Genética
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Papel de la reducción de histonas en la protección de los telómeros durante la pre-senescencia [PhD Thesis]
(2020-01-22)Los telómeros son estructuras nucleoproteícas cuya función principal es evitar que los extremos de los cromosomas sean reconocidos como roturas en el ADN y sean procesados por las maquinarias de checkpoints y reparación, ...
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Crosstalk between DNA end resection and RNA metabolism [PhD Thesis]
(2020-01-23)DNA suffers thousands of lesions from exogenous and endogenous sources. Nevertheless, double-strand breaks (DSBs) are the most dangerous form of DNA damage because if they are not properly repaired they can lead to ...
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What causes an RNA-DNA hybrid to compromise genome integrity? [Article]
(Elsevier, 2019)Transcription is a source of genome instability that stimulates mutation and recombination. Part of the damage produced by transcription is mediated by R-loops, non-B DNA structures that normally form by the re-annealing ...
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Regulation of DNA end resection by cell stemness [PhD Thesis]
(2020-01-20)The ability to reprogram somatic cells into induced pluripotent stem cells (iPSCs) holds great potential for clinic applications, however, acquired genomic instability is one of the major concerns for its clinical use. The ...
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Prolonged quiescence delays somatic stem cell-like divisions in Caenorhabditis elegans and is controlled by insulin signaling [Article]
(Wiley Open Access, 2019)Cells can enter quiescence in adverse conditions and resume proliferation when the environment becomes favorable. Prolonged quiescence comes with a cost, reducing the subsequent speed and potential to return to proliferation. ...
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R Loops: From Physiologicalto Pathological Roles [Article]
(Elsevier, 2019-10-17)DNA-RNA hybrids play a physiological role in cellular processes, but often, they represent non-scheduled co-transcriptional structures with a negative impact on transcription, replication and DNA repair. Accumulating ...
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The DNA damage response acts as a safeguardagainst harmful DNA–RNA hybrids ofdifferent origins [Article]
(EMBO Press, 2019-07-24)Despite playing physiological roles in specific situations, DNA–RNA hybrids threat genome integrity. To investigate how cells do counteract spontaneous DNA–RNA hybrids, here we screen an siRNA library covering 240 human ...
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Mejora de cepas de trichoderma para su utilización como agentes de control biológico [PhD Thesis]
(1998-09-09) -
Estudio de asimetrías asociadas al huso mitótico de Saccharomyces cerevisiae: nuevos reguladores del posicionamiento del huso y la herencia no aleatoria de los centros organizadores de microtúbulos [PhD Thesis]
(2020-01-24)La división celular asimétrica es un tipo particular de división en la que se generan dos células de distinto tamaño, contenido, función y/o destino. Este tipo de división es particularmente relevante durante los procesos ...
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WHI-2 Regulates Intercellular Communication via a MAP Kinase Signaling Complex [Article]
(Frontiers Media, 2020)he formation of the fungal mycelial network is facilitated by somatic cell fusion of germinating asexual spores (or germlings). Neurospora crassa germlings in close proximity display chemotropic growth that is dependent ...
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Transferencia genética entre las especies cultivadas de Brassica [PhD Thesis]
(1991-05) -
Caracterización genética de levaduras para la producción de etanol [PhD Thesis]
(1987) -
Patrones microgeográficos del adn mitocondrial en el sur de la península ibérica [PhD Thesis]
(2003) -
A novel lncRNA as a positive regulator of carotenoid biosynthesis in Fusarium [Article]
(Nature Research, 2020)The fungi Fusarium oxysporum and Fusarium fujikuroi produce carotenoids, lipophilic terpenoid pigments of biotechnological interest, with xanthophyll neurosporaxanthin as the main end product. Their carotenoid biosynthesis ...
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Relación entre reparación recombinación y transcripción en levaduras [PhD Thesis]
(2002-01-21) -
DNA Double Strand Breaks and Chromosomal Translocations Induced by DNA Topoisomerase II [Article]
(Frontiers Media, 2019)DNA double strand breaks (DSBs) are the most cytotoxic lesions of those occurring in the DNA and can lead to cell death or result in genome mutagenesis and chromosomal translocations. Although most of these rearrangements ...
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Geometría del inicio de la transcripción de promotores dependientes del factor σN [PhD Thesis]
(1998-09-07) -
Regulation of bistability in the std fimbrial operon of Salmonella enterica by DNA adenine methylation and transcription factors HdfR, StdE and StdF [Article]
(Oxford Academic, 2019-09-05)Bistable expression of the Salmonella enterica std operon is controlled by an AND logic gate involving three transcriptional activators: the LysR-type factor HdfR and the StdE and StdF regulators encoded by the std operon ...
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Síntesis de fiberelinas y transformación integrativa en Gibberella fujikuroi [PhD Thesis]
(1998-01-09)