Por motivos de mantenimiento se ha deshabilitado el inicio de sesión temporalmente. Rogamos disculpen las molestias.
Perfil del autor: Sánchez Margalet, Víctor
Datos institucionales
| Nombre | Sánchez Margalet, Víctor |
| Departamento | Bioquímica Médica y Biología Molecular e Inmunología |
| Área de conocimiento | Bioquímica y Biología Molecular |
| Categoría profesional | Catedrático de Universidad (V) |
| Correo electrónico | Solicitar |
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Estadísticas
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Nº publicaciones
60
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Nº visitas
9271
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Nº descargas
13599
| Publicaciones |
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Artículo
 Dendritic cells: the yin and yang in disease progression
(Frontiers Media, 2024)
Dendritic cells (DCs) are antigen presenting cells that link innate and adaptive immunity. DCs have been historically ... |
Artículo
Cancer nano-immunotherapy: the novel and promising weapon to fight cancer
(Mdpi Ag, 2024)
Cancer is a complex disease that, despite advances in treatment and the greater understanding of the tumor biology until ... |
Artículo
The Expression of Genes Related to Reverse Cholesterol Transport and Leptin Receptor Pathways in Peripheral Blood Mononuclear Cells Are Decreased in Morbid Obesity and Related to Liver Function
(MDPI, 2024)
Obesity is frequently accompanied by non-alcoholic fatty liver disease (NAFLD). These two diseases are associated with ... |
Artículo
Tissue-specific activated regulatory lymphocytes immunophenotype in chronic rhinosinusitis with nasal polyps
(EDICIONES DOYMA S A, 2023)
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Artículo
Pembrolizumab in combination with gemcitabine for patients with HER2-negative advanced breast cancer: GEICAM/2015–04 (PANGEA-Breast) study
(BMC, 2023)
Background: We evaluated a new chemoimmunotherapy combination based on the anti-PD1 monoclonal antibody pembrolizumab and ... |
Artículo
Defining the Emergence of New Immunotherapy Approaches in Breast Cancer: Role of Myeloid-Derived Suppressor Cells
(Mdpi Ag, 2023)
Breast cancer (BC) continues to be the most diagnosed tumor in women and a very heterogeneous disease both inter- and ... |
Artículo
 Circulating myeloid-derived suppressor cells may be a useful biomarker in the follow-up of unvaccinated COVID-19 patients after hospitalization
(Frontiers Media S.A., 2023)
SARS-CoV-2 infection is the cause of the disease named COVID-19, a major public health challenge worldwide. Differences ... |
Artículo
Role of Leptin as a Link between Asthma and Obesity: A Systematic Review and Meta-Analysis
(MDPI, 2022)
Asthma and obesity are considered as highly prevalent diseases with a great impact on public health. Obesity has been ... |
Artículo
Obesity and Risk for Lymphoma: Possible Role of Leptin
(MDPI, 2022)
Obesity, which is considered a pandemic due to its high prevalence, is a risk factor for many types of cancers, including ... |
Artículo
The effects of dendritic cell-based vaccines in the tumor microenvironment Impact on myeloid-derived suppressor cells
(Frontiers Media, 2022)
Dendritic cells (DCs) are a heterogenous population of professional antigen presenting cells whose main role is diminished ... |
Artículo
Ewing Sarcoma Meets Epigenetics, Immunology and Nanomedicine: Moving Forward into Novel Therapeutic Strategies
(MDPI, 2022)
Ewing Sarcoma (EWS) is an aggressive bone and soft tissue tumor that mainly affects children, adolescents, and young adults. ... |
Artículo
Myeloid-derived suppressor cells and vaccination against pathogens
(Frontiers Media, 2022)
It is widely accepted that the immune system includes molecular and cellular components that play a role in regulating and ... |
Artículo
Decreased Expression of Sam68 Is Associated with Insulin Resistance in Granulosa Cells from PCOS Patients
(MDPI, 2022)
Background and objective: Polycystic ovary syndrome (PCOS) is a complex metabolic disorder associated with ovulatory ... |
Tesis Doctoral
Immune Biomarkers In Peripheral Blood In Patients With HER2 Negative Advanced Breast Cancer Treated With A Chemoimmunotherapy Schedule Based On Pembrolizumab And Gemcitabine. – Translational Substudy Of The PANGEA- Breast Cancer Trial (GEICAM/2015-04)
(2022)
Within the last years, immune checkpoint inhibitors (ICI) have constituted a major breakthrough in cancer research. These ... |
Artículo
Leptin in Dental Pulp and Periapical Tissues: A Narrative Review
(MDPI, 2022)
Abstract: Leptin is a non-glycosylated 16 kDa protein synthesized mainly in adipose cells. The main function of leptin is ... |
Artículo
Obesity as a Risk Factor for Dementia and Alzheimer’s Disease: The Role of Leptin
(MDPI AG, 2022)
Obesity is a growing worldwide health problem, affecting many people due to excessive saturated fat consumption, lack of ... |
Artículo
Low levels of granulocytic myeloid-derived suppressor cells may be a good marker of survival in the follow-up of patients with severe COVID-19
(Frontiers Media S.A., 2022)
Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a disease (coronavirus disease 2019, ... |
Artículo
Tumor Immune Microenvironment in Lymphoma: Focus on Epigenetics
(MDPI, 2022)
Lymphoma is a neoplasm arising from B or T lymphocytes or natural killer cells characterized by clonal lymphoproliferation. ... |
Artículo
Lenalidomide plus R-GDP (R2-GDP) in Relapsed/ Refractory Diffuse Large B-Cell Lymphoma: Final Results of the R2-GDP-GOTEL Trial and Immune Biomarker Subanalysis
(AMER ASSOC CANCER RESEARCH, 2022)
Purpose: New therapeutic options are needed in relapsed/refrac tory diffuse large B-cell lymphoma (R/R DLBCL). Lenalidomide ... |
Artículo
Nutrients and Dietary Approaches in Patients with Type 2 Diabetes Mellitus and Cardiovascular Disease: A Narrative Review
(MDPI, 2021)
Cardiovascular disease (CVD) is the most common cause of morbidity and mortality in developed countries. The prevalence ... |
Artículo
Possible Role of Leptin in Atopic Dermatitis: A Literature Review
(MDPI, 2021)
Atopic dermatitis (AD) is the most frequent chronic inflammatory skin disease, and its incidence has been rapidly increasing ... |
Artículo
Pembrolizumab Plus Gemcitabine in the Subset of Triple-Negative Advanced Breast Cancer Patients in the GEICAM/2015-04 (PANGEA-Breast) Study
(MDPI, 2021)
The PANGEA-Breast trial evaluated a new chemo-immunotherapeutic combination that would synergistically induce long-term ... |
Tesis Doctoral
Papel de la leptina y su resistencia en el síndrome de ovario poliquístico y la diabetes gestacional
(2021)
La resistencia a la insulina y el síndrome metabólico al que se asocia es un problema sociosanitario de primer nivel. En ... |
Artículo
Lower Survival and Increased Circulating Suppressor Cells in Patients with Relapsed/Refractory Diffuse Large B-Cell Lymphoma with Deficit of Vitamin D Levels Using R-GDP Plus Lenalidomide (R2-GDP): Results from the R2-GDP-GOTEL Trial
(MDPI, 2021)
The search of prognostic factors is a priority in diffuse large B-cell lymphoma (DLBCL) due to its aggressiveness. We have ... |
Artículo
Circulating immune biomarkers in peripheral blood correlate with clinical outcomes in advanced breast cancer
(Nature Publishing Group, 2021)
Identification of the different elements intervening at the tumor microenvironment seems key to explain clinical evolution ... |
Artículo
Role of leptin in non-alcoholic fatty liver disease
(MDPI, 2021)
Non-alcoholic fatty liver disease (NAFLD), which affects about a quarter of the global population, poses a substantial ... |
Tesis Doctoral
Análisis del perfil de respuesta inmune en sangre periférica inducido por tratamiento sistémico en el carcinoma de mama avanzado
(2021)
La identificación de los diferentes elementos que intervienen en el proceso de inmunoedición, parece clave para explicar ... |
Artículo
Stem cells and COVID-19: are the human amniotic cells a new hope for therapies against the SARS-CoV-2 virus?
(BMC, 2021)
A new coronavirus respiratory disease (COVID-19) caused by the SARS-CoV-2 virus, surprised the entire world, producing ... |
Artículo
Leptin, both bad and good actor in cancer
(MDPI, 2021)
Leptin is an important regulator of basal metabolism and food intake, with a pivotal role in obesity. Leptin exerts many ... |
Artículo
Circulating myeloid-derived suppressor cells and regulatory T cells as immunological biomarkers in refractory/relapsed diffuse large B-cell lymphoma: translational results from the R2-GDP-GOTEL trial
(BMJ, 2021)
Background The search for immunological markers with ability of predicting clinical outcome is a priority in lymphomas, ... |
Artículo
Circulating immune biomarkers in peripheral blood correlate with clinical outcomes in advanced breast cancer
(Nature publishing group, 2021)
Identifcation of the diferent elements intervening at the tumor microenvironment seems key to explain clinical evolution ... |
Artículo
Stem cells and COVID-19: are the human amniotic cells a new hope for therapies against the SARS-CoV-2 virus?
(BMC, 2021)
A new coronavirus respiratory disease (COVID-19) caused by the SARS-CoV-2 virus, surprised the entire world, producing ... |
Artículo
Role of leptin in inflammation and vice versa
(2020)
Inflammation is an essential immune response for the maintenance of tissue homeostasis. In a general sense, acute and ... |
Tesis Doctoral
Estudio poblaciones celulares en pacientes con linfoma difuso de células B grandes refractarios o en recaída: papel de las células supresoras de origen mieloide en respuesta al tratamiento R2-GDP
(2020)
La inmunoedición, que se caracteriza por el escape que realizan las células malignas de la inmunovigilancia antitumoral, ... |
Artículo
Leptin and Nutrition in Gestational Diabetes
(MPDI, 2020)
Leptin is highly expressed in the placenta, mainly by trophoblastic cells, where it has an important autocrine trophic ... |
Artículo
Sam68 mediates leptin signaling and action in human granulosa cells: possible role in leptin resistance in PCOS
(BioScientifica, 2020)
Introduction: Polycystic ovary syndrome (PCOS) is a complex metabolic disorder associated with ovulatory dysfunction, ... |
Artículo
Screening for Gestational Diabetes Mellitus by Measuring Glycated Hemoglobin Can Reduce the Use of the Glucose Challenge Test
(Korean Society for Laboratory Medicine, 2019)
Background: Physiological changes during pregnancy, such as dilutional anemia and a reduced half-life of red blood cells, ... |
Artículo
Human amniotic membrane conditioned medium inhibits proliferation and modulates related microRNAs expression in hepatocarcinoma cell
(2019)
The placental stem cells have called the focus of attention for their therapeutic potential to treat diferent diseases, ... |
Artículo
Obesity and Breast Cancer: Role of Leptin
(2019)
Obesity-related breast cancer is an important threat that affects especially post-menopausal women. The link between obesity ... |
Artículo
Circulating regulatory T cells from breast cancer patients in response to neoadjuvant chemotherapy
(Amer Publ Co, 2019)
Background: Immune escape of tumor cells is a new hallmark of cancer in general, and breast cancer, in particular. Previous ... |
Tesis Doctoral
Cálculo de un índice de riesgo de padecer diabetes gestacional para su uso como cribado universal.
(2018)
Título:Cálculo de un índice de riesgo de padecer diabetes gestacional para su uso como cribado universal. Introducción: ... |
Tesis Doctoral
Prevalencia del déficit de vitamina D y significado pronóstico en pacientes ancianos ingresados por síndrome coronario agudo.
(2018)
Introducción: La deficiencia de vitamina D (25-OH-VITD) se ha relacionado con la génesis de la ateroesclerosis coronaria ... |
Tesis Doctoral
Evaluación de los resultados en salud tras la implementación de la tromboelastometría rotacional en pacientes sometidos a cirugía cardiovascular con circulación extracorpórea.
(2018)
La cirugía cardiovascular asociada a circulación extracorpórea ocasiona importantes trastornos en el sistema hemostático. ... |
Artículo
Leptin action in normal and pathological pregnancies
(2018)
Leptin is now considered an important signalling molecule of the reproductive system, as it regulates the production of ... |
Tesis Doctoral
Papel de SAM68 en la diferenciación del adipocito
(2017)
Sam68, sustrato de Src en mitosis, es una proteína STAR (transductor de señales y activador del metabolismo de ARN) que ... |
Artículo
Sam68 Mediates the Activation of Insulin and Leptin Signalling in Breast Cancer Cells
(Public Library Science, 2016)
Obesity is a well-known risk factor for breast cancer development in postmenopausal women. High insulin and leptin levels ... |
Tesis Doctoral
Leptina y su receptor en tejido dental humano sano e inflamado
(2014)
Uno de los aspectos más interesantes a los que en la actualidad se enfrenta la comunidad científica médica y odontológica ... |
Artículo
Role of Sam68 in post-transcriptional gene regulation
(MDPI AG, 2013)
The STAR family of proteins links signaling pathways to various aspects of post-transcriptional regulation and processing ... |
Artículo
New insights into the role of the immune microenvironment in breast carcinoma
(2013)
Recently, immune edition has been recognized as a new hallmark of cancer. In this respect, some clinical trials in breast ... |
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Tesis Doctoral
Epigenética de los procesos de autorrenovación, pluripotencialidad y diferenciación de las células troncales
(2010)
El objetivo general de esta tesis ha sido definir la importancia que poseen los procesos epigenéticos sobre el mantenimiento ... |
Tesis Doctoral
Importancia de la calidad analítica con método POCT para el seguimiento estricto de la glucemia capilar
(2010)
El uso del control estricto de la glucemia está muy extendido en los protocolos hospitalarios, sobre todo en las unidades ... |
Tesis Doctoral
Acción y mecanismo de acción de la leptina humana en la placenta
(2007)
La Leptina no es sólo una hormona del tejido adiposo que regula la ingesta y el gasto energético a nivel central, sino que ... |
Tesis Doctoral
Mecanismos de inmunomodulación de la leptina en células T Jurkat
(2006)
La leptina no es sólo una hormona del tejido adiposo que regula la ingesta y el gasto energético a nivel central, sino que ... |
Tesis Doctoral
Leptina. Estudio sobre el estrés oxidativo y la vía de señalización celular en monocitos de pacientes VIH positivos
(2006)
El descubrimiento de la leptina ha arrojado luz en la compleja biología del tejido adiposo. En contra de la visión previa ... |
Artículo
Efecto de la fecha de siembra en el crecimiento, producción y componentes del rendimiento del altramuz blanco
(Asociación Interprofesional para el Desarrollo Agrario, 2002)
Se estudió el efecto de la fecha de siembra de L. a/bus cv. Multolupa sobre el crecimiento, producción y componentes de ... |
Artículo
Extra virgin olive oil-enriched diets protects the NSAID-induced gastric damage in rats: Role of leukocyte adherence
(Publishing House Zaslavsky, 1998)
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Tesis Doctoral
Papel de la pancreastatina en la homeostasis de la glucosa
(1991)
La pancreastatina, un péptido de 49 aminoacidos, fue Aislada del páncreas porcino en diciembre de 1986, se Encuentra ... |