Artículo
Spontaneous DNA-RNA hybrids: differential impacts throughout the cell cycle
Autor/es | Gómez González, Belén
Barroso Ceballos, Sonia Inés Herrera Moyano, Emilia Aguilera López, Andrés |
Departamento | Universidad de Sevilla. Departamento de Genética |
Fecha de publicación | 2020 |
Fecha de depósito | 2020-06-25 |
Publicado en |
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Resumen | A large body of research supports that transcription plays a major role among the many sources of replicative stress contributing to genome instability. It is therefore not surprising that the DNA damage response has a ... A large body of research supports that transcription plays a major role among the many sources of replicative stress contributing to genome instability. It is therefore not surprising that the DNA damage response has a role in the prevention of transcription-induced threatening events such as the formation of DNA-RNA hybrids, as we have recently found through an siRNA screening. Three major DDR pathways were defined to participate in the protection against DNA-RNA hybrids: ATM/CHK2, ATR/CHK1 and Postreplication Repair (PRR). Based on these observations, we envision different scenarios of DNA-RNA hybridization and their consequent DNA damage. |
Identificador del proyecto | ERC2014 AdG669898 TARLOOP |
Cita | Gómez González, B., Barroso Ceballos, S.I., Herrera Moyano, E. y Aguilera López, A. (2020). Spontaneous DNA-RNA hybrids: differential impacts throughout the cell cycle. Cell Cycle, 19 (5), 525-531. |
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Spontaneous DNA-RNA hybrids.pdf | 1.572Mb | [PDF] | Ver/ | |