Artículo
Long distance electron transfer through the aqueous solution between redox partner proteins
Autor/es | Lagunas, Anna
Guerra Castellano, Alejandra Nin Hill, Alba Díaz Moreno, Irene Rosa Acosta, Miguel Ángel de la Samitier, Josep Rovira, Carme Gorostiza, Pau |
Departamento | Universidad de Sevilla. Departamento de Bioquímica Vegetal y Biología Molecular |
Fecha de publicación | 2018 |
Fecha de depósito | 2019-01-22 |
Publicado en |
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Resumen | Despite the importance of electron transfer between redox proteins in photosynthesis and respiration, the inter-protein electron transfer rate between redox partner proteins has never been measured as a function of their ... Despite the importance of electron transfer between redox proteins in photosynthesis and respiration, the inter-protein electron transfer rate between redox partner proteins has never been measured as a function of their separation in aqueous solution. Here, we use electrochemical tunneling spectroscopy to show that the current between two protein partners decays along more than 10 nm in the solution. Molecular dynamics simulations reveal a reduced ionic density and extended electric field in the volume confined between the proteins. The distance-decay factor and the calculated local barrier for electron transfer are regulated by the electrochemical potential applied to the proteins. Redox partners could use electrochemically gated, long distance electron transfer through the solution in order to conciliate high specificity with weak binding, thus keeping high turnover rates in the crowded environment of cells. |
Identificador del proyecto | 2017 SGR 1442, 2014 SGR 1442, and 2017 SGR 1189
BIO198 BFU2015-71017-P |
Cita | Lagunas, A., Guerra Castellano, A., Nin Hill, A., Díaz Moreno, I., Rosa Acosta, M.Á.d.l., Samitier, J.,...,Gorostiza, P. (2018). Long distance electron transfer through the aqueous solution between redox partner proteins. Nature Communications, 9 (art.5157), 1-7. |
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