Data

NameAguilera López, Andrés
DepartmentGenética
Knowledge areaGenética
Professional categoryCatedrático de Universidad
E-mailRequest
           

  Statistics

  • Items

    116

  • Visits

    14093

  • Downloads

    12617

  Publications

 

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BRCA2 promotes DNA-RNA hybrid resolution by DDX5 helicase at DNA breaks to facilitate their repair

Sessa, Gaetana; Gómez González, Belén María; Silva, Sonia; Pérez Calero, Carmen; Beaurepere, Romane; Barroso Ceballos, Sonia Inés; Martineau, Sylvain; Martin, Charlotte A.; Ehlén, Åsa; Martínez, Juan S.; Lombard, Bérangére; Loew, Damarys; Vagner, Stéphan; Aguilera López, Andrés; Carreira, Aura (Wiley-Blackwell, 2021-01-01)
The BRCA2 tumor suppressor is a DNA double-strand break (DSB) repair factor essential for maintaining genome integrity. ...
PhD Thesis
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The influence of chromatin in DNA-RNA hybrid metabolism

Gómez González, Belén; Aguilera López, Andrés; Martínez Cañas, Juan Carlos (2020-07-07)
El genoma, el conjunto de genes de un organismo o especie, debe copiarse de forma fidedigna de célula a célula. Sin embargo, ...
PhD Thesis
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Papel de la helicasa UAP56/DDX39B y otros factores asociados al metabolismo del ARN en la integridad del genoma

Aguilera López, Andrés; Pérez Calero, Carmen (2020-02-12)
Para la transmisión fidedigna de la información genética es indispensable preservar la integridad del genoma. Las células ...
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Spontaneous DNA-RNA hybrids: differential impacts throughout the cell cycle

Gómez González, Belén; Barroso Ceballos, Sonia Inés; Herrera Moyano, Emilia; Aguilera López, Andrés (Taylor & Francis, 2020-01-01)
A large body of research supports that transcription plays a major role among the many sources of replicative stress ...
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Histone deacetylases facilitate the accurate repair of broken forks

Gómez González, Belén; Ortega Moreno, Pedro; Aguilera López, Andrés (Taylor & Francis, 2020-01-01)
We have recently uncovered that loss of the yeast histone deacetylases Rpd3 (Reduced Potassium Dependency 3) and Hda1 ...
Chapter of Book
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The Sister-Chromatid Exchange Assay in Human Cells

Tumini, Emanuela; Aguilera López, Andrés (Humana, 2020-01-01)
The semiconservative nature of DNA replication allows the differential labeling of sister chromatids that isthe fundamental ...
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Harmful DNA:RNA hybrids are formed in cis and in a Rad51-independent manner

Lafuente Barquero, Juan; García Rubio, María Luisa; San Martín Alonso, Marta; Gómez González, Belén; Aguilera López, Andrés (eLife Sciences Publications, 2020-01-01)
DNA:RNA hybrids constitute a well-known source of recombinogenic DNA damage. The current literature is in agreement with ...
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Histone H3E73Q and H4E53A mutations cause recombinogenic DNA damage

Ortega Moreno, Pedro; García Pichardo, Desiré; San Martín Alonso, Marta; García Rondón, Ana; Gómez González, Belén María; Aguilera López, Andrés (Shared Science Publishers OG, 2020-01-01)
The stability and function of eukaryotic genomes is closely linked to histones and to chromatin structure. The state of ...
Chapter of Book
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Detection of DNA Double-Strand Breaks byγ-H2AX Immunodetection

Barroso, Sonia I.; Aguilera López, Andrés (Humana, 2020-01-01)
DNA double-strand breaks (DSBs) are the most deleterious type of DNA damage and a cause of geneticinstability as they can ...
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UAP56/DDX39B is a major cotranscriptional RNA–DNA helicase that unwinds harmful R loops genome-wide

Pérez Calero, Carmen; Bayona Feliu, Aleix; Xue, Xiaoyu; Barroso Ceballos, Sonia Inés; Muñoz Sánchez, Sergio; González Basallote, Víctor M.; Sung, Patrick; Aguilera López, Andrés (Cold Spring Harbor Laboratory Press, 2020-01-01)
Nonscheduled R loops represent a major source of DNA damage and replication stress. Cells have different ways to prevent ...
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TDP-43 mutations link Amyotrophic Lateral Sclerosis with R-loop homeostasis and R loop-mediated DNA damage

Giannini, Marta; Bayona Feliu, Aleix; Sproviero, Daisy; Barroso, Sonia I.; Cereda, Cristina; Aguilera López, Andrés (Public Library of Science, 2020-01-01)
TDP-43 is a DNA and RNA binding protein involved in RNA processing and with structural resemblance to heterogeneous ...
PhD Thesis
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New factors involved in transcription-associated genome instability

Aguilera López, Andrés; García Rondón, Ana; Mérida Cerro, José Antonio (2019-10-23)
El mantenimiento de la integridad del DNA y la transmisión fiel de su información a la descendencia es una prioridad para ...
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R Loops: From Physiologicalto Pathological Roles

García Muse, Tatiana; Aguilera López, Andrés (Elsevier, 2019-10-17)
DNA-RNA hybrids play a physiological role in cellular processes, but often, they represent non-scheduled co-transcriptional ...
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The DNA damage response acts as a safeguardagainst harmful DNA–RNA hybrids ofdifferent origins

Barroso Ceballos, Sonia Inés; Herrera Moyano, Emilia; Muñoz Sánchez, Sergio; García Rubio, María Luisa; Gómez González, Belén; Aguilera López, Andrés (EMBO Press, 2019-07-24)
Despite playing physiological roles in specific situations, DNA–RNA hybrids threat genome integrity. To investigate how ...
PhD Thesis
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New cellular elements associated with DNA:RNA hybrid homeostasis in eukaryotes

García Muse, Tatiana; Aguilera López, Andrés; San Martín Alonso, Marta (2019-07-12)
El mantenimiento de la integridad del genoma es esencial para el correcto funcionamiento de las funciones celulares así ...
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A Meiotic Checkpoint Alters Repair Partner Bias to Permit Inter-sister Repair of Persistent DSBs

García Muse, Tatiana; Galindo Díaz, U.; García Rubio, María Luisa; Martin, Julie S.; Polanowska, Jolanta; O'Reilly, N.; Aguilera López, Andrés; Boulton, Simon J. (Elsevier B.V., 2019-01-01)
Accurate meiotic chromosome segregation critically depends on the formation of inter-homolog crossovers initiated by ...
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Transcription-mediated replication hindrance: a major driver of genome instability

Gómez González, Belén; Aguilera López, Andrés (Cold Spring Harbor Laboratory Press, 2019-01-01)
Genome replication involves dealing with obstacles that can result from DNA damage but also from chromatin alterations, ...
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Elongation Factor TFIIS Prevents Transcription Stress and R-Loop Accumulation to Maintain Genome Stability

Zatreanu, Diana; Han, Zhong; Mitter, Richard; Tumini, Emanuela; Williams, Hannah C.; Gregersen, Lea Haarup; Dirac-Svejstrup, A. Barbara; Roma, Stefania; Stewart, Aengus; Aguilera López, Andrés; Svejstrup, Jesper (Elsevier, 2019-01-01)
Although correlations between RNA polymerase II (RNAPII) transcription stress, R-loops, and genome instability have been ...
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Rpd3L and Hda1 histone deacetylases facilitate repair of broken forks by promoting sister chromatid cohesion

Aguilera López, Andrés; Gómez González, Belén; Ortega Moreno, Pedro (Nature Research, 2019-01-01)
Genome stability involves accurate replication and DNA repair. Broken replication forks, such as those encountering a nick, ...
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The THO Complex as a Paradigm for the Prevention of Cotranscriptional R-Loops

Luna Varo, Rosa María; García Rondón, Ana; Pérez Calero, Carmen; Salas Armenteros, Irene; Aguilera López, Andrés (Cold Spring Harbor Laboratory Press, 2019-01-01)
Different proteins associate with the nascent RNA and the RNA polymerase (RNAP) to catalyze the transcription cycle and ...
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What causes an RNA-DNA hybrid to compromise genome integrity?

García Rondón, Ana; Aguilera López, Andrés (Elsevier, 2019-01-01)
Transcription is a source of genome instability that stimulates mutation and recombination. Part of the damage produced ...
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The Nup84 complex coordinates the DNA damage response to warrant genome integrity

Gaillard, Hélène; Santos Pereira, José María; Aguilera López, Andrés (Oxford University Press, 2019-01-01)
DNA lesions interfere with cellular processes such as transcription and replication and need to be adequately resolved to ...
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Guidelines for DNA recombination and repair studies: Cellular assays of DNA repair pathways

Klein, Hannah L.; Bačinskaja, Giedré; Che, Jun; Cheblal, Anais; Elango, Rajula; Epshtein, Anastasiya; Fitzgerald, Devon M.; Gómez González, Belén; Khan, Sharik R.; Kumar, Sandeep Mothish; Leland, Bryan A.; Marie, Léa; Aguilera López, Andrés (Shared Science Publishers OG, 2019-01-01)
Understanding the plasticity of genomes has been greatly aided by assays for recombination, repair and mutagenesis. These ...
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The antitumor drugs trabectedin and lurbinectedin induce transcription-dependent replication stress and genome instability

Tumini, Emanuela; Herrera Moyano, Emilia; San Martín Alonso, Marta; Barroso Ceballos, Sonia Inés; Galmarini, Carlos María; Aguilera López, Andrés (American Association for Cancer Research, 2019-01-01)
R-loops are a major source of replication stress, DNA damage, and genome instability, which are major hallmarks of cancer ...
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Depletion of the MFAP1/SPP381 Splicing Factor Causes R-Loop-Independent Genome Instability

Salas Armenteros, Irene; Barroso Ceballos, Sonia Inés; García Rondón, Ana; Pérez Calero, Mónica; Andújar, Eloísa; Luna Varo, Rosa María; Aguilera López, Andrés (Elsevier, 2019-01-01)
THO/TREX is a conserved complex with a role in messenger ribonucleoprotein biogenesis that links gene expression and genome ...
PhD Thesis
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Inestabilidad genética asociada a R-loops.

Aguilera López, Andrés; García Benítez, Francisco; Gaillard, Hélène (2018-07-06)
La inestabilidad genómica es una patología celular, la cual se produce cuando una célula acumula variaciones genéticas que ...
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Multiple signaling kinases target Mrc1 to prevent genomic instability triggered by transcription-replication conflicts

Duch, Alba; Barroso Ceballos, Sonia Inés; García Rubio, María Luisa; Seisenbacher, Gerhard; Aguilera López, Andrés (Nature Publishing Group:, 2018-01-01)
Conflicts between replication and transcription machineries represent a major source of genomic instability and cells have ...
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Epigenetic features of human telomeres

Cubiles de la Vega, María Dolores; Barroso Ceballos, Sonia Inés; Vaquero Sedas, María Isabel; Enguix González, Alicia; Aguilera López, Andrés; Vega Palas, Miguel Ángel (Oxford University Press, 2018-01-01)
Although subtelomeric regions in humans are heterochromatic, the epigenetic nature of human telomeres remains controversial. ...
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Yra1-bound RNA–DNA hybrids cause orientation-independent transcription– replication collisions and telomere instability

García Rubio, María Luisa; Aguilera, Paula; Lafuente Barquero, Juan; Ruiz, José F.; Simon, Marie-Noelle; Geli, Vincent; García Rondón, Ana; Aguilera López, Andrés (Cold Spring Harbor Laboratory Press, 2018-01-01)
R loops are an important source of genome instability, largely due to their negative impact on replication progression. ...
Chapter of Book
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Detection of DNA-RNA hybrids in vivo

García Rubio, María Luisa; Barroso Ceballos, Sonia Inés; Aguilera López, Andrés (Humana Press Inc., 2018-01-01)
DNA-RNA hybrids form naturally during essential cellular functions such as transcription and replication. However, they ...
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Gene gating at nuclear pores prevents the formation of R loops

Gaillard, Hélène; García Benítez, Francisco; Aguilera López, Andrés (Taylor and Francis Ltd., 2018-01-01)
Transcription is an important source of genetic variability. A large amount of transcription-associated genome variation ...
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Human mitochondrial degradosome prevents harmful mitochondrial R loops and mitochondrial genome instability

Silva, Sonia; Pérez de Camino Cantos, Dolores; Aguilera López, Andrés (2018-01-01)
R loops are nucleic acid structures comprising an DNA-RNA hybrid and a displaced single-stranded DNA. These structures may ...
PhD Thesis
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Papel de factores de la transcripción y la replicación del ADN en el origen de la inestabilidad genómica.

Aguilera López, Andrés; Lafuente Barquero, Juan Francisco (2017-09-25)
Mantener la integridad del genoma no es tarea fácil para las células. El ADN sufre constantes ataques de agentes químicos ...
PhD Thesis
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Nuevos genes humanos asociados a la biogénesis de mRNPs necesarios para la integridad del genoma

Aguilera López, Andrés; Luna Varo, Rosa María; Salas Armenteros, Irene (2017-09-13)
La integridad del genoma es una condición necesaria para la transmisión fidedigna de la información genética. Numerosos ...
PhD Thesis
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Papel de la cromatina en la formación de R-loops

García Rondón, Ana; Aguilera López, Andrés; García Pichardo, Desiré (2017-09-08)
La inestabilidad genómica es una patología celular asociada a múltiples enfermedades genéticas, incluido el cáncer (Aguilera ...
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A new role for Rrm3 in repair of replication-born DNA breakage by sister chromatid recombination

Muñoz Galván, Sandra; García Rubio, María Luisa; Ortega Moreno, Pedro; Ruiz Pérez, José Francisco; Jimeno González, Sonia; Pardo, Benjamín; Gómez González, Belén; Aguilera López, Andrés (Public Library of Science, 2017-01-01)
Replication forks stall at different DNA obstacles such as those originated by transcription. Fork stalling can lead to ...
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The Role of Replication-Associated Repair Factors on R-Loops

Bhatia, Vaibhav; Herrera Moyano, Emilia; Aguilera López, Andrés; Gómez González, Belén (MDPI, 2017-01-01)
The nascent RNA can reinvade the DNA double helix to form a structure termed the R-loop, where a single-stranded DNA (ssDNA) ...
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The Smc5/6 complex regulates the yeast Mph1 helicase at RNA-DNA hybrid-mediated DNA damage

Lafuente Barquero, Juan; Luke Glaser, Sarah; Graf, Marco; Silva, Sonia; Gómez González, Belén; Aguilera López, Andrés (Public Library of Science, 2017-01-01)
RNA-DNA hybrids are naturally occurring obstacles that must be overcome by the DNA replication machinery. In the absence ...
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Physical proximity of chromatin to nuclear pores prevents harmful R loop accumulation contributing to maintain genome stability

García Benítez, Francisco; Gaillard, Hélène; Aguilera López, Andrés (National Academy of Sciences, 2017-01-01)
During transcription, the mRNA may hybridize with DNA, forming an R loop, which can be physiological or pathological, ...
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Human THO–Sin3A interaction reveals new mechanisms to prevent R-loops that cause genome instability

Salas Armenteros, Irene; Pérez Calero, Carmen; Bayona Feliu, Aleix; Tumini, Emanuela; Luna Varo, Rosa María; Aguilera López, Andrés (Wiley-Blackwell, 2017-01-01)
R-loops, formed by co-transcriptional DNA–RNA hybrids and a displaced DNA single strand (ssDNA), fulfill certain positive ...
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Histone Mutants Separate R Loop Formation from Genome Instability Induction

García Pichardo, Desiré; Cañas, Juan C.; García Rubio, María Luisa; Gómez González, Belén; García Rondón, Ana; Aguilera López, Andrés (Elsevier, 2017-01-01)
R loops have positive physiological roles, but they can also be deleterious by causing genome instability, and the mechanisms ...
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DNA-RNA hybrids: The risks of DNA breakage during transcription

Aguilera López, Andrés; Gómez González, Belén María (Springer Nature, 2017-01-01)
Although R loops can occur at different genomic locations, the factors that determine their formation and frequency remain ...
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The need to regulate replication fork speed

Gómez González, Belén María; Aguilera López, Andrés (American Association for the Advancement of Science, 2017-01-01)
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Excess of Yra1 RNA-Binding Factor Causes Transcription-Dependent Genome Instability, Replication Impairment and Telomere Shortening

Gavaldá Martín, Sandra; Santos Pereira, José María; García Rubio, María Luisa; Luna Varo, Rosa María; Aguilera López, Andrés (Public Library of Science, 2016-01-01)
Yra1 is an essential nuclear factor of the evolutionarily conserved family of hnRNP-like export factors that when overexpressed ...
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Roles of human POLD1 and POLD3 in genome stability

Tumini, Emanuela; Barroso Ceballos, Sonia Inés; Pérez Calero, Carmen; Aguilera López, Andrés (Nature, 2016-01-01)
DNA replication is essential for cellular proliferation. If improperly controlled it can constitute a major source of ...
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High-Resolution Mapping of Homologous Recombination Events in rad3 Hyper-Recombination Mutants in Yeast

Andersen, Sabrina L.; Zhang, Aimee; Dominska, Margaret; Moriel Carretero, María; Herrera Moyano, Emilia; Aguilera López, Andrés (Public Library of Science, 2016-01-01)
The Saccharomyces cerevisae RAD3 gene is the homolog of human XPD, an essential gene encoding a DNA helicase of the TFIIH ...
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FANCD2 facilitates replication through common fragile sites

Madireddy, Advaitha; Aguilera López, Andrés; Herrera Moyano, Emilia; García Rubio, María Luisa; Owen, Nichole; Olson, Susan (Elsevier, 2016-01-01)
Common fragile sites (CFSs) are genomic regions that are unstable under conditions of replicative stress. Although the ...
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Transcription as a Threat to Genome Integrity

Gaillard, Hélène; Aguilera López, Andrés (Annual Reviews Inc., 2016-01-01)
Genomes undergo different types of sporadic alterations, including DNA damage, point mutations, and genome rearrangements, ...
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Transcription-replication conflicts: How they occur and how they are resolved

García Muse, Tatiana; Aguilera López, Andrés (Springer Nature, 2016-01-01)
The frequent occurrence of transcription and DNA replication in cells results in many encounters, and thus conflicts, ...
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The Fanconi Anemia Pathway Protects Genome Integrity from R-loops

García Rubio, María Luisa; Pérez Calero, Carmen; Barroso Ceballos, Sonia Inés; Tumini, Emanuela; Herrera Moyano, Emilia; Aguilera López, Andrés (Public Library of Science, 2015-01-01)
Co-transcriptional RNA-DNA hybrids (R loops) cause genome instability. To prevent harmful R loop accumulation, cells have ...
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A unified model for the molecular basis of Xeroderma pigmentosum-Cockayne Syndrome

Moriel Carretero, María; Herrera Moyano, Emilia; Aguilera López, Andrés (Taylor & Francis Open, 2015-01-01)
Nucleotide Excision Repair (NER) is a pathway that removes lesions distorting the DNA helix. The molecular basis of the ...
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Interdependence of the Rad50 hook and globular domain functions

Hohl, Marcel; Kochańczyk, Tomasz; Tous, Cristina; Aguilera López, Andrés; Krężel, Artur; Petrini, John H J (Elsevier, 2015-01-01)
Rad50 contains a conserved Zn2+ coordination domain (the Rad50 hook) that functions as a homodimerization interface. Hook ...
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Role for RNA: DNA hybrids in origin-independent replication priming in a eukaryotic system

Stuckey, Ruth; García Rodriguez, Néstor; Aguilera López, Andrés; Wellinger, Ralf Erik (National Academy of Sciences, 2015-01-01)
DNA replication initiates at defined replication origins along eukaryotic chromosomes, ensuring complete genome duplication ...
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Polycomb RING1A- and RING1B-dependent histone H2A monoubiquitylation at pericentromeric regions promotes S-phase progression

Bravo, M.; Nicolini, F.; Starowicz, K.; Barroso Ceballos, Sonia Inés; Calés, C.; Aguilera López, Andrés; Vidal, M. (Company of Biologists Ltd, 2015-01-01)
The functions of polycomb products extend beyond their well-known activity as transcriptional regulators to include genome ...
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A genome-wide function of THSC/TREX-2 at active genes prevents transcription–replication collisions

Santos Pereira, José María; García Rubio, María Luisa; González Aguilera, Cristina; Luna Varo, Rosa María; Aguilera López, Andrés (Oxford University Press, 2014-01-01)
The THSC/TREX-2 complex of Saccharomyces cerevisiae mediates the anchoring of transcribed genes to the nuclear pore, linking ...
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Cleavage factor I links transcription termination to DNA damage response and genome integrity maintenance in Saccharomyces cerevisiae

Gaillard, Hélène; Aguilera López, Andrés (Public Library of Science, 2014-01-01)
During transcription, the nascent pre-mRNA undergoes a series of processing steps before being exported to the cytoplasm. ...
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Transcription-coupled nucleotide excision repair factors promote R-loop-induced genome instability

Sollier, Julie; Townsend Stork, Caroline; García Rubio, María Luisa; Aguilera López, Andrés (Elsevier, 2014-01-01)
R-loops, consisting of an RNA-DNA hybrid and displaced single-stranded DNA, are physiological structures that regulate ...
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The rem mutations in the ATP-binding groove of the Rad3/XPD helicase lead to Xeroderma pigmentosum-Cockayne Syndrome-like phenotypes

Herrera Moyano, Emilia; Moriel Carretero, María; Montelone, Beth A.; Aguilera López, Andrés (Public Library of Science, 2014-01-01)
The eukaryotic TFIIH complex is involved in Nucleotide Excision Repair and transcription initiation. We analyzed three ...
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The yeast and human FACT chromatin-reorganizing complexes resolve R-loop-mediated transcription-replication conflicts

Herrera Moyano, Emilia; Mergui, Xenia; García Rubio, María Luisa; Barroso Ceballos, Sonia Inés; Aguilera López, Andrés (Cold Spring Harbor Laboratory Press, 2014-01-01)
FACT (facilitates chromatin transcription) is a chromatin-reorganizing complex that swaps nucleosomes around the RNA ...
PhD Thesis
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Inestabilidad genética y cambios en la cromatina en mutantes del complejo THO en mitosis y meiosis de eucariotas modelo

Aguilera López, Andrés; García Muse, Tatiana; Castellano Pozo, Maikel (2013-12-20)
Para el mantenimiento y el control de los procesos celulares, la integridad genética es un factor clave. Mutaciones o ...
PhD Thesis
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Función de Brd2 en la coordinación entre proliferación y diferenciación en el sistema nervioso central de vertebrados

García Domínguez, Mario; Aguilera López, Andrés; García Gutiérrez, Pablo (2013-07-05)
Durante el desarrollo embrionario de vertebrados se requiere una coordinación muy precisa entre los procesos de proliferación ...
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The Npl3 hnRNP prevents R-loop-mediated transcription–replication conflicts and genome instability

Santos Pereira, José María; Herrero, Ana B.; García Rubio, María Luisa; Marín Rodríguez, Antonio; Moreno, Sergio; Aguilera López, Andrés (Cold Spring Harbor Laboratory Press, 2013-01-01)
Transcription is a major obstacle for replication fork (RF) progression and a cause of genome instability. Part of this ...
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R-Loop Mediated Transcription-Associated Recombination in trf4D Mutants Reveals New Links between RNA Surveillance and Genome Integrity

Gavaldá Martín, Sandra; Gallardo, Mercedes; Luna Varo, Rosa María; Aguilera López, Andrés (Public Library of Science, 2013-01-01)
To get further insight into the factors involved in the maintenance of genome integrity we performed a screening ...
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Yeast pol4 promotes tel1-regulated chromosomal translocations

Sastre Moreno, Guillermo; Aguilera López, Andrés; Ruiz Pérez, José Francisco; Pardo, Benjamín; Blanco Dávila, Luis (2013-01-01)
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Histone H3K56 Acetylation, Rad52, and Non-DNA Repair Factors Control Double-Strand Break Repair Choice with the Sister Chromatid

Muñoz Galván, Sandra; Jimeno González, Sonia; Rothstein, Rodney; Aguilera López, Andrés (Public Library of Science, 2013-01-01)
DNA double-strand breaks (DSBs) are harmful lesions that arise mainly during replication. The choice of the sister chromatid ...
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Competing roles of DNA end resection and non-homologous end joining functions in the repair of replication-born double-strand breaks by sister-chromatid recombination

Muñoz Galván, Sandra; López Saavedra, Ana; Jackson, Stephen P.; Huertas Sánchez, Pablo; Cortés Ledesma, Felipe; Aguilera López, Andrés (Oxford University Press, 2013-01-01)
While regulating the choice between homologous recombination and non-homologous end joining (NHEJ) as mechanisms of ...
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The Caenorhabditis elegans THO complex is required for the mitotic cell cycle and development

Castellano Pozo, Maikel; García Muse, Tatiana; Aguilera López, Andrés (Public Library of Science, 2012-01-01)
THO is a conserved eukaryotic complex involved in mRNP biogenesis and RNA export that plays an important role in preventing ...
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Distinct Roles of Mus81, Yen1, Slx1-Slx4, and Rad1 Nucleases in the Repair of Replication-Born Double-Strand Breaks by Sister Chromatid Exchange

Muñoz Galván, Sandra; Tous, Cristina; Blanco, Miguel G.; Schwartz, Erin K.; Ehmsen, Kirk T.; West, Stephen C.; Heyer, Wolf-Dietrich; Aguilera López, Andrés (2012-01-01)
Most spontaneous DNA double-strand breaks (DSBs) arise during replication and are repaired by homologous recombination ...
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Yeast Sen1 helicase protects the genome from transcription-associated instability

Mischo, Hannah E.; Gómez González, Belén; Grzechnik, Pawel; García Rondón, Ana; Wei, Wu; Steinmetz, Lars; Aguilera López, Andrés; Proudfoot, Nick J. (Elsevier, 2011-01-06)
Sen1 of S. cerevisiae is a known component of the NRD complex implicated in transcription termination of nonpolyadenylated ...
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Genome Instability and Transcription Elongation Impairment in Human Cells Depleted of THO/TREX

Domínguez Sánchez, María Salud; Barroso Ceballos, Sonia Inés; Gómez González, Belén; Luna Varo, Rosa María; Aguilera López, Andrés (Public Library of Science, 2011-01-01)
THO/TREX connects transcription with genome integrity in yeast, but a role of mammalian THO in these processes is uncertain, ...
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Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers

Luna Varo, Rosa María; Japón Rodríguez, Miguel Ángel; Sáez, Carmen; Domínguez Sánchez, María Salud; Aguilera López, Andrés (2011-01-01)
One key step in gene expression is the biogenesis of mRNA ribonucleoparticle complexes (mRNPs). Formation of the mRNP ...
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New suppressors of THO mutations identify Thp3 (Ypr045c)-Csn12 as a protein complex involved in transcription elongation

Jimeno González, Sonia; Tous Rivera, Cristina; García Rubio, María Luisa; Ranes, Michael; González Aguilera, Cristina; Marín Rodríguez, Antonio; Aguilera López, Andrés (American Society for Microbiology, 2011-01-01)
Formation of a ribonucleoprotein particle (mRNP) competent for export requires the coupling of transcription with mRNA ...
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Nab2 functions in the metabolism of RNA driven by polymerases II and III

González Aguilera, Cristina; Tous, Cristina; Babiano González, Reyes; Cruz Díaz, Jesús de la; Luna Varo, Rosa María; Aguilera López, Andrés (American Society for Cell Biology, 2011-01-01)
Gene expression in eukaryotes is an essential process that includes transcription, RNA processing, and export. One ...
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Control of the function of the transcription and repair factor TFIIH by the action of the cochaperone Ydj1

Moriel Carretero, María; Tous Rivera, Cristina; Aguilera López, Andrés (National Academy of Sciences, 2011-01-01)
Yeast rad3-102, a mutant of the TFIIH complex involved in nucleotide excision repair (NER) and transcription, can perform ...
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AID induces double-strand breaks at immunoglobulin switch regions and c-MYC causing chromosomal translocations in yeast THO mutants

Ruiz Pérez, José Francisco; Gómez González, Belén; Aguilera López, Andrés (Public Library of Science, 2011-01-01)
Transcription of the switch (S) regions of immunoglobulin genes in B cells generates stable R-loops that are targeted by ...
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Zim17/Tim15 links mitochondrial iron–sulfur cluster biosynthesis to nuclear genome stability

Díaz de la Loza, María del Carmen; Gallardo Ortega, Mercedes; García Rubio, María Luisa; Izquierdo, Alicia; Herrero, Enrique; Aguilera López, Andrés; Wellinger, Ralf Erik (Oxford University Press, 2011-01-01)
Genomic instability is related to a wide-range of human diseases. Here, we show that mitochondrial iron–sulfur cluster ...
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The replication checkpoint protects fork stability by releasing transcribed genes from nuclear pores

Bermejo, Rodrigo; Gómez González, Belén; Aguilera López, Andrés; Foiani, Marco; Capra, Thelma; Cocito, Andrea (Elsevier, 2011-01-01)
Transcription hinders replication fork progression and stability, and the Mec1/ATR checkpoint protects fork integrity. ...
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The Rad50 coiled-coil domain is indispensable for Mre11 complex functions

Hohl, Marcel; Muñoz Galván, Sandra; Tous Rivera, Cristina; Aguilera López, Andrés; Petrini, John H. J. (Nature Publishing Group, 2011-01-01)
The Mre11 complex (Mre11, Rad50 and Xrs2 in Saccharomyces cerevisiae) influences diverse functions in the DNA damage ...
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The THO complex as a key mRNP biogenesis factor in development and cell differentiation

Jimeno González, Sonia; Aguilera López, Andrés (BioMed Central, 2010-01-01)
The THO complex is a key component in the co-transcriptional formation of messenger ribonucleoparticles that are competent ...
PhD Thesis
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Inestabilidad genética asociada a defectos en el complejo TFIIH

Aguilera López, Andrés; Moriel Carretero, María (2010-01-01)
Los organismos eucarióticos poseen múltiples mecanismos para preservar la integridad de su información genética. Ésta puede ...
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Sem1 is a functional component of the nuclear pore complex–associated messenger RNA export machinery

Boulos Faza, Marius; Kemmler, Stefan; Jimeno González, Sonia; González Aguilera, Cristina; Aguilera López, Andrés; Hurt, E (Rockefeller University Press, 2009-01-01)
The evolutionarily conserved protein Sem1/Dss1 is a subunit of the regulatory particle (RP) of the proteasome, and, in ...
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Genome-wide analysis of factors affecting transcription elongation and DNA repair: a new role for PAF and Ccr4-not in transcription-coupled repair

Gaillard, Hélène; Tous Rivera, Cristina; Botet, Javier; González Aguilera, Cristina; Quintero, María José; Viladevall, Laia; García Rubio, María Luisa; Rodríguez Gil, Alfonso; Marín, Antonio; Ariño, Joaquín; Revuelta, José Luis; Chávez de Diego, Sebastián; Aguilera López, Andrés (Public Library of Science, 2009-01-01)
RNA polymerases frequently deal with a number of obstacles during transcription elongation that need to be removed for ...
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Chromosomal translocations caused by either Pol32-dependent or Pol32-independent triparental break-induced replication

Ruiz Pérez, José Francisco; Gómez González, Belén; Aguilera López, Andrés (American Society for Microbiology, 2009-01-01)
Double-strand breaks (DSBs) are harmful DNA lesions that can generate chromosomal rearrangements or chromosome losses if ...
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The stress-activated protein kinase Hog1 mediates S phase delay in response to osmostress

Yaakov, Gilad; Duch, Alba; García Rubio, María Luisa; Clotet, Josep; Jiménez, Javier; Aguilera López, Andrés; Posas, Francesc (American Society for Cell Biology, 2009-01-01)
Control of cell cycle progression by stress-activated protein kinases (SAPKs) is essential for cell adaptation to extracellular ...
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The S-phase checkpoint is required to respond to R-loops accumulated in THO mutants

Gómez González, Belén; Felipe Abrio, Irene; Aguilera López, Andrés (American Society for Microbiology, 2009-01-01)
Cotranscriptional R-loops are formed in yeast mutants of the THO complex, which functions at the interface between ...
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Transcription at the proximity of the nuclear pore: A role for the THP1-SAC3-SUS1-CDC31 (THSC) complex

Luna Varo, Rosa María; González Aguilera, Cristina; Aguilera López, Andrés (Landes Bioscience, 2009-01-01)
A key aspect of eukaryotic gene expression is the coupling of transcription with RNA processing, polyadenylation and export. ...
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A novel class of Mrna-containing cytoplasmic granules are produced in response to UV-irradiation

Gaillard, Hélène; Aguilera López, Andrés (American Society for Cell Biology, 2008-01-01)
Nucleic acids are substrates for different types of damage, but little is known about the fate of damaged RNAs. We addressed ...
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CDK targets Sae2 to control DNA-end resection and homologous recombination

Huertas Sánchez, Pablo; Cortés Ledesma, Felipe; Sartori, Alessandro A.; Aguilera López, Andrés; Jackson, Stephen P. (Nature Publishing Group, 2008-01-01)
DNA double-strand breaks (DSBs) are repaired by two principal mechanisms: non-homologous end-joining (NHEJ) and homologous ...
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The THP1-SAC3-SUS1-CDC31 complex works in transcription elongation-mRNA export preventing RNA-mediated genome instability

González Aguilera, Cristina; Tous Rivera, Cristina; Gómez González, Belén; Huertas Sánchez, Pablo; Luna Varo, Rosa María; Aguilera López, Andrés (American Society for Cell Biology, 2008-01-01)
The eukaryotic THO/TREX complex, involved in mRNP biogenesis, plays a key role in the maintenance of genome integrity in ...
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Activation-induced cytidine deaminase action is strongly stimulated by mutations of the THO complex

Gómez González, Belén; Aguilera López, Andrés (National Academy of Sciences, 2007-01-01)
Activation-induced cytidine deaminase (AID) is a B cell enzyme essential for Ig somatic hypermutation and class switch ...
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A new connection of mRNP biogenesis and export with transcription-coupled repair

Gaillard, Hélène; Wellinger, Ralf Erik; Aguilera López, Andrés (Oxford University Press, 2007-01-01)
Although DNA repair is faster in the transcribed strand of active genes, little is known about the possible contribution ...
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Nucleoporins prevent DNA damage accumulation by modulating Ulp1-dependent sumoylation processes

Palancade, Benoit; Liu, Xianpeng; García Rubio, María Luisa; Aguilera López, Andrés; Zhao, Xiaolan; Doye, Valérie (American Society for Cell Biology, 2007-01-01)
Increasing evidences suggest that nuclear pore complexes (NPCs) control different aspects of nuclear metabolism, including ...
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Different genetic requirements for repair of replication-born double-strand breaks by sister-chromatid recombination and break-induced replication

Cortés Ledesma, Felipe; Tous Rivera, Cristina; Aguilera López, Andrés (Oxford University Press, 2007-01-01)
Homologous recombination (HR) is the major mechanism used to repair double-strand breaks (DSBs) that result from replication, ...
PhD Thesis
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Reparación postreplicativa de cortes de doble cadena en Saccharomyces Cerevisiae

Aguilera López, Andrés; Cortés Ledesma, Felipe (2006-07-21)
Entendemos como corte de doble cadena (doublé-strand break, DSB) toda interrupción en la continuidad de una molécula de ...
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Smc5–Smc6 mediate DNA double-strand-break repair by promoting sister-chromatid recombination

Piccoli, Giacomo De; Cortes Ledesma, Felipe; Ira, Gregory; Torres Rosell, Jordi; Aguilera López, Andrés (Nature Publishing Group, 2006-01-01)
DNA double-strand breaks (DSB) can arise during DNA replication, or after exposure to DNA-damaging agents, and their correct ...
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Tho1, a novel hnRNP, and Sub2 provide alternative pathways for mRNP biogenesis in yeast THO mutants

Jimeno González, Sonia; Luna Varo, Rosa María; García Rubio, María Luisa; Aguilera López, Andrés (American Society for Microbiology, 2006-01-01)
THO is a protein complex that functions in cotranscriptional mRNP formation. Yeast THO1 and SUB2 (Saccharomyces cerevisiae) ...
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An hpr1 point mutation that impairs transcription and mRNP biogenesis without increasing recombination

Huertas Sánchez, Pablo; García Rubio, María Luisa; Wellinger, Ralf Erik; Luna Varo, Rosa María; Aguilera López, Andrés (American Society for Microbiology, 2006-01-01)
THO/TREX, a conserved eukaryotic protein complex, is a key player at the interface between transcription and mRNP metabolism. ...
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Replication fork progression is impaired by transcription in hyperrecombinant yeast cells lacking a functional THO complex

Wellinger, Ralf Erik; Prado Velasco, José Félix; Aguilera López, Andrés (American Society for Microbiology, 2006-01-01)
THO/TREX is a conserved, eukaryotic protein complex operating at the interface between transcription and messenger ...
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Partial depletion of histone H4 increases homologous recombination-mediated genetic instability

Prado Velasco, José Félix; Aguilera López, Andrés (American Society for Microbiology, 2005-01-01)
DNA replication can be a source of genetic instability. Given the tight connection between DNA replication and nucleosome ...
PhD Thesis
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Papel del RNA en expresión genética y recombinación en Saccharomyces cerevisiae

Aguilera López, Andrés; Huertas Sánchez, Pablo (2004-01-01)
La información necesaria para la supervivencia celular se encuentra codificada en el genoma. Cualquier proceso que conlleve ...
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Molecular evidence that the eukaryotic THO/TREX complex is required for efficient transcription elongation

García Rondón, Ana; Jimeno González, Sonia; García Rubio, María Luisa; Aguilera López, Andrés (American Society for Biochemistry and Molecular Biology Inc., 2003-01-01)
THO/TREX is a conserved eukaryotic complex formed by the core THO complex plus proteins involved in mRNA metabolism and ...
PhD Thesis
PhD Thesis
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Elongación de la transcripción en S. cerevisiae el complejo THO y factores relacionados funcionalmente

Aguilera López, Andrés; García Rondón, Ana (2003-01-01)
La transcripción es el proceso por el cual se copia la información contenida en el DNA, a una molécula de RNA. Se divide ...
PhD Thesis
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Relación entre reparación recombinación y transcripción en levaduras

Aguilera López, Andrés; González Barrera, Sergio (2002-01-21)
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Defective nucleotide excision repair in yeast hpr1 and tho2 mutants

González Barrera, Sergio; Prado Velasco, José Félix; Verhage, Richard; Brouwer, Jaap; Aguilera López, Andrés (Oxford University Press, 2002-01-01)
Nucleotide excision repair (NER) and transcription are intimately related. First, TFIIH has a dual role in transcription ...
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Hpr1 is preferentially required for transcription of either long or G+C-rich DNA sequences in Saccharomyces cerevisiae

Chávez de Diego, Sebastián; García Rubio, María Luisa; Prado Velasco, José Félix; Aguilera López, Andrés (American Society for Microbiology, 2001-01-01)
Hpr1 forms, together with Tho2, Mft1, and Thp2, the THO complex, which controls transcription elongation and genome stability ...
PhD Thesis
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Recombinación mitótica entre repeticiones invertidas de ADN en Saccharomyces cerevisiae

Aguilera López, Andrés; Malagón Bautista, Francisco (2000-07-19)
PhD Thesis
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Relación de la transcripción con la recombinación entre secuencias repetidas en S. cerevisiae

Aguilera López, Andrés; Piruat Palomo, José Ignacio (1998-01-01)
La recombinación genética es un proceso fundamental en el metabolismo del ADN en todos los organismos vivos. Existen multitud de procesos biológicos en los que la recombinación está directamente implicada.
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The yeast HPR1 gene has a functional role in transcriptional elongation that uncovers a novel source of genome instability

Chávez de Diego, Sebastián; Aguilera López, Andrés (Cold Spring Harbor Laboratory Press, 1997-01-01)
The yeast HPR1 gene plays an important role in genome stability, as indicated by the observation that hpr1 mutants have ...
PhD Thesis
PhD Thesis
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Control genético de las deleciones entre secuencias repetidas directas en Saccaromyces cerevisiae

Aguilera López, Andrés; Prado Velasco, José Félix (1996-01-01)
Los genomios de todos los organismos están constituidos por un número variable de secuencias repetidas, que pueden llegar ...
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Selection of wine yeasts for growth and fermentation in the presence of ethanol and sucrose

Benítez, Tahía; Castillo, Lucas del; Aguilera López, Andrés; Conde, Jaime; Cerdá Olmedo, Enrique (American Society for Microbiology, 1983-01-01)
To optimize the conversion of carbohydrates to ethanol, strains of several Saccharomyces species were examined for the ...
PhD Thesis
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Genética y fisiología de la tolerancia al etanol en "Saccharomyces cerevisiae"

Benítez Fernández, Concepción Tahía; Cerdá Olmedo, Enrique; Aguilera López, Andrés (1983-01-01)
En este trabajo se ha determinado el papel que juegan la herencia citoplasmática y la nuclear en la tolerancia al etanol ...