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  Human α-synuclein overexpression in mouse serotonin neurons triggers a depressive-like phenotype. Rescue by oligonucleotide therapy 

  Miquel-Rio, Lluis; Alarcón-Arís, Diana; Torres López, María; Cóppola-Segovia, Valentín; Pavia-Collado, Rubén; Paz, Verónica; Raquel; Bortolozzi, Analia (Springer Nature, 2022)

  Anxiety and depression affect 35–50% of patients with Parkinson’s disease (PD), often precede the onset of motor symptoms, ...

• Article
  

  Cardiac protection induced by urocortin-2 enables the regulation of apoptosis and fibrosis after ischemia and reperfusion involving miR-29a modulation 

  Mayoral-González, Isabel; Calderón Sánchez, Eva M.; Galeano-Otero, Isabel; Martín Bórnez, Marta; Gutierrez Carretero, Encarnacion; Fernández Velasco, María; Ordóñez Fernández, José Antonio; Smani Hajami, Tarik (CELL PRESS (Elsevier), 2022)

  Urocortin-2 (Ucn-2) has demonstrated cardioprotective ac tions against myocardial ischemia-reperfusion (I/R) injuries. Herein, ...

• Article
  

  Editorial: Hypoxia and Cardiorespiratory Control 

  Okada, Yasumasa; Paton, Julian F.R.; López Barneo, José; Wilson, Richard J.A.; Marina, Nephtali; Pokorski, Mieczyslaw (Frontiers Media, 2021-12-22)

  To maintain adequate oxygen levels in the body, which is essential for a healthy life, the respiratory and cardiovascular ...

• Article
  

  Editorial: A Compendium of Recent Research on Stem Cell-Based Therapy for Covid-19 

  Hmadcha, Abdelkrim; Soria, Bernat; Zhao, Robert C.; Smani Hajami, Tarik; Valverde Pérez, Israel (Frontiers Media, 2021-12-14)

  We have been dealing with an unprecedented global health crisis for nearly 2 years now. This started after an outbreak of ...

• Article
  

  Combined treatment of graft versus host disease using donor regulatory T cells and ruxolitinib 

  Rodríguez Gil, Alfonso; Escamilla Gómez, Virginia; Nufer, Melanie; Andújar Sánchez, Félix; Lopes Ramos, Teresa; Bejarano García, José Antonio; Caballero Velázquez, Teresa; Villadiego Luque, Francisco Javier; Pérez Simón, José Antonio (Nature Publishing Group, 2022)

  Donor derived regulatory T lymphocytes and the JAK1/2 kinase inhibitor ruxolitinib are currently being evaluated as ...

• Article
  

  Heterotopic ossification in mice overexpressing Bmp2 in Tie2+ lineages 

  Prados, Belén; Toro Estévez, Raquel del; MacGrogan, Donal; Gómez-Apiñániz, Paula; Papoutsi, Tania; Muñoz-Cánoves, Pura; Méndez-Ferrer, Simón; Pompa, José Luis de la (NATURE PUBLISHING GROUP, 2021-07-22)

  Bone morphogenetic protein (Bmp) signaling is critical for organismal development and homeostasis. To elucidate Bmp2 ...

• Article
  

  Lactate sensing mechanisms in arterial chemoreceptor cells 

  Torres-Torrelo, Hortensia; Ortega Sáenz, Patricia; López Barneo, José (2021)

  Classically considered a by-product of anaerobic metabolism, lactate is now viewed as a fundamental fuel for oxidative ...

• Article
  

  Urocortin Role in Ischemia Cardioprotection and the Adverse Cardiac Remodeling 

  Calderón Sánchez, Eva María; Falcón Boyano, Débora; Martín Bórnez, Marta; Ordóñez Fernández, José Antonio; Smani Hajami, Tarik (MDPI, 2021-11-09)

  Despite the considerable progress in strategies of myocardial protection, ischemic heart diseases (IHD) and consequent ...

• Article
  

  Parkinson’s disease patient-specific neuronal networks carrying the LRRK2 G2019S mutation unveil early functional alterations that predate neurodegeneration 

  Carola, G.; Malagarriga, D.; Calatayud, C.; Pons-Espinal, M.; Blasco-Agell, L.; Richaud-Patin, Y.; Toledo Aral, Juan José; Consiglio, A. (Springer Nature, 2021)

  A deeper understanding of early disease mechanisms occurring in Parkinson’s disease (PD) is needed to reveal restorative ...

• Article
  

  Endothelial cell regulation of systemic haemodynamics and metabolism acts through the HIF transcription factors 

  Lambden, Simon; Cowburn, Andrew S.; Macías, David; Garrud, Tessa A. C.; Krause, Bernardo J.; Giussani, Dino A.; Summers, Charlotte; Johnson, Randall S. (SpringerOpen, 2021-06-11)

  Background The vascular endothelium has important endocrine and paracrine roles, particularly in the regulation of vascular ...

• Article
  

  Targeting HIF2α-ARNT hetero-dimerisation as a novel therapeutic strategy for pulmonary arterial hypertension 

  Macías, David; Moore, Stephen; Crosby, Alexi; Southwood, Mark; Du, Xinlin; Tan, Huiling; Cowburn, Andrew S. (European Respiratory Society, 2021-03-04)

  Pulmonary arterial hypertension (PAH) is a destructive disease of the pulmonary vasculature often leading to right heart ...

• Article
  

  Effect of Vitamin D on Graft-versus-Host Disease 

  Rodríguez Gil, Alfonso; Carrillo-Cruz, Estrella; Marrero-Cepeda, Cristina; Rodríguez, Guillermo; Pérez Simón, José Antonio (MDPI, 2022)

  The different cell subsets of the immune system express the vitamin D receptor (VDR). Through the VDR, vitamin D exerts ...

• Article
  

  Brain charts for the human lifespan 

  Bethlehem, R. A. I.; Seidlitz, J.; White, S. R.; Vogel, J. W.; Anderson, K. M.; Adamson, C.; Romero García, Rafael; Alexander-Bloch, A. F. (Nature Publishing Group, 2022)

  Over the past few decades, neuroimaging has become a ubiquitous tool in basic research and clinical studies of the human ...

• Article
  

  Robustness of PET Radiomics Features: Impact of Co-Registration with MRI 

  Stefano, Alessandro; Leal Plaza, Antonio; Richiusa, Selene; Trang, Phan; Comelli, Albert; Benfante, Viviana (MDPI, 2021-10-30)

  Radiomics holds great promise in the field of cancer management. However, the clinical application of radiomics has been ...

• Article
  

  Modified Geometry of 106Ru Asymmetric Eye Plaques to Improve Dosimetric Calculations in Ophthalmic Brachytherapy 

  Miras, Héctor; Terrón, José Antonio; Bertolet, Alejandro; Leal Plaza, Antonio (MDPI, 2022)

  Ru/Rh asymmetric plaques for ophthalmic brachytherapy have special geometric designs with a cutout intended to prevent ...

• Article
  

  Role of nitric oxide in gene expression regulation during cancer: epigenetic modifications and non-coding RNAs 

  Cruz Ojeda, Patricia de la; Flores-Campos, Rocío; Dios-Barbeito, Sandra; Navarro-Villarán, Elena; Muntané Relat, Jordi (MDPI, 2021-06-10)

  Nitric oxide (NO) has been identified and described as a dual mediator in cancer according to dose-, time- and ...

• Article
  

  Editorial: Molecular Components of Store-Operated Calcium Entry in Health and Disease 

  Gruszczynska-Biegala, Joanna; Martín-Romero, Francisco Javier; Smani Hajami, Tarik; Secondo, Agnese (Frontiers Media, 2021-10-05)

  Store-Operated Calcium Entry (SOCE) is a ubiquitous Ca2+ influx mechanism first described in 1986 (Putney, 1986). This ...

• PhD Thesis
  

  Análisis de la incidencia e identificación de factores de riesgo en el desarrollo de accidentes cerebrovasculares en pacientes con vértigo filiado 

  Mármol Szombathy, Irene (2022-09-26)

  Introducción: las alteraciones del equilibrio son patologías muy prevalentes en la población general. Se han asociado con ...

• Patent
  

  Evaluación en tiempo real de dosis de neutrones en pacientes en tratamiento con radioterapia y detector para llevar a cabo el procedimiento 

  Gomez Rodriguez, Faustino; Domingo Miralles, Carlos; Marin Muñoz, Jesus; Sánchez Doblado, Francisco (Oficina Española de Patentes y Marcas , 2015-06-11)

  Evaluación en tiempo real de dosis de neutrones en pacientes en tratamiento con radioterapia y detector para llevar a cabo ...

• Patent
  

  Uso de la rapamicina para el tratamiento de los déficits cognitivos asociados al síndrome de down. 

  Troca Marín, José Antonio; Alves Sampaio, Alexandra Manuela; Montesinos Gutiérrez, María Luz (Oficina Española de Patentes y Marcas , 2012-01-13)

  Uso de la rapamicina para el tratamiento de los déficits cognitivos asociados al síndrome de Down.La presente invención ...

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