Artículo
The effects of dendritic cell-based vaccines in the tumor microenvironment Impact on myeloid-derived suppressor cells
Autor/es | Sánchez León, María Luisa
Jiménez Cortegana, Carlos Cabrera, Gabriel Vermeulen, Elba Mónica Cruz Merino, Luis de la Sánchez Margalet, Víctor |
Departamento | Universidad de Sevilla. Departamento de Medicina Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología |
Fecha de publicación | 2022-11-15 |
Fecha de depósito | 2023-05-09 |
Publicado en |
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Premios | Premio Mensual Publicación Científica Destacada de la US. Facultad de Medicina |
Resumen | Dendritic cells (DCs) are a heterogenous population of professional antigen presenting cells whose main role is diminished in a variety of malignancies, including cancer, leading to ineffective immune responses. Those ... Dendritic cells (DCs) are a heterogenous population of professional antigen presenting cells whose main role is diminished in a variety of malignancies, including cancer, leading to ineffective immune responses. Those mechanisms are inhibited due to the immunosuppressive conditions found in the tumor microenvironment (TME), where myeloid-derived suppressor cells (MDSCs), a heterogeneous population of immature myeloid cells known to play a key role in tumor immunoevasion by inhibiting T-cell responses, are extremely accumulated. In addition, it has been demonstrated that MDSCs not only suppress DC functions, but also their maturation and development within the myeloid linage. Considering that an increased number of DCs as well as the improvement in their functions boost antitumor immunity, DC-based vaccines were developed two decades ago, and promising results have been obtained throughout these years. Therefore, the remodeling of the TME promoted by DC vaccination has also been explored. Here, we aim to review the effectiveness of different DCs-based vaccines in murine models and cancer patients, either alone or synergistically combined with other treatments, being especially focused on their effect on the MDSC population. |
Agencias financiadoras | Beca «Margarita Salas». Universidad de Sevilla |
Cita | Sánchez León, M.L., Jiménez Cortegana, C., Cabrera, G., Vermeulen, E.M., Cruz Merino, L.d.l. y Sánchez Margalet, V. (2022). The effects of dendritic cell-based vaccines in the tumor microenvironment Impact on myeloid-derived suppressor cells. Frontiers in Immunology, 13, 1050484. https://doi.org/10.3389/fimmu.2022.1050484. |
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