Author profile: Aguilera López, Andrés
Institutional data
| Name | Aguilera López, Andrés |
| Department | Genética |
| Knowledge area | Genética |
| Professional category | Catedrático de Universidad |
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Statistics
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No. publications
147
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No. visits
24076
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No. downloads
26990
| Publications |
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PhD Thesis
 Insights into RNA-mediated genome instability by altering ALY expression and the use of new drugs
(2023)
Las células han desarrollado una serie de mecanismos que utilizan de forma coordinada para mantener la integridad del ... |
Article
 Break-induced RNA–DNA hybrids (BIRDHs) in homologous recombination: friend or foe?
(Wiley-Blackwell, 2023)
Double-strand breaks (DSBs) are the most harmful DNA lesions, with a strong impact on cell proliferation and genome ... |
Article
The chromatin network helps prevent cancer-associated mutagenesis at transcription-replication conflicts
(Nature Research, 2023)
Genome instability is a feature of cancer cells, transcription being an important source of DNA damage. This is in large ... |
Article
Actin nucleators safeguard replication forks by limiting nascent strand degradation
(Oxford University Press, 2023)
Accurate genome replication is essential for all life and a key mechanism of disease prevention, underpinned by the ability ... |
Article
DDX47, MeCP2, and other functionally heterogeneous factors protect cells from harmful R loops
(Elsevier, 2023)
Unscheduled R loops can be a source of genome instability, a hallmark of cancer cells. Although targeted proteomic approaches ... |
PhD Thesis
Global Dynamics of Topoisomerase II Activity
(2022)
DNA topoisomerases are key enzymes in charge of solving topological problems that arise from essential processes of DNA ... |
Article
MutSβ regulates G4-associated telomeric R-loops to maintain telomere integrity in ALT cancer cells
(Elsevier, 2022)
Up to 15% of human cancers maintain their telomeres through a telomerase-independent mechanism, termed “alternative ... |
Article
WASp modulates RPA function on single-stranded DNA in response to replication stress and DNA damage.
(Nature Research, 2022)
Perturbation in the replication-stress response (RSR) and DNA-damage response (DDR) causes genomic instability. Genomic ... |
Article
Topoisomerase 1-dependent R-loop deficiency drives accelerated replication and genomic instability
(Elsevier, 2022)
DNA replication is a complex process tightly regulated to ensure faithful genome duplication, and its perturbation leads ... |
Article
A role for the Saccharomyces cerevisiae Rtt109 histone acetyltransferase in R-loop homeostasis and associated genome instability
(Genetics Society of America, 2022)
The stability of the genome is occasionally challenged by the formation of DNA-RNA hybrids and R-loops, which can be ... |
PhD Thesis
DDX47 and MECP2, two novel human functions controlling R-loop-mediated genome integrity
(2021)
La integridad del genoma es un requisito indispensable para la correcta transmisión de la información genética de una ... |
PhD Thesis
Influence of chromatin factors and DNA-RNA hybrids in the repair of replication-born DSBs
(2021)
La información genética debe estar almacenada de manera segura en la molécula de ADN. Sin embargo, el ADN está continuamente ... |
Article
The role of chromatin at transcription-replication conflicts as a genome safeguard
(Portland Press, 2021)
DNA replication ensures the correct copying of the genome and the faithful transfer of the genetic information to the ... |
Article
ADAR-mediated RNA editing of DNA:RNA hybrids is required for DNA double strand break repair
(Nature Publishing Group, 2021)
The maintenance of genomic stability requires the coordination of multiple cellular tasks upon the appearance of DNA ... |
Article
R-Loop–Mediated ssDNA Breaks Accumulate following Short-Term Exposure to the HDAC Inhibitor Romidepsin
(American Association for Cancer Research, 2021)
Histone deacetylase inhibitors (HDACi) induce hyperacetylation of histones by blocking HDAC catalytic sites. Despite ... |
Article
A new interaction between BRCA2 and DDX5 promotes the repair of DNA breaks at transcribed chromatin
(Taylor & Francis, 2021)
In a recent report, we have revealed a new interaction between the BRCA2 DNA repair associated protein (BRCA2) and the ... |
Article
BRCA2 promotes DNA-RNA hybrid resolution by DDX5 helicase at DNA breaks to facilitate their repair
(Wiley-Blackwell, 2021)
The BRCA2 tumor suppressor is a DNA double-strand break (DSB) repair factor essential for maintaining genome integrity. ... |
Article
A CDK-regulated chromatin segregase promoting chromosome replication
(Springer Nature, 2021)
The replication of chromosomes during S phase is critical for cellular and organismal function. Replicative stress can ... |
Article
A transcription-based mechanism for oncogenic β-catenin-induced lethality in BRCA1/2-deficient cells
(Springer Nature, 2021)
BRCA1 or BRCA2 germline mutations predispose to breast, ovarian and other cancers. High-throughput sequencing of tumour ... |
Article
Harmful R-loops are prevented via different cell cycle-specific mechanisms
(Springer Nature, 2021)
Identifying how R-loops are generated is crucial to know how transcription compromises genome integrity. We show by ... |
Article
C. elegans THSC/TREX-2 deficiency causes replication stress and genome instability
(The Company of Biologists, 2021)
Transcription is an essential process of DNA metabolism, yet it makes DNA more susceptible to DNA damage. THSC/TREX-2 is ... |
Article
The SWI/SNF chromatin remodeling complex helps resolve R-loop-mediated transcription–replication conflicts
(Springer Nature, 2021)
ATP-dependent chromatin remodelers are commonly mutated in human cancer. Mammalian SWI/SNF complexes comprise three conserved ... |
Article
Heterogeneity of DNA damage incidence and repair in different chromatin contexts
(Elsevier, 2021)
It has been long known that some regions of the genome are more susceptible to damage and mutagenicity than others. Recent ... |
Article
VID22 counteracts G-quadruplex-induced genome instability
(Oxford University Press, 2021)
Genome instability is a condition characterized by the accumulation of genetic alterations and is a hallmark of cancer ... |
Article
Dna-rna hybrids at dsbs interfere with repair by homologous recombination
(eLife Sciences Publications, 2021)
DNA double-strand breaks (DSBs) are the most harmful DNA lesions and their repair is crucial for cell viability and genome ... |
Chapter of Book
Analysis of repair of replication-born double-strand breaks by sister chromatid recombination in yeast
(Elsevier, 2021)
The repair of DNA double-strand breaks is crucial for cell viability and the maintenance of genome integrity. When present, ... |
Article
The SWI/SNF complex, transcription-replication conflicts and cancer: a connection with high therapeutic potential
(Taylor & Francis, 2021)
Genome instability is a hallmark of cancer. ATP-dependent chromatin remodelers are frequently altered in cancer. We have ... |
Article
The human nucleoporin Tpr protects cells from RNA-mediated replication stress
(Springer Nature, 2021)
Although human nucleoporin Tpr is frequently deregulated in cancer, its roles are poorly understood. Here we show that Tpr ... |
PhD Thesis
The influence of chromatin in DNA-RNA hybrid metabolism
(2020)
El genoma, el conjunto de genes de un organismo o especie, debe copiarse de forma fidedigna de célula a célula. Sin embargo, ... |
PhD Thesis
Papel de la helicasa UAP56/DDX39B y otros factores asociados al metabolismo del ARN en la integridad del genoma
(2020)
Para la transmisión fidedigna de la información genética es indispensable preservar la integridad del genoma. Las células ... |
Chapter of Book
The Sister-Chromatid Exchange Assay in Human Cells
(Humana, 2020)
The semiconservative nature of DNA replication allows the differential labeling of sister chromatids that isthe fundamental ... |
Article
Histone H3E73Q and H4E53A mutations cause recombinogenic DNA damage
(Shared Science Publishers OG, 2020)
The stability and function of eukaryotic genomes is closely linked to histones and to chromatin structure. The state of ... |
Article
Histone deacetylases facilitate the accurate repair of broken forks
(Taylor & Francis, 2020)
We have recently uncovered that loss of the yeast histone deacetylases Rpd3 (Reduced Potassium Dependency 3) and Hda1 ... |
Article
UAP56/DDX39B is a major cotranscriptional RNA–DNA helicase that unwinds harmful R loops genome-wide
(Cold Spring Harbor Laboratory Press, 2020)
Nonscheduled R loops represent a major source of DNA damage and replication stress. Cells have different ways to prevent ... |
Article
Harmful DNA:RNA hybrids are formed in cis and in a Rad51-independent manner
(eLife Sciences Publications, 2020)
DNA:RNA hybrids constitute a well-known source of recombinogenic DNA damage. The current literature is in agreement with ... |
Article
TDP-43 mutations link Amyotrophic Lateral Sclerosis with R-loop homeostasis and R loop-mediated DNA damage
(Public Library of Science, 2020)
TDP-43 is a DNA and RNA binding protein involved in RNA processing and with structural resemblance to heterogeneous ... |
Article
Spontaneous DNA-RNA hybrids: differential impacts throughout the cell cycle
(Taylor & Francis, 2020)
A large body of research supports that transcription plays a major role among the many sources of replicative stress ... |
Article
Looping the (R) Loop in DSB Repair via RNA Methylation
(Elsevier, 2020)
In this issue of Molecular Cell, Zhang et al. (2020) reveal that ATM triggers RNA methylation of DNA-RNA hybrids formed ... |
Chapter of Book
Detection of DNA Double-Strand Breaks byγ-H2AX Immunodetection
(Humana, 2020)
DNA double-strand breaks (DSBs) are the most deleterious type of DNA damage and a cause of geneticinstability as they can ... |
Article
Homologous recombination and Mus81 promote replication completion in response to replication fork blockage
(Wiley-Blackwell, 2020)
Impediments to DNA replication threaten genome stability. The homologous recombination (HR) pathway has been involved in ... |
PhD Thesis
New factors involved in transcription-associated genome instability
(2019)
El mantenimiento de la integridad del DNA y la transmisión fiel de su información a la descendencia es una prioridad para ... |
Article
R Loops: From Physiologicalto Pathological Roles
(Elsevier, 2019)
DNA-RNA hybrids play a physiological role in cellular processes, but often, they represent non-scheduled co-transcriptional ... |
Article
The DNA damage response acts as a safeguardagainst harmful DNA–RNA hybrids ofdifferent origins
(EMBO Press, 2019)
Despite playing physiological roles in specific situations, DNA–RNA hybrids threat genome integrity. To investigate how ... |
PhD Thesis
New cellular elements associated with DNA:RNA hybrid homeostasis in eukaryotes
(2019)
El mantenimiento de la integridad del genoma es esencial para el correcto funcionamiento de las funciones celulares así ... |
Article
The antitumor drugs trabectedin and lurbinectedin induce transcription-dependent replication stress and genome instability
(American Association for Cancer Research, 2019)
R-loops are a major source of replication stress, DNA damage, and genome instability, which are major hallmarks of cancer ... |
Article
What causes an RNA-DNA hybrid to compromise genome integrity?
(Elsevier, 2019)
Transcription is a source of genome instability that stimulates mutation and recombination. Part of the damage produced ... |
Article
Transcription-mediated replication hindrance: a major driver of genome instability
(Cold Spring Harbor Laboratory Press, 2019)
Genome replication involves dealing with obstacles that can result from DNA damage but also from chromatin alterations, ... |
Article
Elongation Factor TFIIS Prevents Transcription Stress and R-Loop Accumulation to Maintain Genome Stability
(Elsevier, 2019)
Although correlations between RNA polymerase II (RNAPII) transcription stress, R-loops, and genome instability have been ... |
Article
Depletion of the MFAP1/SPP381 Splicing Factor Causes R-Loop-Independent Genome Instability
(Elsevier, 2019)
THO/TREX is a conserved complex with a role in messenger ribonucleoprotein biogenesis that links gene expression and genome ... |
Article
Rpd3L and Hda1 histone deacetylases facilitate repair of broken forks by promoting sister chromatid cohesion
(Nature Research, 2019)
Genome stability involves accurate replication and DNA repair. Broken replication forks, such as those encountering a nick, ... |
Article
A Meiotic Checkpoint Alters Repair Partner Bias to Permit Inter-sister Repair of Persistent DSBs
(Elsevier B.V., 2019)
Accurate meiotic chromosome segregation critically depends on the formation of inter-homolog crossovers initiated by ... |
Article
The THO Complex as a Paradigm for the Prevention of Cotranscriptional R-Loops
(Cold Spring Harbor Laboratory Press, 2019)
Different proteins associate with the nascent RNA and the RNA polymerase (RNAP) to catalyze the transcription cycle and ... |
Article
The Nup84 complex coordinates the DNA damage response to warrant genome integrity
(Oxford University Press, 2019)
DNA lesions interfere with cellular processes such as transcription and replication and need to be adequately resolved to ... |
Article
Guidelines for DNA recombination and repair studies: Cellular assays of DNA repair pathways
(Shared Science Publishers OG, 2019)
Understanding the plasticity of genomes has been greatly aided by assays for recombination, repair and mutagenesis. These ... |
PhD Thesis
Inestabilidad genética asociada a R-loops.
(2018)
La inestabilidad genómica es una patología celular, la cual se produce cuando una célula acumula variaciones genéticas que ... |
Article
Human mitochondrial degradosome prevents harmful mitochondrial R loops and mitochondrial genome instability
(2018)
R loops are nucleic acid structures comprising an DNA-RNA hybrid and a displaced single-stranded DNA. These structures may ... |
Article
Guidelines and recommendations on yeast cell death nomenclature
(Shared Science Publishers, 2018)
Elucidating the biology of yeast in its full complexity has major implications for science, medicine and industry. One of ... |
Article
Yra1-bound RNA–DNA hybrids cause orientation-independent transcription– replication collisions and telomere instability
(Cold Spring Harbor Laboratory Press, 2018)
R loops are an important source of genome instability, largely due to their negative impact on replication progression. ... |
Article
Multiple signaling kinases target Mrc1 to prevent genomic instability triggered by transcription-replication conflicts
(Nature Publishing Group:, 2018)
Conflicts between replication and transcription machineries represent a major source of genomic instability and cells have ... |
Article
Epigenetic features of human telomeres
(Oxford University Press, 2018)
Although subtelomeric regions in humans are heterochromatic, the epigenetic nature of human telomeres remains controversial. ... |
Chapter of Book
Detection of DNA-RNA hybrids in vivo
(Humana Press Inc., 2018)
DNA-RNA hybrids form naturally during essential cellular functions such as transcription and replication. However, they ... |
Article
Gene gating at nuclear pores prevents the formation of R loops
(Taylor and Francis Ltd., 2018)
Transcription is an important source of genetic variability. A large amount of transcription-associated genome variation ... |
PhD Thesis
Papel de factores de la transcripción y la replicación del ADN en el origen de la inestabilidad genómica.
(2017)
Mantener la integridad del genoma no es tarea fácil para las células. El ADN sufre constantes ataques de agentes químicos ... |
PhD Thesis
Nuevos genes humanos asociados a la biogénesis de mRNPs necesarios para la integridad del genoma
(2017)
La integridad del genoma es una condición necesaria para la transmisión fidedigna de la información genética. Numerosos ... |
PhD Thesis
Papel de la cromatina en la formación de R-loops
(2017)
La inestabilidad genómica es una patología celular asociada a múltiples enfermedades genéticas, incluido el cáncer (Aguilera ... |
Article
Physical proximity of chromatin to nuclear pores prevents harmful R loop accumulation contributing to maintain genome stability
(National Academy of Sciences, 2017)
During transcription, the mRNA may hybridize with DNA, forming an R loop, which can be physiological or pathological, ... |
Article
The need to regulate replication fork speed
(American Association for the Advancement of Science, 2017)
|
Article
The Role of Replication-Associated Repair Factors on R-Loops
(MDPI, 2017)
The nascent RNA can reinvade the DNA double helix to form a structure termed the R-loop, where a single-stranded DNA (ssDNA) ... |
Article
DNA-RNA hybrids: The risks of DNA breakage during transcription
(Springer Nature, 2017)
Although R loops can occur at different genomic locations, the factors that determine their formation and frequency remain ... |
Article
Human THO–Sin3A interaction reveals new mechanisms to prevent R-loops that cause genome instability
(Wiley-Blackwell, 2017)
R-loops, formed by co-transcriptional DNA–RNA hybrids and a displaced DNA single strand (ssDNA), fulfill certain positive ... |
Article
Histone Mutants Separate R Loop Formation from Genome Instability Induction
(Elsevier, 2017)
R loops have positive physiological roles, but they can also be deleterious by causing genome instability, and the mechanisms ... |
Article
The Smc5/6 complex regulates the yeast Mph1 helicase at RNA-DNA hybrid-mediated DNA damage
(Public Library of Science, 2017)
RNA-DNA hybrids are naturally occurring obstacles that must be overcome by the DNA replication machinery. In the absence ... |
Article
A new role for Rrm3 in repair of replication-born DNA breakage by sister chromatid recombination
(Public Library of Science, 2017)
Replication forks stall at different DNA obstacles such as those originated by transcription. Fork stalling can lead to ... |
Article
FANCD2 facilitates replication through common fragile sites
(Elsevier, 2016)
Common fragile sites (CFSs) are genomic regions that are unstable under conditions of replicative stress. Although the ... |
Article
Transcription as a Threat to Genome Integrity
(Annual Reviews Inc., 2016)
Genomes undergo different types of sporadic alterations, including DNA damage, point mutations, and genome rearrangements, ... |
Article
Roles of human POLD1 and POLD3 in genome stability
(Nature, 2016)
DNA replication is essential for cellular proliferation. If improperly controlled it can constitute a major source of ... |
Article
High-Resolution Mapping of Homologous Recombination Events in rad3 Hyper-Recombination Mutants in Yeast
(Public Library of Science, 2016)
The Saccharomyces cerevisae RAD3 gene is the homolog of human XPD, an essential gene encoding a DNA helicase of the TFIIH ... |
Article
Transcription-replication conflicts: How they occur and how they are resolved
(Springer Nature, 2016)
The frequent occurrence of transcription and DNA replication in cells results in many encounters, and thus conflicts, ... |
Article
Excess of Yra1 RNA-Binding Factor Causes Transcription-Dependent Genome Instability, Replication Impairment and Telomere Shortening
(Public Library of Science, 2016)
Yra1 is an essential nuclear factor of the evolutionarily conserved family of hnRNP-like export factors that when overexpressed ... |
Article
Role for RNA: DNA hybrids in origin-independent replication priming in a eukaryotic system
(National Academy of Sciences, 2015)
DNA replication initiates at defined replication origins along eukaryotic chromosomes, ensuring complete genome duplication ... |
Article
Interdependence of the Rad50 hook and globular domain functions
(Elsevier, 2015)
Rad50 contains a conserved Zn2+ coordination domain (the Rad50 hook) that functions as a homodimerization interface. Hook ... |
Article
The Fanconi Anemia Pathway Protects Genome Integrity from R-loops
(Public Library of Science, 2015)
Co-transcriptional RNA-DNA hybrids (R loops) cause genome instability. To prevent harmful R loop accumulation, cells have ... |
Article
A unified model for the molecular basis of Xeroderma pigmentosum-Cockayne Syndrome
(Taylor & Francis Open, 2015)
Nucleotide Excision Repair (NER) is a pathway that removes lesions distorting the DNA helix. The molecular basis of the ... |
Article
Polycomb RING1A- and RING1B-dependent histone H2A monoubiquitylation at pericentromeric regions promotes S-phase progression
(Company of Biologists Ltd, 2015)
The functions of polycomb products extend beyond their well-known activity as transcriptional regulators to include genome ... |
Article
A genome-wide function of THSC/TREX-2 at active genes prevents transcription–replication collisions
(Oxford University Press, 2014)
The THSC/TREX-2 complex of Saccharomyces cerevisiae mediates the anchoring of transcribed genes to the nuclear pore, linking ... |
Article
The rem mutations in the ATP-binding groove of the Rad3/XPD helicase lead to Xeroderma pigmentosum-Cockayne Syndrome-like phenotypes
(Public Library of Science, 2014)
The eukaryotic TFIIH complex is involved in Nucleotide Excision Repair and transcription initiation. We analyzed three ... |
Article
The yeast and human FACT chromatin-reorganizing complexes resolve R-loop-mediated transcription-replication conflicts
(Cold Spring Harbor Laboratory Press, 2014)
FACT (facilitates chromatin transcription) is a chromatin-reorganizing complex that swaps nucleosomes around the RNA ... |
Article
Transcription-coupled nucleotide excision repair factors promote R-loop-induced genome instability
(Elsevier, 2014)
R-loops, consisting of an RNA-DNA hybrid and displaced single-stranded DNA, are physiological structures that regulate ... |
Article
Cleavage factor I links transcription termination to DNA damage response and genome integrity maintenance in Saccharomyces cerevisiae
(Public Library of Science, 2014)
During transcription, the nascent pre-mRNA undergoes a series of processing steps before being exported to the cytoplasm. ... |
PhD Thesis
Inestabilidad genética y cambios en la cromatina en mutantes del complejo THO en mitosis y meiosis de eucariotas modelo
(2013)
Para el mantenimiento y el control de los procesos celulares, la integridad genética es un factor clave. Mutaciones o ... |
| Article |
Article
Histone H3K56 Acetylation, Rad52, and Non-DNA Repair Factors Control Double-Strand Break Repair Choice with the Sister Chromatid
(Public Library of Science, 2013)
DNA double-strand breaks (DSBs) are harmful lesions that arise mainly during replication. The choice of the sister chromatid ... |
Article
R-Loop Mediated Transcription-Associated Recombination in trf4D Mutants Reveals New Links between RNA Surveillance and Genome Integrity
(Public Library of Science, 2013)
To get further insight into the factors involved in the maintenance of genome integrity we performed a screening ... |
Article
Competing roles of DNA end resection and non-homologous end joining functions in the repair of replication-born double-strand breaks by sister-chromatid recombination
(Oxford University Press, 2013)
While regulating the choice between homologous recombination and non-homologous end joining (NHEJ) as mechanisms of ... |
Article
The Npl3 hnRNP prevents R-loop-mediated transcription–replication conflicts and genome instability
(Cold Spring Harbor Laboratory Press, 2013)
Transcription is a major obstacle for replication fork (RF) progression and a cause of genome instability. Part of this ... |
Article
Architecture and nucleic acids recognition mechanism of the THO complex, an mRNP assembly factor
(Wiley-Blackwell, 2012)
The THO complex is a key factor in co-transcriptional formation of export-competent messenger ribonucleoprotein particles, ... |
Article
Distinct Roles of Mus81, Yen1, Slx1-Slx4, and Rad1 Nucleases in the Repair of Replication-Born Double-Strand Breaks by Sister Chromatid Exchange
(2012)
Most spontaneous DNA double-strand breaks (DSBs) arise during replication and are repaired by homologous recombination ... |
Article
The Caenorhabditis elegans THO complex is required for the mitotic cell cycle and development
(Public Library of Science, 2012)
THO is a conserved eukaryotic complex involved in mRNP biogenesis and RNA export that plays an important role in preventing ... |
| Article |
Article
Yeast Sen1 helicase protects the genome from transcription-associated instability
(Elsevier, 2011)
Sen1 of S. cerevisiae is a known component of the NRD complex implicated in transcription termination of nonpolyadenylated ... |
Article
Control of the function of the transcription and repair factor TFIIH by the action of the cochaperone Ydj1
(National Academy of Sciences, 2011)
Yeast rad3-102, a mutant of the TFIIH complex involved in nucleotide excision repair (NER) and transcription, can perform ... |
Article
The Rad50 coiled-coil domain is indispensable for Mre11 complex functions
(Nature Publishing Group, 2011)
The Mre11 complex (Mre11, Rad50 and Xrs2 in Saccharomyces cerevisiae) influences diverse functions in the DNA damage ... |
| Article |
Article
The replication checkpoint protects fork stability by releasing transcribed genes from nuclear pores
(Elsevier, 2011)
Transcription hinders replication fork progression and stability, and the Mec1/ATR checkpoint protects fork integrity. ... |
Article
New suppressors of THO mutations identify Thp3 (Ypr045c)-Csn12 as a protein complex involved in transcription elongation
(American Society for Microbiology, 2011)
Formation of a ribonucleoprotein particle (mRNP) competent for export requires the coupling of transcription with mRNA ... |
Article
Zim17/Tim15 links mitochondrial iron–sulfur cluster biosynthesis to nuclear genome stability
(Oxford University Press, 2011)
Genomic instability is related to a wide-range of human diseases. Here, we show that mitochondrial iron–sulfur cluster ... |
Article
Nab2 functions in the metabolism of RNA driven by polymerases II and III
(American Society for Cell Biology, 2011)
Gene expression in eukaryotes is an essential process that includes transcription, RNA processing, and export. One ... |
Article
Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers
(2011)
One key step in gene expression is the biogenesis of mRNA ribonucleoparticle complexes (mRNPs). Formation of the mRNP ... |
Article
AID induces double-strand breaks at immunoglobulin switch regions and c-MYC causing chromosomal translocations in yeast THO mutants
(Public Library of Science, 2011)
Transcription of the switch (S) regions of immunoglobulin genes in B cells generates stable R-loops that are targeted by ... |
Article
Genome Instability and Transcription Elongation Impairment in Human Cells Depleted of THO/TREX
(Public Library of Science, 2011)
THO/TREX connects transcription with genome integrity in yeast, but a role of mammalian THO in these processes is uncertain, ... |
Article
The THO complex as a key mRNP biogenesis factor in development and cell differentiation
(BioMed Central, 2010)
The THO complex is a key component in the co-transcriptional formation of messenger ribonucleoparticles that are competent ... |
PhD Thesis
Inestabilidad genética asociada a defectos en el complejo TFIIH
(2010)
Los organismos eucarióticos poseen múltiples mecanismos para preservar la integridad de su información genética. Ésta puede ... |
Article
Genome-wide analysis of factors affecting transcription elongation and DNA repair: a new role for PAF and Ccr4-not in transcription-coupled repair
(Public Library of Science, 2009)
RNA polymerases frequently deal with a number of obstacles during transcription elongation that need to be removed for ... |
Article
The S-phase checkpoint is required to respond to R-loops accumulated in THO mutants
(American Society for Microbiology, 2009)
Cotranscriptional R-loops are formed in yeast mutants of the THO complex, which functions at the interface between ... |
Article
The stress-activated protein kinase Hog1 mediates S phase delay in response to osmostress
(American Society for Cell Biology, 2009)
Control of cell cycle progression by stress-activated protein kinases (SAPKs) is essential for cell adaptation to extracellular ... |
Article
Transcription at the proximity of the nuclear pore: A role for the THP1-SAC3-SUS1-CDC31 (THSC) complex
(Landes Bioscience, 2009)
A key aspect of eukaryotic gene expression is the coupling of transcription with RNA processing, polyadenylation and export. ... |
Article
Sem1 is a functional component of the nuclear pore complex–associated messenger RNA export machinery
(Rockefeller University Press, 2009)
The evolutionarily conserved protein Sem1/Dss1 is a subunit of the regulatory particle (RP) of the proteasome, and, in ... |
Article
Chromosomal translocations caused by either Pol32-dependent or Pol32-independent triparental break-induced replication
(American Society for Microbiology, 2009)
Double-strand breaks (DSBs) are harmful DNA lesions that can generate chromosomal rearrangements or chromosome losses if ... |
| Article |
Article
CDK targets Sae2 to control DNA-end resection and homologous recombination
(Nature Publishing Group, 2008)
DNA double-strand breaks (DSBs) are repaired by two principal mechanisms: non-homologous end-joining (NHEJ) and homologous ... |
Article
The THP1-SAC3-SUS1-CDC31 complex works in transcription elongation-mRNA export preventing RNA-mediated genome instability
(American Society for Cell Biology, 2008)
The eukaryotic THO/TREX complex, involved in mRNP biogenesis, plays a key role in the maintenance of genome integrity in ... |
Article
A novel class of Mrna-containing cytoplasmic granules are produced in response to UV-irradiation
(American Society for Cell Biology, 2008)
Nucleic acids are substrates for different types of damage, but little is known about the fate of damaged RNAs. We addressed ... |
Article
Different genetic requirements for repair of replication-born double-strand breaks by sister-chromatid recombination and break-induced replication
(Oxford University Press, 2007)
Homologous recombination (HR) is the major mechanism used to repair double-strand breaks (DSBs) that result from replication, ... |
Article
A new connection of mRNP biogenesis and export with transcription-coupled repair
(Oxford University Press, 2007)
Although DNA repair is faster in the transcribed strand of active genes, little is known about the possible contribution ... |
Article
Activation-induced cytidine deaminase action is strongly stimulated by mutations of the THO complex
(National Academy of Sciences, 2007)
Activation-induced cytidine deaminase (AID) is a B cell enzyme essential for Ig somatic hypermutation and class switch ... |
Article
Nucleoporins prevent DNA damage accumulation by modulating Ulp1-dependent sumoylation processes
(American Society for Cell Biology, 2007)
Increasing evidences suggest that nuclear pore complexes (NPCs) control different aspects of nuclear metabolism, including ... |
PhD Thesis
Reparación postreplicativa de cortes de doble cadena en Saccharomyces Cerevisiae
(2006)
Entendemos como corte de doble cadena (doublé-strand break, DSB) toda interrupción en la continuidad de una molécula de ... |
Article
Tho1, a novel hnRNP, and Sub2 provide alternative pathways for mRNP biogenesis in yeast THO mutants
(American Society for Microbiology, 2006)
THO is a protein complex that functions in cotranscriptional mRNP formation. Yeast THO1 and SUB2 (Saccharomyces cerevisiae) ... |
Article
Replication fork progression is impaired by transcription in hyperrecombinant yeast cells lacking a functional THO complex
(American Society for Microbiology, 2006)
THO/TREX is a conserved, eukaryotic protein complex operating at the interface between transcription and messenger ... |
Article
Smc5–Smc6 mediate DNA double-strand-break repair by promoting sister-chromatid recombination
(Nature Publishing Group, 2006)
DNA double-strand breaks (DSB) can arise during DNA replication, or after exposure to DNA-damaging agents, and their correct ... |
Article
An hpr1 point mutation that impairs transcription and mRNP biogenesis without increasing recombination
(American Society for Microbiology, 2006)
THO/TREX, a conserved eukaryotic protein complex, is a key player at the interface between transcription and mRNP metabolism. ... |
Article
Partial depletion of histone H4 increases homologous recombination-mediated genetic instability
(American Society for Microbiology, 2005)
DNA replication can be a source of genetic instability. Given the tight connection between DNA replication and nucleosome ... |
PhD Thesis
Papel del RNA en expresión genética y recombinación en Saccharomyces cerevisiae
(2004)
La información necesaria para la supervivencia celular se encuentra codificada en el genoma. Cualquier proceso que conlleve ... |
Article
Molecular evidence that the eukaryotic THO/TREX complex is required for efficient transcription elongation
(American Society for Biochemistry and Molecular Biology Inc., 2003)
THO/TREX is a conserved eukaryotic complex formed by the core THO complex plus proteins involved in mRNA metabolism and ... |
Article
Nab2p and the Thp1p-Sac3p Complex Functionally Interact at the Interface between Transcription and mRNA Metabolism
(Elsevier, 2003)
THP1 is a conserved eukaryotic gene whose null mutations confer, in yeast, transcription and genetic instability phenotypes ... |
PhD Thesis
 Elongación de la transcripción en S. cerevisiae el complejo THO y factores relacionados funcionalmente
(2003)
La transcripción es el proceso por el cual se copia la información contenida en el DNA, a una molécula de RNA. Se divide ... |
| PhD Thesis |
| PhD Thesis |
Article
Defective nucleotide excision repair in yeast hpr1 and tho2 mutants
(Oxford University Press, 2002)
Nucleotide excision repair (NER) and transcription are intimately related. First, TFIIH has a dual role in transcription ... |
Article
Hpr1 is preferentially required for transcription of either long or G+C-rich DNA sequences in Saccharomyces cerevisiae
(American Society for Microbiology, 2001)
Hpr1 forms, together with Tho2, Mft1, and Thp2, the THO complex, which controls transcription elongation and genome stability ... |
| PhD Thesis |
PhD Thesis
Relación de la transcripción con la recombinación entre secuencias repetidas en S. cerevisiae
(1998)
La recombinación genética es un proceso fundamental en el metabolismo del ADN en todos los organismos vivos. Existen multitud de procesos biológicos en los que la recombinación está directamente implicada. |
Article
The yeast HPR1 gene has a functional role in transcriptional elongation that uncovers a novel source of genome instability
(Cold Spring Harbor Laboratory Press, 1997)
The yeast HPR1 gene plays an important role in genome stability, as indicated by the observation that hpr1 mutants have ... |
| PhD Thesis |
PhD Thesis
Control genético de las deleciones entre secuencias repetidas directas en Saccaromyces cerevisiae
(1996)
Los genomios de todos los organismos están constituidos por un número variable de secuencias repetidas, que pueden llegar ... |
Article
Selection of wine yeasts for growth and fermentation in the presence of ethanol and sucrose
(American Society for Microbiology, 1983)
To optimize the conversion of carbohydrates to ethanol, strains of several Saccharomyces species were examined for the ... |
PhD Thesis
Genética y fisiología de la tolerancia al etanol en "Saccharomyces cerevisiae"
(1983)
En este trabajo se ha determinado el papel que juegan la herencia citoplasmática y la nuclear en la tolerancia al etanol ... |