NameRosa Acosta, Miguel Ángel de la
DepartmentBioquímica Vegetal y Biología Molecular
Knowledge areaBioquímica y Biología Molecular
Professional categoryCatedrático de Universidad
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PhD Thesis
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Novel insights into the mechanism of electron transfer in mitochondrial cytochrome c and its regulation by post-translational modifications

Pérez Mejías, Gonzalo; Díaz Moreno, Irene; Rosa Acosta, Miguel Ángel de la (2023)
Las células que componen nuestro cuerpo obtienen la mayor parte de la energía que necesitan para vivir, de los alimentos ...
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Cytochrome c lysine acetylation regulates cellular respiration and cell death in ischemic skeletal muscle

Morse, Paul T.; Pérez Mejías, Gonzalo; Wan, Junmei; Turner, Alice A.; Márquez Escudero, Inmaculada; Kalpage, Hasini A.; Vaishnav, Asmita; Zurek, Matthew P.; Huettemann, Philipp P.; Kim, Katherine; Arroum, Tasnim; Rosa Acosta, Miguel Ángel de la; Chowdhury, Dipanwita Dutta; Díaz Moreno, Irene; Hüttemann, Maik (Springer Nature, 2023)
Skeletal muscle is more resilient to ischemia-reperfusion injury than other organs. Tissue specific post-translational ...
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Nucleus-translocated mitochondrial cytochrome c liberates nucleophosmin-sequestered ARF tumor suppressor by changing nucleolar liquid-liquid phase separation.

González Arzola, Katiuska; Díaz Quintana, Antonio Jesús; Bernardo García, Noelia; Martínez Fábregas, Jonathan; Rivero Rodríguez, Francisco; Casado Combreras, Miguel Ángel; Elena-Real, Carlos A.; Velázquez Cruz, Alejandro; Gil Caballero, Sergio; Velázquez Campoy, Adrián; Szulc, Elzbieta; Gavilán Dorronzoro, María de la Paz; Ayala, Isabel; Arranz, Rocío; Ríos, Rosa M.; Salvatella, Xavier; Valpuesta, José María; Hermoso, Juan A.; Rosa Acosta, Miguel Ángel de la; Díaz Moreno, Irene (Nature Research, 2022)
The regular functioning of the nucleolus and nucleus-mitochondria crosstalk are considered unrelated processes, yet ...
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Thinking up an original scientific research project

Rosa Acosta, Miguel Ángel de la (Turk Biyokimya Dernegi, 2022)
Writing a research proposal is not a simple task if we wish-and we do usually wish!-to succeed in putting our project into ...
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PP2A is activated by cytochrome c upon formation of a diffuse encounter complex with SET/TAF-Iβ

Casado Combreras, Miguel Ángel; Rivero Rodríguez, Francisco; Elena-Real, Carlos A.; Molodenskiy, Dmitry; Díaz Quintana, Antonio Jesús; Martinho, Marlène; Gerbaud, Guillaume; González Arzola, Katiuska; Velázquez Campoy, Adrián; Svergun, Dmitri; Belle, Valérie; Rosa Acosta, Miguel Ángel de la; Díaz Moreno, Irene (Elsevier, 2022)
Intrinsic protein flexibility is of overwhelming relevance for intermolecular recognition and adaptability of highly dynamic ...
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Phosphorylation disrupts long-distance electron transport in cytochrome c

Gomila, Alexandre M.J.; Pérez Mejías, Gonzalo; Nin-Hill, Alba; Guerra Castellano, Alejandra; Casas Ferrer, Laura; Ortiz Tescari, Sthefany; Díaz Quintana, Antonio Jesús; Samitier, Josep; Rovira, Carme; Rosa Acosta, Miguel Ángel de la; Díaz Moreno, Irene; Gorostiza, Pau; Giannotti, Marina I.; Lagunas, Anna (Springer Nature, 2022)
t has been recently shown that electron transfer between mitochondrial cytochrome c and the cytochrome c1 subunit of the ...
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Ensuring image integrity in the digital age

Wright, Duncan E.; Rosa Acosta, Miguel Ángel de la (Wiley-Blackwell, 2022)
FEBS Open Bio and our fellow FEBS Press journals have a strong commitment to maintaining the integrity of the scientific ...
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Entering the second decade: FEBS Open Bio in 2022

Wright, Duncan E.; Rosa Acosta, Miguel Ángel de la (Wiley-Blackwell, 2022)
FEBS Open Bio continues to go from strength to strength, with 2021 perhaps marking its most exciting year. In this Editorial, ...
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PP2A is activated by cytochrome c upon formation of a diffuse encounter complex with SET/TAF-Iβ

Casado Combreras, Miguel Ángel; Rivero Rodríguez, Francisco; Elena-Real, Carlos A.; Molodenskiy, Dmitry; Díaz Quintana, Antonio Jesús; Martinho, Marlène; Gerbaud, Guillaume; González Arzola, Katiuska; Velázquez Campoy, Adrián; Svergun, Dmitri; Belle, Valérie; Rosa Acosta, Miguel Ángel de la; Díaz Moreno, Irene (Research Network of Computational and Structural Biotechnology, 2022)
Intrinsic protein flexibility is of overwhelming relevance for intermolecular recognition and adaptability of highly dynamic ...
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Proposed mechanism for regulation of H2O2-induced programmed cell death in plants by binding of cytochrome c to 14-3-3 proteins

Elena-Real, Carlos A.; González Arzola, Katiuska; Pérez Mejías, Gonzalo; Díaz Quintana, Antonio Jesús; Velázquez Campoy, Adrián; Desvoyes, Bénédicte; Gutiérrez, Crisanto; Rosa Acosta, Miguel Ángel de la; Díaz Moreno, Irene (Wiley-Blackwell, 2021)
Programmed cell death (PCD) is crucial for development and homeostasis of all multicellular organisms. In human cells, the ...
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Membraneless organelles: a smart design for metabolic control

Díaz Moreno, Irene; Rosa Acosta, Miguel Ángel de la (Wiley Online Library, 2021)
While most organelles are surrounded by membranes, cells also contain membraneless organelles, which remain separated in ...
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Ten years of FEBS Open Bio

Wright, Duncan E.; Rosa Acosta, Miguel Ángel de la (Wiley, 2021)
This month, FEBS Open Bio celebrates its 10th birthday. To celebrate the journal's first decade, we present this special ...
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Post-translational Control of RNA-Binding Proteins and Disease-Related Dysregulation

Velázquez Cruz, Alejandro; Baños Jaime, Blanca; Díaz Quintana, Antonio Jesús; Rosa Acosta, Miguel Ángel de la; Díaz Moreno, Irene (Frontiers Media S.A., 2021)
Cell signaling mechanisms modulate gene expression in response to internal and external stimuli. Cellular adaptation ...
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Structural and functional insights into lysine acetylation of cytochrome c using mimetic point mutants

Márquez Escudero, Inmaculada; Pérez Mejías, Gonzalo; Guerra Castellano, Alejandra; Olloqui Sariego, José Luis; Andreu Fondacabe, Rafael Jesús; Calvente Pacheco, Juan José; Rosa Acosta, Miguel Ángel de la; Díaz Moreno, Irene (Wiley-Blackwell, 2021)
Post-translational modifications frequently modulate protein functions. Lysine acetylation in particular plays a key role ...
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Inhibition of the PP2A activity by the histone chaperone ANP32B is long-range allosterically regulated by respiratory cytochrome c

Rivero Rodríguez, Francisco; Díaz Quintana, Antonio Jesús; Velázquez Cruz, Alejandro; González Arzola, Katiuska; Gavilán Dorronzoro, María de la Paz; Velázquez Campoy, Adrián; Ríos Sánchez, Rosa María; Rosa Acosta, Miguel Ángel de la; Díaz Moreno, Irene (Elsevier, 2021)
Repair of injured DNA relies on nucleosome dismantling by histone chaperones and de-phosphorylation events carried out by ...
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Mitochondrial cytochrome c shot towards histone chaperone condensates in the nucleus

González Arzola, Katiuska; Guerra Castellano, Alejandra; Rivero Rodríguez, Francisco; Casado Combreras, Miguel Ángel; Pérez Mejías, Gonzalo; Díaz Quintana, Antonio Jesús; Díaz Moreno, Irene; Rosa Acosta, Miguel Ángel de la (Wiley-Blackwell, 2021)
Despite mitochondria being key for the control of cell homeostasis and fate, their role in DNA damage response is usually ...
PhD Thesis
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Regulatory network built by Cytochrome c with Histone Chaperones in response to DNA damage

Rivero Rodríguez, Francisco; Rosa Acosta, Miguel Ángel de la; Díaz Moreno, Irene (2020)
The maintenance of genome integrity is a critical process for cell life. To face DNA lesions, living beings have developed ...
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Post-Translational Modifications of Cytochrome c in Cell Life and Disease

Guerra Castellano, Alejandra; Márquez Escudero, Inmaculada; Pérez Mejías, Gonzalo; Díaz Quintana, Antonio Jesús; Rosa Acosta, Miguel Ángel de la; Díaz Moreno, Irene (MDPI, 2020)
Mitochondria are the powerhouses of the cell, whilst their malfunction is related to several human pathologies, including ...
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Exploring protein phosphorylation by combining computational approaches and biochemical methods

Pérez Mejías, Gonzalo; Velázquez Cruz, Alejandro; Guerra Castellano, Alejandra; Baños Jaime, Blanca; Díaz Quintana, Antonio Jesús; González Arzola, Katiuska; Rosa Acosta, Miguel Ángel de la; Díaz Moreno, Irene (Elsevier, 2020)
Post-translational modifications of proteins expand their functional diversity, regulating the response of cells to a ...
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Wheel and Deal in the Mitochondrial Inner Membranes: The Tale of Cytochrome c and Cardiolipin

Díaz Quintana, Antonio Jesús; Pérez Mejías, Gonzalo; Guerra Castellano, Alejandra; Rosa Acosta, Miguel Ángel de la; Díaz Moreno, Irene (Hindawi, 2020)
Cardiolipin oxidation and degradation by different factors under severe cell stress serve as a trigger for genetically ...
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Cytochrome c: Surfing Off of the Mitochondrial Membrane on the Tops of Complexes III and IV

Pérez Mejías, Gonzalo; Guerra Castellano, Alejandra; Díaz Quintana, Antonio Jesús; Rosa Acosta, Miguel Ángel de la; Díaz Moreno, Irene (Elsevier, 2019)
The proper arrangement of protein components within the respiratory electron transport chain is nowadays a matter of intense ...
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Protein crosslinking improves the thermal resistance of plastocyanin immobilized on a modified gold electrode

Olloqui Sariego, José Luis; Díaz Quintana, Antonio Jesús; Rosa Acosta, Miguel Ángel de la; Calvente Pacheco, Juan José; Márquez Escudero, Inmaculada; Díaz Moreno, Irene; Andreu Fondacabe, Rafael Jesús (Elsevier, 2018)
Increasing the thermal stability of immobilized proteins is a motivating goal for improving the performance of electrochemical ...
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Key Role of the Local Hydrophobicity in the East Patch of Plastocyanins on Their Thermal Stability and Redox Properties

Olloqui Sariego, José Luis; Márquez Escudero, Inmaculada; Frutos Beltrán, Estrella; Díaz Moreno, Irene; Rosa Acosta, Miguel Ángel de la; Calvente Pacheco, Juan José; Andreu Fondacabe, Rafael Jesús; Díaz Quintana, Antonio Jesús (American Chemical Society, 2018)
Understanding the molecular basis of the thermal stability and functionality of redox proteins has important practical ...
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Oxidative stress is tightly regulated by cytochrome c phosphorylation and respirasome factors in mitochondria

Guerra Castellano, Alejandra; Díaz Quintana, Antonio Jesús; Pérez Mejías, Gonzalo; Elena-Real, Carlos A.; González Arzola, Katiuska; García Mauriño, Sofía M.; Rosa Acosta, Miguel Ángel de la; Díaz Moreno, Irene (National Academy of Sciences, 2018)
Respiratory cytochrome c has been found to be phosphorylated at tyrosine 97 in the postischemic brain upon neuroprotective ...
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Long distance electron transfer through the aqueous solution between redox partner proteins

Lagunas, Anna; Guerra Castellano, Alejandra; Nin Hill, Alba; Díaz Moreno, Irene; Rosa Acosta, Miguel Ángel de la; Samitier, Josep; Rovira, Carme; Gorostiza, Pau (Nature Research, 2018)
Despite the importance of electron transfer between redox proteins in photosynthesis and respiration, the inter-protein ...
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Cytochrome c speeds up caspase cascade activation by blocking 14-3-3ε-dependent Apaf-1 inhibition

Elena-Real, Carlos A.; Díaz Quintana, Antonio Jesús; González Arzola, Katiuska; Velázquez Campoy, Adrián; Orzáez, Mar; López Rivas, Abelardo; Gil Caballero, Sergio; Rosa Acosta, Miguel Ángel de la; Díaz Moreno, Irene (Nature Publishing Group, 2018)
Apoptosis is a highly regulated form of programmed cell death, essential to the development and homeostasis of multicellular ...
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Nuclear cytochrome c – a mitochondrial visitor regulating damaged chromatin dynamics

Díaz Moreno, Irene; Velázquez Cruz, Alejandro; Curran French, Seamus; Díaz Quintana, Antonio Jesús; Rosa Acosta, Miguel Ángel de la (Wiley-Blackwell, 2018)
Over the past decade, evidence has emerged suggesting a broader role for cytochrome c (Cyt c) in programmed cell death. ...
PhD Thesis
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Cytosolic interaction between respiratory cytochrome c and 14-3-3 protein family members facilitates programmed cell death in humans and plants

Elena-Real, Carlos A.; Díaz Moreno, Irene; Rosa Acosta, Miguel Ángel de la (2017)
The development, as well as the homeostatic control of multi-cellular organisms, requires programmed cell death processes. ...
PhD Thesis
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Phosphorylation of cytochrome C: functional and structural features

Guerra Castellano, Alejandra; Díaz Quintana, Antonio Jesús; Rosa Acosta, Miguel Ángel de la (2017)
Post-translational modifications often modulate protein function. Actually, phosphorylation of cytochrome c occurs in vivo ...
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Histone chaperone activity of Arabidopsis thaliana NRP1 is blocked by cytochrome c

González Arzola, Katiuska; Díaz Quintana, Antonio Jesús; Rivero Rodríguez, Francisco; Velázquez Campoy, Adrián; Rosa Acosta, Miguel Ángel de la; Díaz Moreno, Irene (Oxford University Press, 2017)
Higher-order plants and mammals use similar mechanisms to repair and tolerate oxidative DNA damage. Most studies on the ...
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Structural basis of mitochondrial dysfunction in response to cytochrome c phosphorylation at tyrosine 48

Moreno Beltrán, José Blas; Guerra Castellano, Alejandra; Díaz Quintana, Antonio Jesús; Conte, Rebecca del; García Mauriño, Sofía M.; González Arzola, Katiuska; Rosa Acosta, Miguel Ángel de la; Díaz Moreno, Irene (National Academy of Sciences, 2017)
Regulation of mitochondrial activity allows cells to adapt to changing conditions and to control oxidative stress, and its ...
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RNA Binding Protein Regulation and Cross-Talk in the Control of AU-rich mRNA Fate

García Mauriño, Sofía M.; Rivero Rodríguez, Francisco; Velázquez Cruz, Alejandro; Hernández Vellisca, Marian; Díaz Quintana, Antonio Jesús; Rosa Acosta, Miguel Ángel de la; Díaz Moreno, Irene (Frontiers Media, 2017)
mRNA metabolism is tightly orchestrated by highly-regulated RNA Binding Proteins (RBPs) that determine mRNA fate, thereby ...
PhD Thesis
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Estructura y estabilidad en plastocianinas de cianobacterias

Frutos Beltrán, Estrella; Díaz Quintana, Antonio Jesús; Rosa Acosta, Miguel Ángel de la (2016)
ESTRUCTURA Y ESTABILIDAD EN PLASTOCIANINAS DE CIANOBACTERIAS La elucidación de los factores que determinan las diferencias ...
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The Dynamics of the Human Leukocyte Antigen Head Domain Modulates Its Recognition by the T-Cell Receptor

García Guerrero, Estefanía; Pérez Simón, José Antonio; Sánchez Abarca, Luis Ignacio; Díaz Moreno, Irene; Rosa Acosta, Miguel Ángel de la; Díaz Quintana, Antonio Jesús (Public Library of Science, 2016)
Generating the immune response requires the discrimination of peptides presented by the human leukocyte antigen complex ...
PhD Thesis
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Redox biointeractome of cytochromes in respiration and photosynthesis

Moreno Beltrán, José Blas; Rosa Acosta, Miguel Ángel de la; Díaz Moreno, Irene (2015)
Protein complex formation is at least a two-step process in which the formation of a final, well-defined complex entails ...
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Respiratory complexes III and IV can each bind two molecules of cytochrome c at low ionic strength

Moreno Beltrán, José Blas; Díaz Moreno, Irene; González Arzola, Katiuska; Guerra Castellano, Alejandra; Velázquez Campoy, Adrián; Rosa Acosta, Miguel Ángel de la; Díaz Quintana, Antonio Jesús (Elsevier, 2015)
The transient interactions of respiratory cytochrome c with complexes III and IV is herein investigated by using heterologous ...
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Structural basis for inhibition of the histone chaperone activity of SET/TAF-Iβ by cytochrome c

González Arzola, Katiuska; Díaz Moreno, Irene; Cano González, Ana María; Díaz Quintana, Antonio Jesús; Velázquez Campoy, Adrián; Moreno Beltrán, José Blas; López Rivas, Abelardo; Rosa Acosta, Miguel Ángel de la (National Academy of Sciences, 2015)
Chromatin is pivotal for regulation of the DNA damage process insofar as it influences access to DNA and serves as a DNA ...
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A common signalosome for programmed cell death in humans and plants

Martínez Fábregas, Jonathan; Díaz Moreno, Irene; González Arzola, Katiuska; Díaz Quintana, Antonio Jesús; Rosa Acosta, Miguel Ángel de la (Nature Publishing Group, 2014)
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The dynamic complex of cytochrome c6 and cytochrome f studied with paramagnetic NMR spectroscopy

Díaz Moreno, Irene; Hulsker, R; Skubak, O.; Foerster, J.M.; Cavazzini, D; Finiguerra, M.G.; Díaz Quintana, Antonio Jesús; Moreno Beltrán, José Blas; Rossi, G.-L.; Ullmann, G.M.; Pannu, N.S.; Rosa Acosta, Miguel Ángel de la; Ubbink, Marcellus (Elsevier B.V., 2014)
The rapid transfer of electrons in the photosynthetic redox chain is achieved by the formation of short-lived complexes ...
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Cytochrome c1 exhibits two binding sites for cytochrome c in plants

Moreno Beltrán, José Blas; Díaz Quintana, Antonio Jesús; González Arzola, Katiuska; Velázquez Campoy, Adrián; Rosa Acosta, Miguel Ángel de la; Díaz Moreno, Irene (Elsevier, 2014)
n plants, channeling of cytochrome c molecules between complexes III and IV has been purported to shuttle electrons within ...
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Structural and Functional Analysis of Novel Human Cytochrome c Targets in Apoptosis

Martínez Fábregas, Jonathan; Díaz Moreno, Irene; González Arzola, Katiuska; Janocha, Simon; Navarro Carruesco, José Antonio; Hervás Morón, Manuel; Bernhardt, Rita; Velázquez Campoy, Adrián; Díaz Quintana, Antonio Jesús; Rosa Acosta, Miguel Ángel de la (American Society for Biochemistry and Molecular Biology, 2014)
Since the first description of apoptosis four decades ago, great efforts have been made to elucidate, both in vivo and in ...
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Temperature-driven changeover in the electron-transfer mechanism of a thermophilic plastocyanin

Olloqui Sariego, José Luis; Moreno Beltrán, José Blas; Díaz Quintana, Antonio Jesús; Rosa Acosta, Miguel Ángel de la; Calvente Pacheco, Juan José; Andreu Fondacabe, Rafael Jesús (American Chemical Society, 2014)
Electron-transfer kinetics of the thermophilic protein Plastocyanin fromPhormidium laminosumadsorbed on 1,ω-alkanedithiol ...
PhD Thesis
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Structural approach to the hur function

Scheiba, Rafael Manfred; Díaz Moreno, Irene; Rosa Acosta, Miguel Ángel de la (2013)
En esta tesis se presenta un análisis estructural de la proteína de unión a ARN HuR y, en particular, se profundiza en el ...
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Communication between L–galactono–1,4–lactone dehydrogenase and cytochrome c

Hervás Morón, Manuel; Bashir, Qamar; Leferink, Nicole G.H.; Ferreira, Patricia; Moreno Beltrán, José Blas; Westphal, Adrie H; Díaz Moreno, Irene; Medina, Milagros; Rosa Acosta, Miguel Ángel de la; Ubbink, Marcellus; Navarro Carruesco, José Antonio; Berkel, Willem, J.H. van (Wiley: FEBS Journal, 2013)
l‐galactono‐1,4‐lactone dehydrogenase (GALDH) catalyzes the terminal step of vitamin C biosynthesis in plant mitochondria. ...
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New Arabidopsis thaliana cytochrome c partners: A look into the elusive role of cytochrome c in programmed cell death in plants

Martínez Fábregas, Jonathan; Díaz Moreno, Irene; González Arzola, Katiuska; Janocha, Simon; Navarro Carruesco, José Antonio; Hervás Morón, Manuel; Bernhardt, Rita; Díaz Quintana, Antonio Jesús; Rosa Acosta, Miguel Ángel de la (American Society for Biochemistry and Molecular Biology, 2013)
Programmed cell death is an event displayed by many different organisms along the evolutionary scale. In plants, programmed ...
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Antimalarial activity of cupredoxins: the interaction of Plasmodium Merozoite Surface Protein 119 (MSP119) and Rusticyanin

Cruz Gallardo, Isabel; Díaz Moreno, Irene; Díaz Quintana, Antonio Jesús; Velázquez Campoy, Adrián; Curd, Rachel D.; Rangachari, Caveri; Bridsall, Berry; Ramos, Andrés; Holder, Anthony A.; Rosa Acosta, Miguel Ángel de la (American Society for Biochemistry and Molecular Biology, 2013)
Background: The interaction of MSP119 with the cupredoxin azurin inhibits the growth of Plasmodium falciparum in red blood ...
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Preface to the mini-theme issue of IUBMB life on biointeractomics

Díaz Moreno, Irene; Rosa Acosta, Miguel Ángel de la (Taylor & Francis, 2013)
PhD Thesis
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Desvelando el curso evolutivo de la red de proteínas que interaccionan con el Citocromo C en la muerte celular programada

Martínez Fábregas, Jonathan; Navarro Carruesco, José Antonio; Rosa Acosta, Miguel Ángel de la (2012)
La organización celular de los organismos fue descubierta a mediados del siglo XIX por Schwann y Schleiden (1847). Poco ...
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The cytochrome f–plastocyanin complex as a model to study transient interactions between redox proteins

Cruz Gallardo, Isabel; Díaz Moreno, Irene; Díaz Quintana, Antonio Jesús; Rosa Acosta, Miguel Ángel de la (Wiley, 2012)
Transient complexes, with a lifetime ranging between microseconds and seconds, are essential forbiochemical reactions ...
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Voltammetric study of the adsorbed thermophilic plastocyanin from Phormidium laminosum up to 90 °c

Olloqui Sariego, José Luis; Frutos Beltrán, Estrella; Roldán González, Emilio; Rosa Acosta, Miguel Ángel de la; Calvente Pacheco, Juan José; Díaz Quintana, Antonio Jesús; Andreu Fondacabe, Rafael Jesús (Elsevier, 2012)
Redox thermodynamics and kinetics of plastocyanin from Phormidium laminosum, and of azurin from Pseudonomas aeruginosa, ...
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Specific nitration of tyrosines 46 and 48 makes cytochrome c assemble a non-functional apoptosome

García Heredia, José Manuel; Díaz Moreno, Irene; Díaz Quintana, Antonio Jesús; Orzáez, Mar; Navarro Carruesco, José Antonio; Hervás Morón, Manuel; Rosa Acosta, Miguel Ángel de la (Elsevier, 2012)
Under nitroxidative stress, a minor fraction of cytochrome c can be modified by tyrosine nitration. Here we analyze the ...
PhD Thesis
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Análisis Estructural de los Determinantes de la Estabilidad en Plastocianinas

Muñoz López, Francisco Jesús; Díaz Quintana, Antonio Jesús; Rosa Acosta, Miguel Ángel de la (2011)
La vida se encuentra en casi cualquier lugar de la Tierra, tanto en las grietas hidrotermales de los suelos marinos o en ...
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Cytochrome c signalosome in mitochondria

Díaz Moreno, Irene; García Heredia, José Manuel; Díaz Quintana, Antonio Jesús; Rosa Acosta, Miguel Ángel de la (Springer, 2011)
Cytochrome c delicately tilts the balance between cell life (respiration) and cell death (apoptosis). Whereas cell life ...
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How the Local Geometry of the Cu-Binding Site Determines the Thermal Stability of Blue Copper Proteins

Chaboy, Jesús; Díaz Moreno, Sofía; Díaz Moreno, Irene; Rosa Acosta, Miguel Ángel de la; Díaz Quintana, Antonio Jesús (Elsevier, 2011)
Identifying the factors that govern the thermal resistance of cupredoxins is essential for understanding their folding and ...
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Modulation of copper site properties by remote residues determines the stability of plastocyanins

Muñoz López, Francisco Jesús; Frutos Beltrán, Estrella; Díaz Moreno, Sofía; Díaz Moreno, Irene; Subías Peruga, Maria Gloria; Rosa Acosta, Miguel Ángel de la; Díaz Quintana, Antonio Jesús (Elsevier, 2010)
The metal cofactor determines the thermal stability in cupredoxins, but how the redox state of copper modulates their ...
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Nitration of tyrosine 74 prevents human cytochrome c to play a key role in apoptosis signaling by blocking caspase-9 activation

García Heredia, José Manuel; Díaz Moreno, Irene; Nieto Mesa, Pedro Manuel; Orzáez, Mar; Kocanis, Stella; Teixeira, Miguel; Pérez Payá, Enrique; Díaz Quintana, Antonio Jesús; Rosa Acosta, Miguel Ángel de la (Elsevier, 2010)
Tyrosine nitration is one of the most common post-transcriptional modifications of proteins, so affecting their structure ...
Patent. Invention
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Construcción génica que codifica para el citocromo c y procedimiento de obtención

Rosa Acosta, Miguel Ángel de la; Cerda Haynes, Berta de la; Molina Heredia, Fernando Publio; Rodríguez Roldán, Vicente; Hervás Morón, Manuel; García Heredia, José Manuel; Navarro Carruesco, José Antonio (Oficina Española de Patentes y Marcas (OEPM), 2009)
Construcción génica que codifica para el citocromo c y procedimiento de obtención. Se describe una construcción génica que ...
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Electrostatic strain and concerted motions in the transient complex between plastocyanin and cytochrome f from the cyanobacterium Phormidium laminosum

Díaz Moreno, Irene; Muñoz López, Francisco Jesús; Frutos Beltrán, Estrella; Rosa Acosta, Miguel Ángel de la; Díaz Quintana, Antonio Jesús (Elsevier, 2009)
Many fleeting macromolecular interactions, like those being involved in electron transport, are essential in biology. ...
PhD Thesis
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Análisis comparado en animales y plantas de la función del citocromo c respiratorio en el proceso de muerte celular programada

García Heredia, José Manuel; Rosa Acosta, Miguel Ángel de la; Navarro Carruesco, José Antonio (2008)
PhD Thesis
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Alteración de las propiedades físico-químicas y funcionales de los citocromos C respiratorios ocasionada por la nitración de tirosinas

Rodríguez Roldán, Vicente; Rosa Acosta, Miguel Ángel de la; Hervás Morón, Manuel (2008)
PhD Thesis
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Transferencia de electrones y complejos transitorios entre proteínas: análisis funcional de la interacción entre el citocromo f y la platocianina

Albarrán Nogales, Cristina; Hervás Morón, Manuel; Rosa Acosta, Miguel Ángel de la (2007)
Con el presente trabajo de Tesis se pretende establecer las diferencias funcionales entre sistemas de transferencia de ...
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The atypical iron-coordination geometry of cytochrome f remains unchanged upon binding to plastocyanin, as inferred by XAS

Díaz Moreno, Irene; Díaz Moreno, Sofía; Subías Peruga, Maria Gloria; Rosa Acosta, Miguel Ángel de la; Díaz Quintana, Antonio Jesús (Springer Verlag, 2006)
The transient complex between cytochrome f and plastocyanin from the cyanobacterium Nostoc sp. PCC 7119 has been analysed ...
PhD Thesis
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Análisis de la transferencia electrónica in vivo mediada por plastocianina y citocromo c₆ en cianobacterias

Durán Díaz, Raúl V.; Rosa Acosta, Miguel Ángel de la; Navarro Carruesco, José Antonio (2005)
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Structure of the Complex between Plastocyanin and Cytochrome f from the Cyanobacterium Nostoc sp. PCC 7119 as Determined by Paramagnetic NMR

Díaz Moreno, Irene; Díaz Quintana, Antonio Jesús; Rosa Acosta, Miguel Ángel de la; Ubbink, Marcellus (Elsevier, 2005)
The complex between cytochrome f and plastocyanin from the cyanobacterium Nostoc has been characterized by NMR spectroscopy. ...
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NMR analysis of the transient complex between membrane photosystem I and soluble cytochrome c6

Díaz Moreno, Irene; Díaz Quintana, Antonio Jesús; Molina Heredia, Fernando Publio; Nieto Mesa, Pedro Manuel; Hansson, Örjan; Rosa Acosta, Miguel Ángel de la; Karlsson, B. Göran (Elsevier, 2005)
A structural analysis of the surface areas of cytochrome c6, responsible for the transient interaction with photosystem ...
PhD Thesis
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Reconocimiento molecular y análisis estructural de complejos transitorios entre proteínas

Díaz Moreno, Irene; Rosa Acosta, Miguel Ángel de la; Díaz Quintana, Antonio Jesús (2005)
Las interacciones trasitorias entre biomoléculas se han convertido en el centro de la investigación de muchas áreas de la ...
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The Efficient Functioning of Photosynthesis and Respiration in Synechocystis sp. PCC 6803 Strictly Requires the Presence of either Cytochrome c6 or Plastocyanin

Durán Díaz, Raúl V.; Hervás Morón, Manuel; Rosa Acosta, Miguel Ángel de la; Navarro Carruesco, José Antonio (Elsevier, 2004)
In cyanobacteria, cytochrome c6 and plastocyanin are able to replace each other as redox carriers in the photosynthetic ...
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The Interactions of Cyanobacterial Cytochromec6 and Cytochrome f, Characterized by NMR

Crowley, Peter B.; Díaz Quintana, Antonio Jesús; Molina Heredia, Fernando Publio; Nieto, Pedro; Sutter, Martin; Haehnel, Wolfgang; Rosa Acosta, Miguel Ángel de la; Ubbínk, Marcellus (Elsevier, 2002)
During oxygenic photosynthesis, cytochromec6 shuttles electrons between the membrane-bound complexes cytochrome bf and ...
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Anabaena sp. PCC 7119 Flavodoxin as Electron Carrier from Photosystem I to Ferredoxin-NADP+Reductase: ROLE OF TRP57 AND TYR94

Arregui Casaus, José Luis; Navarro Carruesco, José Antonio; Hervás Morón, Manuel; Lostao, Anabel; Rosa Acosta, Miguel Ángel de la; Gómez Moreno, Carlos; Sancho, Javier; Medina, Milagros (Elsevier, 2002)
The influence of the amino acid residues sandwiching the flavin ring in flavodoxin (Fld) from the cyanobacteriumAnabaena ...
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An evolutionary analysis of the reaction mechanisms of photosystem I reduction by cytochrome c6 and plastocyanin

Rosa Acosta, Miguel Ángel de la; Navarro Carruesco, José Antonio; Díaz Quintana, Antonio Jesús; Cerda Haynes, Berta de la; Molina Heredia, Fernando Publio; Balme, Alexis; Murdoch, Piedad del Socorro; Díaz Moreno, Irene; Durán Díaz, Raúl V.; Hervás Morón, Manuel (Elsevier, 2002)
Photosystem I reduction by the soluble metalloproteins cytochrome c6 and plastocyanin, which are alternatively synthesized ...
PhD Thesis
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Identificación de regiones isofuncionales en el citocromo c6 y en la plastocianina

Molina Heredia, Fernando Publio; Rosa Acosta, Miguel Ángel de la; Hervás Morón, Manuel (2001)
Una de las líneas de investigación mas intereses de la bioquímica contemporánea es el estudio de la relación entre la ...
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A Single Arginyl Residue in Plastocyanin and in Cytochrome c6 from the Cyanobacterium Anabaenasp. PCC 7119 Is Required for Efficient Reduction of Photosystem I

Molina Heredia, Fernando Publio; Hervás Morón, Manuel; Navarro Carruesco, José Antonio; Rosa Acosta, Miguel Ángel de la (Elsevier, 2001)
Positively charged plastocyanin from Anabaena sp. PCC 7119 was investigated by site-directed mutagenesis. The reactivity ...
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Site-directed Mutagenesis of Cytochromec 6 from Synechocystissp. PCC 6803

Cerda Haynes, Berta de la; Díaz Quintana, Antonio Jesús; Navarro Carruesco, José Antonio; Hervás Morón, Manuel; Rosa Acosta, Miguel Ángel de la (Elsevier, 1999)
This paper reports the first site-directed mutagenesis analysis of any cytochrome c 6, a heme protein that performs the ...
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Sobre la teoría y práctica de la ciencia

Rosa Acosta, Miguel Ángel de la (CSIC, 1999)
La investigación y el desarrollo —normalmente conocidos por su abreviatura I+D—, así como la innovación tecnológica se ...
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Oxidizing Side of the Cyanobacterial Photosystem I

Sun, J.; Xu, W.; Hervás Morón, Manuel; Navarro Carruesco, José Antonio; Rosa Acosta, Miguel Ángel de la; Chitnis, Parag R. (Elsevier, 1999)
Photosystem I (PSI) interacts with plastocyanin or cytochrome c 6 on the luminal side. To identify sites of interaction ...
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Site-directed Mutagenesis of Cytochromec 6 from Anabaena Species PCC 7119

Molina Heredia, Fernando Publio; Díaz Quintana, Antonio Jesús; Hervás Morón, Manuel; Navarro Carruesco, José Antonio; Rosa Acosta, Miguel Ángel de la (Elsevier, 1999)
A number of surface residues of cytochromec 6 from the cyanobacterium Anabaenasp. PCC 7119 have been modified by site-directed ...
PhD Thesis
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Citocromo c6 y plastocianina de la cianobacteria Synechocystis PCC 6803: estudio de la relación estructura-función en las proteínas nativas y modificadas por mutagénesis dirigida

Cerda Haynes, Berta de la; Rosa Acosta, Miguel Ángel de la; Navarro Carruesco, José Antonio (1998)
El estudio de los mecanismos de reconocimiento molecular y transferencia de electrones entre proteína se ha abordado en ...
PhD Thesis
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Transferencia de electrones en el lado oxidante del fotosistema I. Equivalencia funcional entre el citocromo c6 y la plastocianina

Díaz Quintana, Antonio Jesús; Rosa Acosta, Miguel Ángel de la; Hervás Morón, Manuel (1995)
El presente trabajo forma parte del realizado por el grupo al que el doctorando se encuentra adscrito, en el que se busca ...
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Fotosíntesis: sol, agua, tierra y aire

Rosa Acosta, Miguel Ángel de la; García Guerrero, Miguel; Losada Villasante, Manuel (RBA Revistas, 1993)
PhD Thesis
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Conversión química y biológica de la energía luminosa fotoproducción de peroxido de hidrógeno

Roncel Gil, Mercedes; Rosa Acosta, Miguel Ángel de la (1988)
Todas las formas de vida hasta ahora conocidas en nuestro planeta requieren energía para su crecimiento y conservación. ...
PhD Thesis
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Producción fotoquímica y fotobiológica de peróxido de hidrógeno

Navarro Carruesco, José Antonio; Rosa Acosta, Francisco Fernando de la; Rosa Acosta, Miguel Ángel de la (1986)
Se ha estudiado la optimización del proceso de reducción del oxigeno molecular a peróxido de hidrogeno impulsado por energía ...
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Cytochrome b-559 as an energy-transducer in the chloroplast electron transport chain between the two photosystems

Hervás Morón, Manuel; Ortega Rodríguez, José María; Rosa Acosta, Miguel Ángel de la; Rosa Acosta, Francisco Fernando de la; Losada Villasante, Manuel (, 1985)
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Carbon dioxide-mediated decomposition of hydrogen peroxide in alkaline solutions

Rosa Acosta, Miguel Ángel de la; Rosa Acosta, Francisco Fernando de la; Navarro Carruesco, José Antonio; Roncel Gil, Mercedes (Faraday Division of the Chemical Society, 1984)
Rapid hydrogen peroxide decomposition in aerated alkaline solutions is described, the maximum rate being attained at pH ...
PhD Thesis