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Artículo
Replication fork progression is impaired by transcription in hyperrecombinant yeast cells lacking a functional THO complex
(American Society for Microbiology, 2006)
THO/TREX is a conserved, eukaryotic protein complex operating at the interface between transcription and messenger ribonucleoprotein (mRNP) metabolism. THO mutations impair transcription and lead to increased transcrip ...
Artículo
Regulation of conjugal transfer by Lrp and dam methylation in plasmid R100
(Sociedad Española de Microbiología, 2005-12)
Conjugal transfer of the F-like plasmid R100 occurs at higher frequencies in the absence of DNA adenine methylation. Lower levels of R100-encoded FinP RNA were found in a Dam- host, suggesting that Dam methylation regulates ...
Artículo
DNA adenine methylation regulates virulence gene expression in Salmonella enterica serovar typhimurium
(American Society for Microbiology, 2006)
Transcriptomic analyses during growth in Luria-Bertani medium were performed in strain SL1344 of Salmonella enterica serovar Typhimurium and in two isogenic derivatives lacking Dam methylase. More genes were repressed than ...
Artículo
An hpr1 point mutation that impairs transcription and mRNP biogenesis without increasing recombination
(American Society for Microbiology, 2006)
THO/TREX, a conserved eukaryotic protein complex, is a key player at the interface between transcription and mRNP metabolism. The lack of a functional THO complex impairs transcription, leads to transcriptiondependent ...
Artículo
YhdJ, a nonessential CcrM-like DNA methyltransferase of Escherichia coli and Salmonella enterica
(American Society for Microbiology, 2007)
The Caulobacter crescentus DNA adenine methyltransferase CcrM and its homologs in the α-Proteobacteria are essential for viability. CcrM is 34% identical to the yhdJ gene products of Escherichia coli and Salmonella enterica. ...
Artículo
A new connection of mRNP biogenesis and export with transcription-coupled repair
(Oxford University Press, 2007)
Although DNA repair is faster in the transcribed strand of active genes, little is known about the possible contribution of mRNP biogenesis and export in transcription-coupled repair (TCR). Interestingly, mutants of THO, ...
Artículo
Sem1 is a functional component of the nuclear pore complex–associated messenger RNA export machinery
(Rockefeller University Press, 2009)
The evolutionarily conserved protein Sem1/Dss1 is a subunit of the regulatory particle (RP) of the proteasome, and, in mammalian cells, binds the tumor suppressor protein BRCA2. Here, we describe a new function for yeast ...
Artículo
A gene-specific requirement for FACT during transcription is related to the chromatin organization of the transcribed region
(2006)
The FACT complex stimulates transcription elongation on nucleosomal templates. In vivo experiments also involve FACT in the reassembly of nucleosomes traversed by RNA polymerase II. Since several features of chromatin ...
Artículo
Recruitment of a chromatin remodelling complex by the Hog1 MAP kinase to stress genes
(EMBO Press, 2009)
For efficient transcription, RNA PolII must overcome the presence of nucleosomes. The p38-related MAPK Hog1 is an important regulator of transcription upon osmostress in yeast and thereby it is involved in initiation and ...
Artículo
Characterization of NO-Induced Nitrosative Status in Human Placenta from Pregnant Women with Gestational Diabetes Mellitus
(Hindawi Publishing Corporation, 2017)
Dysregulation of NO production is implicated in pregnancy-related diseases, including gestational diabetes mellitus (GDM). The role of NO and its placental targets in GDM pregnancies has yet to be determined. S-Nitrosylation ...