RNA Binding Protein Regulation and Cross-Talk in the Control of AU-rich mRNA Fate
|Author||García Mauriño, Sofía M.
Rivero Rodríguez, Francisco
Velázquez Cruz, Alejandro
Hernández Vellisca, Marian
Díaz Quintana, Antonio Jesús
Rosa Acosta, Miguel Ángel de la
Díaz Moreno, Irene
|Department||Universidad de Sevilla. Departamento de Bioquímica Vegetal y Biología Molecular
Universidad de Sevilla. Departamento de Biología Vegetal y Ecología
|Abstract||mRNA metabolism is tightly orchestrated by highly-regulated RNA Binding Proteins (RBPs) that determine mRNA fate, thereby influencing multiple cellular functions across biological contexts. Here, we review the interplay ...
mRNA metabolism is tightly orchestrated by highly-regulated RNA Binding Proteins (RBPs) that determine mRNA fate, thereby influencing multiple cellular functions across biological contexts. Here, we review the interplay between six well-known RBPs (TTP, AUF-1, KSRP, HuR, TIA-1, and TIAR) that recognize AU-rich elements (AREs) at the 3′ untranslated regions of mRNAs, namely ARE-RBPs. Examples of the links between their cross-regulations and modulation of their targets are analyzed during mRNA processing, turnover, localization, and translational control. Furthermore, ARE recognition can be self-regulated by several factors that lead to the prevalence of one RBP over another. Consequently, we examine the factors that modulate the dynamics of those protein-RNA transient interactions to better understand the final consequences of the regulation mediated by ARE-RBPs. For instance, factors controlling the RBP isoforms, their conformational state or their post-translational modifications (PTMs) can strongly determine the fate of the protein-RNA complexes. Moreover, mRNA specific sequence and secondary structure or subtle environmental changes are also key determinants to take into account. To sum up, the whole understanding of such a fine tuned regulation is a challenge for future research and requires the integration of all the available structural and functional data by in vivo, in vitro and in silico approaches.
|Funding agencies||Ministerio de Economía y Competitividad (MINECO). España
Ministerio de Educación, Cultura y Deporte (MECD). España
|Citation||García Mauriño, S.M., Rivero Rodríguez, F., Velázquez Cruz, A., Hernández Vellisca, M., Díaz Quintana, A.J., Rosa Acosta, M.Á.d.l. y Díaz Moreno, I. (2017). RNA Binding Protein Regulation and Cross-Talk in the Control of AU-rich mRNA Fate. Frontiers in Molecular Biosciences, 4 (71), 1-8.|