUSE) regulatory system promotes a peak in the concentration of c-Myc during cell cycle. First, ...

Tyrosine nitration is one of the most common post-transcriptional modifications of proteins, so affecting their structure ...

The metal cofactor determines the thermal stability in cupredoxins, but how the redox state of copper modulates their ...

Many fleeting macromolecular interactions, like those being involved in electron transport, are essential in biology. ...

The AU-rich element (ARE)-mediated mRNA-degradation activity of the RNA binding K-homology splicing regulator protein ...

K-homology (KH) splicing regulator protein (KSRP) is a multi-domain RNA-binding protein that regulates different steps of ...

The transient complex between cytochrome f and plastocyanin from the cyanobacterium Nostoc sp. PCC 7119 has been analysed ...

Las interacciones trasitorias entre biomoléculas se han convertido en el centro de la investigación de muchas áreas de la ...

A structural analysis of the surface areas of cytochrome c6, responsible for the transient interaction with photosystem ...

The complex between cytochrome f and plastocyanin from the cyanobacterium Nostoc has been characterized by NMR spectroscopy. ...

Photosystem I reduction by the soluble metalloproteins cytochrome c6 and plastocyanin, which are alternatively synthesized ...