Data

NameGaillard, Hélène
DepartmentGenética
Knowledge areaGenética
Professional categoryProfesora Titular de Universidad
E-mailRequest
           

  Statistics

  • Items

    10

  • Visits

    1150

  • Downloads

    997

  Publications

 

Article
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The human nucleoporin Tpr protects cells from RNA-mediated replication stress

Kosar, Martin; Giannattasio, Michele; Piccini, Daniele; Maya Mendoza, Apolinar; García Benítez, Francisco; Bartkova, Jirina; Barroso Ceballos, Sonia Inés; Gaillard, Hélène; Martini, Emanuele; Restuccia, Umberto; Ramírez Otero, Miguel Ángel; Garre, Massimiliano; Verga, Eleonora; Andújar Sánchez, Miguel; Maynard, Scott; Hodny, Zdenek; Costanzo, Vincenzo; Kumar, Amit; Bachi, Angela; Aguilera López, Andrés; Bartek, Jiri; Foiani, Marco (Springer Nature, 2021-01-01)
Although human nucleoporin Tpr is frequently deregulated in cancer, its roles are poorly understood. Here we show that Tpr ...
Article
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The Nup84 complex coordinates the DNA damage response to warrant genome integrity

Gaillard, Hélène; Santos Pereira, José María; Aguilera López, Andrés (Oxford University Press, 2019-01-01)
DNA lesions interfere with cellular processes such as transcription and replication and need to be adequately resolved to ...
PhD Thesis
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Inestabilidad genética asociada a R-loops.

Aguilera López, Andrés; García Benítez, Francisco; Gaillard, Hélène (2018-07-06)
La inestabilidad genómica es una patología celular, la cual se produce cuando una célula acumula variaciones genéticas que ...
Article
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Gene gating at nuclear pores prevents the formation of R loops

Gaillard, Hélène; García Benítez, Francisco; Aguilera López, Andrés (Taylor and Francis Ltd., 2018-01-01)
Transcription is an important source of genetic variability. A large amount of transcription-associated genome variation ...
Article
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Physical proximity of chromatin to nuclear pores prevents harmful R loop accumulation contributing to maintain genome stability

García Benítez, Francisco; Gaillard, Hélène; Aguilera López, Andrés (National Academy of Sciences, 2017-01-01)
During transcription, the mRNA may hybridize with DNA, forming an R loop, which can be physiological or pathological, ...
Article
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Transcription as a Threat to Genome Integrity

Gaillard, Hélène; Aguilera López, Andrés (Annual Reviews Inc., 2016-01-01)
Genomes undergo different types of sporadic alterations, including DNA damage, point mutations, and genome rearrangements, ...
Article
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Cleavage factor I links transcription termination to DNA damage response and genome integrity maintenance in Saccharomyces cerevisiae

Gaillard, Hélène; Aguilera López, Andrés (Public Library of Science, 2014-01-01)
During transcription, the nascent pre-mRNA undergoes a series of processing steps before being exported to the cytoplasm. ...
Article
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Genome-wide analysis of factors affecting transcription elongation and DNA repair: a new role for PAF and Ccr4-not in transcription-coupled repair

Gaillard, Hélène; Tous Rivera, Cristina; Botet, Javier; González Aguilera, Cristina; Quintero, María José; Viladevall, Laia; García Rubio, María Luisa; Rodríguez Gil, Alfonso; Marín, Antonio; Ariño, Joaquín; Revuelta, José Luis; Chávez de Diego, Sebastián; Aguilera López, Andrés (Public Library of Science, 2009-01-01)
RNA polymerases frequently deal with a number of obstacles during transcription elongation that need to be removed for ...
Article
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A novel class of Mrna-containing cytoplasmic granules are produced in response to UV-irradiation

Gaillard, Hélène; Aguilera López, Andrés (American Society for Cell Biology, 2008-01-01)
Nucleic acids are substrates for different types of damage, but little is known about the fate of damaged RNAs. We addressed ...
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A new connection of mRNP biogenesis and export with transcription-coupled repair

Gaillard, Hélène; Wellinger, Ralf Erik; Aguilera López, Andrés (Oxford University Press, 2007-01-01)
Although DNA repair is faster in the transcribed strand of active genes, little is known about the possible contribution ...