Author profile: Cruz Merino, Luis de la
Institutional data
| Name | Cruz Merino, Luis de la |
| Department | Medicina |
| Knowledge area | Medicina |
| Professional category | Profesor Asociado CIS |
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Statistics
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No. publications
30
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No. visits
1552
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No. downloads
1089
| Publications |
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Article
 Obesity and Risk for Lymphoma: Possible Role of Leptin
(MDPI, 2022-12-08)
Obesity, which is considered a pandemic due to its high prevalence, is a risk factor for many types of cancers, including ... |
Article
The effects of dendritic cell-based vaccines in the tumor microenvironment Impact on myeloid-derived suppressor cells
(Frontiers Media, 2022-11-15)
Dendritic cells (DCs) are a heterogenous population of professional antigen presenting cells whose main role is diminished ... |
Article
Ewing Sarcoma Meets Epigenetics, Immunology and Nanomedicine: Moving Forward into Novel Therapeutic Strategies
(MDPI, 2022-11-07)
Ewing Sarcoma (EWS) is an aggressive bone and soft tissue tumor that mainly affects children, adolescents, and young adults. ... |
PhD Thesis
 Immune Biomarkers In Peripheral Blood In Patients With HER2 Negative Advanced Breast Cancer Treated With A Chemoimmunotherapy Schedule Based On Pembrolizumab And Gemcitabine. – Translational Substudy Of The PANGEA- Breast Cancer Trial (GEICAM/2015-04)
(2022-03-31)
Within the last years, immune checkpoint inhibitors (ICI) have constituted a major breakthrough in cancer research. These ... |
Article
Genes involved in immune reinduction may constitute biomarkers of response for metastatic melanoma patients treated with targeted therapy
(MDPI, 2022-01-01)
Targeted therapy in metastatic melanoma often achieves a major tumour regression response and significant long-term survival ... |
Article
Lenalidomide plus R-GDP (R2-GDP) in Relapsed/ Refractory Diffuse Large B-Cell Lymphoma: Final Results of the R2-GDP-GOTEL Trial and Immune Biomarker Subanalysis
(AMER ASSOC CANCER RESEARCH, 2022-01-01)
Purpose: New therapeutic options are needed in relapsed/refrac tory diffuse large B-cell lymphoma (R/R DLBCL). Lenalidomide ... |
Article
Randomized phase II study of fulvestrant plus palbociclib or placebo in endocrine-sensitive, hormone receptor-positive/HER2–advanced breast cancer: GEICAM/2014–12 (FLIPPER)
(ELSEVIER SCI LTD, 2022-01-01)
Background The potential benefit of adding palbociclib to fulvestrant as first-line treatment in hormone receptor ... |
Article
Low levels of granulocytic myeloid-derived suppressor cells may be a good marker of survival in the follow-up of patients with severe COVID-19
(Frontiers Media S.A., 2022-01-01)
Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a disease (coronavirus disease 2019, ... |
Article
Persistence of SARS-CoV-2 Infection in Severely Immunocompromised Patients With Complete Remission B-Cell Lymphoma and Anti-CD20 Monoclonal Antibody Therapy: A Case Report of Two Cases
(Frontiers Media S.A., 2022-01-01)
Immunosuppressant conditions such as hematological malignancies increase the risk of severe acute respiratory syndrome ... |
Article
The complexity of cancer immunotherapy illustrated through skin tumors
(Wichtig Editore, 2022-01-01)
Skin tumours are among the cancer types most sensitive to immunotherapy, due to their unique immunogenic features including ... |
Article
Tumor Immune Microenvironment in Lymphoma: Focus on Epigenetics
(MDPI, 2022-01-01)
Lymphoma is a neoplasm arising from B or T lymphocytes or natural killer cells characterized by clonal lymphoproliferation. ... |
Article
Intermittent BRAF inhibition in advanced BRAF mutated melanoma results of a phase II randomized trial
(Nature Research, 2021-12-01)
Combination treatment with BRAF (BRAFi) plus MEK inhibitors (MEKi) has demonstrated survival benefit in patients with ... |
Article
Pembrolizumab Plus Gemcitabine in the Subset of Triple-Negative Advanced Breast Cancer Patients in the GEICAM/2015-04 (PANGEA-Breast) Study
(MDPI, 2021-10-29)
The PANGEA-Breast trial evaluated a new chemo-immunotherapeutic combination that would synergistically induce long-term ... |
Article
Lower Survival and Increased Circulating Suppressor Cells in Patients with Relapsed/Refractory Diffuse Large B-Cell Lymphoma with Deficit of Vitamin D Levels Using R-GDP Plus Lenalidomide (R2-GDP): Results from the R2-GDP-GOTEL Trial
(MDPI, 2021-09-15)
The search of prognostic factors is a priority in diffuse large B-cell lymphoma (DLBCL) due to its aggressiveness. We have ... |
Article
Adjuvant nivolumab for stage III/IV melanoma: evaluation of safety outcomes and association with recurrence-free survival
(BMJ Publishing Group, 2021-08-21)
Background Several therapeutic options are now available in the adjuvant melanoma setting, mandating an understanding ... |
Article
Circulating immune biomarkers in peripheral blood correlate with clinical outcomes in advanced breast cancer
(Nature Publishing Group, 2021-07-13)
Identification of the different elements intervening at the tumor microenvironment seems key to explain clinical evolution ... |
Article
Immunometabolism modulation in therapy
(MDPI, 2021-07-09)
The study of cancer biology should be based around a comprehensive vision of the entire tumor ecosystem, considering the ... |
PhD Thesis
Análisis del perfil de respuesta inmune en sangre periférica inducido por tratamiento sistémico en el carcinoma de mama avanzado
(2021-06-09)
La identificación de los diferentes elementos que intervienen en el proceso de inmunoedición, parece clave para explicar ... |
Article
Ribociclib plus fulvestrant for postmenopausal women with hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced breast cancer in the phase III randomized MONALEESA-3 trial: updated overall survival
(Elsevier, 2021-01-01)
Background: Ribociclib plus fulvestrant demonstrated significant progression-free survival (PFS) and overall survival (OS) ... |
Article
Leptin, both bad and good actor in cancer
(MDPI, 2021-01-01)
Leptin is an important regulator of basal metabolism and food intake, with a pivotal role in obesity. Leptin exerts many ... |
Article
Role of Isolated Limb Perfusion in the Era of Targeted Therapies and Immunotherapy in Melanoma. A Systematic Review of The Literature
(MDPI, 2021-01-01)
Background. Isolated limb perfusion (ILP) is a locoregional procedure indicated by the unresectable melanoma of the limbs. ... |
Article
Circulating myeloid-derived suppressor cells and regulatory T cells as immunological biomarkers in refractory/relapsed diffuse large B-cell lymphoma: translational results from the R2-GDP-GOTEL trial
(BMJ, 2021-01-01)
Background The search for immunological markers with ability of predicting clinical outcome is a priority in lymphomas, ... |
Article
Metabolic classification and intervention opportunities for tumor energy dysfunction
(MDPI, 2021-01-01)
A comprehensive view of cell metabolism provides a new vision of cancer, conceptualized as tissue with cellular-altered ... |
Article
5-year outcomes with cobimetinib plus vemurafenib in BRAFV600 mutation⇓positive advanced melanoma: extended follow-up of the coBRIM study
(American Association for Cancer Research, 2021-01-01)
Purpose: The randomized phase III coBRIM study (NCT01689519) demonstrated improved progression-free survival (PFS) and ... |
Article
SEOM clinical guideline for the management of cutaneous melanoma (2020)
(Springer Nature, 2021-01-01)
Melanoma afects about 6000 patients a year in Spain. A group of medical oncologists from Spanish Society of Medical Oncology ... |
PhD Thesis
Estudio poblaciones celulares en pacientes con linfoma difuso de células B grandes refractarios o en recaída: papel de las células supresoras de origen mieloide en respuesta al tratamiento R2-GDP
(2020-07-13)
La inmunoedición, que se caracteriza por el escape que realizan las células malignas de la inmunovigilancia antitumoral, ... |
PhD Thesis
Caracterización del perfil inmunitario en sangre periférica y en tejido de carcinoma de mama con tratamiento neoadyuvante. Estudio de su potencial papel pronóstico y predictivo de respuesta
(2020-01-16)
Introducción: Los estudios traslacionales permiten una correcta interrelación entre la investigación básica y la clínica. ... |
Article
Long-term complete response to intrathecal trastuzumab in a patient with leptomeningeal carcinomatosis due to her2- overexpressing breast cancer: Case report
(Lippincott Williams & Wilkins, 2020-01-01)
Introduction: Leptomeningeal dissemination due to HER2-overexpressing breast cancer is a rare and hard to treat complication ... |
Article
Obesity and Breast Cancer: Role of Leptin
(2019-07-18)
Obesity-related breast cancer is an important threat that affects especially post-menopausal women. The link between obesity ... |
Article
New insights into the role of the immune microenvironment in breast carcinoma
(2013-01-01)
Recently, immune edition has been recognized as a new hallmark of cancer. In this respect, some clinical trials in breast ... |