NombreCruz Merino, Luis de la
DepartamentoMedicina
Área de conocimientoMedicina
Categoría profesionalProfesor Titular de Universidad (Pza. V)
Correo electrónicoSolicitar
         
  • Nº publicaciones

    73

  • Nº visitas

    3901

  • Nº descargas

    2856


 

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Dendritic cells: the yin and yang in disease progression

Jiménez Cortegana, Carlos; Palomares, Francisca; Alba Jiménez, Gonzalo; Santa-María Pérez, Consuelo; Cruz Merino, Luis de la; Sánchez Margalet, Víctor; López Enriquez, Soledad (Frontiers Media, 2024)
Dendritic cells (DCs) are antigen presenting cells that link innate and adaptive immunity. DCs have been historically ...
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Pembrolizumab versus placebo as adjuvant therapy in resected stage IIB or IIC melanoma: Outcomes in histopathologic subgroups from the randomized, double-blind, phase 3 KEYNOTE-716 trial

Schadendorf, Dirk; Luke, Jason John; Ascierto, Paolo A.; Long, Georgina V.; Rutkowski, Piotr; Khattak, Adnan; Cruz Merino, Luis de la; Scolyer, Richard A. (BMC, 2024)
Background Adjuvant pembrolizumab significantly improved recurrence-free survival (RFS) and distant metastasis-free survival ...
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Cancer nano-immunotherapy: the novel and promising weapon to fight cancer

García-Domínguez, Daniel J.; López Enriquez, Soledad; Alba Jiménez, Gonzalo; Garnacho Montero, Carmen; Jiménez Cortegana, Carlos; Flores-Campos, Rocío; Cruz Merino, Luis de la; Hajji, Nabil; Sánchez Margalet, Víctor; Hontecillas-Prieto, Lourdes (Mdpi Ag, 2024)
Cancer is a complex disease that, despite advances in treatment and the greater understanding of the tumor biology until ...
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Overall survival from tebentafusp versus nivolumab plus ipilimumab in first-line metastatic uveal melanoma: a propensity score-weighted analysis

Piulats, J. M.; Watkins, C.; Costa García, M.; del Carpio, L.; Piperno-Neumann, S.; Rutkowski, P.; Cruz Merino, Luis de la; Nathan, P. (Oxford University Press, 2024)
Background: Tebentafusp demonstrated a superior overall survival (OS) benefit [hazard ratio (HR) 0.51] compared to investigator’s ...
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Prognostic implications of the residual tumor microenvironment after neoadjuvant chemotherapy in triple-negative breast cancer patients without pathological complete response

Lejeune, Marylène; Reverte, Laia; Sauras, Esther; Gallardo, Noelia; Bosch, Ramón; Roso, Albert; Cruz Merino, Luis de la; López, Carlos (MDPI, 2023)
With a high risk of relapse and death, and a poor or absent response to therapeutics, the triple-negative breast cancer ...
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Sarcoidosis-like reaction induced by immune checkpoint inhibitor in a patient with hepatocellular carcinoma: a case report

Torres-Zurita, Alberto; Vázquez Montero, Lucía; Gallego López, Laura; Mediano Rambla, María Dolores; Cruz Merino, Luis de la (Frontiers Media S.A., 2023)
Nowadays, immune checkpoint inhibitors (ICI) have become the cornerstone of treatment for many tumors, either as monotherapy ...
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Pembrolizumab in combination with gemcitabine for patients with HER2-negative advanced breast cancer: GEICAM/2015–04 (PANGEA-Breast) study

Cruz Merino, Luis de la; Gion, M.; Cruz, J.; Alonso-Romero, J. L.; Quiroga, V.; Moreno, F.; Jiménez Cortegana, Carlos; Sánchez Margalet, Víctor; Rojo, F. (BMC, 2023)
Background: We evaluated a new chemoimmunotherapy combination based on the anti-PD1 monoclonal antibody pembrolizumab and ...
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Adjuvant Nivolumab versus Ipilimumab in Resected Stage III/IV Melanoma: 5-Year Efficacy and Biomarker Results from CheckMate 238

Larkin, James; Del Vecchio, Michele; Mandalá, Mario; Gogas, Helen; Arance Fernandez, Ana M.; Dalle, Stéphane; Cruz Merino, Luis de la; Weber, Jeffrey (American Association Cancer Research, 2023)
lumab significantly improved recurrence-free survival (RFS) and distant metastasis-free survival versus ipilimumab in ...
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Quality of life with palbociclib plus fulvestrant versus placebo plus fulvestrant in postmenopausal women with endocrine-sensitive hormone receptor-positive and HER2-negative advanced breast cancer: patient-reported outcomes from the FLIPPER trial

Tibau, Ariadna; Martínez, M. Teresa; Ramos, Manuel; Cruz Merino, Luis de la; Santaballa, Ana; O’Connor, Miriam; Albanell, Joan (Sage Journals, 2023)
Background: In the FLIPPER trial, palbociclib/fulvestrant significantly improved progression free survival (PFS) compared ...
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A genetic profling guideline to support diagnosis and clinical management of lymphomas

Sánchez Beato, Margarita; Méndez, Miriam; Criado Guirado, María José; Pedrosa, Lucía; Sequero, Silvia; Yanguas-Casás, Natalia; Cruz Merino, Luis de la; Gálvez, Laura; Llanos, Marta; García, Juan Fernando; Provencio, Mariano (Springer Nature, 2023)
The new lymphoma classifcations (International Consensus Classifcation of Mature Lymphoid Neoplasms, and 5th World Health ...
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Adjuvant Therapy of Nivolumab Combined With Ipilimumab Versus Nivolumab Alone in Patients With Resected Stage IIIB-D or Stage IV Melanoma (CheckMate 915)

Weber, Jeffrey S.; Schadendorf, Dirk; Del Vecchio, Michele; Larkin, James; Atkinson, Victoria; Schenker, Michael; Cruz Merino, Luis de la; Long, Georgina V. (American Society of Clinical Oncology, 2023)
PURPOSE Ipilimumab and nivolumab have each shown treatment benefit for high-risk resected melanoma. The phase III CheckMate ...
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Defining the Emergence of New Immunotherapy Approaches in Breast Cancer: Role of Myeloid-Derived Suppressor Cells

Sánchez León, María Luisa; Jiménez Cortegana, Carlos; Silva Romeiro, Silvia; Garnacho Montero, Carmen; Cruz Merino, Luis de la; García-Domínguez, Daniel J.; Hontecillas-Prieto, Lourdes; Sánchez Margalet, Víctor (Mdpi Ag, 2023)
Breast cancer (BC) continues to be the most diagnosed tumor in women and a very heterogeneous disease both inter- and ...
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Matrix Metalloproteinase-9 Expression Is Associated with the Absence of Response to Neoadjuvant Chemotherapy in Triple-Negative Breast Cancer Patients

Lejeune, Marylène; Reverte, Laia; Gallardo, Noelia; Sauras, Esther; Bosch, Ramón; Mata, Daniel; Cruz Merino, Luis de la; López, Carlos (Mdpi Ag, 2023)
Triple-negative breast cancer (TNBC) is particularly challenging due to the weak or absent response to therapeutics and ...
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Nivolumab plus ipilimumab in metastatic melanoma: a critical appraisal focused on specific subpopulations

Vázquez Montero, Lucía; Álamo de la Gala, María del Carmen; Cruz Merino, Luis de la (Frontiers Media S.A., 2023)
The development of immune checkpoint inhibitors has revolutionized the landscape of treatment of advanced melanoma in ...
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Updated overall survival from the MONALEESA-3 trial in postmenopausal women with HR+/HER2− advanced breast cancer receiving frst-line ribociclib plus fulvestrant

Neven, P.; Fasching, P. A.; Chia, S.; Jerusalem, G.; De Laurentiis, M.; Im, S. A.; Cruz Merino, Luis de la; Slamon, D. J. (Biomed Central LTD, 2023)
Background The phase III MONALEESA-3 trial included frst- (1L) and second-line (2L) patients and demonstrated a signifcant ...
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Circulating myeloid-derived suppressor cells may be a useful biomarker in the follow-up of unvaccinated COVID-19 patients after hospitalization

Jiménez Cortegana, Carlos; Salamanca, Elena; Palazón Carrión, Natalia; Sánchez Jiménez, Flora; Pérez Pérez, Antonio; Vilariño García, Teresa; Gutiérrez Gutiérrez, Belén; Garnacho Montero, José; Cruz Merino, Luis de la; Rodríguez-Baño, Jesús; Sánchez Margalet, Víctor (Frontiers Media S.A., 2023)
SARS-CoV-2 infection is the cause of the disease named COVID-19, a major public health challenge worldwide. Differences ...
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Obesity and Risk for Lymphoma: Possible Role of Leptin

Jiménez Cortegana, Carlos; Hontecillas Prieto, Lourdes; García-Domínguez, Daniel J.; Zapata, Fernando; Palazón Carrión, Natalia; Sánchez León, María Luisa; Tami, Malika; Pérez Pérez, Antonio; Sánchez Jiménez, Flora; Vilariño García, Teresa; Cruz Merino, Luis de la; Sánchez Margalet, Víctor (MDPI, 2022)
Obesity, which is considered a pandemic due to its high prevalence, is a risk factor for many types of cancers, including ...
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The effects of dendritic cell-based vaccines in the tumor microenvironment Impact on myeloid-derived suppressor cells

Sánchez León, María Luisa; Jiménez Cortegana, Carlos; Cabrera, Gabriel; Vermeulen, Elba Mónica; Cruz Merino, Luis de la; Sánchez Margalet, Víctor (Frontiers Media, 2022)
Dendritic cells (DCs) are a heterogenous population of professional antigen presenting cells whose main role is diminished ...
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Ewing Sarcoma Meets Epigenetics, Immunology and Nanomedicine: Moving Forward into Novel Therapeutic Strategies

Sánchez Molina, Sara; Figuerola Bou, Elisabet; Sánchez Margalet, Víctor; Cruz Merino, Luis de la; Mora, Jaume; Álava Casado, Enrique de; García-Domínguez, Daniel J.; Hontecillas Prieto, Lourdes (MDPI, 2022)
Ewing Sarcoma (EWS) is an aggressive bone and soft tissue tumor that mainly affects children, adolescents, and young adults. ...
Tesis Doctoral
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Immune Biomarkers In Peripheral Blood In Patients With HER2 Negative Advanced Breast Cancer Treated With A Chemoimmunotherapy Schedule Based On Pembrolizumab And Gemcitabine. – Translational Substudy Of The PANGEA- Breast Cancer Trial (GEICAM/2015-04)

Araujo Fernández, Isabel; Cruz Merino, Luis de la; Sánchez Margalet, Víctor (2022)
Within the last years, immune checkpoint inhibitors (ICI) have constituted a major breakthrough in cancer research. These ...
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Adjuvant nivolumab versus ipilimumab (CheckMate 238 trial): Reassessment of 4-year efficacy outcomes in patients with stage III melanoma per AJCC-8 staging criteria

Larkin, James; Weber, Jeffrey; Del Vecchio, Michele; Gogas, Helen; Arance, Ana M.; Dalle, Stephane; Cruz Merino, Luis de la; Mandalá, Mario (Elsevier Science Ltd, 2022)
Abstract Purpose: Nivolumab was approved as adjuvant therapy for melanoma based on data from CheckMate 238, which enrolled ...
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BERENICE Final Analysis: Cardiac Safety Study of Neoadjuvant Pertuzumab, Trastuzumab, and Chemotherapy Followed by Adjuvant Pertuzumab and Trastuzumab in HER2-Positive Early Breast Cancer

Dang, Chau; Ewer, Michael S.; Delaloge, Suzette; Ferrero, Jean-Marc; Colomer, Ramon; Cruz Merino, Luis de la; Swain, Sandra M. (MDPI, 2022)
BERENICE (NCT02132949) assessed the cardiac safety of the neoadjuvant–adjuvant pertuzumab–trastuzumab-based therapy for ...
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Safety and efficacy of ribociclib plus letrozole in patients with HR+, HER2– advanced breast cancer: Results from the Spanish sub-population of the phase 3b CompLEEment-1 trial

Salvador Bofill, Francisco Javier; Moreno Antón, Fernando; Rodríguez Sánchez, César Augusto; Galve Calvo, Elena; Hernando Melia, Cristina; Ciruelos Gil; Cruz Merino, Luis de la; Martín, Miguel (Elsevier, 2022)
Background: Breast cancer is the most common malignancy and the second leading cause of cancer-related mortality in Spanish ...
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Low levels of granulocytic myeloid-derived suppressor cells may be a good marker of survival in the follow-up of patients with severe COVID-19

Jiménez Cortegana, Carlos; Sánchez Jiménez, Flora; Pérez Pérez, Antonio; Álvarez, Nerissa; Sousa, Alberto; Cantón Bulnes, María Luisa; Cruz Merino, Luis de la; Sánchez Margalet, Víctor (Frontiers Media S.A., 2022)
Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a disease (coronavirus disease 2019, ...
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Genes involved in immune reinduction may constitute biomarkers of response for metastatic melanoma patients treated with targeted therapy

Berciano Guerrero, Miguel Ángel; Lavado Valenzuela, Rocío; Moya, Aurelio; Cruz Merino, Luis de la; Toscano, Fátima; Valdivia, Javier; Alba, Emilio (MDPI, 2022)
Targeted therapy in metastatic melanoma often achieves a major tumour regression response and significant long-term survival ...
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Randomized phase II study of fulvestrant plus palbociclib or placebo in endocrine-sensitive, hormone receptor-positive/HER2–advanced breast cancer: GEICAM/2014–12 (FLIPPER)

Albanell, J.; Martínez, M. T.; Ramos, M.; O´Connor, M.; Cruz Merino, Luis de la; Santaballa, A.; Rojo, F. (ELSEVIER SCI LTD, 2022)
Background The potential benefit of adding palbociclib to fulvestrant as first-line treatment in hormone receptor ...
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Adjuvant pembrolizumab versus placebo in resected high risk stage II melanoma: Health-related quality of life from the randomized phase 3 KEYNOTE-716 study

Khattak, Muhammad A.; Luke, Jason J.; Long, Georgina V.; Ascierto, Paolo A.; Rutkowski, Piotr; Schadendorf, Dirk; Cruz Merino, Luis de la; Kirkwood, John M. (Elsevier Science Ltd, 2022)
Abstract Background: Adjuvant pembrolizumab significantly improved recurrence-free survival (RFS) versus placebo in resected ...
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Persistence of SARS-CoV-2 Infection in Severely Immunocompromised Patients With Complete Remission B-Cell Lymphoma and Anti-CD20 Monoclonal Antibody Therapy: A Case Report of Two Cases

Martínez-Chinchilla, Carlos; Vazquez Montero, Lucía; Palazón Carrión, Natalia; Fernández Román, Isabel M.; López Barba, José; Cruz Merino, Luis de la; Rodríguez-Baño, Jesús; Palacios-Baena, Zaira R. (Frontiers Media S.A., 2022)
Immunosuppressant conditions such as hematological malignancies increase the risk of severe acute respiratory syndrome ...
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The complexity of cancer immunotherapy illustrated through skin tumors

Vieco-Martí, Isaac; López Carrasco, Amparo; Cruz Merino, Luis de la; Noguera, R.; Naranjo, Tomás Álvaro (Wichtig Editore, 2022)
Skin tumours are among the cancer types most sensitive to immunotherapy, due to their unique immunogenic features including ...
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Tumor Immune Microenvironment in Lymphoma: Focus on Epigenetics

García-Domínguez, Daniel J.; Hontecillas Prieto, Lourdes; Palazón Carrión, Natalia; Jiménez Cortegana, Carlos; Sánchez Margalet, Víctor; Cruz Merino, Luis de la (MDPI, 2022)
Lymphoma is a neoplasm arising from B or T lymphocytes or natural killer cells characterized by clonal lymphoproliferation. ...
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Lenalidomide plus R-GDP (R2-GDP) in Relapsed/ Refractory Diffuse Large B-Cell Lymphoma: Final Results of the R2-GDP-GOTEL Trial and Immune Biomarker Subanalysis

Palazón Carrión, Natalia; Martín García-Sancho, Alejandro; Nogales-Fernández, Esteban; Jiménez Cortegana, Carlos; Carnicero-González, Fernando; Ríos Herranz, Eduardo; Sánchez Margalet, Víctor; Rueda Domínguez, Antonio; Cruz Merino, Luis de la (AMER ASSOC CANCER RESEARCH, 2022)
Purpose: New therapeutic options are needed in relapsed/refrac tory diffuse large B-cell lymphoma (R/R DLBCL). Lenalidomide ...
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Intermittent BRAF inhibition in advanced BRAF mutated melanoma results of a phase II randomized trial

González Cao, María; Mayo de las Casas, Clara; Oramas, Juana; Berciano Guerrero, Miguel Ángel; Cruz Merino, Luis de la; Cerezuela, Pablo; Berrocal, Alfonso (Nature Research, 2021)
Combination treatment with BRAF (BRAFi) plus MEK inhibitors (MEKi) has demonstrated survival benefit in patients with ...
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Pembrolizumab Plus Gemcitabine in the Subset of Triple-Negative Advanced Breast Cancer Patients in the GEICAM/2015-04 (PANGEA-Breast) Study

Cruz Merino, Luis de la; Gion, María; Cruz Jurado, Josefina; Quiroga, Vanesa; Andrés, Raquel; Moreno, Fernando; Jiménez Cortegana, Carlos; Sánchez Margalet, Víctor; Rojo, Federico (MDPI, 2021)
The PANGEA-Breast trial evaluated a new chemo-immunotherapeutic combination that would synergistically induce long-term ...
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Lower Survival and Increased Circulating Suppressor Cells in Patients with Relapsed/Refractory Diffuse Large B-Cell Lymphoma with Deficit of Vitamin D Levels Using R-GDP Plus Lenalidomide (R2-GDP): Results from the R2-GDP-GOTEL Trial

Jiménez Cortegana, Carlos; Sánchez Martínez, Pilar M.; Palazón Carrión, Natalia; Nogales Fernández, Esteban; Henao Carrasco, Fernando Manuel; García Sancho, Alejandro Martín; Rueda, Antonio; Provencio, Mariano; Cruz Merino, Luis de la; Sánchez Margalet, Víctor (MDPI, 2021)
The search of prognostic factors is a priority in diffuse large B-cell lymphoma (DLBCL) due to its aggressiveness. We have ...
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Adjuvant nivolumab for stage III/IV melanoma: evaluation of safety outcomes and association with recurrence-free survival

Mandala, Mario; Larkin, James R.; Ascierto, Paolo Antonio; Del Vecchio, Michele; Gogas, Helen; Cruz Merino, Luis de la; Weber, Jeffrey; Lobo, Maurice (BMJ Publishing Group, 2021)
Background Several therapeutic options are now available in the adjuvant melanoma setting, mandating an understanding ...
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Circulating immune biomarkers in peripheral blood correlate with clinical outcomes in advanced breast cancer

Palazón Carrión, Natalia; Jiménez Cortegana, Carlos; Sánchez León, María Luisa; Nieto García, María Adoración; Sánchez Margalet, Víctor; Cruz Merino, Luis de la (Nature Publishing Group, 2021)
Identification of the different elements intervening at the tumor microenvironment seems key to explain clinical evolution ...
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Immunometabolism modulation in therapy

Monferrer, E.; Sanegre, S.; Vieco-Martí, I.; López-Carrasco, A.; Fariñas, F.; Villatoro, A.; Cruz Merino, Luis de la; Álvaro Naranjo, T. (MDPI, 2021)
The study of cancer biology should be based around a comprehensive vision of the entire tumor ecosystem, considering the ...
Tesis Doctoral
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Análisis del perfil de respuesta inmune en sangre periférica inducido por tratamiento sistémico en el carcinoma de mama avanzado

Sánchez León, María Luisa; Cruz Merino, Luis de la; Sánchez Margalet, Víctor (2021)
La identificación de los diferentes elementos que intervienen en el proceso de inmunoedición, parece clave para explicar ...
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Ribociclib plus fulvestrant for postmenopausal women with hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced breast cancer in the phase III randomized MONALEESA-3 trial: updated overall survival

Slamon, D. J.; Neven, P.; Chia, S.; Jerusalem, G.; De Laurentiis, M.; Im, S.; Cruz Merino, Luis de la; Fasching, P. A. (Elsevier, 2021)
Background: Ribociclib plus fulvestrant demonstrated significant progression-free survival (PFS) and overall survival (OS) ...
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Leptin, both bad and good actor in cancer

Jiménez Cortegana, Carlos; López-Saavedra, Ana; Sánchez Jiménez, Flora; Pérez Pérez, Antonio; Castiñeiras Fernández, Jesús; Virizuela-Echaburu, Juan A.; Cruz Merino, Luis de la; Sánchez Margalet, Víctor (MDPI, 2021)
Leptin is an important regulator of basal metabolism and food intake, with a pivotal role in obesity. Leptin exerts many ...
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Role of Isolated Limb Perfusion in the Era of Targeted Therapies and Immunotherapy in Melanoma. A Systematic Review of The Literature

Sevilla Ortega, Lourdes; Ferrándiz Pulido, Lara; Palazón Carrión, Natalia; Araji Tiliani, Omar; Barquero Aroca, José M.; Moreno Ramírez, David; Cruz Merino, Luis de la (MDPI, 2021)
Background. Isolated limb perfusion (ILP) is a locoregional procedure indicated by the unresectable melanoma of the limbs. ...
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Metabolic classification and intervention opportunities for tumor energy dysfunction

Monferrer, Ezequiel; Vieco-Martí, Isaac; López-Carrasco, Amparo; Fariñas, Fernando; Abanades, Sergio; Cruz Merino, Luis de la; Noguera, Rosa; Naranjo, Tomás Álvaro (MDPI, 2021)
A comprehensive view of cell metabolism provides a new vision of cancer, conceptualized as tissue with cellular-altered ...
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Circulating myeloid-derived suppressor cells and regulatory T cells as immunological biomarkers in refractory/relapsed diffuse large B-cell lymphoma: translational results from the R2-GDP-GOTEL trial

Jiménez Cortegana, Carlos; Palazón Carrión, Natalia; Martín García-Sancho, Alejandro; Nogales-Fernández, Esteban; Carnicero-González, Fernando; Ríos Herranz, Eduardo; Sánchez Margalet, Víctor; Cruz Merino, Luis de la (BMJ, 2021)
Background The search for immunological markers with ability of predicting clinical outcome is a priority in lymphomas, ...
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SEOM clinical guideline for the management of cutaneous melanoma (2020)

Majem, M.; Manzano, J. L.; Marquez-Rodas, I.; Mujika, K.; Muñoz-Couselo, E.; Pérez-Ruiz, E.; Cruz Merino, Luis de la; Espinosa, E.; Gonzalez-Cao, M.; Berrocal, A. (Springer Nature, 2021)
Melanoma afects about 6000 patients a year in Spain. A group of medical oncologists from Spanish Society of Medical Oncology ...
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5-year outcomes with cobimetinib plus vemurafenib in BRAFV600 mutation⇓positive advanced melanoma: extended follow-up of the coBRIM study

Ascierto, Paolo Antonio; Dreno, Brigitte; Larkin, James; Ribas, Antoni; Cruz Merino, Luis de la; McArthur, Grant A. (American Association for Cancer Research, 2021)
Purpose: The randomized phase III coBRIM study (NCT01689519) demonstrated improved progression-free survival (PFS) and ...
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Circulating immune biomarkers in peripheral blood correlate with clinical outcomes in advanced breast cancer

Palazón Carrión, Natalia; Jiménez Cortegana, Carlos; Sánchez-León, M. Luisa; Henao Carrasco, Fernando Manuel; Nogales-Fernández, Esteban; Chiesa, Massimo; Caballero, Rosalía; Rojo, Federico; Nieto García, María Adoración; Sánchez Margalet, Víctor; Cruz Merino, Luis de la (Nature publishing group, 2021)
Identifcation of the diferent elements intervening at the tumor microenvironment seems key to explain clinical evolution ...
Tesis Doctoral
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Estudio poblaciones celulares en pacientes con linfoma difuso de células B grandes refractarios o en recaída: papel de las células supresoras de origen mieloide en respuesta al tratamiento R2-GDP

Jiménez Cortegana, Carlos; Sánchez Margalet, Víctor; Cruz Merino, Luis de la (2020)
La inmunoedición, que se caracteriza por el escape que realizan las células malignas de la inmunovigilancia antitumoral, ...
Tesis Doctoral
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Caracterización del perfil inmunitario en sangre periférica y en tejido de carcinoma de mama con tratamiento neoadyuvante. Estudio de su potencial papel pronóstico y predictivo de respuesta

Palazón Carrión, Natalia; Cruz Merino, Luis de la (2020)
Introducción: Los estudios traslacionales permiten una correcta interrelación entre la investigación básica y la clínica. ...
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Long-term complete response to intrathecal trastuzumab in a patient with leptomeningeal carcinomatosis due to her2- overexpressing breast cancer: Case report

García, Francisco José Valdivia; Carrión, Natalia Palazón; Cruz Merino, Luis de la (Lippincott Williams & Wilkins, 2020)
Introduction: Leptomeningeal dissemination due to HER2-overexpressing breast cancer is a rare and hard to treat complication ...
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SEOM clinical guideline for the management of immune-related adverse events in patients treated with immune checkpoint inhibitors (2019)

Majem, M.; García-Martínez, E.; Martinez, M.; Muñoz-Couselo, E.; Rodriguez-Abreu, D.; Alvarez, R.; Cruz Merino, Luis de la; Lopez-Martin, J. A. (Springer, 2020)
The use of immune checkpoint inhibitors has emerged as an effective treatment option for patients with several tumor types. ...
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GEICAM Guidelines for the Management of Patients with Breast Cancer During the COVID-19 Pandemic in Spain

Martín, Miguel; Guerrero-Zotano, Ángel; Montero, Ángel; Jara, Carlos; Filipovich, Elena; Rojo, Federico; Cruz Merino, Luis de la; López Tarruella, Sara (2020)
Breast cancer (BC) is the most common cancer in women in Spain. During the COVID-19 pandemic caused by the SARS-CoV-2 ...
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Integrating the tumor microenvironment into cancer therapy

Sanegre, Sabina; Lucantoni, Federico; Burgos-Panadero, Rebeca; Cruz Merino, Luis de la; Noguera, Rosa; Naranjo, Tomás Álvaro (MDPI, 2020)
Tumor progression is mediated by reciprocal interaction between tumor cells and their surrounding tumor microenvironment ...
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Obesity and Breast Cancer: Role of Leptin

Sánchez Jiménez, Flora; Pérez Pérez, Antonio; Cruz Merino, Luis de la; Sánchez Margalet, Víctor (2019)
Obesity-related breast cancer is an important threat that affects especially post-menopausal women. The link between obesity ...
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Development and validation of a sexual relations satisfaction scale in patients with breast cancer — “SEXSAT-Q”

González Mancha, Rosario; Muñoz, Montserrat; Cruz Merino, Luis de la; Calvo, Lourdes; Cruz, Josefina; Baena-Cañada, Jose Manuel; Ruiz, Miguel Ángel (Biomed Central LTD, 2019)
Purpose: Because the currently available questionnaires to evaluate sexual changes on breast cancer women only address the ...
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Circulating regulatory T cells from breast cancer patients in response to neoadjuvant chemotherapy

Sánchez Margalet, Víctor; Barco Sánchez, Antonio; Vilariño García, Teresa; Jiménez Cortegana, Carlos; Pérez Pérez, Antonio; Henao Carrasco, Fernando Manuel; Lobo Acosta, María Ángeles; Cruz Merino, Luis de la (Amer Publ Co, 2019)
Background: Immune escape of tumor cells is a new hallmark of cancer in general, and breast cancer, in particular. Previous ...
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The tumour microenvironment as an integrated framework to understand cancer biology

Burgos-Panadero, Rebeca; Lucantoni, Federico; Gamero-Sandemetrio, Esther; Cruz Merino, Luis de la; Álvaro, Tomás; Noguera, Rosa (Elsevier Ireland Ltd, 2019)
Cancer cells all share the feature of being immersed in a complex environment with altered cell-cell/cell-ex tracellular ...
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SEOM clinical guidelines in advanced and recurrent breast cancer (2018)

Chacón López-Muñiz, J. I.; Cruz Merino, Luis de la; Gavilá Gregori, J.; Martínez Dueñas, E.; Oliveira, M.; Seguí Palmer, M. A.; Álvarez López, I.; Antolin Novoa, S.; Bellet Ezquerra, M.; López-Tarruella Cobo, S. (Springer, 2019)
Although the metastasic breast cancer is still an incurable disease, recent advances have increased signifcantly the time ...
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Next generation sequencing of PD-L1 for predicting response to immune checkpoint inhibitors

Conroy, Jeffrey M.; Pabla, Sarabjot; Nesline, Mary K.; Glenn, Sean T.; Papanicolau Sengos, Antonios; Burgher, Blake; Cruz Merino, Luis de la; Morrison, Carl (BMC, 2019)
Background PD-L1 immunohistochemistry (IHC) has been traditionally used for predicting clinical responses to immune ...
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New horizons in breast cancer: the promise of immunotherapy

Cruz Merino, Luis de la; Palazón Carrión, N.; Henao-Carrasco, F.; Nogales-Fernández, E.; Álamo de la Gala, M.; Vallejo Benítez, A.; Chiesa, M. (Springer, 2019)
Immunology and immunotherapy of cancer is an expanding feld in oncology, with recent great achievements obtained through ...
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Unraveling transformation of follicular lymphoma to diffuse large B-cell lymphoma

González-Rincón, Julia; Méndez, Miriam; Gómez, Sagrario; García, Juan F.; Martín, Paloma; Bellas, Carmen; Cruz Merino, Luis de la; Sánchez-Beato, Margarita (Public Library Science, 2019)
Follicular lymphoma (FL) is an indolent but largely incurable disease. Some patients suffer histological transformation ...
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Predicting response to checkpoint inhibitors in melanoma beyond PD-L1 and mutational burden

Morrison, Carl; Pabla, Sarabjot; Conroy, Jeffrey M.; Nesline, Mary K.; Glenn, Sean T.; Dressman, Devin; Cruz Merino, Luis de la; Ernstoff, Marc S. (BMC, 2018)
Background: Immune checkpoint inhibitors (ICIs) have changed the clinical management of melanoma. However, not all patients ...
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Health-related quality of life impact of cobimetinib in combination with vemurafenib in patients with advanced or metastatic BRAFV600 mutation–positive melanoma

Dreno, Brigitte; Ascierto, Paolo A.; Atkinson, Victoria; Liszkay, Gabriella; Maio, Michele; Mandala, Mario; Cruz Merino, Luis de la; Ribas, Antoni (Nature publishing group, 2018)
Background: In the coBRIM study, cobimetinib plus vemurafenib (C þ V) significantly improved survival outcomes vs placebo ...
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2018 consensus statement by the Spanish Society of Pathology and the Spanish Society of Medical Oncology on the diagnosis and treatment of cancer of unknown primary

Losa, F.; Iglesias, L.; Pane, M.; Sanz, J.; Nieto, B.; Fuste, V.; Cruz Merino, Luis de la; Concha, A.; Balana, C.; Matias-Guiu, X. (Springer, 2018)
Cancer of unknown primary (CUP) is defned as a heterogeneous group of tumours that present with metastasis, and in which ...
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SEOM clinical guideline for the management of malignant melanoma (2017)

Berrocal, A.; Arance, A.; Castellón, V. E.; Cruz Merino, Luis de la; Espinosa, E.; Cao, M. G.; Larriba, J. L. G.; Marquez-Rodas, I.; Soria, A.; Algarra, S. M. (Springer Int Publ Ag, 2018)
All melanoma suspected patients must be con firmed histologically and resected. Sentinel node biopsy must be done when ...
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nab-Paclitaxel plus carboplatin or gemcitabine versus gemcitabine plus carboplatin as first-line treatment of patients with triple-negative metastatic breast cancer: results from the tnAcity trial

Yardley, D.A.; Coleman, R.; Conte, P.; Cortes, J.; Brufsky, A.; Shtivelband, M.; Cruz Merino, Luis de la; Harbeck, N. (Oxford University Press, 2018)
Background: Metastatic triple-negative breast cancer (mTNBC) has a poor prognosis and aggressive clinical course. tnAcity ...
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Clinical features of serous retinopathy observed with cobimetinib in patients with BRAF‑mutated melanoma treated in the randomized coBRIM study

Cruz Merino, Luis de la; Di Guardo, Lorenza; Grob, Jean Jacques; Venosa, Alfredo; Larkin, James; McArthur, Grant A.; Dreno, Brigitte (Biomed Central LTD, 2017)
Background: Serous chorioretinopathy has been associated with MEK inhibitors, including cobimetinib. We describe the ...
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Sam68 Mediates the Activation of Insulin and Leptin Signalling in Breast Cancer Cells

Pérez Pérez, Antonio; Sánchez Jiménez, Flora; Vilariño-García, Teresa; Cruz Merino, Luis de la; Virizuela, Juan A.; Sánchez Margalet, Víctor (Public Library Science, 2016)
Obesity is a well-known risk factor for breast cancer development in postmenopausal women. High insulin and leptin levels ...
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SEOM clinical guidelines for the treatment of Hodgkin’s lymphoma

Rueda Domínguez, A.; Alfaro Lizaso, J.; Cruz Merino, Luis de la; Gumá i Padró, J.; Quero Blanco, C.; Gómez Codina, J.; Llanos Muñoz, M.; Martínez Banaclocha, N.; Rodriguez Abreu, D.; Provencio Pulla, M. (Springer, 2015)
Hodgkin lymphoma (HL) is an uncommon B cell lymphoid malignancy representing approximately 10–15 % of all lymphomas. HL ...
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SEOM clinical guidelines in metastatic breast cancer 2015

Gavilá, J.; Lopez-Tarruella, S.; Saura, C.; Muñoz, M.; Oliveira, M.; Cruz Merino, Luis de la; Morales, S.; Alvarez, I.; Virizuela, J. A.; Martin, M. (Springer, 2015)
Metastatic breast cancer is essentially an incurable disease. However, recent advances have resulted in a significant ...
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SEOM clinical guidelines for the treatment of follicular non-Hodgkin’s lymphoma

Provencio Pulla, M.; Alfaro Lizaso, J.; Cruz Merino, Luis de la; Gumá i Padró, J.; Quero Blanco, C.; Gómez Codina, J.; Llanos Muñoz, M.; Martínez Banaclocha, N.; Rodriguez Abreu, D.; Rueda Domínguez, A. (Springer, 2015)
Follicular non-Hodgkin’s lymphoma (FL) is a nodal B lymphoid malignancy that originates from the germinal center of a lymph ...
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Prospective study of the impact of the Prosigna assay on adjuvant clinical decision-making in unselected patients with estrogen receptor-positive, HER2-negative, node-negative early-stage breast cancer

Martín, Miguel; González-Rivera, Milagros; Morales, Serafín; De La Haba-Rodriguez, Juan; González-Cortijo, Lucía; Manso, Luis; Albanell, Joan; Cruz Merino, Luis de la; Prat, Aleix (Taylor and Francis Group, 2015)
Purpose: Improved understanding of risk of recurrence (ROR) is needed to reduce cases of recurrence and more effectively ...
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New insights into the role of the immune microenvironment in breast carcinoma

Nieto García, María Adoración; Sánchez Margalet, Víctor; Alba Conejo, Emilio; Ruiz Borrego, Manuel; Cruz Merino, Luis de la; Codes Manuel de Villena, Manuel; Henao Carrasco, Fernando Manuel; Vallejo Benítez, Ana; Barco Sánchez, Antonio; Nogales Fernández, Esteban; Brugal Molina, Javier; Martínez Peinado, Antonio; Grueso López, Ana; Casares Lagar, Noelia; Ibáñez Martínez, José (2013)
Recently, immune edition has been recognized as a new hallmark of cancer. In this respect, some clinical trials in breast ...
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Isolated Limb Perfusion for Malignant Melanoma: Systematic Review on Effectiveness and Safety

Moreno Ramírez, David; Cruz Merino, Luis de la; Ferrándiz Pulido, Lara; Villegas-Portero, Roman; Nieto García, María Adoración (Oxford Academic, 2010)
Background. Isolated limb perfusion (ILP) involves the administration of chemotherapy drugs directly into a limb involved ...