Artículo
The complexity of cancer immunotherapy illustrated through skin tumors
Autor/es | Vieco-Martí, Isaac
López Carrasco, Amparo Cruz Merino, Luis de la Noguera, R. Naranjo, Tomás Álvaro |
Departamento | Universidad de Sevilla. Departamento de Medicina |
Fecha de publicación | 2022 |
Fecha de depósito | 2022-11-22 |
Publicado en |
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Resumen | Skin tumours are among the cancer types most sensitive to immunotherapy, due to their unique immunogenic features
including skin-associated lymphoid tissue, high mutational load, overexpression of tumour antigens, and ... Skin tumours are among the cancer types most sensitive to immunotherapy, due to their unique immunogenic features including skin-associated lymphoid tissue, high mutational load, overexpression of tumour antigens, and high frequency of viral antigens. Despite this high immunotherapy response rate, however, ultimately most skin tumours develop simi lar treatment resistance to most other malignant tumours, which highlights the need for in-depth study of mechanisms of response and resistance to immunotherapy. A bibliographic review of the most recent publications regarding cur rently in use and emerging biomarkers on skin tumors has been done. Predictive biomarkers of treatment response, biomarkers that warn of possible resistance, and emerging markers, the majority of a systemic nature, are described. Including factors affecting not only genomics, but also the immune system, nervous system, microbiota, tumour micro environment, metabolism and stress. For accurate diagnosis of tumour type, knowledge of its functional mechanisms and selection of a comprehensive therapeutic protocol, this inclusive view of biology, health and disease is fundamental. This field of study could also become a valuable source of practical information applicable to other areas of oncology and immunotherapy. |
Agencias financiadoras | Instituto de Salud Carlos III European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) |
Identificador del proyecto | PI20/01107 |
Cita | Vieco-Martí, I., López Carrasco, A., Cruz Merino, L.d.l., Noguera, R. y Naranjo, T.Á. (2022). The complexity of cancer immunotherapy illustrated through skin tumors. International Journal of Biological Markers, 37 (2), 113-122. https://doi.org/10.1177/03936155221088884. |
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