Artículo
Antimalarial activity of cupredoxins: the interaction of Plasmodium Merozoite Surface Protein 119 (MSP119) and Rusticyanin
Autor/es | Cruz Gallardo, Isabel
Díaz Moreno, Irene Díaz Quintana, Antonio Jesús Velázquez Campoy, Adrián Curd, Rachel D. Rangachari, Caveri Bridsall, Berry Ramos, Andrés Holder, Anthony A. Rosa Acosta, Miguel Ángel de la |
Departamento | Universidad de Sevilla. Departamento de Bioquímica Vegetal y Biología Molecular |
Fecha de publicación | 2013 |
Fecha de depósito | 2018-02-12 |
Publicado en |
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Resumen | Background: The interaction of MSP119 with the cupredoxin azurin inhibits the growth of Plasmodium falciparum in red blood cells. Results: Rusticyanin forms a well-defined complex with MSP119 upon binding at the same surface ... Background: The interaction of MSP119 with the cupredoxin azurin inhibits the growth of Plasmodium falciparum in red blood cells. Results: Rusticyanin forms a well-defined complex with MSP119 upon binding at the same surface area than inhibitory antibodies. Conclusion: Rusticyanin becomes an excellent therapeutic agent for malaria. Significance: Knowing the rusticyanin- MSP119 interface will allow the design of novel anti-malarial drugs |
Identificador del proyecto | P08-CVI-3876
BIO198 SAF2011- 26611 15354/PI/10 BFU2010-19451 U117574558 U117532067 |
Cita | Cruz Gallardo, I., Díaz Moreno, I., Díaz Quintana, A.J., Velázquez Campoy, A., Curd, R.D., Rangachari, C.,...,Rosa Acosta, M.Á.d.l. (2013). Antimalarial activity of cupredoxins: the interaction of Plasmodium Merozoite Surface Protein 119 (MSP119) and Rusticyanin. Journal of Biological Chemistry, 288 (29), 20896-20907. |
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