Leptin, both bad and good actor in cancer
|Author/s||Jiménez Cortegana, Carlos
Sánchez Jiménez, Flora
Pérez Pérez, Antonio
Castiñeiras Fernández, Jesús
Virizuela-Echaburu, Juan A.
Cruz Merino, Luis de la
Sánchez Margalet, Víctor
|Department||Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología
Universidad de Sevilla. Departamento de Cirugía
Universidad de Sevilla. Departamento de Medicina
|Abstract||Leptin is an important regulator of basal metabolism and food intake, with a pivotal role in obesity. Leptin exerts many different actions on various tissues and systems, including cancer, and is considered as a linkage ...
Leptin is an important regulator of basal metabolism and food intake, with a pivotal role in obesity. Leptin exerts many different actions on various tissues and systems, including cancer, and is considered as a linkage between metabolism and the immune system. During the last decades, obesity and leptin have been associated with the initiation, proliferation and progression of many types of cancer. Obesity is also linked with complications and mortality, irrespective of the therapy used, affecting clinical outcomes. However, some evidence has suggested its beneficial role, called the “obesity paradox”, and the possible antitumoral role of leptin. Recent data regarding the immunotherapy of cancer have revealed that overweight leads to a more effective response and leptin may probably be involved in this beneficial process. Since leptin is a positive modulator of both the innate and the adaptive immune system, it may contribute to the increased immune response stimulated by immunotherapy in cancer patients and may be proposed as a good actor in cancer. Our purpose is to review this dual role of leptin in cancer, as well as trying to clarify the future perspectives of this adipokine, which further highlights its importance as a cornerstone of the immunometabolism in oncology.
|Funding agencies||Asociacion Cambia el Guion
Asociacion Lazo Rosa
Asociacion Verenia Sta Agueda de Brenes
|Citation||Jiménez Cortegana, C., López-Saavedra, A., Sánchez Jiménez, F., Pérez Pérez, A., Castiñeiras Fernández, J., Virizuela-Echaburu, J.A.,...,Sánchez Margalet, V. (2021). Leptin, both bad and good actor in cancer. https://doi.org/10.3390/biom11060913.|
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