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Antimalarial activity of cupredoxins: the interaction of Plasmodium Merozoite Surface Protein 119 (MSP119) and Rusticyanin

dc.creatorCruz Gallardo, Isabeles
dc.creatorDíaz Moreno, Irenees
dc.creatorDíaz Quintana, Antonio Jesúses
dc.creatorVelázquez Campoy, Adriánes
dc.creatorCurd, Rachel D.es
dc.creatorRangachari, Caveries
dc.creatorBridsall, Berryes
dc.creatorRamos, Andréses
dc.creatorHolder, Anthony A.es
dc.creatorRosa Acosta, Miguel Ángel de laes
dc.date.accessioned2018-02-12T14:39:56Z
dc.date.available2018-02-12T14:39:56Z
dc.date.issued2013
dc.identifier.citationCruz Gallardo, I., Díaz Moreno, I., Díaz Quintana, A.J., Velázquez Campoy, A., Curd, R.D., Rangachari, C.,...,Rosa Acosta, M.Á.d.l. (2013). Antimalarial activity of cupredoxins: the interaction of Plasmodium Merozoite Surface Protein 119 (MSP119) and Rusticyanin. Journal of Biological Chemistry, 288 (29), 20896-20907.
dc.identifier.issn0021-9258 (impreso)es
dc.identifier.issn1083-351X (electrónico)es
dc.identifier.urihttps://hdl.handle.net/11441/70218
dc.description.abstractBackground: The interaction of MSP119 with the cupredoxin azurin inhibits the growth of Plasmodium falciparum in red blood cells. Results: Rusticyanin forms a well-defined complex with MSP119 upon binding at the same surface area than inhibitory antibodies. Conclusion: Rusticyanin becomes an excellent therapeutic agent for malaria. Significance: Knowing the rusticyanin- MSP119 interface will allow the design of novel anti-malarial drugses
dc.description.sponsorshipJunta de Andalucía P08-CVI-3876, BIO198es
dc.description.sponsorshipMinisterio de Economía y Competitividad SAF2011- 26611es
dc.description.sponsorshipFundación Séneca de la Región de Murcia 15354/PI/10es
dc.description.sponsorshipMinisterio de Ciencia e Innovación BFU2010-19451es
dc.description.sponsorshipMedical Research Council U117574558, U117532067es
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherAmerican Society for Biochemistry and Molecular Biologyes
dc.relation.ispartofJournal of Biological Chemistry, 288 (29), 20896-20907.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectMalariaes
dc.subjectPlamodiumes
dc.subjectMSP1es
dc.subjectRustycianines
dc.subjectNMRes
dc.subjectITCes
dc.titleAntimalarial activity of cupredoxins: the interaction of Plasmodium Merozoite Surface Protein 119 (MSP119) and Rusticyanines
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Bioquímica Vegetal y Biología Moleculares
dc.relation.projectIDP08-CVI-3876es
dc.relation.projectIDBIO198es
dc.relation.projectIDSAF2011- 26611es
dc.relation.projectID15354/PI/10es
dc.relation.projectIDBFU2010-19451es
dc.relation.projectIDU117574558es
dc.relation.projectIDU117532067es
dc.relation.publisherversionhttp://dx.doi.org/10.1074/jbc.M113.460162es
dc.identifier.doi10.1074/jbc.M113.460162es
idus.format.extent13 p.es
dc.journaltitleJournal of Biological Chemistryes
dc.publication.volumen288es
dc.publication.issue29es
dc.publication.initialPage20896es
dc.publication.endPage20907es

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