Instituto de Investigaciones Químicas (IIQ) – CIC Cartuja
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Reactivity of a gold(i)/platinum(0) frustrated Lewis pair with germanium and tin dihalides [Article]
(Royal Society of Chemistry, 2019)The reactivity of germanium and tin dichlorides with a transition metal-only frustrated Lewis pair based on Au(i) and Pt(0) compounds bearing bulky phosphine ligands is described in this work. We have examined both the ...
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Trehalose-based Siamese twin amphiphiles with tunable self-assembling, DNA nanocomplexing and gene delivery properties [Article]
(The Society, 2019-06-19)An original family of multivalent vectors encompassing gemini and facial amphiphilicity, namely cationic Siamese twin surfactants, has been prepared from the disaccharide trehalose; molecular engineering lets us modulate ...
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Synthesis, properties, and some rhodium, iridium, and platinum complexes of a series of bulky m-terphenylphosphine ligands [Article]
(Elsevier, 2016)A series of sterically demanding aryl phosphine ligands (L) bearing terphenyl substituents, PR2Ar′ (R = hydrocarbyl, Ar′ = 2,6-diarylphenyl radical) has been prepared and characterized. The stability of these ligands towards ...
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Synthesis and reactivity of half-sandwich (η 5 -C 5 Me 5 )Ir(iii) complexes of a cyclometallated aryl phosphine ligand [Article]
(Royal Society of Chemistry, 2011)Reaction of the Ir(iii) dimer [(η 5 -C 5 Me 5 )IrCl 2 ] 2 with PMeXyl 2 (Xyl = 2,6-C 6 H 3 Me 2 ), in the presence of the poorly coordinating base 2,2,6,6-tetramethyl piperidine, gives a chloride complex 1-Cl, resulting ...
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Experimental and theoretical characterization of the Zn - Zn bond in [Zn2(η5-C5Me5)2] [Article]
(Wiley-Blackwell, 2007)The existence and characterization of a bond between the Zn atoms in the recently synthesized complex [Zn2(5-C5Me5)2], as well as between Zn and ligand C atoms is firmly based on neutron diffraction and low-temperature ...
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Experimental and computational studies of the molybdenum-flanking arene interaction in quadruply bonded dimolybdenum complexes with terphenyl ligands [Article]
(Wiley-VCH Verlag, 2015)To clarify the nature of the Mo-Carene interaction in terphenyl complexes with quadruple Mo-Mo bonds, ether adducts of composition [Mo2(Ar')(I)(O2CR)2(OEt2)] have been prepared and characterized (Ar'=ArXyl 2, R=Me; Ar'=ArMes2, ...
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Different coordination modes of an aryl-substituted hydrotris(pyrazolyl) borate ligand in rhodium and iridium complexes [Article]
(Elsevier, 2011)Complexes TptolRh(C2H4)2 (1a) and TptolRh(CH2C(Me)C(Me)CH2) (1b) have been prepared by reaction of KTptol with the appropriate [RhCl(olefin)2]2 dimer (Tptol means hydrotris(3-p-tolylpyrazol-1-yl)borate). The two complexes ...
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Cationic (η5-C5Me4R)RhIII Complexes with Metalated Aryl Phosphines Featuring η4-Phosphorus plus Pseudo-Allylic Coordination [Article]
(American Chemical Society, 2018)In this contribution we study experimentally and computationally some electrophilic cationic (η5-C5Me4R)RhIII complexes containing a cyclometalated bis(aryl) phosphine, PR′Ar2. The phosphine Ar groups feature methyl ...
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Activation of Small Molecules by the Metal-Amido Bond of Rhodium(III) and Iridium(III) (η5-C5Me5)M-Aminopyridinate Complexes [Article]
(American Chemical Society, 2018)We report the synthesis and structural characterization of five-coordinate complexes of rhodium and iridium of the type [(η5-C5Me5)M(N^N)]+ (3-M+), where N^N represents the aminopyridinate ligand derived from 2-NH(Ph)-6-(Xyl)C5H3N ...
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Cytochrome c: Surfing Off of the Mitochondrial Membrane on the Tops of Complexes III and IV [Article]
(Elsevier, 2019)The proper arrangement of protein components within the respiratory electron transport chain is nowadays a matter of intense debate, since altering it leads to cell aging and other related pathologies. Here, we discuss ...
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Nuclear cytochrome c – a mitochondrial visitor regulating damaged chromatin dynamics [Article]
(Wiley-Blackwell, 2018)Over the past decade, evidence has emerged suggesting a broader role for cytochrome c (Cyt c) in programmed cell death. Recently, we demonstrated the ability of Cyt c to inhibit the nucleosome assembly activity of histone ...
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Cytochrome c speeds up caspase cascade activation by blocking 14-3-3ϵ-dependent Apaf-1 inhibition article [Article]
(Springer Nature, 2018)Apoptosis is a highly regulated form of programmed cell death, essential to the development and homeostasis of multicellular organisms. Cytochrome c is a central figure in the activation of the apoptotic intrinsic pathway, ...
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Glycosylated nanostructures in sublingual immunotherapy induce long-lasting tolerance in LTP allergy mouse model [Article]
(Nature, 2019-02-11)An effective specific immunotherapy should contain elements to generate specific recognition (T-cell peptides) and to modulate the immunological response towards a Th1/Treg pattern by enhancing dendritic cells (DCs). We ...
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Base-Promoted, Remote C−H Activation at a Cationic (η5 ‑C5Me5)Ir(III) Center Involving Reversible C−C Bond Formation of Bound C5Me5 [Article]
(American Chemical Society, 2019)C-H bond activation at cationic [(η5-C5Me5)Ir(PMe2Ar')] centers is described, where PMe2Ar' are the terphenyl phosphine ligands PMe2ArXyl2 and PMe2ArDipp2. Different pathways are defined for the conversion of the five-coordinate ...
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Editorial: Weak Interactions in Molecular Machinery [Article]
(Frontiers Media, 2018) -
HuR biological function involves RRM3-mediated dimerization and RNA binding by all three RRMs [Article]
(Oxford University Press, 2018)HuR/ELAVL1 is an RNA-binding protein involved in differentiation and stress response that acts primarily by stabilizing messenger RNA (mRNA) targets. HuR comprises three RNA recognition motifs (RRMs) where the structure ...
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SUMOylation regulates LKB1 localization and its oncogenic activity in liver cancer [Article]
(Elsevier, 2018)BACKGROUND: Even though liver kinase B1 (LKB1) is usually described as a tumor suppressor in a wide variety of tissues, it has been shown that LKB1 aberrant expression is associated with bad prognosis in Hepatocellular ...
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Long distance electron transfer through the aqueous solution between redox partner proteins [Article]
(Nature Research, 2018)Despite the importance of electron transfer between redox proteins in photosynthesis and respiration, the inter-protein electron transfer rate between redox partner proteins has never been measured as a function of their ...
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A glycomimetic compound inhibits DC-SIGN mediated HIV infection in cellular and cervical explant models [Article]
(Lippincott, Williams & Wilkins, 2012)Objective: Dendritic cell-specific intercellular adhesion molecule (ICAM)-3 grabbing nonintegrin (DC-SIGN) participates in the initial stages of sexually transmitted HIV-1 infection by recognizing highly mannosylated ...
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Dibenzyl and diallyl 2,6-bisiminopyridinezinc (ii) complexes: Selective alkyl migration to the pyridine ring leads to remarkably stable dihydropyridinates [Article]
(Royal Society of Chemistry, 2013)Diorganozinc compounds (ZnR2) with R = CH2Ph or CH2CH[double bond, length as m-dash]CH2 react with 2,6-bisiminopyridines (iPrBIP) to afford thermally stable dihydropyridinate(−1) complexes, and do not react if R = CH2SiMe3 ...