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  Aquaporin-4 Mediates Permanent Brain Alterations in a Mouse Model of Hypoxia-Aged Hydrocephalus 

  Trillo-Contreras, José Luis; Toledo Aral, Juan José; Villadiego Luque, Francisco Javier; Echevarría Irusta, Miriam (MDPI, 2021-09-09)

  Aquaporin-4 (AQP4) is the principal water channel in the brain being expressed in astrocytes and ependymal cells. AQP4 ...

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  Evaluation of aquaporins in the cerebrospinal fluid in patients with idiopathic normal pressure hydrocephalus 

  Hiraldo González, Laura; Trillo Contreras, José Luis; García Miranda, Pablo; Pineda Sánchez, Rocío; Ramírez Lorca, Reposo; Rodrigo Herrero, Silvia; Olivares Blanco, Magdalena; Oliver, María; Bernal, María; Franco Macías, Emilio; Villadiego Luque, Francisco Javier; Echevarría Irusta, Miriam (PLOS, 2021)

  Brain aquaporin 1 (AQP1) and AQP4 are involved in cerebrospinal fluid (CSF) homeostasis and might participate in the origin ...

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  Orai2 Modulates Store-Operated Ca2+ Entry and Cell Cycle Progression in Breast Cancer Cells 

  Sánchez Collado, José; Lopez, Jose J.; Cantonero, Carlos; Jardin, Isaac; Smani Hajami, Tarik; Rosado, Juan Antonio (MDPI, 2021-12-27)

  Breast cancer is a heterogeneous disease from the histological and molecular expression point of view, and this heterogeneity ...

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  Leukocyte Overexpression of Intracellular NAMPT Attenuates Atherosclerosis by Regulating PPARγ-Dependent Monocyte Differentiation and Function 

  Bermúdez Pulgarín, Beatriz; Dahl, Tuva Borresdatter; Medina, Indira; Groeneweg, Mathijs; Holm, Sverre; Montserrat de la Paz, Sergio; Rousch, Mat; Otten, Jeroen; Herias, Veronica; Varela Pérez, Lourdes María; Biessen, Erik Anna Leonardus (Wolters Kluwer Health, 2017)

  Objective-Extracellular nicotinamide phosphoribosyltransferase (eNAMPT) mediates inflammatory and potentially proatherogenic ...

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  Broad Transcriptomic Impact of Sorafenib and Its Relation to the Antitumoral Properties in Liver Cancer Cells 

  Contreras Bernal, Laura; Rodríguez Gil, Alfonso; Muntané Relat, Jordi; Cruz Díaz, Jesús de la (Multidisciplinary Digital Publishing Institute (MDPI), 2022)

  Hepatocellular carcinoma (HCC) is one of the most frequent and essentially incurable cancers in its advanced stages. The ...

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  Brugada syndrome masked by complete left bundle branch block: A clinical and functional study of its association with the p.1449Y>H SCN5A variant 

  Arana Rueda, Eduardo; Pezzotti, María R.; Pedrote, Alonso; Acosta, Juan; Frutos-López, Manuel; Varela, Lourdes M.; García-Fernández, Noelia; Castellano Orozco, Antonio Gonzalo (Wiley Periodicals, LLC., 2021-07)

  SCN5A gene variants are associated with both Brugada syndrome and conduction disturbances, sometimes expressing an ...

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  Selective expression of the neurexin substrate for presenilin in the adult forebrain causes deficits in associative memory and presynaptic plasticity 

  Sánchez Hidalgo, Ana Carmen; Arias-Aragón, Francisco; Romero Barragán, M. Teresa; Martín-Cuevas, Celia; Delgado-García, José M; Martinez-Mir, Amalia; Gómez Scholl, Francisco Manuel (Elsevier, 2021-10-15)

  Presenilins (PS) form the active subunit of the gamma-secretase complex, which mediates the proteolytic clearance of a ...

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  SARAF and EFHB Modulate Store-Operated Ca2+ Entry and Are Required for Cell Proliferation, Migration and Viability in Breast Cancer Cells 

  Jardin, Isaac; Nieto Felipe, Enrique; Alvarado, Sandra; Diez Bello, Raquel; López, Jose J.; Smani Hajami, Tarik; Rosado, Juan Antonio (MDPI, 2021)

  Breast cancer is among the most common malignancies in women. From the molecular point of view, breast cancer can be ...

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  Theranostics in boron neutron capture therapy 

  Sauerwein, Wolfgang A. G.; Sancey, Lucie; Hey-Hawkins, Evamarie; Kellert, Martin; Panza, Luigi; Imperio, Daniela; Balcerzyk, Marcin (MDPI, 2021-04-10)

  Boron neutron capture therapy (BNCT) has the potential to specifically destroy tumor cells without damaging the tissues ...

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  A cross-sectional study of foot growth and its correlation with anthropometric parameters in a representative cohort of schoolchildren from southern spain 

  González Elena, María Luisa; Fernández-Espejo, Emilio; Castro Méndez, Aurora; Guerra Martín, María Dolores; Córdoba Fernández, Antonio (MDPI, 2021-04-12)

  Background: The relationship between growth of the foot and other anthropometric parameters during body development until ...

• Article
  

  Prolyl Hydroxylase-dependent Modulation of Eukaryotic Elongation Factor 2 Activity and Protein Translation under Acute Hypoxia 

  Romero-Ruiz, Antonio; Bautista, Lucía; Navarro, Virginia; Heras Garvín, Antonio; Castellano Orozco, Antonio Gonzalo; López Barneo, José; Pascual, Alberto (American Society for Biochemistry and Molecular Biology, 2012-02-03)

  Early adaptive responses to hypoxia are essential for cell survival, but their nature and underlying mechanisms are poorly ...

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  The HERC1 ubiquitin ligase regulates presynaptic membrane dynamics of central synapses 

  Montes Fernández, María de los Ángeles; Pérez Villegas, Eva María; García-Gonzalo, Francesc R.; Pedrazza, Leonardo; Rosa, José Luis; Álvarez de Toledo Naranjo, Guillermo; Armengol, José Ángel (Nature Research, 2020-07-21)

  HERC1 is a ubiquitin ligase protein, which, when mutated, induces several malformations and intellectual disability in ...

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  Simulación en cirugía cardíaca: ¿el futuro de la docencia en nuestra especialidad? 

  Juvin-Bouvier, Charles E.; Torrejón-Domínguez, José M.; Tena-Santana, Gonzalo; Laviana-Martínez, Fernando; Rojas-Bermúdez, Camilo; Rodríguez-Mora, Felipe; Álvarez de Toledo Naranjo, Guillermo (Sociedad Española de Cirugía Cardiovascular y Endovascular (SECCE), 2017-04-05)

  Introducción: La simulación como herramienta docente se está estableciendo como una prioridad en los currículos de nuestra ...

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  Proteoglycans involved in bidirectional communication between mast cells and hippocampal neurons 

  Flores Cordero, Juan Antonio; Ramírez-Ponce, M. Pilar; Montes Fernández, María de los Ángeles; Balseiro Gómez, Santiago; Acosta López, Jorge; Álvarez de Toledo Naranjo, Guillermo; Alés González de la Higuera, Eva María (BMC, 2019-05-20)

  Background: Mast cells (MCs) in the brain can respond to environmental cues and relay signals to neurons that may directly ...

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  A New Role for Myosin II in Vesicle Fission 

  Flores Cordero, Juan Antonio; Balseiro Gómez, Santiago; Cabeza, Jose M.; Acosta López, Jorge; Ramirez-Ponce, Pilar; Alés González de la Higuera, Eva María (Public Library of Science, 2014-06-24)

  An endocytic vesicle is formed from a flat plasma membrane patch by a sequential process of invagination, bud formation and ...

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  Mechanisms of Granule Membrane Recapture followingExocytosis in Intact Mast Cells 

  Cabeza, Jose M.; Acosta López, Jorge; Alés González de la Higuera, Eva María (American Society for Biochemistry and Molecular Biology, 2013-05-24)

  In secretory cells, several exocytosis-coupled forms of endocytosis have been proposed including clathrin-mediated ...

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  Glucose sensing by carotid body glomus cells: potential implications in disease 

  Gao Chen, Lin; Ortega Sáenz, Patricia; García Fernández, María; González Rodríguez, Patricia; Caballero Eraso, Candela; López Barneo, José (Frontiers Media, 2014-10-15)

  The carotid body (CB) is a key chemoreceptor organ in which glomus cells sense changes in blood O2, CO2, and pH levels. ...

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  Resistance of subventricular neural stem cells to chronic hypoxemia despite structural disorganization of the germinal center and impairment of neuronal and oligodendrocyte survival 

  D'Anglemont De Tassigny, Xavier; Sirerol-Piquer, M Salomé; Gómez-Pinedo, Ulises; Pardal Redondo, Ricardo; Bonilla, Sonia; Capilla González, Vivian; López Barneo, José (Dove Medical Press Ltd., 2015)

  Chronic hypoxemia, as evidenced in de-acclimatized high-altitude residents or in patients with chronic obstructive ...

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  Integrated molecular signaling involving mitochondrial dysfunction and alteration of cell metabolism induced by tyrosine kinase inhibitors in cancer 

  Rodríguez Hernández, María A.; Cruz Ojeda, Patricia de la; López-Grueso, María José; Navarro Villarán, Elena; Requejo-Aguilar, Raquel; Castejón Vega, Beatriz; Muntané Relat, Jordi (Elsevier, 2020-03-16)

  Cancer cells have unlimited replicative potential, insensitivity to growth-inhibitory signals, evasion of apoptosis,cellular ...

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  Native α-synuclein, 3-nitrotyrosine proteins, and patterns of nitro-α-synuclein-immunoreactive inclusions in saliva and submandibulary gland in parkinson’s disease 

  Fernández-Espejo, Emilio; Rodríguez de Fonseca, Fernando; Suárez, Juan; Tolosa, Eduardo; Vilas, Dolores; Aldecoa, Iban (MDPI, 2021-05-01)

  Background. Salivary α-synuclein (aSyn) and its nitrated form, or 3-nitrotyrosine-αsynuclein (3-NT-αSyn), hold promise as ...

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