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Mostrando ítems 1-8 de 8
Artículo
The role of chromatin at transcription-replication conflicts as a genome safeguard
(Portland Press, 2021)
DNA replication ensures the correct copying of the genome and the faithful transfer of the genetic information to the offspring. However, obstacles to replication fork (RF) progression cause RF stalling and compromise ...
Artículo
UAP56/DDX39B is a major cotranscriptional RNA–DNA helicase that unwinds harmful R loops genome-wide
(Cold Spring Harbor Laboratory Press, 2020)
Nonscheduled R loops represent a major source of DNA damage and replication stress. Cells have different ways to prevent R-loop accumulation. One mechanism relies on the conserved THO complex in association with cotranscriptional ...
Artículo
C. elegans THSC/TREX-2 deficiency causes replication stress and genome instability
(The Company of Biologists, 2021)
Transcription is an essential process of DNA metabolism, yet it makes DNA more susceptible to DNA damage. THSC/TREX-2 is a conserved eukaryotic protein complex with a key role in mRNP biogenesis and maturation that prevents ...
Artículo
Human mitochondrial degradosome prevents harmful mitochondrial R loops and mitochondrial genome instability
(2018)
R loops are nucleic acid structures comprising an DNA-RNA hybrid and a displaced single-stranded DNA. These structures may occur transiently during transcription, playing essential biological functions. However, persistent ...
Artículo
Physical proximity of chromatin to nuclear pores prevents harmful R loop accumulation contributing to maintain genome stability
(National Academy of Sciences, 2017)
During transcription, the mRNA may hybridize with DNA, forming an R loop, which can be physiological or pathological, constituting in this case a source of genomic instability. To understand the mechanism by which eukaryotic ...
Artículo
The SWI/SNF complex, transcription-replication conflicts and cancer: a connection with high therapeutic potential
(Taylor & Francis, 2021)
Genome instability is a hallmark of cancer. ATP-dependent chromatin remodelers are frequently altered in cancer. We have recently reported that the SWItch/Sucrose Non-Fermentable (SWI/SNF) complex protects the genome by ...
Artículo
Expression of human RECQL5 in Saccharomyces cerevisiae causes transcription defects and transcription-associated genome instability
(Springer Nature, 2024-05-26)
RECQL5 is a member of the conserved RecQ family of DNA helicases involved in the maintenance of genome stability that is specifically found in higher eukaryotes and associates with the elongating RNA polymerase II. To ...
Artículo
Heterogeneity of DNA damage incidence and repair in different chromatin contexts
(Elsevier, 2021)
It has been long known that some regions of the genome are more susceptible to damage and mutagenicity than others. Recent advances have determined a critical role of chromatin both in the incidence of damage and in its ...