Artículos (Medicina)
Envíos recientes
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Artículo
Pembrolizumab versus placebo as adjuvant therapy in resected stage IIB or IIC melanoma: Outcomes in histopathologic subgroups from the randomized, double-blind, phase 3 KEYNOTE-716 trial
(BMC, 2024)Background Adjuvant pembrolizumab significantly improved recurrence-free survival (RFS) and distant metastasis-free survival ...
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Performance of a Point-of-Care Test for Infliximab Levels in Patients with Inflammatory Bowel Disease: A Comparison to ELISA
(Springer, 2023-11-09)Background Therapeutic drug monitoring of infliximab levels in patients with inflammatory bowel disease (IBD) optimizes ...
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Evaluation of temocillin efficacy against KPC-2-producing Klebsiella pneumoniae isolates in a hollow-fibre infection model
(Oxford University Press, 2024-02-09)Background: Temocillin is an old antimicrobial that is resistant to hydrolysis by ESBLs but has variable activity against ...
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Safety and efficacy of colistin versus meropenem in the empirical treatment of ventilator-associated pneumonia as part of a macro-project funded by the Seventh Framework Program of the European Commission studying off-patent antibiotics: study protocol for a randomized controlled trial
(BMC, 2015)Background Ventilator-associated pneumonia (VAP) is one of the most common and severe hospital-adquired infections, and ...
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Sam68 Mediates the Activation of Insulin and Leptin Signalling in Breast Cancer Cells
(Public Library Science, 2016)Obesity is a well-known risk factor for breast cancer development in postmenopausal women. High insulin and leptin levels ...
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Clinical features of serous retinopathy observed with cobimetinib in patients with BRAF‑mutated melanoma treated in the randomized coBRIM study
(Biomed Central LTD, 2017)Background: Serous chorioretinopathy has been associated with MEK inhibitors, including cobimetinib. We describe the ...
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SEOM clinical guideline for the management of malignant melanoma (2017)
(Springer Int Publ Ag, 2018)All melanoma suspected patients must be con firmed histologically and resected. Sentinel node biopsy must be done when ...
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nab-Paclitaxel plus carboplatin or gemcitabine versus gemcitabine plus carboplatin as first-line treatment of patients with triple-negative metastatic breast cancer: results from the tnAcity trial
(Oxford University Press, 2018)Background: Metastatic triple-negative breast cancer (mTNBC) has a poor prognosis and aggressive clinical course. tnAcity ...
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High incidence of pandrug-resistant Acinetobacter baumannii isolates collected from patients with ventilator-associated pneumonia in Greece, Italy and Spain as part of the MagicBullet clinical trial
(Oxford Academic, 2017-12)Objectives: To investigate the molecular epidemiology, antimicrobial susceptibility and carbapenem resistance determinants ...
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Predicting response to checkpoint inhibitors in melanoma beyond PD-L1 and mutational burden
(BMC, 2018)Background: Immune checkpoint inhibitors (ICIs) have changed the clinical management of melanoma. However, not all patients ...
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Health-related quality of life impact of cobimetinib in combination with vemurafenib in patients with advanced or metastatic BRAFV600 mutation–positive melanoma
(Nature publishing group, 2018)Background: In the coBRIM study, cobimetinib plus vemurafenib (C þ V) significantly improved survival outcomes vs placebo ...
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The efficacy and safety of granulocyte colony-stimulating factor in the treatment of acute-on-chronic liver failure: A systematic review and meta-analysis
(Public Library Science, 2023-11-30)Background and objectives The safety and efficacy of granulocyte-colony stimulating factor (G-CSF) for the treatment of ...
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2018 consensus statement by the Spanish Society of Pathology and the Spanish Society of Medical Oncology on the diagnosis and treatment of cancer of unknown primary
(Springer, 2018)Cancer of unknown primary (CUP) is defned as a heterogeneous group of tumours that present with metastasis, and in which ...
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Inhibition of adenovirus transport from the endosome to the cell nucleus by rotenone
(Frontiers Media S.A., 2024-01-24)Regardless of the clinical impact of human adenovirus (HAdV) infections in the healthy population and its high morbidity ...
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Identification of Potential miRNA-mRNA Regulatory Axis of Intrahepatic cccDNA in Patients with Chronic Hepatitis B Virus Infection in the Grey Zone
(BRIEFLAND, 2023)Background: Intrahepatic covalently closed circular DNA (cccDNA) plays a critical role in the life cycle of the hepatitis ...
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Unraveling transformation of follicular lymphoma to diffuse large B-cell lymphoma
(Public Library Science, 2019)Follicular lymphoma (FL) is an indolent but largely incurable disease. Some patients suffer histological transformation ...
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The tumour microenvironment as an integrated framework to understand cancer biology
(Elsevier Ireland Ltd, 2019)Cancer cells all share the feature of being immersed in a complex environment with altered cell-cell/cell-ex tracellular ...
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SEOM clinical guidelines in advanced and recurrent breast cancer (2018)
(Springer, 2019)Although the metastasic breast cancer is still an incurable disease, recent advances have increased signifcantly the time ...
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Virulence role of the outer membrane protein CarO in carbapenem-resistant Acinetobacter baumannii
(Taylor and Francis, 2020)Novel approaches to treat carbapenem-resistant Acinetobacter baumannii (CRAB) infections are urgently needed and anti-virulence ...
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Next generation sequencing of PD-L1 for predicting response to immune checkpoint inhibitors
(BMC, 2019)Background PD-L1 immunohistochemistry (IHC) has been traditionally used for predicting clinical responses to immune ...