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  Rearrangement of cell types in the rat carotid body neurogenic niche induced by chronic intermittent hypoxia 

  Caballero Eraso, Candela; Colinas Miranda, Olalla; González Montelongo, Rafaela; Cabeza, Jose M.; Gao Chen, Lin; Pardal Redondo, Ricardo; López Barneo, José; Ortega Sáenz, Patricia (Wiley, 2023-01-17)

  The carotid body (CB) is a prototypical acute oxygen (O2)-sensing organ that mediates reflex hyperventilation and increased ...

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  Carotid body function in tyrosine hydroxylase conditional Olfr78 knockout mice 

  Colinas Miranda, Olalla; Mombaerts, Peter; López Barneo, José; Ortega Sáenz, Patricia (Oxford University Press, 2024-02-22)

  The Olfr78 gene encodes a G-protein-coupled olfactory receptor that is expressed in several ectopic sites. Olfr78 is one ...

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  Presenilin/γ-Secretase Regulates Neurexin Processing at Synapses 

  Saura, Carlos A.; Servián Morilla, Emilia; Gómez Scholl, Francisco Manuel (Public Library of Science, 2011-04-29)

  Neurexins are a large family of neuronal plasma membrane proteins, which function as trans-synaptic receptors during ...

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  Dual-promoter lentiviral vectors for constitutive and regulated gene expression in neurons 

  Gascón, Sergio; Páez Gómez, Juan A.; Díaz-Guerra, Margarita; Scheiffele, Peter; Gómez Scholl, Francisco Manuel (Elsevier, 2008-02-15)

  Gene transfer methods for efficient co-expression of exogenous proteins in neurons are crucial tools towards the understanding ...

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  Rare variants analysis of neurexin-1β in autism reveals a novel start codon mutation affecting protein levels at synapses 

  Camacho García, Rafael J.; Hervás, Amaia; Toma, Claudio; Balmaña, Noemí; Cormand, Bru; Martinez-Mir, Amalia; Gómez Scholl, Francisco Manuel (Lippincott, Williams & Wilkins, 2013-08-07)

  Neurexins are synaptic plasma membrane proteins encoded by three genes (NRXN1, -2, -3) with alternative promoters. Mutations ...

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  A truncating mutation in Alzheimer's disease inactivates neuroligin-1 synaptic function 

  Tristán Clavijo, Enriqueta; Camacho García, Rafael J.; Robles Lanuza, Estefanía; Ruiz, Agustín; Van der Zee, Julie; Van Broeckhoven, Christine; Hernandez, Isabel; Martinez-Mir, Amalia; Gómez Scholl, Francisco Manuel (Elsevier, 2015-09-03)

  Neuroligins (NLs) are cell-adhesion proteins that regulate synapse formation and function. Neuroligin 1 (NL1) promotes the ...

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  Molecular and Cellular Mechanisms of Synaptopathies 

  Ardiles, Álvaro O.; Grabrucker, Andreas M.; Gómez Scholl, Francisco Manuel; Rudenko, Gabby; Borsello, Tiziana (Wiley Open Access, 2017-04-30)

  Synapses, contact points between neurons, are essential elements supporting the ability of neurons to communicate and to ...

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  Proteolytic Processing of Neurexins by Presenilins Sustains Synaptic Vesicle Release 

  Servián Morilla, Emilia; Robles Lanuza, Estefanía; Sánchez Hidalgo, Ana Carmen; Camacho García, Rafael J.; Páez Gómez, Juan A.; Mavillard Saborido, Fabiola; Saura, Carlos A.; Martinez-Mir, Amalia; Gómez Scholl, Francisco Manuel (Society for Neuroscience, 2018-01-24)

  Proteolytic processing of synaptic adhesion components can accommodate the function of synapses to activity-dependent ...

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  A Neuroligin-1 mutation associated with Alzheimer’s disease produces memory and age-dependent impairments in hippocampal plasticity 

  Arias-Aragón, Francisco; Tristán Clavijo, Enriqueta; Martínez Gallego, Irene; Robles Lanuza, Estefanía; Coatl-Cuaya, Heriberto; Martín-Cuevas, Celia; Sánchez Hidalgo, Ana Carmen; Rodríguez Moreno, Antonio; Martínez Mir, Amalia; Gómez Scholl, Francisco Manuel (Cell Press, 2023-05-13)

  Alzheimer’s disease (AD) is characterized by memory impairments and age-dependent synapse loss. Experimental and clinical ...

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  Microglia mitochondrial complex I deficiency during development induces glial dysfunction and early lethality 

  Mora Romero, Bella; Capelo Carrasco, Nicolás; Pérez Moreno, Juan José; Álvarez Vergara, María Isabel; Trujillo Estrada, Laura Isabel; Romero Molina, Carmen; Martínez Márquez, Emilio; Morano Catalan, Noelia; Vizuete Chacón, María Luisa; López Barneo, José; Nieto González, José Luis; García-Junco Clemente, Pablo; Vitorica Ferrández, Francisco Javier; Gutiérrez, Antonia; Macías, David; Rosales Nieves, Alicia E.; Pascual Bravo, Alberto (Nature, 2024-07-24)

  Primary mitochondrial diseases (PMDs) are associated with pediatric neurological disorders and are traditionally related ...

• Article
  

  The Complex Role of Store Operated Calcium Entry Pathways and Related Proteins in the Function of Cardiac, Skeletal and Vascular Smooth Muscle Cells 

  Ávila Medina, Javier; Mayoral González, Isabel; Dominguez Rodriguez, Alejandro; Gallardo Castillo, Isabel; Ribas Serna, Juan; Ordóñez Fernández, Antonio; Rosado, Juan Antonio; Smani Hajami, Tarik (Frontiers Media, 2018-03-21)

  Cardiac, skeletal, and smooth muscle cells shared the common feature of contraction in response to different stimuli. ...

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  Valor pronóstico de la bioimpedancia eléctrica medida con el dispositivo IVOL en la insuficiencia cardiaca aguda 

  Gutiérrez Carretero, Encarnación; Campos, Ana Maria; Gimenez-Miranda, Luis; Rezaei, Kambitz; Pena, Amelia; Rossel, Javier; Praena, Juan Manuel; Smani Hajami, Tarik; Ordonez, Antonio; Medrano Ortega, Francisco Javier (Elsevier, 2024)

  Introducción y objetivos: La evaluación actual de la insuficiencia cardiaca (IC) aguda no permite predecir adecuadamente ...

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  Amitriptyline induces mitophagy that precedes apoptosis in human HepG2 cells 

  Villanueva-Paz, Marina; Cordero, Mario D.; Pavón, Ana Delgado; Castejón Vega, Beatriz; Cotán, David; De la Mata, Mario; Oropesa-Ávila, Manuel; Alcocer-Gómez, Elísabet; Muntané Relat, Jordi; Miguel Rodríguez, Manuel de; Sánchez-Alcázar, José Antonio (2016-08-07)

  Systemic treatments for hepatocellular carcinoma (HCC) have been largely unsuccessful. This study investigated the ...

• Article
  

  An Indocyanine Green-Based Nanoprobe for In Vivo Detection of Cellular Senescence 

  Baker, Andrew G.; Hartono, Muhamad; Ou, Hui-Ling; Popov, Andrea Bistrovic; Brown, Emma L.; Joseph, James; Golinska, Monika; Gonzalez-Gualda, Estela; Macías, David; Fruk, Ljiljana (Wiley, 2024)

  Abstract: There is an urgent need to improve conventional cancer-treatments by preventing detrimental side effects, cancer ...

• Article
  

  Redox signaling in acute oxygen sensing 

  Gao Chen, Lin; González Rodríguez, Patricia; Ortega Sáenz, Patricia; López Barneo, José (Elsevier, 2017-04-26)

  Acute oxygen (O2) sensing is essential for individuals to survive under hypoxic conditions. The carotid body (CB) is the ...

• Article
  

  NLRP3-inflammasome inhibition prevents high fat and high sugar diets-induced heart damage through autophagy induction 

  Pavillard, Luís E.; Cañadas-Lozano, Diego; Alcocer-Gómez, Elísabet; Marín Aguilar, Fabiola; Pereira, Sheila; Robertson, Avril A.B.; Muntané Relat, Jordi; Ryffel, Bernhard; Cooper, Matthew A.; Quiles, José L.; Bullon, Pedro; Ruiz-Cabello, Jesús; Cordero, Mario D. (Impact Journals LLC, 2017-09-08)

  The NLRP3-inflammasome complex has emerged as an important component of inflammatory processes in metabolic dysfunction ...

• Article
  

  A Conditional Mouse Mutant in the Tumor Suppressor SdhD Gene Unveils a Link between p21(WAF1/Cip1) Induction and Mitochondrial Dysfunction 

  Millán-Uclés, África; Díaz-Castro, Blanca; García-Flores, Paula; Báez, Alicia; Pérez Simón, José Antonio; Piruat, José I. (Public Library Science, 2021-01-20)

  Mutations in mitochondrial complex II (MCII; succinate dehydrogenase, Sdh) genes cause familiar pheochromocytoma/ paraganglioma ...

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  IGF-1 regulates astrocytic phagocytosis and inflammation through the p110α isoform of PI3K in a sex-specific manner 

  Pinto-Benito, Daniel; Paradela Leal, Carmen; Ganchala, Danny; Castro-Molina, Paula de; Arevalo, Maria-Angeles (Willey, 2022)

  Insulin-like growth factor-I (IGF-I) signaling plays a key role in neuroinflammation. Here we show that IGF-1 also regulates ...

• Article
  

  The carotid body, a neurogenic niche in the adult peripheral nervous system 

  Pardal Redondo, Ricardo; Ortega Sáenz, Patricia; Durán, Rocío; Platero-Luengo, Aida; López Barneo, José (Univ pisa, 2010)

  We have described a new population of adult neural stem cells residing in the carotid body, a chemoreceptor organ in the ...

• Article
  

  Genetic divergence and demography of pudu deer (Pudu puda) in five provinces of southern Chile, analyzed through latitudinal and longitudinal ranges 

  Colihueque, Nelson; Cabello, Javier; Fuentes Moliz, Andrea (Pensoft Publishers, 2022)

  Pudu deer (Pudu puda) is endemic to the temperate rainforests of Chile. Genetic studies at different geographic scales for ...

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