Artículo
A novel class of Mrna-containing cytoplasmic granules are produced in response to UV-irradiation
Autor/es | Gaillard, Hélène
Aguilera López, Andrés |
Departamento | Universidad de Sevilla. Departamento de Genética |
Fecha de publicación | 2008 |
Fecha de depósito | 2015-10-06 |
Publicado en |
|
Resumen | Nucleic acids are substrates for different types of damage, but little is known about the fate of damaged RNAs. We addressed the existence of an RNA-damage response in yeast. The decay kinetics of GAL1p-driven mRNAs revealed ... Nucleic acids are substrates for different types of damage, but little is known about the fate of damaged RNAs. We addressed the existence of an RNA-damage response in yeast. The decay kinetics of GAL1p-driven mRNAs revealed a dose-dependent mRNA stabilization upon UV-irradiation that was not observed after heat or saline shocks, or during nitrogen starvation. UV-induced mRNA stabilization did not depend on DNA repair, damage checkpoint or mRNA degradation machineries. Notably, fluorescent in situ hybridization revealed that after UV-irradiation, polyadenylated mRNA accumulated in cytoplasmic foci that increased in size with time. In situ colocalization showed that these foci are not processing-bodies, eIF4E-, eIF4G-, and Pab1-containing bodies, stress granules, autophagy vesicles, or part of the secretory or endocytic pathways. These results point to the existence of a specific eukaryotic RNA-damage response, which leads to new polyadenylated mRNA-containing granules (UV-induced mRNA granules; UVGs). We propose that potentially damaged mRNAs, which may be deleterious to the cell, are temporarily stored in UVG granules to safeguard cell viability. |
Cita | Gaillard, H. y Aguilera López, A. (2008). A novel class of Mrna-containing cytoplasmic granules are produced in response to UV-irradiation. Molecular Biology of the Cell, 19 (11), 4980-4992. |
Ficheros | Tamaño | Formato | Ver | Descripción |
---|---|---|---|---|
Mol. Biol. Cell-2008-Gaillard- ... | 1.582Mb | [PDF] | Ver/ | |