• PhD Thesis
  

  Remodelado ventricular adverso tras reperfusión aguda. Efecto cardioprotector de la Urocortina-2 

  Mayoral González, Isabel (2021-07-02)

  Las enfermedades cardiovasculares son la principal causa de muerte en el mundo desarrollado, siendo tres de ellas las más ...

• Article
  

  Brugada syndrome masked by complete left bundle branch block: A clinical and functional study of its association with the p.1449Y>H SCN5A variant 

  Arana Rueda, Eduardo; Pezzotti, María R.; Pedrote, Alonso; Acosta, Juan; Frutos-López, Manuel; Varela, Lourdes M.; García-Fernández, Noelia; Castellano Orozco, Antonio Gonzalo (Wiley Periodicals, LLC., 2021-07)

  SCN5A gene variants are associated with both Brugada syndrome and conduction disturbances, sometimes expressing an ...

• Article
  

  Selective expression of the neurexin substrate for presenilin in the adult forebrain causes deficits in associative memory and presynaptic plasticity 

  Sánchez Hidalgo, Ana Carmen; Arias-Aragón, Francisco; Romero Barragán, M. Teresa; Martín-Cuevas, Celia; Delgado-García, José M; Martinez-Mir, Amalia; Gómez Scholl, Francisco Manuel (Elsevier, 2021-10-15)

  Presenilins (PS) form the active subunit of the gamma-secretase complex, which mediates the proteolytic clearance of a ...

• PhD Thesis
  

  Papel de la proteína de supervivencia de la motoneurona (SMN) en la maduración sináptica 

  Franco Espín, Antonio (2021-07-30)

  La atrofia muscular espinal (AME), la causa genética más frecuente de mortalidad infantil, es una enfermedad neurodegenerativa ...

• Article
  

  SARAF and EFHB Modulate Store-Operated Ca2+ Entry and Are Required for Cell Proliferation, Migration and Viability in Breast Cancer Cells 

  Jardin, Isaac; Nieto Felipe, Enrique; Alvarado, Sandra; Diez Bello, Raquel; López, Jose J.; Smani Hajami, Tarik; Rosado, Juan Antonio (MDPI, 2021)

  Breast cancer is among the most common malignancies in women. From the molecular point of view, breast cancer can be ...

• Article
  

  Theranostics in boron neutron capture therapy 

  Sauerwein, Wolfgang A. G.; Sancey, Lucie; Hey-Hawkins, Evamarie; Kellert, Martin; Panza, Luigi; Imperio, Daniela; Balcerzyk, Marcin (MDPI, 2021-04-10)

  Boron neutron capture therapy (BNCT) has the potential to specifically destroy tumor cells without damaging the tissues ...

• Article
  

  A cross-sectional study of foot growth and its correlation with anthropometric parameters in a representative cohort of schoolchildren from southern spain 

  González Elena, María Luisa; Fernández-Espejo, Emilio; Castro Méndez, Aurora; Guerra Martín, María Dolores; Córdoba Fernández, Antonio (MDPI, 2021-04-12)

  Background: The relationship between growth of the foot and other anthropometric parameters during body development until ...

• Article
  

  Prolyl Hydroxylase-dependent Modulation of Eukaryotic Elongation Factor 2 Activity and Protein Translation under Acute Hypoxia 

  Romero-Ruiz, Antonio; Bautista, Lucía; Navarro, Virginia; Heras Garvín, Antonio; Castellano Orozco, Antonio Gonzalo; López Barneo, José; Pascual, Alberto (American Society for Biochemistry and Molecular Biology, 2012-02-03)

  Early adaptive responses to hypoxia are essential for cell survival, but their nature and underlying mechanisms are poorly ...

• Article
  

  The HERC1 ubiquitin ligase regulates presynaptic membrane dynamics of central synapses 

  Montes Fernández, María de los Ángeles; Pérez Villegas, Eva María; García-Gonzalo, Francesc R.; Pedrazza, Leonardo; Rosa, José Luis; Álvarez de Toledo Naranjo, Guillermo; Armengol, José Ángel (Nature Research, 2020-07-21)

  HERC1 is a ubiquitin ligase protein, which, when mutated, induces several malformations and intellectual disability in ...

• Article
  

  Simulación en cirugía cardíaca: ¿el futuro de la docencia en nuestra especialidad? 

  Juvin-Bouvier, Charles E.; Torrejón-Domínguez, José M.; Tena-Santana, Gonzalo; Laviana-Martínez, Fernando; Rojas-Bermúdez, Camilo; Rodríguez-Mora, Felipe; Álvarez de Toledo Naranjo, Guillermo (Sociedad Española de Cirugía Cardiovascular y Endovascular (SECCE), 2017-04-05)

  Introducción: La simulación como herramienta docente se está estableciendo como una prioridad en los currículos de nuestra ...

• Article
  

  Proteoglycans involved in bidirectional communication between mast cells and hippocampal neurons 

  Flores Cordero, Juan Antonio; Ramírez-Ponce, M. Pilar; Montes Fernández, María de los Ángeles; Balseiro Gómez, Santiago; Acosta López, Jorge; Álvarez de Toledo, Guillermo; Alés González de la Higuera, Eva María (BMC, 2019-05-20)

  Background: Mast cells (MCs) in the brain can respond to environmental cues and relay signals to neurons that may directly ...

• Article
  

  A New Role for Myosin II in Vesicle Fission 

  Flores Cordero, Juan Antonio; Balseiro Gómez, Santiago; Cabeza, Jose M.; Acosta, Jorge; Ramirez-Ponce, Pilar; Alés González de la Higuera, Eva María (Public Library of Science, 2014-06-24)

  An endocytic vesicle is formed from a flat plasma membrane patch by a sequential process of invagination, bud formation and ...

• Article
  

  Mechanisms of Granule Membrane Recapture followingExocytosis in Intact Mast Cells 

  Cabeza, Jose M.; Acosta López, Jorge; Alés González de la Higuera, Eva María (American Society for Biochemistry and Molecular Biology, 2013-05-24)

  In secretory cells, several exocytosis-coupled forms of endocytosis have been proposed including clathrin-mediated ...

• Article
  

  Glucose sensing by carotid body glomus cells: potential implications in disease 

  Gao Chen, Lin; Ortega Sáenz, Patricia; García Fernández, María; González Rodríguez, Patricia; Caballero Eraso, Candela; López Barneo, José (Frontiers Media, 2014-10-15)

  The carotid body (CB) is a key chemoreceptor organ in which glomus cells sense changes in blood O2, CO2, and pH levels. ...

• Article
  

  Resistance of subventricular neural stem cells to chronic hypoxemia despite structural disorganization of the germinal center and impairment of neuronal and oligodendrocyte survival 

  D'Anglemont De Tassigny, Xavier; Sirerol-Piquer, M Salomé; Gómez-Pinedo, Ulises; Pardal Redondo, Ricardo; Bonilla, Sonia; Capilla-González, Vivian; López Barneo, José (Dove Medical Press Ltd., 2015)

  Chronic hypoxemia, as evidenced in de-acclimatized high-altitude residents or in patients with chronic obstructive ...

• Article
  

  Integrated molecular signaling involving mitochondrial dysfunction and alteration of cell metabolism induced by tyrosine kinase inhibitors in cancer 

  Rodríguez Hernández, María A.; Cruz Ojeda, Patricia de la; López-Grueso, María José; Navarro Villarán, Elena; Requejo-Aguilar, Raquel; Castejón Vega, Beatriz; Muntané Relat, Jordi (Elsevier, 2020-03-16)

  Cancer cells have unlimited replicative potential, insensitivity to growth-inhibitory signals, evasion of apoptosis,cellular ...

• Article
  

  Native α-synuclein, 3-nitrotyrosine proteins, and patterns of nitro-α-synuclein-immunoreactive inclusions in saliva and submandibulary gland in parkinson’s disease 

  Fernández-Espejo, Emilio; Rodríguez de Fonseca, Fernando; Suárez, Juan; Tolosa, Eduardo; Vilas, Dolores; Aldecoa, Iban (MDPI, 2021-05-01)

  Background. Salivary α-synuclein (aSyn) and its nitrated form, or 3-nitrotyrosine-αsynuclein (3-NT-αSyn), hold promise as ...

• Article
  

  Role of the holoenzyme PP1-SPN in the dephosphorylation of the rb family of tumor suppressors during cell cycle 

  Verdugo Sivianes, Eva María; Carnero Moya, Amancio (MDPI, 2021-05-06)

  Cell cycle progression is highly regulated by modulating the phosphorylation status of the retinoblastoma protein (pRB) ...

• Article
  

  Neurexin Dysfunction in Adult Neurons Results in Autistic-like Behavior in Mice 

  Rabaneda, Luis G.; Robles Lanuza, Estefanía; Nieto González, José Luis; Gómez Scholl, Francisco Manuel (Cell Press, 2014)

  Autism spectrum disorders (ASDs) comprise a group of clinical phenotypes characterized by repetitive behavior and social ...

• Article
  

  HIF-2a is essential for carotid body development and function 

  Macías, David; Cowburn, Andrew S.; Torres Torrelo, Hortensia; Ortega Sáenz, Patricia; López Barneo, José; Johnson, Randall S (eLife Sciences Publications, 2018-04-19)

  Mammalian adaptation to oxygen flux occurs at many levels, from shifts in cellular metabolism to physiological adaptations ...

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