Por motivos de mantenimiento se ha deshabilitado el inicio de sesión temporalmente. Rogamos disculpen las molestias.
Artículo
Lysosomes: multifunctional compartments ruled by a complex regulatory network
Autor/es | Martínez Fábregas, Jonathan
Tamargo Azpilicueta, Joaquín Díaz Moreno, Irene |
Departamento | Universidad de Sevilla. Departamento de Bioquímica Vegetal y Biología Molecular |
Fecha de publicación | 2022 |
Fecha de depósito | 2022-04-07 |
Publicado en |
|
Resumen | More than 50 years have passed since Nobel laureate Cristian de Duve described for the first time the presence of tiny subcellular compartments filled with hydrolytic enzymes: the lysosome. For a long time, lysosomes were ... More than 50 years have passed since Nobel laureate Cristian de Duve described for the first time the presence of tiny subcellular compartments filled with hydrolytic enzymes: the lysosome. For a long time, lysosomes were deemed simple waste bags exerting a plethora of hydrolytic activities involved in the recycling of biopolymers, and lysosomal genes were considered to just be simple housekeeping genes, transcribed in a constitutive fashion. However, lysosomes are emerging as multifunctional signalling hubs involved in multiple aspects of cell biology, both under homeostatic and pathological conditions. Lysosomes are involved in the regulation of cell metabolism through the mTOR/TFEB axis. They are also key players in the regulation and onset of the immune response. Furthermore, it is becoming clear that lysosomal hydrolases can regulate several biological processes outside of the lysosome. They are also implicated in a complex communication network among subcellular compartments that involves intimate organelle‐to‐organelle contacts. Furthermore, lysosomal dysfunction is nowadays accepted as the causative event behind several human pathologies: low frequency inherited diseases, cancer, or neurodegenerative, metabolic, inflammatory, and autoimmune diseases. Recent advances in our knowledge of the complex biology of lysosomes have established them as promising therapeutic targets for the treatment of different pathologies. Although recent discoveries have started to highlight that lysosomes are controlled by a complex web of regulatory networks, which in some cases seem to be cell‐ and stimuli‐dependent, to harness the full potential of lysosomes as therapeutic targets, we need a deeper understanding of the little‐known signalling pathways regulating this subcellular compartment and its functions. Keywords: lysosomes, mTORC1, signalling pathways, STATs, TFEB, transcriptional regulation |
Agencias financiadoras | European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) Junta de Andalucía Ministerio de Ciencia, Innovación y Universidades (MICINN). España Universidad de Sevilla |
Identificador del proyecto | Project PGC2018-096049- B-I00
BIO198, US-1254317 P18-FR-3487 and P18-HO-5091 |
Cita | Martínez Fábregas, J., Tamargo Azpilicueta, J. y Díaz Moreno, I. (2022). Lysosomes: multifunctional compartments ruled by a complex regulatory network. FEBS Open Bio, 12 (4), 758-774. |
Ficheros | Tamaño | Formato | Ver | Descripción |
---|---|---|---|---|
pubFEB4-12-758.pdf | 957.7Kb | [PDF] | Ver/ | |