• Article
  

  Effects of membrane depolarization and divalent-cations on anaphylactic histamine secretion 

  Pintado, E.; Dorado, M.E.; Tabares, Lucía; López Barneo, José (1986)

  The effects of membrane depolariz.ation and divalent cations on histamine release have been studied in sensitized mast ...

• Article
  

  Neuroprotective effect of adult hematopoietic stem cells in a mouse model of motoneuron degeneration 

  Cabanes, Carmen; Bonilla, Sonia; Tabares, Lucía; Martínez, Salvador (2007)

  Degenerative spinal motor diseases, like amyotrophic lateral sclerosis, are produced by progressive degeneration of ...

• Article
  

  Nanostructured fibrin agarose hydrogel as a novel haemostatic agent 

  Campos-Cuerva, Rafael; Fernández Muñoz, Beatriz; Farfán López, Francisco; Pereira Arenas, Sheila; Santos-González, Mónica; Lopez-Navas, Luis; Alaminos, Miguel; Campos, Antonio; Muntané Relat, Jordi; Cepeda-Franco, Carmen; Gómez Bravo, Miguel Ángel (Wiley, 2019)

  Blood loss remains a major concern during surgery and can increase the morbidity of the intervention. The use of topical ...

• Article
  

  Galacto-conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity 

  González-Gualda, E.; Páez-Ribes, M.; Lozano-Torres, B.; Macías, David; Wilson III, J. R.; González-López, C.; Ou, H. L. (Wiley Open Access, 2020)

  Pharmacologically active compounds with preferential cytotoxic activity for senescent cells, known as senolytics, can ...

• Article
  

  2-hydroxyglutarate metabolism is altered in an in vivo model of LPS induced endotoxemia 

  Fitzpatrick, S. F.; Lambden, S.; Macías, David; Puthucheary, Z.; Pietsch, S.; Mendil, L. (Frontiers Media, 2020)

  The metabolic response to endotoxemia closely mimics those seen in sepsis. Here, we show that the urinary excretion of the ...

• Article
  

  SOS GEFs in health and disease 

  Calvo Baltanás, Fernando; Zarich, N; Rojas-Cabaneros, JM; Santos, E (Elsevier, 2020)

  SOS1 and SOS2 are the most universal and widely expressed family of guanine exchange factors (GEFs) capable or activating ...

• Article
  

  The high mobility group protein HMG20A cooperates with the histone reader PHF14 to modulate TGF and Hippo pathways 

  Gomez Marin, Elena; Posavec Marjanovic, Melanija; Zarzuela, Laura; Basurto Cayuela, Laura; Guerrero Martinez, Jose A.; Arribas, Gonzalo; Yerbes, Rosario; Reyes, Jose C. (OXFORD UNIV PRESS, 2022)

  High mobility group (HMG) proteins are chromatin regulators with essential functions in development, cell differentiation ...

• Article
  

  Distribution modelling of the Pudu deer (Pudu puda) in southern Chile 

  Colihueque, N; Arriagada, A; Fuentes Moliz, Andrea (Pensoft Publishers, 2020)

  The Pudu deer (Pudu puda) is endemic to the temperate rainforest of Chile and Argentina and currently faces serious ...

• Article
  

  Molecular targets for endogenous glial cell line-derived neurotrophic factor modulation in striatal parvalbumin interneurons 

  Enterría-Morales, Daniel; López-González del Rey, Natalia; Blesa, Javier; López-López, Ivette; Gallet, Sarah; Prévot, Vincent; López Barneo, José; D'Anglemont De Tassigny, Xavier (Oxford University Press, 2020)

  Administration of recombinant glial cell line-derived neurotrophic factor into the putamen has been tested in preclinical ...

• Article
  

  Changes in adhesion and the expression of adhesion molecules in PBMCs after aneurysmal subarachnoid hemorrhage: relation to cerebral vasospasm 

  Revilla Gonzalez, Gonzalo; Varela Pérez, Lourdes María; Ruiz de Azua-López, Zaida; Amaya-Villar, Rosario; Rosa Pezzotti, Maria; Castro, María José; Ureña López, Juan; González-Montelongo, María del Carmen; Castellano Orozco, Antonio Gonzalo (Springer, 2023)

  Aneurysmal subarachnoid hemorrhage (aSAH) is a neurovascular disease produced by extravasation of blood to the subarachnoid ...

• Article
  

  Aquaporin-4 expression switches from white to gray matter regions during postnatal development of the central nervous system 

  Mayo Leon, Francisco; Gonzalez Vinceiro, Lourdes; Hiraldo Gonzalez, Laura; Calle-Castillejo, Claudia; Morales-Álvarez, Sara; Ramírez Lorca, Reposo; Echevarría Irusta, Miriam (MDPI, 2023-02-03)

  Aquaporin-4 (AQP4) is the most abundant water channel in the central nervous system and plays a fundamental role in ...

• Article
  

  Complete loss of KCNA1 activity causes neonatal epileptic encephalopathy and dyskinesia 

  Verdura, Edgard; Fons, Carme; Schlüter, Agatha; Ruiz, Montserrat; Fourcade, Stéphane; Casasnovas, Carlos; Castellano Orozco, Antonio Gonzalo; Pujol, Aurora (BMJ Publishing Group, 2020)

  Background: Since 1994, over 50 families affected by the episodic ataxia type 1 disease spectrum have been described with ...

• Article
  

  Mechanisms of action of metformin in type 2 diabetes: Effects on mitochondria and leukocyte-endothelium interactions 

  Apostolova, Nadezda; Iannantuoni, Francesca; Gruevska, Aleksandra; Muntané Relat, Jordi; Rocha, Milagros; Victor, Victor M. (Elsevier, 2020)

  Type 2 diabetes (T2D) is a very prevalent, multisystemic, chronic metabolic disorder closely related to atherosclerosis ...

• Article
  

  Compulsivity is linked to reduced adolescentdevelopment of goal-directed control andfrontostriatal functional connectivity 

  Vaghi, Matilde M.; Moutoussis, Michael; Vása, Frantisek; Kievit, Rogier A.; Hauser, Tobias U.; Vértes, Petra E.; Romero García, Rafael; Dolan, Raymond J. (National Academy of Sciences, 2020)

  A characteristic of adaptive behavior is its goal-directed nature. Anability to act in a goal-directed manner is progressively ...

• Article
  

  Genetic, cellular, and connectomic characterization of the brain regions commonly plagued by glioma 

  Mandal, Ayan; Romero García, Rafael; Hart, Michael G.; Suckling, John (Oxford University Press, 2020)

  For decades, it has been known that gliomas follow a non-random spatial distribution, appearing more often in some brain ...

• Article
  

  Neuroprotective effect of adult hematopoietic stem cells in a mouse model of motoneuron degeneration 

  Cabanes, Carmen; Bonilla, Sonia; Tabares, Lucía; Martínez, Salvador (2007)

  Degenerative spinal motor diseases, like amyotrophic lateral sclerosis, are produced by progressive degeneration ...

• Article
  

  Analysis of serial neuroblastoma PDX passages in mice allows the identification of new mediators of neuroblastoma aggressiveness 

  Gomez Muñoz, Maria De Los Angeles; Aguilar Morante, Diana; Colmenero-Repiso, Ana; Amador Álvarez, Aida; Ojeda-Puertas, Mónica; Cordero Varela, Juan Antonio; Rodríguez-Prieto, Ismael; Pardal Redondo, Ricardo; Vega Moreno, Francisco Manuel (MDPI, 2023-01-13)

  Neuroblastoma is a neural crest cell-derived pediatric tumor characterized by high interand intra-tumor heterogeneity, and ...

• Article
  

  Mitochondria and T2D: Role of Autophagy, ER Stress, and Inflammasome 

  Rocha, Milagros; Apostolova, Nadezda; Diaz-Rua, Ruben; Muntané Relat, Jordi; Victor, Victor M. (Cell Press, 2020)

  Type 2 diabetes (T2D) is one of the main current threats to human health. Both T2D and its numerous clinical complications ...

• Article
  

  Store-operated calcium entry in breast cancer cells is insensitive to Orai1 and STIM1 N-linked glycosylation 

  Sánchez-Collado, José; Nieto-Felipe, Joel; Jardín, Isaac; Bhardwaj, Rajesh; Berna-Erro, Alejandro; Salido, Ginés M.; Smani Hajami, Tarik; Rosado, Juan A. (MDPI, 2022-12-29)

  N-linked glycosylation is a post-translational modification that affects protein function, structure, and interaction ...

• Article
  

  Proteomic characterization of spinal cord synaptoneurosomes from Tg-SOD1/G93A mice supports a role for MNK1 and local translation in the early stages of amyotrophic lateral sclerosis 

  Casañas, Juan José; Montesinos Gutiérrez, María Luz (Elsevier, 2022-11)

  The isolation of synaptoneurosomes (SNs) represents a useful means to study synaptic events. However, the size and density ...

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