Now showing items 1-20 of 93

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      3D VMAT Verification Based on Monte Carlo Log File Simulation with Experimental Feedback from Film Dosimetry.  [Article]

      Pereira Barbeiro, Ana Rita; Ureba Sánchez, Ana María; Baeza Ortega, Jose Antonio; Linares, R.; Perucha, M.A; Jiménez Ortega, Elisa Eugenia; Mateos Pérez, Juan Carlos; Leal Plaza, Antonio (Public Library Of Science., 2016-11-21)
      A model based on a specific phantom, called QuAArC, has been designed for the evaluation of planning and verification systems of complex radiotherapy treatments, such as volumetric modulated arc therapy (VMAT). This model ...
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      A Conditional Mouse Mutant in the Tumor Suppressor SdhD Gene Unveils a Link between p21(WAF1/Cip1) Induction and Mitochondrial Dysfunction  [Article]

      Díaz Castro, Blanca; García Flores, Gloria Paula; Báez Palomo, Alicia; Millán Uclés, África; Pérez Simón, José Antonio; Piruat Palomo, José Ignacio; López Barneo, José (2014)
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      A Poglut1 mutation causes a muscular dystrophy with reduced Notch signaling and satellite cell loss  [Article]

      Nieto González, José Luis; Fernández-Chacón, Rafael; Servián Morilla, Emilia; Rivero, María C; Cabrera Serrano, Macarena; Gómez-Sánchez, Leonardo (Wiley-Blackwell Publishing Ltd., 2016)
      Skeletal muscle regeneration by muscle satellite cells is a physiological mechanism activated upon muscle damage and regulated by Notch signaling. In a family with autosomal recessive limbgirdle muscular dystrophy, we ...
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      A Small Domain in the N Terminus of the Regulatory a-Subunit Kv2.3 Modulates Kv2.1 Potassium Channel Gating  [Article]

      Chiara, María D.; Monje Quiroga, Francisco; Castellano Orozco, Antonio Gonzalo; López Barneo, José (1999)
      Recent work has demonstrated the existence of regulatory K1 channel a-subunits that are electrically silent but capable of forming heterotetramers with other pore-forming subunits to modify their function. We have investigated ...
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      Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice  [Article]

      Bishop, Tammie; Gallagher, Denis; Pascual Bravo, Alberto; Lygate, Craig A.; Bono, Joseph P. de; Nicholls, Lynn G.; Ortega Sáenz, Patricia; Oster, Henrik; Wijeyekoon, Bhathiya; Sutherland, Andrew I.; Grosfeld, Alexandra; Aragones, Julian; Schneider, Martin; Geyte, Katie van; Teixeira, Dania; Diez Juan, Antonio; López Barneo, José; Channon, Keith M.; Maxwell, Patrick H.; Pugh, Christopher W.; Davies, Alun M.; Carmeliet, Peter; Ratcliffe, Peter J. (2008)
      Cell culture studies have implicated the oxygen-sensitive hypoxia-inducible factor (HIF) prolyl hydroxylase PHD3 in the regulation of neuronal apoptosis. To better understand this function in vivo, we have created PHD3_/_ ...
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      Accurate,robust and harmonized implementation of morpho-functional imaging in treatment planning for personalized radiotherapy  [Article]

      Jiménez Ortega, Elisa Eugenia; Ureba Sánchez, Ana María; Baeza, José Antonio; Pereira Barbeiro, Ana Rita; Balcerzyk, Marcin; Parrado-Gallego, Ángel; Wals-Zurita, Amadeo; García-Gómez, Francisco Javier; Leal Plaza, Antonio (Public Library of Science, 2019-01-09)
      In this work we present a methodology able to use harmonized PET/CT imaging in dose painting by number (DPBN) approach by means of a robust and accurate treatment planning system. Image processing and treatment planning ...
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      Acute oxygen sensing in heme oxygenase-2 null mice  [Article]

      Ortega Sáenz, Patricia; López Barneo, José; Pascual Bravo, Alberto; Gómez Díaz, Raquel (2006)
      Hemeoxygenase-2 (HO-2) is an antioxidant enzyme that can modulate recombinant maxi-K+ channels and has been proposed to be the acute O2 sensor in the carotid body (CB). We have tested the physiological contribution of this ...
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      Acute Oxygen-Sensing Mechanisms  [Article]

      Kenneth E., Weir; López Barneo, José; Buckler, Keith J.; Archer, Stephen L. (2005)
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      Adenylyl Cyclase Type 8 Overexpression Impairs Phosphorylation-Dependent Orai1 Inactivation and Promotes Migration in MDA-MB-231 Breast Cancer Cells.  [Article]

      Smani Hajami, Tarik; Falcón Boyano, Débora (2019-10-23)
      Orai1 plays a major role in store-operated Ca 2+ entry (SOCE) in triple-negative breast cancer (TNBC) cells. This channel is inactivated via different mechanisms, including protein kinase C (PKC) and protein kinase A ...
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      Age-mediated transcriptomic changes in adult mouse substantia nigra  [Article]

      Gao Chen, Lin; Hidalgo-Figueroa, María; Escudero Cuadrado, Luis María; Díaz Martín, Juan; López Barneo, José; Pascual Bravo, Alberto (2013)
      Substantia nigra pars compacta (SNpc) is highly sensitive to normal aging and selectively degenerates in Parkinson’s disease (PD). Until now, molecular mechanisms behind SNpc aging have not been fully investigated using ...
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      Agregación de alfa-sinucleína y degeneración Parkinsoniana  [Article]

      Fernández-Espejo, Emilio (Sociedad Española de Ciencias Fisiológicas, 2013)
      La alfa-sinucleína es la proteína principal de los cuerpos de Lewy, marcador anatomopatológico de la enfermedad de Parkinson. Dicha proteína puede ver alterada su conformación y adquirir capacidad autoagregante, lo que ...
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      Autoevaluación con refuerzo, como herramienta informática infividual de apoyo en el aprendizaje  [Article]

      Serra, J.M.; Serra Simal, Rafael José (Universidad de Sevilla, 1998)
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      Bases neurobiológicas de la drogadicción  [Article]

      Fernández-Espejo, Emilio (Viguera, 2002)
      Introduction. Drugs of abuse cause addiction, characterized by compulsive and out of control drug use. Several neurochemical and molecular changes take place in the brain during the first phase of drug use which lead to ...
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      Carotid body chemosensory responses in mice deficient of TASK channels  [Article]

      Ortega Sáenz, Patricia; Levitski, Konstantín; Marcos Almaraz, María Teresa; Bonilla Henao, Victoria; Pascual Bravo, Alberto; López Barneo, José (2010)
      Background K+ channels of the TASK family are believed to participate in sensory transduction by chemoreceptor (glomus) cells of the carotid body (CB). However, studies on the systemic CB-mediated ventilatory response to ...
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      Collapse of conductance Is prevented by a Glutamate residue conserved in voltage-dependent K+ channels  [Article]

      Ortega Sáenz, Patricia; Pardal Redondo, Ricardo; Castellano Orozco, Antonio Gonzalo; López Barneo, José (2000)
      Voltage-dependent K 1 channel gating is influenced by the permeating ions. Extracellular K 1 determines the occupation of sites in the channels where the cation interferes with the motion of the gates. When external [K 1] ...
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      Comparative analysis for the presence of IgG anti-aquaporin-1 in patients with NMO-Spectrum disorders  [Article]

      Sánchez Gomar, Ismael; Díaz Sánchez, María; Uclés Sánchez, Antonio José; Casado Chocán, José Luis; Suárez-Luna, Nela; Ramírez Lorca, Reposo; Villadiego Luque, Francisco Javier; Toledo Aral, Juan José; Echevarría Irusta, Miriam (MDPI AG, 2016-07-23)
      Detection of IgG anti-Aquaporin-4 (AQP4) in serum of patients with Neuromyelitis optica syndrome disorders (NMOSD) has improved diagnosis of these processes and differentiation from Multiple sclerosis (MS). Recent findings ...
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      ¿Cómo funciona el nucleus accumbens?  [Article]

      Fernández-Espejo, Emilio (2000)
      El nucleus accumbens se considera una interfase neural entre motivación y acción motora, y participa de modo decisivo en la ingesta, conducta sexual, recompensa, respuesta al estrés, autoadminstración de drogas, etc. ...
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      CSP -deficiency causes massive and rapid photoreceptor degeneration  [Article]

      Schmitz, Frank; Tabares Domínguez, Lucía; Khimich, Darina; Strenzke, Nicola; Villa Polo, Pedro de la; Castellano Muñoz, Manuel; Bulankina, Anna; Moser, Tobias; Fernández-Chacón, Rafael; Südhof, Thomas C. (2006)
      Cysteine string protein (CSP) _ is an abundant synaptic vesicle protein that contains a DNA-J domain characteristic of Hsp40-type cochaperones. Previous studies showed that deletion of CSP_ in mice leads to massive lethal ...
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      Currents recorded through small areas of squid axon membrane with an internal virtual ground voltage clamp  [Article]

      López Barneo, José; Matteson, Donald R.; Armstrong, Clay M. (1981)
      A new voltage-clamp apparatus for the squid axon has been implemented to enable recording of currents through small areas of axon membrane. The performance of this clamp was tested by recording total sodium currents from ...
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      Cysteine String Protein- Prevents Activity-Dependent Degeneration in GABAergic Synapses  [Article]

      García-Junco Clemente, Pablo; Cantero Nieto, Gloria; Gómez-Sánchez, Leonardo; Linares Clemente, Pedro; Martínez López, José Antonio; Luján, Rafael; Fernández-Chacón, Rafael (2010)
      The continuous release of neurotransmitter could be seen to place a persistent burden on presynaptic proteins, one that could compromise nerve terminal function. This supposition and the molecular mechanisms that might ...