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Tesis Doctoral
The role of RNA Polymerase II-dependent transcription elongation in the cross-talk between mRNA synthesis and decay.
(2018-02-06)
The main molecule in gene expression is messenger RNA (mRNA) which transfers the information contained in genes in the nucleus to the cytoplasm where it is translated into proteins that carry out cellular functions. mRNA ...
Artículo
Genome-wide analysis of factors affecting transcription elongation and DNA repair: a new role for PAF and Ccr4-not in transcription-coupled repair
(Public Library of Science, 2009)
RNA polymerases frequently deal with a number of obstacles during transcription elongation that need to be removed for transcription resumption. One important type of hindrance consists of DNA lesions, which are removed ...
Artículo
Overexpression of canonical prefoldin associates with the risk of mortality and metastasis in non-small cell lung cancer
(2020-04-24)
Canonical prefoldin is a protein cochaperone composed of six di erent subunits (PFDN1 to 6). PFDN1 overexpression promotes epithelial–mesenchymal transition (EMT) and increases the growth of xenograft lung cancer (LC) ...
Artículo
The Total mRNA Concentration Buffering System in Yeast is Global Rather than Gene-specific
(Cold Spring Harbor Laboratory Press, 2021)
Gene expression in eukaryotes does not follow a linear process from transcription to translation and mRNA degradation. Instead it follows a circular process in which cytoplasmic mRNA decay crosstalks with nuclear transcription. ...
Artículo
Tesis Doctoral
Contribución de prefoldina a la expresión génica en células humanas
(2019-03-15)
La prefoldina es una cochaperona que está presente en todos los organismos eucarióticos. Es conocida principalmente por su importante función en la dinámica del citoesqueleto, al favorecer el plegamiento de los monómeros ...
Tesis Doctoral
Elongación transcripcional en Saccharomyces Cerevisiae influencia en el control del ciclo celular y nuevas herramientas para su estudio "in vivo"
(2007)
La transcripción es el proceso mediante el cual la información genética, contenida en el DNA, es expresada en forma de RNA. La mayor parte de los genes eucarióticos, tanto aquellos que codifican proteínas como la mayoría ...
Artículo
Flow Cytometry of Microencapsulated Colonies for Genetics Analysis of Filamentous Fungi
(Genetics Society of America:, 2014)
The analysis of filamentous fungi by flow cytometry has been impossible to date due to their filamentous nature and size. In this work, we have developed a method that combines single-spore microencapsulation and large-particle ...
Artículo
FACT Prevents the Accumulation of Free Histones Evicted from Transcribed Chromatin and a Subsequent Cell Cycle Delay in G1
(Public Library of Science, 2010)
The FACT complex participates in chromatin assembly and disassembly during transcription elongation. The yeast mutants affected in the SPT16 gene, which encodes one of the FACT subunits, alter the expression of G1 cyclins ...
Artículo
Chromatin reassembly factors are involved in transcriptional interference promoting HIV latency
(American Society for Microbiology, 2011)
The establishment of a stable reservoir of latently infected cells allows HIV to persist in the host. Usually, HIV infection of T cells results in integration of the viral genome, with a preference for regions in the human ...