NameGómez González, Belén
DepartmentGenética
Knowledge areaGenética
Professional categoryProfesora Contratada Doctora
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  • No. publications

    35

  • No. visits

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Break-induced RNA–DNA hybrids (BIRDHs) in homologous recombination: friend or foe?

Gómez González, Belén; Aguilera López, Andrés (Wiley-Blackwell, 2023)
Double-strand breaks (DSBs) are the most harmful DNA lesions, with a strong impact on cell proliferation and genome ...
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A role for the Saccharomyces cerevisiae Rtt109 histone acetyltransferase in R-loop homeostasis and associated genome instability

Cañas, Juan Carlos; García Rubio, María Luisa; García, Alicia; Antequera, Francisco; Gómez González, Belén; Aguilera López, Andrés (Genetics Society of America, 2022)
The stability of the genome is occasionally challenged by the formation of DNA-RNA hybrids and R-loops, which can be ...
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Editorial: The Role of RNA in Genome Stability: To Wreck or Repair?

Gómez González, Belén; Dutta, Arijit; Feng, Wenyi (Frontiers Media S.A., 2022)
PhD Thesis
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Influence of chromatin factors and DNA-RNA hybrids in the repair of replication-born DSBs

Ortega Moreno, Pedro; Aguilera López, Andrés; Gómez González, Belén (2021)
La información genética debe estar almacenada de manera segura en la molécula de ADN. Sin embargo, el ADN está continuamente ...
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A new interaction between BRCA2 and DDX5 promotes the repair of DNA breaks at transcribed chromatin

Gómez González, Belén; Sessa, Gaetana; Carreira, Aura; Aguilera López, Andrés (Taylor & Francis, 2021)
In a recent report, we have revealed a new interaction between the BRCA2 DNA repair associated protein (BRCA2) and the ...
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VID22 counteracts G-quadruplex-induced genome instability

Galati, Elena; Bosio, Maria C.; Novarina, Daniele; Chiara, Matteo; Bernini, Giulia M.; Mozzarelli, Alessandro M.; García Rubio, María Luisa; Gómez González, Belén; Aguilera López, Andrés; Carzaniga, Thomas; Todisco, Marco; Bellini, Tommaso; Nava, Giulia M.; Frige, Gianmaria; Lazzaro, Federico (Oxford University Press, 2021)
Genome instability is a condition characterized by the accumulation of genetic alterations and is a hallmark of cancer ...
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Dna-rna hybrids at dsbs interfere with repair by homologous recombination

Ortega Moreno, Pedro; Mérida Cerro, José Antonio; García Rondón, Ana; Gómez González, Belén; Aguilera López, Andrés (eLife Sciences Publications, 2021)
DNA double-strand breaks (DSBs) are the most harmful DNA lesions and their repair is crucial for cell viability and genome ...
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A CDK-regulated chromatin segregase promoting chromosome replication

Chacin, Erika; Bansal, Priyanka; Reusswig, Karl-Uwe; Díaz Santín, Luis M.; Ortega Moreno, Pedro; Vizjak, Petra; Gómez González, Belén; Müller-Planitz, Felix; Aguilera López, Andrés; Pfander, Boris; Cheung, Alan C. M.; Kurat, Christoph F. (Springer Nature, 2021)
The replication of chromosomes during S phase is critical for cellular and organismal function. Replicative stress can ...
Chapter of Book
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Analysis of repair of replication-born double-strand breaks by sister chromatid recombination in yeast

Gómez González, Belén; Ortega Moreno, Pedro; Aguilera López, Andrés (Elsevier, 2021)
The repair of DNA double-strand breaks is crucial for cell viability and the maintenance of genome integrity. When present, ...
PhD Thesis
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The influence of chromatin in DNA-RNA hybrid metabolism

Martínez Cañas, Juan Carlos; Gómez González, Belén; Aguilera López, Andrés (2020)
El genoma, el conjunto de genes de un organismo o especie, debe copiarse de forma fidedigna de célula a célula. Sin embargo, ...
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Spontaneous DNA-RNA hybrids: differential impacts throughout the cell cycle

Gómez González, Belén; Barroso Ceballos, Sonia Inés; Herrera Moyano, Emilia; Aguilera López, Andrés (Taylor & Francis, 2020)
A large body of research supports that transcription plays a major role among the many sources of replicative stress ...
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Looping the (R) Loop in DSB Repair via RNA Methylation

Gómez González, Belén; Aguilera López, Andrés (Elsevier, 2020)
In this issue of Molecular Cell, Zhang et al. (2020) reveal that ATM triggers RNA methylation of DNA-RNA hybrids formed ...
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Histone H3E73Q and H4E53A mutations cause recombinogenic DNA damage

Ortega Moreno, Pedro; García Pichardo, Desiré; San Martín Alonso, Marta; García Rondón, Ana; Gómez González, Belén; Aguilera López, Andrés (Shared Science Publishers OG, 2020)
The stability and function of eukaryotic genomes is closely linked to histones and to chromatin structure. The state of ...
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Histone deacetylases facilitate the accurate repair of broken forks

Gómez González, Belén; Ortega Moreno, Pedro; Aguilera López, Andrés (Taylor & Francis, 2020)
We have recently uncovered that loss of the yeast histone deacetylases Rpd3 (Reduced Potassium Dependency 3) and Hda1 ...
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Harmful DNA:RNA hybrids are formed in cis and in a Rad51-independent manner

Lafuente Barquero, Juan; García Rubio, María Luisa; San Martín Alonso, Marta; Gómez González, Belén; Aguilera López, Andrés (eLife Sciences Publications, 2020)
DNA:RNA hybrids constitute a well-known source of recombinogenic DNA damage. The current literature is in agreement with ...
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The DNA damage response acts as a safeguardagainst harmful DNA–RNA hybrids ofdifferent origins

Barroso Ceballos, Sonia Inés; Herrera Moyano, Emilia; Muñoz Sánchez, Sergio; García Rubio, María Luisa; Gómez González, Belén; Aguilera López, Andrés (EMBO Press, 2019)
Despite playing physiological roles in specific situations, DNA–RNA hybrids threat genome integrity. To investigate how ...
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Rpd3l contributes to the DNA damage sensitivity of saccharomyces cerevisiae checkpoint mutants

Gómez González, Belén; Patel, Harshil M.; Early, Anne; Diffley, John F.X. (Genetics Society of America, 2019)
DNA replication forks that are stalled by DNA damage activate an S-phase checkpoint that prevents irreversible fork arrest ...
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Rpd3L and Hda1 histone deacetylases facilitate repair of broken forks by promoting sister chromatid cohesion

Aguilera López, Andrés; Gómez González, Belén; Ortega Moreno, Pedro (Nature Research, 2019)
Genome stability involves accurate replication and DNA repair. Broken replication forks, such as those encountering a nick, ...
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Guidelines for DNA recombination and repair studies: Cellular assays of DNA repair pathways

Klein, Hannah L.; Bačinskaja, Giedré; Che, Jun; Cheblal, Anais; Elango, Rajula; Epshtein, Anastasiya; Fitzgerald, Devon M.; Gómez González, Belén; Khan, Sharik R.; Kumar, Sandeep Mothish; Leland, Bryan A.; Marie, Léa; Aguilera López, Andrés (Shared Science Publishers OG, 2019)
Understanding the plasticity of genomes has been greatly aided by assays for recombination, repair and mutagenesis. These ...
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Transcription-mediated replication hindrance: a major driver of genome instability

Gómez González, Belén; Aguilera López, Andrés (Cold Spring Harbor Laboratory Press, 2019)
Genome replication involves dealing with obstacles that can result from DNA damage but also from chromatin alterations, ...
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A new role for Rrm3 in repair of replication-born DNA breakage by sister chromatid recombination

Muñoz Galván, Sandra; García Rubio, María Luisa; Ortega Moreno, Pedro; Ruiz Pérez, José Francisco; Jimeno González, Sonia; Pardo, Benjamín; Gómez González, Belén; Aguilera López, Andrés (Public Library of Science, 2017)
Replication forks stall at different DNA obstacles such as those originated by transcription. Fork stalling can lead to ...
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The Role of Replication-Associated Repair Factors on R-Loops

Bhatia, Vaibhav; Herrera Moyano, Emilia; Aguilera López, Andrés; Gómez González, Belén (MDPI, 2017)
The nascent RNA can reinvade the DNA double helix to form a structure termed the R-loop, where a single-stranded DNA (ssDNA) ...
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Histone Mutants Separate R Loop Formation from Genome Instability Induction

García Pichardo, Desiré; Cañas, Juan C.; García Rubio, María Luisa; Gómez González, Belén; García Rondón, Ana; Aguilera López, Andrés (Elsevier, 2017)
R loops have positive physiological roles, but they can also be deleterious by causing genome instability, and the mechanisms ...
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DNA-RNA hybrids: The risks of DNA breakage during transcription

Aguilera López, Andrés; Gómez González, Belén (Springer Nature, 2017)
Although R loops can occur at different genomic locations, the factors that determine their formation and frequency remain ...
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The need to regulate replication fork speed

Gómez González, Belén; Aguilera López, Andrés (American Association for the Advancement of Science, 2017)
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The Smc5/6 complex regulates the yeast Mph1 helicase at RNA-DNA hybrid-mediated DNA damage

Lafuente Barquero, Juan; Luke Glaser, Sarah; Graf, Marco; Silva, Sonia; Gómez González, Belén; Aguilera López, Andrés (Public Library of Science, 2017)
RNA-DNA hybrids are naturally occurring obstacles that must be overcome by the DNA replication machinery. In the absence ...
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Yeast Sen1 helicase protects the genome from transcription-associated instability

Mischo, Hannah E.; Gómez González, Belén; Grzechnik, Pawel; García Rondón, Ana; Wei, Wu; Steinmetz, Lars; Aguilera López, Andrés; Proudfoot, Nick J. (Elsevier, 2011)
Sen1 of S. cerevisiae is a known component of the NRD complex implicated in transcription termination of nonpolyadenylated ...
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The replication checkpoint protects fork stability by releasing transcribed genes from nuclear pores

Bermejo, Rodrigo; Gómez González, Belén; Aguilera López, Andrés; Foiani, Marco; Capra, Thelma; Cocito, Andrea (Elsevier, 2011)
Transcription hinders replication fork progression and stability, and the Mec1/ATR checkpoint protects fork integrity. ...
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Genome Instability and Transcription Elongation Impairment in Human Cells Depleted of THO/TREX

Domínguez Sánchez, María Salud; Barroso Ceballos, Sonia Inés; Gómez González, Belén; Luna Varo, Rosa María; Aguilera López, Andrés (Public Library of Science, 2011)
THO/TREX connects transcription with genome integrity in yeast, but a role of mammalian THO in these processes is uncertain, ...
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AID induces double-strand breaks at immunoglobulin switch regions and c-MYC causing chromosomal translocations in yeast THO mutants

Ruiz Pérez, José Francisco; Gómez González, Belén; Aguilera López, Andrés (Public Library of Science, 2011)
Transcription of the switch (S) regions of immunoglobulin genes in B cells generates stable R-loops that are targeted by ...
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The S-phase checkpoint is required to respond to R-loops accumulated in THO mutants

Gómez González, Belén; Felipe Abrio, Irene; Aguilera López, Andrés (American Society for Microbiology, 2009)
Cotranscriptional R-loops are formed in yeast mutants of the THO complex, which functions at the interface between ...
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Chromosomal translocations caused by either Pol32-dependent or Pol32-independent triparental break-induced replication

Ruiz Pérez, José Francisco; Gómez González, Belén; Aguilera López, Andrés (American Society for Microbiology, 2009)
Double-strand breaks (DSBs) are harmful DNA lesions that can generate chromosomal rearrangements or chromosome losses if ...
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The THP1-SAC3-SUS1-CDC31 complex works in transcription elongation-mRNA export preventing RNA-mediated genome instability

González Aguilera, Cristina; Tous Rivera, Cristina; Gómez González, Belén; Huertas Sánchez, Pablo; Luna Varo, Rosa María; Aguilera López, Andrés (American Society for Cell Biology, 2008)
The eukaryotic THO/TREX complex, involved in mRNP biogenesis, plays a key role in the maintenance of genome integrity in ...
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Activation-induced cytidine deaminase action is strongly stimulated by mutations of the THO complex

Gómez González, Belén; Aguilera López, Andrés (National Academy of Sciences, 2007)
Activation-induced cytidine deaminase (AID) is a B cell enzyme essential for Ig somatic hypermutation and class switch ...