Perfil del autor: Barroso Ceballos, Sonia Inés
Datos institucionales
Nombre | Barroso Ceballos, Sonia Inés |
Departamento | Sin Departamento Específico |
Área de conocimiento | No existe área para esta sección. |
Categoría profesional | TITULADO SUPERIOR |
Correo electrónico | Solicitar |
Estadísticas
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Nº publicaciones
19
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Nº visitas
2975
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Nº descargas
5321
Publicaciones |
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Artículo
MutSβ regulates G4-associated telomeric R-loops to maintain telomere integrity in ALT cancer cells
(Elsevier, 2022)
Up to 15% of human cancers maintain their telomeres through a telomerase-independent mechanism, termed “alternative ... |
Artículo
Topoisomerase 1-dependent R-loop deficiency drives accelerated replication and genomic instability
(Elsevier, 2022)
DNA replication is a complex process tightly regulated to ensure faithful genome duplication, and its perturbation leads ... |
Artículo
The SWI/SNF chromatin remodeling complex helps resolve R-loop-mediated transcription–replication conflicts
(Springer Nature, 2021)
ATP-dependent chromatin remodelers are commonly mutated in human cancer. Mammalian SWI/SNF complexes comprise three conserved ... |
Artículo
A transcription-based mechanism for oncogenic β-catenin-induced lethality in BRCA1/2-deficient cells
(Springer Nature, 2021)
BRCA1 or BRCA2 germline mutations predispose to breast, ovarian and other cancers. High-throughput sequencing of tumour ... |
Artículo
The human nucleoporin Tpr protects cells from RNA-mediated replication stress
(Springer Nature, 2021)
Although human nucleoporin Tpr is frequently deregulated in cancer, its roles are poorly understood. Here we show that Tpr ... |
Artículo
BRCA2 promotes DNA-RNA hybrid resolution by DDX5 helicase at DNA breaks to facilitate their repair
(Wiley-Blackwell, 2021)
The BRCA2 tumor suppressor is a DNA double-strand break (DSB) repair factor essential for maintaining genome integrity. ... |
Artículo
UAP56/DDX39B is a major cotranscriptional RNA–DNA helicase that unwinds harmful R loops genome-wide
(Cold Spring Harbor Laboratory Press, 2020)
Nonscheduled R loops represent a major source of DNA damage and replication stress. Cells have different ways to prevent ... |
Artículo
Spontaneous DNA-RNA hybrids: differential impacts throughout the cell cycle
(Taylor & Francis, 2020)
A large body of research supports that transcription plays a major role among the many sources of replicative stress ... |
Artículo
The DNA damage response acts as a safeguardagainst harmful DNA–RNA hybrids ofdifferent origins
(EMBO Press, 2019)
Despite playing physiological roles in specific situations, DNA–RNA hybrids threat genome integrity. To investigate how ... |
Artículo
Depletion of the MFAP1/SPP381 Splicing Factor Causes R-Loop-Independent Genome Instability
(Elsevier, 2019)
THO/TREX is a conserved complex with a role in messenger ribonucleoprotein biogenesis that links gene expression and genome ... |
Artículo
The antitumor drugs trabectedin and lurbinectedin induce transcription-dependent replication stress and genome instability
(American Association for Cancer Research, 2019)
R-loops are a major source of replication stress, DNA damage, and genome instability, which are major hallmarks of cancer ... |
Artículo
Multiple signaling kinases target Mrc1 to prevent genomic instability triggered by transcription-replication conflicts
(Nature Publishing Group:, 2018)
Conflicts between replication and transcription machineries represent a major source of genomic instability and cells have ... |
Artículo
Epigenetic features of human telomeres
(Oxford University Press, 2018)
Although subtelomeric regions in humans are heterochromatic, the epigenetic nature of human telomeres remains controversial. ... |
Capítulo de Libro
Detection of DNA-RNA hybrids in vivo
(Humana Press Inc., 2018)
DNA-RNA hybrids form naturally during essential cellular functions such as transcription and replication. However, they ... |
Artículo
Roles of human POLD1 and POLD3 in genome stability
(Nature, 2016)
DNA replication is essential for cellular proliferation. If improperly controlled it can constitute a major source of ... |
Artículo
The Fanconi Anemia Pathway Protects Genome Integrity from R-loops
(Public Library of Science, 2015)
Co-transcriptional RNA-DNA hybrids (R loops) cause genome instability. To prevent harmful R loop accumulation, cells have ... |
Artículo
Polycomb RING1A- and RING1B-dependent histone H2A monoubiquitylation at pericentromeric regions promotes S-phase progression
(Company of Biologists Ltd, 2015)
The functions of polycomb products extend beyond their well-known activity as transcriptional regulators to include genome ... |
Artículo
The yeast and human FACT chromatin-reorganizing complexes resolve R-loop-mediated transcription-replication conflicts
(Cold Spring Harbor Laboratory Press, 2014)
FACT (facilitates chromatin transcription) is a chromatin-reorganizing complex that swaps nucleosomes around the RNA ... |
Artículo
Genome Instability and Transcription Elongation Impairment in Human Cells Depleted of THO/TREX
(Public Library of Science, 2011)
THO/TREX connects transcription with genome integrity in yeast, but a role of mammalian THO in these processes is uncertain, ... |