Artículos (Fisiología Médica y Biofísica)
Recent Submissions
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Aquaporin-4 Mediates Permanent Brain Alterations in a Mouse Model of Hypoxia-Aged Hydrocephalus
(MDPI, 2021-09-09)Aquaporin-4 (AQP4) is the principal water channel in the brain being expressed in astrocytes and ependymal cells. AQP4 ...
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Evaluation of aquaporins in the cerebrospinal fluid in patients with idiopathic normal pressure hydrocephalus
(PLOS, 2021)Brain aquaporin 1 (AQP1) and AQP4 are involved in cerebrospinal fluid (CSF) homeostasis and might participate in the origin ...
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Orai2 Modulates Store-Operated Ca2+ Entry and Cell Cycle Progression in Breast Cancer Cells
(MDPI, 2021-12-27)Breast cancer is a heterogeneous disease from the histological and molecular expression point of view, and this heterogeneity ...
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Leukocyte Overexpression of Intracellular NAMPT Attenuates Atherosclerosis by Regulating PPARγ-Dependent Monocyte Differentiation and Function
(Wolters Kluwer Health, 2017)Objective-Extracellular nicotinamide phosphoribosyltransferase (eNAMPT) mediates inflammatory and potentially proatherogenic ...
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Broad Transcriptomic Impact of Sorafenib and Its Relation to the Antitumoral Properties in Liver Cancer Cells
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)Hepatocellular carcinoma (HCC) is one of the most frequent and essentially incurable cancers in its advanced stages. The ...
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Brugada syndrome masked by complete left bundle branch block: A clinical and functional study of its association with the p.1449Y>H SCN5A variant
(Wiley Periodicals, LLC., 2021-07)SCN5A gene variants are associated with both Brugada syndrome and conduction disturbances, sometimes expressing an ...
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Selective expression of the neurexin substrate for presenilin in the adult forebrain causes deficits in associative memory and presynaptic plasticity
(Elsevier, 2021-10-15)Presenilins (PS) form the active subunit of the gamma-secretase complex, which mediates the proteolytic clearance of a ...
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SARAF and EFHB Modulate Store-Operated Ca2+ Entry and Are Required for Cell Proliferation, Migration and Viability in Breast Cancer Cells
(MDPI, 2021)Breast cancer is among the most common malignancies in women. From the molecular point of view, breast cancer can be ...
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Theranostics in boron neutron capture therapy
(MDPI, 2021-04-10)Boron neutron capture therapy (BNCT) has the potential to specifically destroy tumor cells without damaging the tissues ...
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A cross-sectional study of foot growth and its correlation with anthropometric parameters in a representative cohort of schoolchildren from southern spain
(MDPI, 2021-04-12)Background: The relationship between growth of the foot and other anthropometric parameters during body development until ...
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Prolyl Hydroxylase-dependent Modulation of Eukaryotic Elongation Factor 2 Activity and Protein Translation under Acute Hypoxia
(American Society for Biochemistry and Molecular Biology, 2012-02-03)Early adaptive responses to hypoxia are essential for cell survival, but their nature and underlying mechanisms are poorly ...
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The HERC1 ubiquitin ligase regulates presynaptic membrane dynamics of central synapses
(Nature Research, 2020-07-21)HERC1 is a ubiquitin ligase protein, which, when mutated, induces several malformations and intellectual disability in ...
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Article
Simulación en cirugía cardíaca: ¿el futuro de la docencia en nuestra especialidad?
(Sociedad Española de Cirugía Cardiovascular y Endovascular (SECCE), 2017-04-05)Introducción: La simulación como herramienta docente se está estableciendo como una prioridad en los currículos de nuestra ...
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Proteoglycans involved in bidirectional communication between mast cells and hippocampal neurons
(BMC, 2019-05-20)Background: Mast cells (MCs) in the brain can respond to environmental cues and relay signals to neurons that may directly ...
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A New Role for Myosin II in Vesicle Fission
(Public Library of Science, 2014-06-24)An endocytic vesicle is formed from a flat plasma membrane patch by a sequential process of invagination, bud formation and ...
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Mechanisms of Granule Membrane Recapture followingExocytosis in Intact Mast Cells
(American Society for Biochemistry and Molecular Biology, 2013-05-24)In secretory cells, several exocytosis-coupled forms of endocytosis have been proposed including clathrin-mediated ...
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Glucose sensing by carotid body glomus cells: potential implications in disease
(Frontiers Media, 2014-10-15)The carotid body (CB) is a key chemoreceptor organ in which glomus cells sense changes in blood O2, CO2, and pH levels. ...
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Resistance of subventricular neural stem cells to chronic hypoxemia despite structural disorganization of the germinal center and impairment of neuronal and oligodendrocyte survival
(Dove Medical Press Ltd., 2015)Chronic hypoxemia, as evidenced in de-acclimatized high-altitude residents or in patients with chronic obstructive ...
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Integrated molecular signaling involving mitochondrial dysfunction and alteration of cell metabolism induced by tyrosine kinase inhibitors in cancer
(Elsevier, 2020-03-16)Cancer cells have unlimited replicative potential, insensitivity to growth-inhibitory signals, evasion of apoptosis,cellular ...
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Article
Native α-synuclein, 3-nitrotyrosine proteins, and patterns of nitro-α-synuclein-immunoreactive inclusions in saliva and submandibulary gland in parkinson’s disease
(MDPI, 2021-05-01)Background. Salivary α-synuclein (aSyn) and its nitrated form, or 3-nitrotyrosine-αsynuclein (3-NT-αSyn), hold promise as ...