Artículo
Circulating myeloid-derived suppressor cells may be a useful biomarker in the follow-up of unvaccinated COVID-19 patients after hospitalization
Autor/es | Jiménez Cortegana, Carlos
Salamanca, Elena Palazón Carrión, Natalia Sánchez Jiménez, Flora Pérez Pérez, Antonio Vilariño García, Teresa Gutiérrez Gutiérrez, Belén Garnacho Montero, José Cruz Merino, Luis de la Rodríguez-Baño, Jesús Sánchez Margalet, Víctor |
Departamento | Universidad de Sevilla. Departamento de Medicina Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología |
Fecha de publicación | 2023 |
Fecha de depósito | 2024-03-01 |
Publicado en |
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Premios | Premio Mensual Publicación Científica Destacada de la US. Facultad de Medicina |
Resumen | SARS-CoV-2 infection is the cause of the disease named COVID-19, a major
public health challenge worldwide. Differences in the severity, complications and
outcomes of the COVID-19 are intriguing and, patients with similar ... SARS-CoV-2 infection is the cause of the disease named COVID-19, a major public health challenge worldwide. Differences in the severity, complications and outcomes of the COVID-19 are intriguing and, patients with similar baseline clinical conditions may have very different evolution. Myeloid-derived suppressor cells (MDSCs) have been previously found to be recruited by the SARS-CoV-2 infection and may be a marker of clinical evolution in these patients. We have studied 90 consecutive patients admitted in the hospital before the vaccination program started in the general population, to measure MDSCs and lymphocyte subpopulations at admission and one week after to assess the possible association with unfavorable outcomes (dead or Intensive Care Unit admission). We analyzed MDSCs and lymphocyte subpopulations by flow cytometry. In the 72 patients discharged from the hospital, there were significant decreases in the monocytic and total MDSC populations measured in peripheral blood after one week but, most importantly, the number of MDSCs (total and both monocytic and granulocytic subsets) were much higher in the 18 patients with unfavorable outcome. In conclusion, the number of circulating MDSCs may be a good marker of evolution in the follow-up of unvaccinated patients admitted in the hospital with the diagnosis of COVID-19. |
Cita | Jiménez Cortegana, C., Salamanca, E., Palazón Carrión, N., Sánchez Jiménez, F., Pérez Pérez, A., Vilariño García, T.,...,Sánchez Margalet, V. (2023). Circulating myeloid-derived suppressor cells may be a useful biomarker in the follow-up of unvaccinated COVID-19 patients after hospitalization. Frontiers in Immunology, 14, 1266659. https://doi.org/10.3389/fimmu.2023.1266659. |
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