Recent Submissions

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    Physical proximity of chromatin to nuclear pores prevents harmful R loop accumulation contributing to maintain genome stability  [Article]

    García Benítez, Francisco; Gaillard, Hélène; Aguilera López, Andrés (National Academy of Sciences, 2017)
    During transcription, the mRNA may hybridize with DNA, forming an R loop, which can be physiological or pathological, constituting in this case a source of genomic instability. To understand the mechanism by which eukaryotic ...
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    Surface modulation of single-walled carbon nanotubes for selective bacterial cell agglutination  [Article]

    Romero Ben, Elena; Cid, Juan José; Assali, Mohyeddin; Fernández García, Elisabet; Wellinger, Ralf Erik; Khiar, Noureddine (Dove Medical Press, 2019)
    Background: Bacterial resistance to antibiotics is one of the biggest challenges facing medicine today. Anti-adhesive therapy, using inhibitors of bacterial adhesion to epithelial cells, one of the first stages of ...
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    PAI1 is a Marker of Bad Prognosis in Rectal Cancer but Predicts a Better Response to Treatment with PIM Inhibitor AZD1208  [Article]

    Muñoz Galván, Sandra; Rivero, María; Peinado Serrano, Javier; Martinez Pérez, Julia; Fernández Fernández, María del Carmen; Ortiz, María José; García Heredia, José Manuel; Carnero Moya, Amancio (MDPI, 2020)
    Colorectal cancer (CRC) is the third most common cancer worldwide. The standard treatment in locally advanced rectal cancer is preoperative radiation alone or in combination with chemotherapy, followed by adjuvant chemotherapy. ...
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    Control of the neuroprotective Lipocalin Apolipoprotein D expression by alternative promoter regions and differentially expressed mRNA 5’ UTR variants  [Article]

    Diez-Hermano, Sergio; Mejías Romero, Andrés; Sánchez, Diego; Gutiérrez Pozo, Gabriel; Ganfornina, Maria D. (Public Library of Science, 2020)
    The Lipocalin Apolipoprotein D (ApoD) is one of the few genes consistently overexpressed in the aging brain, and in most neurodegenerative and psychiatric diseases. Its functions include metabolism regulation, myelin ...
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    Salmonella Heterogeneously Expresses Flagellin During Colonization of Plants  [Article]

    Zarkani, Azhar A.; López Pagán, Nieves; Grimm, Maja; Sánchez Romero, María Antonia; Ruiz Albert, Javier; Beuzón López, Carmen del Rosario; Schikora, Adam (MDPI, 2020)
    Minimally processed or fresh fruits and vegetables are unfortunately linked to an increasing number of food-borne diseases, such as salmonellosis. One of the relevant virulence factors during the initial phases of the ...
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    Molecular Pathways Leading to Induction of Cell Death and Anti-Proliferative Properties by Tacrolimus and mTOR Inhibitors in Liver Cancer Cells  [Article]

    Navarro Villarán, Elena; Cruz Ojeda, Patricia de la; Contreras, Laura; González, Raul; Negrete, María; Rodríguez Hernández, María A.; Marín Gómez, Luis Miguel; Álamo Martínez, José M.; Calvo, Antonio; Gómez Bravo, Miguel Ángel; Cruz Díaz, Jesús de la; Padillo Ruiz, Javier; Muntané Relat, Jordi (1421-9778, 2020)
    Background/Aims: Orthotopic liver transplantation (OLT) is the recommended treatment for patients at early stages of hepatocarcinoma (HCC) with portal hypertension and/or increased bilirubinemia, but without ...
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    ALC1/eIF4A1-mediated regulation of CtIP mRNA stability controls DNA end resection  [Article]

    Mejías Navarro, Fernando; Rodríguez Leal, Jesús M.; Ramón, Javier; Camarillo Daza, María Rosa; Huertas Sánchez, Pablo (Public Library of Science, 2020)
    During repair of DNA double-strand breaks, resection of DNA ends influences how these lesions will be repaired. If resection is activated, the break will be channeled through homologous recombination; if not, it will be ...
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    Molecular Pathways Leading to Induction of Cell Death and Anti-Proliferative Properties by Tacrolimus and mTOR Inhibitors in Liver Cancer Cells  [Article]

    Navarro Villarán, Elena; Cruz Ojeda, Patricia de la; Contreras, Laura; González, Raúl; Negrete, María; Rodríguez Hernández, María A.; Marín Gómez, Luis Miguel; Álamo Martínez, José M.; Calvo, Antonio; Gómez Bravo, Miguel Ángel; Cruz Díaz, Jesús de la (Elsevier, 2020)
    BACKGROUND/AIMS: Orthotopic liver transplantation (OLT) is the recommended treatment for patients at early stages of hepatocarcinoma (HCC) with portal hypertension and/or increased bilirubinemia, but without vascular-associated ...
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    Tubulin Folding Cofactor TBCB is a Target of the Salmonella Effector Protein SseK1  [Article]

    Araujo Garrido, Juan Luis; Baisón Olmo, Fernando; Bernal Bayard, Joaquín; Romero Portillo, Francisco; Ramos Morales, Francisco (MDPI, 2020)
    Salmonella enterica serovar Typhimurium is a human and animal pathogen that uses type III secretion system effectors to manipulate the host cell and fulfill infection. SseK1 is a Salmonella effector with glycosyltransferase ...
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    Light and developmental regulation of the gene con-10 of neurospora crassa  [Article]

    Corrochano Peláez, Luis María; Lauter, Frank Roman; Ebbole, Daniel J.; Yanofsky, Charles A. (Elsevier, 1995)
    The gene con-10 of Neurospora crassa is expressed preferentially during conidiation and following illumination of vegetative mycelia with blue light. In this study we have examined the segmental locations of the genetic ...
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    Fungal stress biology: a preface to the Fungal Stress Responses special edition  [Article]

    Rangel, Drauzio E.N.; Alder-Rangel, Alene; Dadachova, Ekaterina A.; Finlay, Roger D.; Kupiec, Martin; Dijksterhuis, Jan F.; Braga, Gilberto Ú.L.; Corrochano Peláez, Luis María; Hallsworth, John Edward (Springer Nature, 2015)
    There is currently an urgent need to increase global food security, reverse the trends of increasing cancer rates, protect environmental health, and mitigate climate change. Toward these ends, it is imperative to improve ...
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    The ribotoxin α-sarcin can cleave the sarcin/ricin loop on late 60S pre-ribosomes  [Article]

    Olombrada, Miriam; Pena, Cohue; Rodríguez Galán, Olga; Klingauf Nerurkar, Purnima; Portugal Calisto, Daniela; Oborska Oplová, Michaela; Altvater, Martín; Gavilanes, Jose G.; Martínez del Pozo, Álvaro; Cruz Díaz, Jesús de la (Oxford University Press, 2020)
    The ribotoxin α-sarcin belongs to a family of ribonucleases that cleave the sarcin/ricin loop (SRL), a critical functional rRNA element within the large ribosomal subunit (60S), thereby abolishing translation. Whether ...
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    Expansion of Signal Transduction Pathways in Fungi by Extensive Genome Duplication  [Article]

    Corrochano Peláez, Luis María; Kuo, Alan; Ávalos Cordero, Francisco Javier; Camino, Lola P.; Cánovas López, David; Cerdá Olmedo, Enrique; Gutiérrez Pozo, Gabriel; Luque Fobelo, Eva Milagros; Marcos Rodríguez, Ana Teresa; Ramírez Medina, Humberto; Miralles Durán, Alejandro; Olmedo López, María; Rodríguez Romero, Julio; García Tagua, Víctor; Grigoriev, Igor V. (Elsevier, 2016)
    Plants and fungi use light and other signals to regulate development, growth, and metabolism. The fruiting bodies of the fungus Phycomyces blakesleeanus are single cells that react to environmental cues, including light, ...
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    Functional Characterization of Lysophosphatidylcholine: Acyl-CoA Acyltransferase Genes From Sunflower (Helianthus annuus L.)  [Article]

    Mapelli Brahm, Ana; Sánchez Rodriguez, Rosario; Pan, Xue; Moreno Pérez, Antonio Javier; Garcés, Rafael; Martínez Force, Enrique; Weselake, Randall J.; Salas Liñán, Joaquín Jesús; Venegas Calerón, Mónica (MDPI, 2020)
    Lysophosphatidylcholine acyltransferase (LPCAT, EC 2.3.1.23) is an evolutionarily conserved key enzyme in the Lands cycle that catalyzes acylation of lysophosphatidylcholine (LPC) to produce phosphatidylcholine (PC), the ...
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    Sensitivity of hematopoietic stem cells to mitochondrial dysfunction by SdhD gene deletion  [Article]

    Bejarano García, José Antonio; Millán-Uclés, África; Valle Rosado, Iván; Sánchez Abarca, Luis Ignacio; Caballero Velázquez, Teresa; Durán Galván, María José; Pérez Simón, José Antonio; Piraut Palomo, José Ignacio (2016)
    It is established that hematopoietic stem cells (HSC) in the hypoxic bone marrow have adapted their metabolism to oxygen-limiting conditions. This adaptation includes suppression of mitochondrial activity, induction of ...
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    Oils and fats on food: is it possible to have a healthy diet?  [Article]

    Garcés Mancheño, Rafael; Martínez-Force, Enrique; Venegas Calerón, Mónica; Salas, Joaquín J. (CSIC, 2017)
    Oils and fats are an important part of our diet as components of many food formulations. Thus, they are retailed for domestic or hostelry uses and broadly used by food industry for the elaboration of margarines, ice ...
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    UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors  [Article]

    Checa Rodríguez, Cintia; Jachimowicz, Ron D.; Beleggia, Filippo; Isensee, Jo¨rg; Reinhardt, Christian; Wieczorek, Dagmar; Shiloh, Yosef (Elsevier, 2020)
    Genomic instability can be a hallmark of both human genetic disease and cancer. We identify a deleterious UBQLN4 mutation in families with an autosomal recessive syndrome reminiscent of genome instability disorders. UBQLN4 ...
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    An ER-Localized SNARE Protein Is Exported in Specific COPII Vesicles for Autophagosome Biogenesis  [Article]

    Lemus Rodríguez,Leticia; Ribas Salgueiro, Juan Luis; Sikorska, Natalia; Goder, Veit (Elsevier (Cell Press): OAJ, 2016)
    The de novo formation of autophagosomes for the targeting of cytosolic material to the vacuole/lysosome is upregulated upon starvation. How autophagosomes acquire membranes remains still unclear. Here, we report that, in ...
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    Studying DNA Double-Strand Break Repair: An Ever-Growing Toolbox  [Article]

    Vítor, Alexandra C.; Huertas Sánchez, Pablo; Legube, Gaëlle; Almeida, Sérgio F. de (Frontiers Media, 2020)
    To ward off against the catastrophic consequences of persistent DNA double-strand breaks (DSBs), eukaryotic cells have developed a set of complex signaling networks that detect these DNA lesions, orchestrate cell cycle ...
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    Type III Secretion Effectors with Arginine N-Glycosyltransferase Activity  [Article]

    Araujo Garrido, Juan Luis; Bernal Bayard, Joaquín; Ramos Morales, Francisco (MDPI, 2020)
    Type III secretion systems are used by many Gram-negative bacterial pathogens to inject proteins, known as effectors, into the cytosol of host cells. These virulence factors interfere with a diverse array of host signal ...

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