Artículo
New horizons in breast cancer: the promise of immunotherapy
Autor/es | Cruz Merino, Luis de la
![]() ![]() ![]() ![]() ![]() ![]() Palazón Carrión, N. Henao-Carrasco, F. Nogales-Fernández, E. Álamo de la Gala, M. Vallejo Benítez, A. Chiesa, M. |
Departamento | Universidad de Sevilla. Departamento de Medicina Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología |
Fecha de publicación | 2019 |
Fecha de depósito | 2024-03-07 |
Publicado en |
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Resumen | Immunology and immunotherapy of cancer is an expanding feld in oncology, with recent great achievements obtained
through the new successful approaches implemented to circumvent immune evasion, which is undoubtedly ... Immunology and immunotherapy of cancer is an expanding feld in oncology, with recent great achievements obtained through the new successful approaches implemented to circumvent immune evasion, which is undoubtedly considered a novel hallmark of cancer. Translational research in this topic has revealed targets that can be modulated in the clinical setting with new compounds and strategies. Like most of the tumors, breast cancer is considered a complex and heterogeneous disease in which host immune responses have been also recently demonstrated of critical relevance. T infltrating lymphocyte measure ment is suggested as a powerful new tool necessary to predict early breast cancer evolution, especially for the her2-positive and triple-negative subtypes. Other biomarkers in tissue and peripheral blood are under intense scrutiny to ascertain their eventual role as prognostic and/or predictive factors. This background has fueled the interest in developing clinical research strategies to test activity of modern immunotherapy in breast cancer, which constitutes the main focus of this review. |
Cita | Cruz Merino, L.d.l., Palazón Carrión, N., Henao-Carrasco, F., Nogales-Fernández, E., Álamo de la Gala, M., Vallejo Benítez, A. y Chiesa, M. (2019). New horizons in breast cancer: the promise of immunotherapy. Clinical and Translational Oncology, 21 (2), 117-125. https://doi.org/10.1007/s12094-018-1907-3. |
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