Fisiología Médica y Biofísica
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Papel de la quinasa humana VRK1 en la biología del neuroblastoma [PhD Thesis]
(2020-01-29)El neuroblastoma es el tumor extracraneal sólido más frecuente en la infancia. Su comportamiento es muy heterogéneo, pudiéndose dar desde regresión espontánea hasta tumores metastásicos muy agresivos. Uno de los ...
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Estudio de la relevancia de la interacción entre SPN Y PP1 en tumorigénesis [PhD Thesis]
(2019-12-13)El gen SPN es un supresor de tumores importante en la progresión y malignidad tumoral en muchos tipos de tumores, entre ellos el cáncer de mama. Esta característica parece ser dependiente, al menos parcialmente, de su ...
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Estudio del calcio mitocondrial en terminales nerviosos motores y su relación en el proceso de neurotransmisión. Alteraciones en la atrofia muscular espinal [PhD Thesis]
(2019-11-07)La mitocondria es uno de los principales moduladores de los niveles de calcio citosólico además de la principal fuente de energía de la célula. De particular importancia es el papel que tiene en células polarizadas como ...
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Caracterización de EMX1 y EMX2 como nuevos genes supresores de tumores en sarcoma [PhD Thesis]
(2019-06-28)En esta tesis se estudia la biología de los genes EMX1 y EMX2 y se proponen como los factores de transcripción responsables de la reducción de las poblaciones de las células madre del cáncer (CSCs) que intervienen en el ...
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Single‐cell transcriptomic and functional characterization of cortical parvalbumin interneurons in a novel conditional knock‐out mouse lacking CSPα/DNAJC5 [PhD Thesis]
(2019-07-05)Neurodegenerative diseases are progressive disorders currently without cure. Indeed, the molecular mechanisms underlying synaptic and neuronal degeneration are poorly understood. Cysteine String Protein‐α/DNAJC5 (CSPα/DNAJC5) ...
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Improvements in Pain, Well-being, Arterial Pressure, and Lower Limb Volume Following Andullation Therapy in Healthy and Unhealthy Humans [Article]
(International Dose-Response Society, 2019-04-01)Our aim was to test the effects of Andullation therapy on pain threshold, pain perception, feeling of well-being, arterial pressure, and leg volume in healthy and unhealthy patients. We used a multidirectional vibration ...
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A Poglut1 mutation causes a muscular dystrophy with reduced Notch signaling and satellite cell loss [Article]
(Wiley-Blackwell Publishing Ltd., 2016)Skeletal muscle regeneration by muscle satellite cells is a physiological mechanism activated upon muscle damage and regulated by Notch signaling. In a family with autosomal recessive limbgirdle muscular dystrophy, we ...
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Factores neurotroficos y antioxidantes en el liquido cefalorraquideo durante el envejecimiento normal o con deterioro cognitivo leve y en la enfermedad de parkinson [PhD Thesis]
(2019)El líquido cefalorraquídeo (LCR) se encuentra en íntimo contacto con el tejido nervioso, y en su composición puede reflejar lo que acontece en el mismo. Constituye una fuente ideal de biomarcadores, pudiéndose considerar ...
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Accurate,robust and harmonized implementation of morpho-functional imaging in treatment planning for personalized radiotherapy [Article]
(Public Library of Science, 2019-01-09)In this work we present a methodology able to use harmonized PET/CT imaging in dose painting by number (DPBN) approach by means of a robust and accurate treatment planning system. Image processing and treatment planning ...
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Rotenone selectively occludes sensitivity to hypoxia in rat carotid body glomus cells [Article]
(Wiley-Blackwell Publishing Ltd., 2003)Carotid body glomus cells release transmitters in response to hypoxia due to the increase of excitability resulting from inhibition of O2 -regulated K+ channels. However, the mechanisms involved in the detection of changes ...
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MECHANISMS OF DISEASE Acute Oxygen-Sensing Mechanisms [Article]
(Massachusetts Medical Society, 2005)JOSEPH PRIESTLEY, ONE OF THE THREE SCIENTISTS CREDITED WITH THE discovery of oxygen, described the death of mice that were deprived of oxygen. However, he was also well aware of the toxicity of too much oxygen, stating, ...
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First aid kit for hypoxic survival: sensors and strategies [Article]
(University of Chicago Press, 2010)Survival success under conditions of acute oxygen deprivation depends on efficiency of the central and peripheral chemoreception, optimization of oxygen extraction from the hypoxic environment and its delivery to the ...
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Two novel therapies for the treatment of type 1 diabetes mellitus. [PhD Thesis]
(2019-01-14)Type 1 diabetes mellitus (T1DM) is caused by an autoimmune destruction of islet β cells. Current treatments are based on replacement therapy using insulin analogs but, due to the impossibility to simulate physiological ...
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Activación de las células glómicas por hipoxia y lactato: el cuerpo carotídeo como sensor metabólico. [PhD Thesis]
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Presynaptic calcium dynamics, neuronal excitability and synaptic vesicle Cycle in central synapses lacking cysteine string protein-alpha (CSP-ALPHA). [PhD Thesis]
(2017-12-22)Cysteine String Protein-α (CSP-α) is a molecular co-chaperone of the synaptic vesicles that prevents presynaptic degeneration. The role of CSP-α in the machinery of calcium dependent release of neurotransmitter from synaptic ...
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Efectos de los fotoperiodos, administración de estrógenos y castración sobre la actividad peptidásica y metabolismo oxidativo en hipotálamo y corteza cerebral [PhD Thesis]
(1978-05-18)CONCLUSIONES: 1. En el grupo de animales controles la actividad LAP es mayor en el hipotálamo que en la corteza. La actividad enzimática oxidativa es mayor en el hipotálamo para ICDH y menor para MDH. 2. La administración ...
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Exocytotic catecholamine release is not associated with cation flux through channels in the vesicle membrane but Na+ influx through the fusion pore [Article]
(Macmillan, 2007-07-22)Release of charged neurotransmitter molecules through a narrow fusion pore requires charge compensation by other ions. It has been proposed that this may occur by ion flow from the cytosol through channels in the vesicle ...
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