Perfil del autor: Gómez González, Belén
Datos institucionales
| Nombre | Gómez González, Belén |
| Departamento | Genética |
| Área de conocimiento | Genética |
| Categoría profesional | Profesora Contratada Doctora |
| Correo electrónico | Solicitar |
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Estadísticas
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Nº publicaciones
35
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Nº visitas
4637
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Nº descargas
4798
| Publicaciones |
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Artículo
 Break-induced RNA–DNA hybrids (BIRDHs) in homologous recombination: friend or foe?
(Wiley-Blackwell, 2023)
Double-strand breaks (DSBs) are the most harmful DNA lesions, with a strong impact on cell proliferation and genome ... |
Artículo
Editorial: The Role of RNA in Genome Stability: To Wreck or Repair?
(Frontiers Media S.A., 2022)
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Artículo
A role for the Saccharomyces cerevisiae Rtt109 histone acetyltransferase in R-loop homeostasis and associated genome instability
(Genetics Society of America, 2022)
The stability of the genome is occasionally challenged by the formation of DNA-RNA hybrids and R-loops, which can be ... |
Tesis Doctoral
Influence of chromatin factors and DNA-RNA hybrids in the repair of replication-born DSBs
(2021)
La información genética debe estar almacenada de manera segura en la molécula de ADN. Sin embargo, el ADN está continuamente ... |
Artículo
A CDK-regulated chromatin segregase promoting chromosome replication
(Springer Nature, 2021)
The replication of chromosomes during S phase is critical for cellular and organismal function. Replicative stress can ... |
Artículo
A new interaction between BRCA2 and DDX5 promotes the repair of DNA breaks at transcribed chromatin
(Taylor & Francis, 2021)
In a recent report, we have revealed a new interaction between the BRCA2 DNA repair associated protein (BRCA2) and the ... |
Artículo
Dna-rna hybrids at dsbs interfere with repair by homologous recombination
(eLife Sciences Publications, 2021)
DNA double-strand breaks (DSBs) are the most harmful DNA lesions and their repair is crucial for cell viability and genome ... |
Capítulo de Libro
Analysis of repair of replication-born double-strand breaks by sister chromatid recombination in yeast
(Elsevier, 2021)
The repair of DNA double-strand breaks is crucial for cell viability and the maintenance of genome integrity. When present, ... |
Artículo
VID22 counteracts G-quadruplex-induced genome instability
(Oxford University Press, 2021)
Genome instability is a condition characterized by the accumulation of genetic alterations and is a hallmark of cancer ... |
Tesis Doctoral
The influence of chromatin in DNA-RNA hybrid metabolism
(2020)
El genoma, el conjunto de genes de un organismo o especie, debe copiarse de forma fidedigna de célula a célula. Sin embargo, ... |
Artículo
Histone H3E73Q and H4E53A mutations cause recombinogenic DNA damage
(Shared Science Publishers OG, 2020)
The stability and function of eukaryotic genomes is closely linked to histones and to chromatin structure. The state of ... |
Artículo
Histone deacetylases facilitate the accurate repair of broken forks
(Taylor & Francis, 2020)
We have recently uncovered that loss of the yeast histone deacetylases Rpd3 (Reduced Potassium Dependency 3) and Hda1 ... |
Artículo
Harmful DNA:RNA hybrids are formed in cis and in a Rad51-independent manner
(eLife Sciences Publications, 2020)
DNA:RNA hybrids constitute a well-known source of recombinogenic DNA damage. The current literature is in agreement with ... |
Artículo
Spontaneous DNA-RNA hybrids: differential impacts throughout the cell cycle
(Taylor & Francis, 2020)
A large body of research supports that transcription plays a major role among the many sources of replicative stress ... |
Artículo
Looping the (R) Loop in DSB Repair via RNA Methylation
(Elsevier, 2020)
In this issue of Molecular Cell, Zhang et al. (2020) reveal that ATM triggers RNA methylation of DNA-RNA hybrids formed ... |
Artículo
The DNA damage response acts as a safeguardagainst harmful DNA–RNA hybrids ofdifferent origins
(EMBO Press, 2019)
Despite playing physiological roles in specific situations, DNA–RNA hybrids threat genome integrity. To investigate how ... |
Artículo
Transcription-mediated replication hindrance: a major driver of genome instability
(Cold Spring Harbor Laboratory Press, 2019)
Genome replication involves dealing with obstacles that can result from DNA damage but also from chromatin alterations, ... |
Artículo
Rpd3L and Hda1 histone deacetylases facilitate repair of broken forks by promoting sister chromatid cohesion
(Nature Research, 2019)
Genome stability involves accurate replication and DNA repair. Broken replication forks, such as those encountering a nick, ... |
Artículo
Rpd3l contributes to the DNA damage sensitivity of saccharomyces cerevisiae checkpoint mutants
(Genetics Society of America, 2019)
DNA replication forks that are stalled by DNA damage activate an S-phase checkpoint that prevents irreversible fork arrest ... |
Artículo
Guidelines for DNA recombination and repair studies: Cellular assays of DNA repair pathways
(Shared Science Publishers OG, 2019)
Understanding the plasticity of genomes has been greatly aided by assays for recombination, repair and mutagenesis. These ... |
Artículo
The need to regulate replication fork speed
(American Association for the Advancement of Science, 2017)
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Artículo
DNA-RNA hybrids: The risks of DNA breakage during transcription
(Springer Nature, 2017)
Although R loops can occur at different genomic locations, the factors that determine their formation and frequency remain ... |
Artículo
The Role of Replication-Associated Repair Factors on R-Loops
(MDPI, 2017)
The nascent RNA can reinvade the DNA double helix to form a structure termed the R-loop, where a single-stranded DNA (ssDNA) ... |
Artículo
The Smc5/6 complex regulates the yeast Mph1 helicase at RNA-DNA hybrid-mediated DNA damage
(Public Library of Science, 2017)
RNA-DNA hybrids are naturally occurring obstacles that must be overcome by the DNA replication machinery. In the absence ... |
Artículo
Histone Mutants Separate R Loop Formation from Genome Instability Induction
(Elsevier, 2017)
R loops have positive physiological roles, but they can also be deleterious by causing genome instability, and the mechanisms ... |
Artículo
A new role for Rrm3 in repair of replication-born DNA breakage by sister chromatid recombination
(Public Library of Science, 2017)
Replication forks stall at different DNA obstacles such as those originated by transcription. Fork stalling can lead to ... |
Artículo
Yeast Sen1 helicase protects the genome from transcription-associated instability
(Elsevier, 2011)
Sen1 of S. cerevisiae is a known component of the NRD complex implicated in transcription termination of nonpolyadenylated ... |
Artículo
The replication checkpoint protects fork stability by releasing transcribed genes from nuclear pores
(Elsevier, 2011)
Transcription hinders replication fork progression and stability, and the Mec1/ATR checkpoint protects fork integrity. ... |
Artículo
AID induces double-strand breaks at immunoglobulin switch regions and c-MYC causing chromosomal translocations in yeast THO mutants
(Public Library of Science, 2011)
Transcription of the switch (S) regions of immunoglobulin genes in B cells generates stable R-loops that are targeted by ... |
Artículo
Genome Instability and Transcription Elongation Impairment in Human Cells Depleted of THO/TREX
(Public Library of Science, 2011)
THO/TREX connects transcription with genome integrity in yeast, but a role of mammalian THO in these processes is uncertain, ... |
Artículo
The S-phase checkpoint is required to respond to R-loops accumulated in THO mutants
(American Society for Microbiology, 2009)
Cotranscriptional R-loops are formed in yeast mutants of the THO complex, which functions at the interface between ... |
Artículo
Chromosomal translocations caused by either Pol32-dependent or Pol32-independent triparental break-induced replication
(American Society for Microbiology, 2009)
Double-strand breaks (DSBs) are harmful DNA lesions that can generate chromosomal rearrangements or chromosome losses if ... |
| Artículo |
Artículo
The THP1-SAC3-SUS1-CDC31 complex works in transcription elongation-mRNA export preventing RNA-mediated genome instability
(American Society for Cell Biology, 2008)
The eukaryotic THO/TREX complex, involved in mRNP biogenesis, plays a key role in the maintenance of genome integrity in ... |
Artículo
Activation-induced cytidine deaminase action is strongly stimulated by mutations of the THO complex
(National Academy of Sciences, 2007)
Activation-induced cytidine deaminase (AID) is a B cell enzyme essential for Ig somatic hypermutation and class switch ... |