Cytochrome c signalosome in mitochondria
|Author/s||Díaz Moreno, Irene
García Heredia, José Manuel
Díaz Quintana, Antonio Jesús
Rosa Acosta, Miguel Ángel de la
|Department||Universidad de Sevilla. Departamento de Bioquímica Vegetal y Biología Molecular|
|Abstract||Cytochrome c delicately tilts the balance between cell life (respiration) and cell death (apoptosis). Whereas cell life is governed by transient electron transfer interactions of cytochrome c inside the mitochondria, the ...
Cytochrome c delicately tilts the balance between cell life (respiration) and cell death (apoptosis). Whereas cell life is governed by transient electron transfer interactions of cytochrome c inside the mitochondria, the cytoplasmic adducts of cytochrome c that lead to cell death are amazingly stable. Interestingly, the contacts of cytochrome c with its counterparts shift from the area surrounding the heme crevice for the redox complexes to the opposite molecule side when the electron flow is not necessary. The cytochrome c signalosome shows a higher level of regulation by post-translational modifications—nitration and phosphorylation—of the hemeprotein. Understanding protein interfaces, as well as protein modifications, would puzzle the mitochondrial cytochrome c-controlled pathways out and enable the design of novel drugs to silence the action of pro-survival and pro-apoptotic partners of cytochrome c.
|Citation||Díaz Moreno, I., García Heredia, J.M., Díaz Quintana, A.J. y Rosa Acosta, M.Á.d.l. (2011). Cytochrome c signalosome in mitochondria. European Biophysics Journal, 40 (12), 1301-1315.|