Artículos (Fisiología Médica y Biofísica)
Recent Submissions
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Physiological Plasticity of Neural-Crest-Derived Stem Cells in the Adult Mammalian Carotid Body [Article]
(Cell Press, 2017)Adult stem cell plasticity, or the ability of somatic stem cells to cross boundaries and differentiate into unrelated cell types, has been amatter of debate in the last decade. Neural-crest-derived stem cells (NCSCs) ...
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Adenylyl Cyclase Type 8 Overexpression Impairs Phosphorylation-Dependent Orai1 Inactivation and Promotes Migration in MDA-MB-231 Breast Cancer Cells. [Article]
(2019-10-23)Orai1 plays a major role in store-operated Ca 2+ entry (SOCE) in triple-negative breast cancer (TNBC) cells. This channel is inactivated via different mechanisms, including protein kinase C (PKC) and protein kinase A ...
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Improvements in Pain, Well-being, Arterial Pressure, and Lower Limb Volume Following Andullation Therapy in Healthy and Unhealthy Humans [Article]
(International Dose-Response Society, 2019-04-01)Our aim was to test the effects of Andullation therapy on pain threshold, pain perception, feeling of well-being, arterial pressure, and leg volume in healthy and unhealthy patients. We used a multidirectional vibration ...
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A Poglut1 mutation causes a muscular dystrophy with reduced Notch signaling and satellite cell loss [Article]
(Wiley-Blackwell Publishing Ltd., 2016)Skeletal muscle regeneration by muscle satellite cells is a physiological mechanism activated upon muscle damage and regulated by Notch signaling. In a family with autosomal recessive limbgirdle muscular dystrophy, we ...
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Accurate,robust and harmonized implementation of morpho-functional imaging in treatment planning for personalized radiotherapy [Article]
(Public Library of Science, 2019-01-09)In this work we present a methodology able to use harmonized PET/CT imaging in dose painting by number (DPBN) approach by means of a robust and accurate treatment planning system. Image processing and treatment planning ...
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Rotenone selectively occludes sensitivity to hypoxia in rat carotid body glomus cells [Article]
(Wiley-Blackwell Publishing Ltd., 2003)Carotid body glomus cells release transmitters in response to hypoxia due to the increase of excitability resulting from inhibition of O2 -regulated K+ channels. However, the mechanisms involved in the detection of changes ...
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MECHANISMS OF DISEASE Acute Oxygen-Sensing Mechanisms [Article]
(Massachusetts Medical Society, 2005)JOSEPH PRIESTLEY, ONE OF THE THREE SCIENTISTS CREDITED WITH THE discovery of oxygen, described the death of mice that were deprived of oxygen. However, he was also well aware of the toxicity of too much oxygen, stating, ...
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First aid kit for hypoxic survival: sensors and strategies [Article]
(University of Chicago Press, 2010)Survival success under conditions of acute oxygen deprivation depends on efficiency of the central and peripheral chemoreception, optimization of oxygen extraction from the hypoxic environment and its delivery to the ...
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TRPC6 channels are required for proliferation, migration and invasion of breast cancer cell lines by modulation of Orai1 and Orai3 surface exposure [Article]
(MDPI AC, 2018-09-14)Transient receptor potential channels convey signaling information from a number of stimuli to a wide variety of cellular functions, mainly by inducing changes in cytosolic Ca2+ concentration. Different members of the TRPC, ...
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Psychostimulant drugs and neuroplasticity [Article]
(MDPI AC, 2011-06-30)Drugs of abuse induce plastic changes in the brain that seem to underlie addictive phenomena. These plastic changes can be structural (morphological) or synaptic (biochemical), and most of them take place in the mesolimbic ...
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Comparative analysis for the presence of IgG anti-aquaporin-1 in patients with NMO-Spectrum disorders [Article]
(MDPI AG, 2016-07-23)Detection of IgG anti-Aquaporin-4 (AQP4) in serum of patients with Neuromyelitis optica syndrome disorders (NMOSD) has improved diagnosis of these processes and differentiation from Multiple sclerosis (MS). Recent findings ...
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Urocortin-2 Prevents Dysregulation of Ca2+ Homeostasis and Improves Early Cardiac Remodeling After Ischemia and Reperfusion [Article]
(Frontiers Research Foundation, 2018-07-03)Aims: Urocortin-2 (Ucn-2) is a potent cardioprotector against Ischemia and Reperfusion (I/R) injuries. However, little is known about its role in the regulation of intracellular Ca2+ concentration ([Ca2+]i) under I/R. Here, ...
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Effect of hypoxia on lung gene expression and proteomic profile: insights into the pulmonary surfactant response [Article]
(Elsevier, 2014)Exposure of lung to hypoxia has been previously reported to be associated with significant alterations in the protein content of bronchoalveolar lavage (BAL) and lung tissue. In the present work we have used a proteomic ...
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May the evaluation of nitrosative stress through selective increase of 3-nitrotyrosine proteins other than nitroalbumin and dominant tyrosine-125/136 nitrosylation of serum α-synuclein serve for diagnosis of sporadic Parkinson's disease? [Article]
(Mary Ann Liebert, Inc. Publishers, 2013)Nitrosative stress, where nitrosylation of tyrosine (Tyr) leading to 3-nitrotyrosine proteins or free 3-nitrotyrosine is the most prominent change, has been proposed as a pathogenic mechanism in Parkinson's disease (PD). ...
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Orai1 and TRPC1 Proteins Co-localize with CaV1.2 Channels to Form a Signal Complex in Vascular Smooth Muscle Cells [Article]
(American Society for Biochemistry and Molecular Biology, 2016)Voltage-dependent CaV1.2 L-type Ca2 channels (LTCC) are the main route for calcium entry in vascular smooth muscle cells (VSMC). Several studies have also determined the relevant role of store-operated Ca2 channels ...
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May anomalous X chromosome methylation be responsible for the spontaneous abortion of a male foetus? [Article]
(Indian Academy of Sciences, 2008-12-01)Pregnancy loss is an important reproductive problem which appears to be highly associated with genetic factors. A spontaneous abortion occurred before prenatal diagnosis could be performed, in a woman who carried a fragile ...
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Autoevaluación con refuerzo, como herramienta informática infividual de apoyo en el aprendizaje [Article]
(Universidad de Sevilla, 1998) -
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