Artículos (Fisiología Médica y Biofísica)
Recent Submissions
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Effects of membrane depolarization and divalent-cations on anaphylactic histamine secretion
(1986)The effects of membrane depolariz.ation and divalent cations on histamine release have been studied in sensitized mast ...
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Neuroprotective effect of adult hematopoietic stem cells in a mouse model of motoneuron degeneration
(2007)Degenerative spinal motor diseases, like amyotrophic lateral sclerosis, are produced by progressive degeneration of ...
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Nanostructured fibrin agarose hydrogel as a novel haemostatic agent
(Wiley, 2019)Blood loss remains a major concern during surgery and can increase the morbidity of the intervention. The use of topical ...
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Galacto-conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity
(Wiley Open Access, 2020)Pharmacologically active compounds with preferential cytotoxic activity for senescent cells, known as senolytics, can ...
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2-hydroxyglutarate metabolism is altered in an in vivo model of LPS induced endotoxemia
(Frontiers Media, 2020)The metabolic response to endotoxemia closely mimics those seen in sepsis. Here, we show that the urinary excretion of the ...
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SOS GEFs in health and disease
(Elsevier, 2020)SOS1 and SOS2 are the most universal and widely expressed family of guanine exchange factors (GEFs) capable or activating ...
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The high mobility group protein HMG20A cooperates with the histone reader PHF14 to modulate TGF and Hippo pathways
(OXFORD UNIV PRESS, 2022)High mobility group (HMG) proteins are chromatin regulators with essential functions in development, cell differentiation ...
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Distribution modelling of the Pudu deer (Pudu puda) in southern Chile
(Pensoft Publishers, 2020)The Pudu deer (Pudu puda) is endemic to the temperate rainforest of Chile and Argentina and currently faces serious ...
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Molecular targets for endogenous glial cell line-derived neurotrophic factor modulation in striatal parvalbumin interneurons
(Oxford University Press, 2020)Administration of recombinant glial cell line-derived neurotrophic factor into the putamen has been tested in preclinical ...
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Changes in adhesion and the expression of adhesion molecules in PBMCs after aneurysmal subarachnoid hemorrhage: relation to cerebral vasospasm
(Springer, 2023)Aneurysmal subarachnoid hemorrhage (aSAH) is a neurovascular disease produced by extravasation of blood to the subarachnoid ...
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Aquaporin-4 expression switches from white to gray matter regions during postnatal development of the central nervous system
(MDPI, 2023-02-03)Aquaporin-4 (AQP4) is the most abundant water channel in the central nervous system and plays a fundamental role in ...
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Complete loss of KCNA1 activity causes neonatal epileptic encephalopathy and dyskinesia
(BMJ Publishing Group, 2020)Background: Since 1994, over 50 families affected by the episodic ataxia type 1 disease spectrum have been described with ...
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Mechanisms of action of metformin in type 2 diabetes: Effects on mitochondria and leukocyte-endothelium interactions
(Elsevier, 2020)Type 2 diabetes (T2D) is a very prevalent, multisystemic, chronic metabolic disorder closely related to atherosclerosis ...
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Compulsivity is linked to reduced adolescentdevelopment of goal-directed control andfrontostriatal functional connectivity
(National Academy of Sciences, 2020)A characteristic of adaptive behavior is its goal-directed nature. Anability to act in a goal-directed manner is progressively ...
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Genetic, cellular, and connectomic characterization of the brain regions commonly plagued by glioma
(Oxford University Press, 2020)For decades, it has been known that gliomas follow a non-random spatial distribution, appearing more often in some brain ...
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Article
Neuroprotective effect of adult hematopoietic stem cells in a mouse model of motoneuron degeneration
(2007)Degenerative spinal motor diseases, like amyotrophic lateral sclerosis, are produced by progressive degeneration ...
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Article
Analysis of serial neuroblastoma PDX passages in mice allows the identification of new mediators of neuroblastoma aggressiveness
(MDPI, 2023-01-13)Neuroblastoma is a neural crest cell-derived pediatric tumor characterized by high interand intra-tumor heterogeneity, and ...
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Mitochondria and T2D: Role of Autophagy, ER Stress, and Inflammasome
(Cell Press, 2020)Type 2 diabetes (T2D) is one of the main current threats to human health. Both T2D and its numerous clinical complications ...
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Store-operated calcium entry in breast cancer cells is insensitive to Orai1 and STIM1 N-linked glycosylation
(MDPI, 2022-12-29)N-linked glycosylation is a post-translational modification that affects protein function, structure, and interaction ...
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Proteomic characterization of spinal cord synaptoneurosomes from Tg-SOD1/G93A mice supports a role for MNK1 and local translation in the early stages of amyotrophic lateral sclerosis
(Elsevier, 2022-11)The isolation of synaptoneurosomes (SNs) represents a useful means to study synaptic events. However, the size and density ...