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Artículo
Prognostic value of CtIP/RBBP8 expression in breast cancer
(Wiley Open Access, 2013)
CtIP/RBBP8 is a multifunctional protein involved in transcription, DNA replication, DNA repair by homologous recombination and the G1 and G2 checkpoints. Its multiple roles are controlled by its interaction with several ...
Artículo
Genome-wide analysis of factors affecting transcription elongation and DNA repair: a new role for PAF and Ccr4-not in transcription-coupled repair
(Public Library of Science, 2009)
RNA polymerases frequently deal with a number of obstacles during transcription elongation that need to be removed for transcription resumption. One important type of hindrance consists of DNA lesions, which are removed ...
Artículo
The Helicase PIF1 Facilitates Resection over Sequences Prone to Forming G4 Structures
(Elsevier, 2018)
DNA breaks are complex lesions that can be repaired either by non-homologous end joining (NHEJ) or by homologous recombination (HR). The decision between these two routes of DNA repair is a key point of the DNA damage ...
Artículo
Studying DNA Double-Strand Break Repair: An Ever-Growing Toolbox
(Frontiers Media, 2020)
To ward off against the catastrophic consequences of persistent DNA double-strand breaks (DSBs), eukaryotic cells have developed a set of complex signaling networks that detect these DNA lesions, orchestrate cell cycle ...
Artículo
Xpf suppresses the mutagenic consequences of phagocytosis in Dictyostelium
(The Company of Biologists, 2016)
As time passes, mutations accumulate in the genomes of all living organisms. These changes promote genetic diversity, but also precipitate ageing and the initiation of cancer. Food is a common source of mutagens, but ...
Artículo
Interdependence of the Rad50 hook and globular domain functions
(Elsevier, 2015)
Rad50 contains a conserved Zn2+ coordination domain (the Rad50 hook) that functions as a homodimerization interface. Hook ablation phenocopies Rad50 deficiency in all respects. Here we focused on rad50 mutations flanking ...
Artículo
The Emerging Role of RNA Modifications in DNA Double-Strand Break Repair
(Frontiers Media S.A., 2021)
The correct repair of DNA double-strand breaks is essential for maintaining the stability of the genome, thus ensuring the survival and fitness of any living organism. Indeed, the repair of these lesions is a complicated ...
Artículo
Therapeutic Opportunities of Disrupting Genome Integrity inAdult Diffuse Glioma
(MDPI, 2022)
Adult diffuse glioma, particularly glioblastoma (GBM), is a devastating tumor of the central nervous system. The existential threat of this disease requires on-going treatment to counteract tumor progression. The present ...
Artículo
MRGBP, a member of the NuA4 complex, inhibits DNA double-strand break repair
(Wiley-Blackwell, 2021)
The repair of DNA breaks takes place in the context of chromatin and thus involves the activity of chromatin remodelers. The nucleosome acetyltransferase of H4 (NuA4) remodeler complex enables DNA break repair by relaxing ...
Artículo
Cleavage factor I links transcription termination to DNA damage response and genome integrity maintenance in Saccharomyces cerevisiae
(Public Library of Science, 2014)
During transcription, the nascent pre-mRNA undergoes a series of processing steps before being exported to the cytoplasm. The 3′-end processing machinery involves different proteins, this function being crucial to cell ...