Author profile: Sánchez Margalet, Víctor
Institutional data
| Name | Sánchez Margalet, Víctor |
| Department | Bioquímica Médica y Biología Molecular e Inmunología |
| Knowledge area | Bioquímica y Biología Molecular |
| Professional category | Catedrático de Universidad (V) |
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Statistics
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No. publications
48
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No. visits
5940
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No. downloads
7976
| Publications |
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Article
 Role of Leptin as a Link between Asthma and Obesity: A Systematic Review and Meta-Analysis
(MDPI, 2022-12-29)
Asthma and obesity are considered as highly prevalent diseases with a great impact on public health. Obesity has been ... |
Article
Obesity and Risk for Lymphoma: Possible Role of Leptin
(MDPI, 2022-12-08)
Obesity, which is considered a pandemic due to its high prevalence, is a risk factor for many types of cancers, including ... |
Article
The effects of dendritic cell-based vaccines in the tumor microenvironment Impact on myeloid-derived suppressor cells
(Frontiers Media, 2022-11-15)
Dendritic cells (DCs) are a heterogenous population of professional antigen presenting cells whose main role is diminished ... |
Article
Ewing Sarcoma Meets Epigenetics, Immunology and Nanomedicine: Moving Forward into Novel Therapeutic Strategies
(MDPI, 2022-11-07)
Ewing Sarcoma (EWS) is an aggressive bone and soft tissue tumor that mainly affects children, adolescents, and young adults. ... |
Article
Myeloid-derived suppressor cells and vaccination against pathogens
(Frontiers Media, 2022-09-29)
It is widely accepted that the immune system includes molecular and cellular components that play a role in regulating and ... |
Article
Decreased Expression of Sam68 Is Associated with Insulin Resistance in Granulosa Cells from PCOS Patients
(MDPI, 2022-09-09)
Background and objective: Polycystic ovary syndrome (PCOS) is a complex metabolic disorder associated with ovulatory ... |
PhD Thesis
 Immune Biomarkers In Peripheral Blood In Patients With HER2 Negative Advanced Breast Cancer Treated With A Chemoimmunotherapy Schedule Based On Pembrolizumab And Gemcitabine. – Translational Substudy Of The PANGEA- Breast Cancer Trial (GEICAM/2015-04)
(2022-03-31)
Within the last years, immune checkpoint inhibitors (ICI) have constituted a major breakthrough in cancer research. These ... |
Article
Leptin in Dental Pulp and Periapical Tissues: A Narrative Review
(MDPI, 2022-02-11)
Abstract: Leptin is a non-glycosylated 16 kDa protein synthesized mainly in adipose cells. The main function of leptin is ... |
Article
Obesity as a Risk Factor for Dementia and Alzheimer’s Disease: The Role of Leptin
(MDPI AG, 2022-01-01)
Obesity is a growing worldwide health problem, affecting many people due to excessive saturated fat consumption, lack of ... |
Article
Lenalidomide plus R-GDP (R2-GDP) in Relapsed/ Refractory Diffuse Large B-Cell Lymphoma: Final Results of the R2-GDP-GOTEL Trial and Immune Biomarker Subanalysis
(AMER ASSOC CANCER RESEARCH, 2022-01-01)
Purpose: New therapeutic options are needed in relapsed/refrac tory diffuse large B-cell lymphoma (R/R DLBCL). Lenalidomide ... |
Article
Low levels of granulocytic myeloid-derived suppressor cells may be a good marker of survival in the follow-up of patients with severe COVID-19
(Frontiers Media S.A., 2022-01-01)
Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a disease (coronavirus disease 2019, ... |
Article
Tumor Immune Microenvironment in Lymphoma: Focus on Epigenetics
(MDPI, 2022-01-01)
Lymphoma is a neoplasm arising from B or T lymphocytes or natural killer cells characterized by clonal lymphoproliferation. ... |
Article
Nutrients and Dietary Approaches in Patients with Type 2 Diabetes Mellitus and Cardiovascular Disease: A Narrative Review
(MDPI, 2021-11-19)
Cardiovascular disease (CVD) is the most common cause of morbidity and mortality in developed countries. The prevalence ... |
Article
Possible Role of Leptin in Atopic Dermatitis: A Literature Review
(MDPI, 2021-11-05)
Atopic dermatitis (AD) is the most frequent chronic inflammatory skin disease, and its incidence has been rapidly increasing ... |
Article
Pembrolizumab Plus Gemcitabine in the Subset of Triple-Negative Advanced Breast Cancer Patients in the GEICAM/2015-04 (PANGEA-Breast) Study
(MDPI, 2021-10-29)
The PANGEA-Breast trial evaluated a new chemo-immunotherapeutic combination that would synergistically induce long-term ... |
PhD Thesis
Papel de la leptina y su resistencia en el síndrome de ovario poliquístico y la diabetes gestacional
(2021-10-06)
La resistencia a la insulina y el síndrome metabólico al que se asocia es un problema sociosanitario de primer nivel. En ... |
Article
Lower Survival and Increased Circulating Suppressor Cells in Patients with Relapsed/Refractory Diffuse Large B-Cell Lymphoma with Deficit of Vitamin D Levels Using R-GDP Plus Lenalidomide (R2-GDP): Results from the R2-GDP-GOTEL Trial
(MDPI, 2021-09-15)
The search of prognostic factors is a priority in diffuse large B-cell lymphoma (DLBCL) due to its aggressiveness. We have ... |
Article
Circulating immune biomarkers in peripheral blood correlate with clinical outcomes in advanced breast cancer
(Nature Publishing Group, 2021-07-13)
Identification of the different elements intervening at the tumor microenvironment seems key to explain clinical evolution ... |
Article
Role of leptin in non-alcoholic fatty liver disease
(MDPI, 2021-06-30)
Non-alcoholic fatty liver disease (NAFLD), which affects about a quarter of the global population, poses a substantial ... |
PhD Thesis
Análisis del perfil de respuesta inmune en sangre periférica inducido por tratamiento sistémico en el carcinoma de mama avanzado
(2021-06-09)
La identificación de los diferentes elementos que intervienen en el proceso de inmunoedición, parece clave para explicar ... |
Article
Stem cells and COVID-19: are the human amniotic cells a new hope for therapies against the SARS-CoV-2 virus?
(BMC, 2021-03-01)
A new coronavirus respiratory disease (COVID-19) caused by the SARS-CoV-2 virus, surprised the entire world, producing ... |
Article
Leptin, both bad and good actor in cancer
(MDPI, 2021-01-01)
Leptin is an important regulator of basal metabolism and food intake, with a pivotal role in obesity. Leptin exerts many ... |
Article
Circulating myeloid-derived suppressor cells and regulatory T cells as immunological biomarkers in refractory/relapsed diffuse large B-cell lymphoma: translational results from the R2-GDP-GOTEL trial
(BMJ, 2021-01-01)
Background The search for immunological markers with ability of predicting clinical outcome is a priority in lymphomas, ... |
Article
Stem cells and COVID-19: are the human amniotic cells a new hope for therapies against the SARS-CoV-2 virus?
(BMC, 2021-01-01)
A new coronavirus respiratory disease (COVID-19) caused by the SARS-CoV-2 virus, surprised the entire world, producing ... |
Article
Role of leptin in inflammation and vice versa
(2020-08-16)
Inflammation is an essential immune response for the maintenance of tissue homeostasis. In a general sense, acute and ... |
PhD Thesis
Estudio poblaciones celulares en pacientes con linfoma difuso de células B grandes refractarios o en recaída: papel de las células supresoras de origen mieloide en respuesta al tratamiento R2-GDP
(2020-07-13)
La inmunoedición, que se caracteriza por el escape que realizan las células malignas de la inmunovigilancia antitumoral, ... |
Article
Leptin and Nutrition in Gestational Diabetes
(MPDI, 2020-07-02)
Leptin is highly expressed in the placenta, mainly by trophoblastic cells, where it has an important autocrine trophic ... |
Article
Human amniotic membrane conditioned medium inhibits proliferation and modulates related microRNAs expression in hepatocarcinoma cell
(2019-10-02)
The placental stem cells have called the focus of attention for their therapeutic potential to treat diferent diseases, ... |
Article
Obesity and Breast Cancer: Role of Leptin
(2019-07-18)
Obesity-related breast cancer is an important threat that affects especially post-menopausal women. The link between obesity ... |
PhD Thesis
Cálculo de un índice de riesgo de padecer diabetes gestacional para su uso como cribado universal.
(2018-07-18)
Título:Cálculo de un índice de riesgo de padecer diabetes gestacional para su uso como cribado universal. Introducción: ... |
PhD Thesis
Prevalencia del déficit de vitamina D y significado pronóstico en pacientes ancianos ingresados por síndrome coronario agudo.
(2018-06-19)
Introducción: La deficiencia de vitamina D (25-OH-VITD) se ha relacionado con la génesis de la ateroesclerosis coronaria ... |
PhD Thesis
Evaluación de los resultados en salud tras la implementación de la tromboelastometría rotacional en pacientes sometidos a cirugía cardiovascular con circulación extracorpórea.
(2018-03-12)
La cirugía cardiovascular asociada a circulación extracorpórea ocasiona importantes trastornos en el sistema hemostático. ... |
Article
Leptin action in normal and pathological pregnancies
(2018-01-01)
Leptin is now considered an important signalling molecule of the reproductive system, as it regulates the production of ... |
PhD Thesis
Papel de SAM68 en la diferenciación del adipocito
(2017-09-22)
Sam68, sustrato de Src en mitosis, es una proteína STAR (transductor de señales y activador del metabolismo de ARN) que ... |
PhD Thesis
 Leptina y su receptor en tejido dental humano sano e inflamado
(2014-09-24)
Uno de los aspectos más interesantes a los que en la actualidad se enfrenta la comunidad científica médica y odontológica ... |
Article
Role of Sam68 in post-transcriptional gene regulation
(MDPI AG, 2013-11-28)
The STAR family of proteins links signaling pathways to various aspects of post-transcriptional regulation and processing ... |
Article
New insights into the role of the immune microenvironment in breast carcinoma
(2013-01-01)
Recently, immune edition has been recognized as a new hallmark of cancer. In this respect, some clinical trials in breast ... |
| Article |
Article
Role of leptin in the activation of immune cells
(2010-01-01)
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PhD Thesis
Epigenética de los procesos de autorrenovación, pluripotencialidad y diferenciación de las células troncales
(2010-01-01)
El objetivo general de esta tesis ha sido definir la importancia que poseen los procesos epigenéticos sobre el mantenimiento ... |
PhD Thesis
Importancia de la calidad analítica con método POCT para el seguimiento estricto de la glucemia capilar
(2010-01-01)
El uso del control estricto de la glucemia está muy extendido en los protocolos hospitalarios, sobre todo en las unidades ... |
PhD Thesis
Acción y mecanismo de acción de la leptina humana en la placenta
(2007-06-28)
La Leptina no es sólo una hormona del tejido adiposo que regula la ingesta y el gasto energético a nivel central, sino que ... |
PhD Thesis
Mecanismos de inmunomodulación de la leptina en células T Jurkat
(2006-07-04)
La leptina no es sólo una hormona del tejido adiposo que regula la ingesta y el gasto energético a nivel central, sino que ... |
PhD Thesis
Leptina. Estudio sobre el estrés oxidativo y la vía de señalización celular en monocitos de pacientes VIH positivos
(2006-06-13)
El descubrimiento de la leptina ha arrojado luz en la compleja biología del tejido adiposo. En contra de la visión previa ... |
Article
Efecto de la fecha de siembra en el crecimiento, producción y componentes del rendimiento del altramuz blanco
(Asociación Interprofesional para el Desarrollo Agrario, 2002-01-01)
Se estudió el efecto de la fecha de siembra de L. a/bus cv. Multolupa sobre el crecimiento, producción y componentes de ... |
Article
Extra virgin olive oil-enriched diets protects the NSAID-induced gastric damage in rats: Role of leukocyte adherence
(Publishing House Zaslavsky, 1998-04-01)
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| Article |
PhD Thesis
Papel de la pancreastatina en la homeostasis de la glucosa
(1991-07-05)
La pancreastatina, un péptido de 49 aminoacidos, fue Aislada del páncreas porcino en diciembre de 1986, se Encuentra ... |