Author profile: Rosa Acosta, Miguel Ángel de la
Data
| Name | Rosa Acosta, Miguel Ángel de la |
| Department | Bioquímica Vegetal y Biología Molecular |
| Knowledge area | Bioquímica y Biología Molecular |
| Professional category | Catedrático de Universidad |
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| Publications |
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Article
 Post-translational Control of RNA-Binding Proteins and Disease-Related Dysregulation
(Frontiers Media S.A., 2021-01-01)
Cell signaling mechanisms modulate gene expression in response to internal and external stimuli. Cellular adaptation ... |
Article
Mitochondrial cytochrome c shot towards histone chaperone condensates in the nucleus
(Wiley-Blackwell, 2021-01-01)
Despite mitochondria being key for the control of cell homeostasis and fate, their role in DNA damage response is usually ... |
Article
Inhibition of the PP2A activity by the histone chaperone ANP32B is long-range allosterically regulated by respiratory cytochrome c
(Elsevier, 2021-01-01)
Repair of injured DNA relies on nucleosome dismantling by histone chaperones and de-phosphorylation events carried out by ... |
Article
Membraneless organelles: a smart design for metabolic control
(Wiley Online Library, 2021-01-01)
While most organelles are surrounded by membranes, cells also contain membraneless organelles, which remain separated in ... |
Article
Structural and functional insights into lysine acetylation of cytochrome c using mimetic point mutants
(Wiley-Blackwell, 2021-01-01)
Post-translational modifications frequently modulate protein functions. Lysine acetylation in particular plays a key role ... |
PhD Thesis
Regulatory network built by Cytochrome c with Histone Chaperones in response to DNA damage
(2020-01-17)
The maintenance of genome integrity is a critical process for cell life. To face DNA lesions, living beings have developed ... |
Article
Wheel and Deal in the Mitochondrial Inner Membranes: The Tale of Cytochrome c and Cardiolipin
(Hindawi, 2020-01-01)
Cardiolipin oxidation and degradation by different factors under severe cell stress serve as a trigger for genetically ... |
Article
Post-Translational Modifications of Cytochrome c in Cell Life and Disease
(MDPI, 2020-01-01)
Mitochondria are the powerhouses of the cell, whilst their malfunction is related to several human pathologies, including ... |
Article
Exploring protein phosphorylation by combining computational approaches and biochemical methods
(Elsevier, 2020-01-01)
Post-translational modifications of proteins expand their functional diversity, regulating the response of cells to a ... |
Article
Cytochrome c: Surfing Off of the Mitochondrial Membrane on the Tops of Complexes III and IV
(Elsevier, 2019-01-01)
The proper arrangement of protein components within the respiratory electron transport chain is nowadays a matter of intense ... |
Article
Cytochrome c speeds up caspase cascade activation by blocking 14-3-3ε-dependent Apaf-1 inhibition
(Nature Publishing Group, 2018-01-01)
Apoptosis is a highly regulated form of programmed cell death, essential to the development and homeostasis of multicellular ... |
Article
Oxidative stress is tightly regulated by cytochrome c phosphorylation and respirasome factors in mitochondria
(National Academy of Sciences, 2018-01-01)
Respiratory cytochrome c has been found to be phosphorylated at tyrosine 97 in the postischemic brain upon neuroprotective ... |
Article
Long distance electron transfer through the aqueous solution between redox partner proteins
(Nature Research, 2018-01-01)
Despite the importance of electron transfer between redox proteins in photosynthesis and respiration, the inter-protein ... |
Article
Nuclear cytochrome c – a mitochondrial visitor regulating damaged chromatin dynamics
(Wiley-Blackwell, 2018-01-01)
Over the past decade, evidence has emerged suggesting a broader role for cytochrome c (Cyt c) in programmed cell death. ... |
Article
Key Role of the Local Hydrophobicity in the East Patch of Plastocyanins on Their Thermal Stability and Redox Properties
(American Chemical Society, 2018-01-01)
Understanding the molecular basis of the thermal stability and functionality of redox proteins has important practical ... |
PhD Thesis
Cytosolic interaction between respiratory cytochrome c and 14-3-3 protein family members facilitates programmed cell death in humans and plants
(2017-09-22)
The development, as well as the homeostatic control of multi-cellular organisms, requires programmed cell death processes. ... |
PhD Thesis
 Phosphorylation of cytochrome C: functional and structural features
(2017-01-27)
Post-translational modifications often modulate protein function. Actually, phosphorylation of cytochrome c occurs in vivo ... |
Article
Structural basis of mitochondrial dysfunction in response to cytochrome c phosphorylation at tyrosine 48
(National Academy of Sciences, 2017-01-01)
Regulation of mitochondrial activity allows cells to adapt to changing conditions and to control oxidative stress, and its ... |
Article
Histone chaperone activity of Arabidopsis thaliana NRP1 is blocked by cytochrome c
(Oxford University Press, 2017-01-01)
Higher-order plants and mammals use similar mechanisms to repair and tolerate oxidative DNA damage. Most studies on the ... |
Article
RNA Binding Protein Regulation and Cross-Talk in the Control of AU-rich mRNA Fate
(Frontiers Media, 2017-01-01)
mRNA metabolism is tightly orchestrated by highly-regulated RNA Binding Proteins (RBPs) that determine mRNA fate, thereby ... |
PhD Thesis
Estructura y estabilidad en plastocianinas de cianobacterias
(2016-01-29)
ESTRUCTURA Y ESTABILIDAD EN PLASTOCIANINAS DE CIANOBACTERIAS La elucidación de los factores que determinan las diferencias ... |
Article
The Dynamics of the Human Leukocyte Antigen Head Domain Modulates Its Recognition by the T-Cell Receptor
(Public Library of Science, 2016-01-01)
Generating the immune response requires the discrimination of peptides presented by the human leukocyte antigen complex ... |
PhD Thesis
Redox biointeractome of cytochromes in respiration and photosynthesis
(2015-10-06)
Protein complex formation is at least a two-step process in which the formation of a final, well-defined complex entails ... |
Article
Structural basis for inhibition of the histone chaperone activity of SET/TAF-Iβ by cytochrome c
(National Academy of Sciences, 2015-01-01)
Chromatin is pivotal for regulation of the DNA damage process insofar as it influences access to DNA and serves as a DNA ... |
Article
Respiratory complexes III and IV can each bind two molecules of cytochrome c at low ionic strength
(Elsevier, 2015-01-01)
The transient interactions of respiratory cytochrome c with complexes III and IV is herein investigated by using heterologous ... |
Article
Structural and Functional Analysis of Novel Human Cytochrome c Targets in Apoptosis
(American Society for Biochemistry and Molecular Biology, 2014-01-01)
Since the first description of apoptosis four decades ago, great efforts have been made to elucidate, both in vivo and in ... |
Article
A common signalosome for programmed cell death in humans and plants
(Nature Publishing Group, 2014-01-01)
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Article
Cytochrome c1 exhibits two binding sites for cytochrome c in plants
(Elsevier, 2014-01-01)
n plants, channeling of cytochrome c molecules between complexes III and IV has been purported to shuttle electrons within ... |
Article
The dynamic complex of cytochrome c6 and cytochrome f studied with paramagnetic NMR spectroscopy
(Elsevier B.V., 2014-01-01)
The rapid transfer of electrons in the photosynthetic redox chain is achieved by the formation of short-lived complexes ... |
Article
Temperature-driven changeover in the electron-transfer mechanism of a thermophilic plastocyanin
(American Chemical Society, 2014-01-01)
Electron-transfer kinetics of the thermophilic protein Plastocyanin fromPhormidium laminosumadsorbed on 1,ω-alkanedithiol ... |
PhD Thesis
Structural approach to the hur function
(2013-06-06)
En esta tesis se presenta un análisis estructural de la proteína de unión a ARN HuR y, en particular, se profundiza en el ... |
Article
Communication between L–galactono–1,4–lactone dehydrogenase and cytochrome c
(Wiley: FEBS Journal, 2013-02-25)
l‐galactono‐1,4‐lactone dehydrogenase (GALDH) catalyzes the terminal step of vitamin C biosynthesis in plant mitochondria. ... |
Article
Preface to the mini-theme issue of IUBMB life on biointeractomics
(Taylor & Francis, 2013-01-01)
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Article
Antimalarial activity of cupredoxins: the interaction of Plasmodium Merozoite Surface Protein 119 (MSP119) and Rusticyanin
(American Society for Biochemistry and Molecular Biology, 2013-01-01)
Background: The interaction of MSP119 with the cupredoxin azurin inhibits the growth of Plasmodium falciparum in red blood ... |
Article
New Arabidopsis thaliana cytochrome c partners: A look into the elusive role of cytochrome c in programmed cell death in plants
(American Society for Biochemistry and Molecular Biology, 2013-01-01)
Programmed cell death is an event displayed by many different organisms along the evolutionary scale. In plants, programmed ... |
PhD Thesis
Desvelando el curso evolutivo de la red de proteínas que interaccionan con el Citocromo C en la muerte celular programada
(2012-03-02)
La organización celular de los organismos fue descubierta a mediados del siglo XIX por Schwann y Schleiden (1847). Poco ... |
Article
Specific nitration of tyrosines 46 and 48 makes cytochrome c assemble a non-functional apoptosome
(Elsevier, 2012-01-01)
Under nitroxidative stress, a minor fraction of cytochrome c can be modified by tyrosine nitration. Here we analyze the ... |
Article
Voltammetric study of the adsorbed thermophilic plastocyanin from Phormidium laminosum up to 90 °c
(Elsevier, 2012-01-01)
Redox thermodynamics and kinetics of plastocyanin from Phormidium laminosum, and of azurin from Pseudonomas aeruginosa, ... |
Article
How the Local Geometry of the Cu-Binding Site Determines the Thermal Stability of Blue Copper Proteins
(Elsevier, 2011-01-01)
Identifying the factors that govern the thermal resistance of cupredoxins is essential for understanding their folding and ... |
PhD Thesis
Análisis Estructural de los Determinantes de la Estabilidad en Plastocianinas
(2011-01-01)
La vida se encuentra en casi cualquier lugar de la Tierra, tanto en las grietas hidrotermales de los suelos marinos o en ... |
Article
Cytochrome c signalosome in mitochondria
(Springer, 2011-01-01)
Cytochrome c delicately tilts the balance between cell life (respiration) and cell death (apoptosis). Whereas cell life ... |
Article
Modulation of copper site properties by remote residues determines the stability of plastocyanins
(Elsevier, 2010-01-01)
The metal cofactor determines the thermal stability in cupredoxins, but how the redox state of copper modulates their ... |
Article
Nitration of tyrosine 74 prevents human cytochrome c to play a key role in apoptosis signaling by blocking caspase-9 activation
(Elsevier, 2010-01-01)
Tyrosine nitration is one of the most common post-transcriptional modifications of proteins, so affecting their structure ... |
Article
Electrostatic strain and concerted motions in the transient complex between plastocyanin and cytochrome f from the cyanobacterium Phormidium laminosum
(Elsevier, 2009-01-01)
Many fleeting macromolecular interactions, like those being involved in electron transport, are essential in biology. ... |
| PhD Thesis |
| PhD Thesis |
PhD Thesis
Transferencia de electrones y complejos transitorios entre proteínas: análisis funcional de la interacción entre el citocromo f y la platocianina
(2007-05-31)
Con el presente trabajo de Tesis se pretende establecer las diferencias funcionales entre sistemas de transferencia de ... |
Article
The atypical iron-coordination geometry of cytochrome f remains unchanged upon binding to plastocyanin, as inferred by XAS
(Springer Verlag, 2006-10-01)
The transient complex between cytochrome f and plastocyanin from the cyanobacterium Nostoc sp. PCC 7119 has been analysed ... |
| PhD Thesis |
PhD Thesis
Reconocimiento molecular y análisis estructural de complejos transitorios entre proteínas
(2005-01-01)
Las interacciones trasitorias entre biomoléculas se han convertido en el centro de la investigación de muchas áreas de la ... |
Article
An evolutionary analysis of the reaction mechanisms of photosystem I reduction by cytochrome c6 and plastocyanin
(Elsevier, 2002-01-01)
Photosystem I reduction by the soluble metalloproteins cytochrome c6 and plastocyanin, which are alternatively synthesized ... |
PhD Thesis
Identificación de regiones isofuncionales en el citocromo c6 y en la plastocianina
(2001-01-01)
Una de las líneas de investigación mas intereses de la bioquímica contemporánea es el estudio de la relación entre la ... |
PhD Thesis
Citocromo c6 y plastocianina de la cianobacteria Synechocystis PCC 6803: estudio de la relación estructura-función en las proteínas nativas y modificadas por mutagénesis dirigida
(1998-01-01)
El estudio de los mecanismos de reconocimiento molecular y transferencia de electrones entre proteína se ha abordado en ... |
PhD Thesis
Transferencia de electrones en el lado oxidante del fotosistema I. Equivalencia funcional entre el citocromo c6 y la plastocianina
(1995-01-01)
El presente trabajo forma parte del realizado por el grupo al que el doctorando se encuentra adscrito, en el que se busca ... |
Article
Fotosíntesis: sol, agua, tierra y aire
(RBA Revistas, 1993-01-01)
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PhD Thesis
Conversión química y biológica de la energía luminosa fotoproducción de peroxido de hidrógeno
(1988-01-01)
Todas las formas de vida hasta ahora conocidas en nuestro planeta requieren energía para su crecimiento y conservación. ... |
PhD Thesis
Producción fotoquímica y fotobiológica de peróxido de hidrógeno
(1986-01-01)
Se ha estudiado la optimización del proceso de reducción del oxigeno molecular a peróxido de hidrogeno impulsado por energía ... |
| Article |
Article
Carbon dioxide-mediated decomposition of hydrogen peroxide in alkaline solutions
(Faraday Division of the Chemical Society, 1984-01-01)
Rapid hydrogen peroxide decomposition in aerated alkaline solutions is described, the maximum rate being attained at pH ... |
| PhD Thesis |